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Redox Report
Communications in Free Radical Research
Volume 5, 2000 - Issue 1
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The antihypertensive hydralazine is an efficient scavenger of acrolein

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Pages 47-49 | Published online: 19 Jul 2013

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William B. Rizzo. (2016) Genetics and prospective therapeutic targets for Sjögren-Larsson Syndrome. Expert Opinion on Orphan Drugs 4:4, pages 395-406.
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R. Shi, J. C. Page & M. Tully. (2015) Molecular mechanisms of acrolein-mediated myelin destruction in CNS trauma and disease. Free Radical Research 49:7, pages 888-895.
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V. R. Mali & S. S. Palaniyandi. (2014) Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease. Free Radical Research 48:3, pages 251-263.
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Articles from other publishers (44)

Chaoyong Tian, Yao Li, Yang Yang, Juan Qu & Dingjun Zha. (2024) Hydralazine alleviates noise-induced hearing loss by scavenging acrolein. Neuroscience Letters 818, pages 137540.
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Edmond A. Rogers, Timothy Beauclair, Jhon Martinez, Shatha J. Mufti, David Kim, Siyuan Sun, Rachel L. Stingel, Alexandra M. Dieterly, Nikita Krishnan, Jennifer Crodian & Riyi Shi. (2023) The contribution of initial concussive forces and resulting acrolein surge to β-amyloid accumulation and functional alterations in neuronal networks using a TBI-on-a-chip model. Lab on a Chip 23:15, pages 3388-3404.
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Edmond A. Rogers, Timothy Beauclair, Andrew Thyen & Riyi Shi. (2022) Utilizing novel TBI-on-a-chip device to link physical impacts to neurodegeneration and decipher primary and secondary injury mechanisms. Scientific Reports 12:1.
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Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen & Riyi Shi. (2021) Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1. Translational Neurodegeneration 10:1.
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Josy Augustine, Evan P. Troendle, Peter Barabas, Corey A. McAleese, Thomas Friedel, Alan W. Stitt & Tim M. Curtis. (2021) The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy. Frontiers in Endocrinology 11.
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Houssem Boulebd, Nguyen Minh Tam, Adam Mechler & Quan V. Vo. (2020) Substitution effects on the antiradical activity of hydralazine: a DFT analysis. New Journal of Chemistry 44:38, pages 16577-16583.
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Houssem Boulebd, Imene Amine Khodja, Mai Van Bay, Nguyen Thi Hoa, Adam Mechler & Quan V. Vo. (2020) Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights. The Journal of Physical Chemistry B 124:20, pages 4123-4131.
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Chengzong Li, Zhongping Su, Liqi Ge, Yuchen Chen, Xuguan Chen & Yong Li. (2020) Cardioprotection of hydralazine against myocardial ischemia/reperfusion injury in rats. European Journal of Pharmacology 869, pages 172850.
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Yong Li, Daorong Hou, Xuguan Chen, Jingfeng Zhu, Ruyi Zhang, Wei Sun, Peng Li, Yunfan Tian & Xiangqing Kong. (2019) Hydralazine protects against renal ischemia-reperfusion injury in rats. European Journal of Pharmacology 843, pages 199-209.
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Rosemary E. McDowell, Peter Barabas, Josy Augustine, Olivier Chevallier, Philip McCarron, Mei Chen, J. Graham McGeown & Tim M. Curtis. (2018) Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine. Diabetologia 61:12, pages 2654-2667.
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Yazhou Lin, Zhe Chen, Jonathan Tang, Peng Cao & Riyi Shi. (2018) Acrolein Contributes to the Neuropathic Pain and Neuron Damage after Ischemic–Reperfusion Spinal Cord Injury. Neuroscience 384, pages 120-130.
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Philip C. Burcham. (2018) Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation. Biochemical Pharmacology 154, pages 397-406.
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Melissa Tully, Jonathan Tang, Lingxing Zheng, Glen Acosta, Ran Tian, Lee Hayward, Nicholas Race, David Mattson & Riyi Shi. (2018) Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis. Frontiers in Neurology 9.
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Jacqueline R. KulbeIndrapal N. SinghJuan A. WangJohn E. CebakEdward D. Hall. (2018) Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats. Journal of Neurotrauma 35:11, pages 1280-1293.
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Abeje Ambaw, Lingxing Zheng, Mitali A. Tambe, Katherine E. Strathearn, Glen Acosta, Scott A. Hubers, Fang Liu, Seth A. Herr, Jonathan Tang, Alan Truong, Elwood Walls, Amber Pond, Jean-Christophe Rochet & Riyi Shi. (2018) Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease. Molecular and Cellular Neuroscience 88, pages 70-82.
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Anne Nègre-Salvayre, Sandra Garoby-Salom, Audrey Swiader, Myriam Rouahi, Mélanie Pucelle & Robert Salvayre. (2017) Proatherogenic effects of 4-hydroxynonenal. Free Radical Biology and Medicine 111, pages 127-139.
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Dan Li, Na Wang, Jingdong Zhang, Shuren Ma, Zhuangzhuang Zhao & Elizabeth M. Ellis. (2017) Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2. Chemico-Biological Interactions 276, pages 203-209.
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Lu Yao, Yun-Tao Wu, Guo-Xiang Tian, Chang-Quan Xia, Feng Zhang & Wei Zhang. (2017) Acrolein Scavenger Hydralazine Prevents Streptozotocin-Induced Painful Diabetic Neuropathy and Spinal Neuroinflammation in Rats. The Anatomical Record 300:10, pages 1858-1864.
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Ran Tian & Riyi Shi. (2017) Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. Journal of Neurochemistry 141:5, pages 708-720.
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Giulio Vistoli, Mara Colzani, Angelica Mazzolari, Danilo De Maddis, Giovanni Grazioso, Alessandro Pedretti, Marina Carini & Giancarlo Aldini. (2016) Computational approaches in the rational design of improved carbonyl quenchers: focus on histidine containing dipeptides. Future Medicinal Chemistry 8:14, pages 1721-1737.
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Wei-Yang Chen, Jingwen Zhang, Smita Ghare, Shirish Barve, Craig McClain & Swati Joshi-Barve. (2016) Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. Cellular and Molecular Gastroenterology and Hepatology 2:5, pages 685-700.
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Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega-Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao & Riyi Shi. (2016) Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. Journal of Neurochemistry 138:2, pages 328-338.
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Jonghyuck Park, Lingxing Zheng, Andrew Marquis, Michael Walls, Brad Duerstock, Amber Pond, Sasha Vega-Alvarez, He Wang, Zheng Ouyang & Riyi Shi. (2014) Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage. Journal of Neurochemistry 129:2, pages 339-349.
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Rosemary E McDowell, J Graham McGeown, Alan W Stitt & Tim M Curtis. (2013) Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease. Future Medicinal Chemistry 5:2, pages 189-211.
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Zhengzhi Xie, Shahid P. Baba, Brooke R. Sweeney & Oleg A. Barski. (2013) Detoxification of aldehydes by histidine-containing dipeptides: From chemistry to clinical implications. Chemico-Biological Interactions 202:1-3, pages 288-297.
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Philip C. Burcham, Albert Raso & Lisa M. Kaminskas. (2012) Chaperone Heat Shock Protein 90 Mobilization and Hydralazine Cytoprotection against Acrolein-Induced Carbonyl Stress. Molecular Pharmacology 82:5, pages 876-886.
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Dan Li & Elizabeth M. Ellis. (2012) Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. NeuroToxicology 33:5, pages 1368-1374.
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Riyi Shi, Todd Rickett & Wenjing Sun. (2011) Acrolein-mediated injury in nervous system trauma and diseases. Molecular Nutrition & Food Research 55:9, pages 1320-1331.
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Qin Zhu, Zheng Sun, Yue Jiang, Feng Chen & Mingfu Wang. (2011) Acrolein scavengers: Reactivity, mechanism and impact on health. Molecular Nutrition & Food Research 55:9, pages 1375-1390.
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G. Leung, W. Sun, L. Zheng, S. Brookes, M. Tully & R. Shi. (2011) Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse. Neuroscience 173, pages 150-155.
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Mukesh Maheshwari, Jessica K. Roberts, Brent DeSutter, Karen T. Duong, Joseph Tingling, Janelle N. Fawver, Hayley E. Schall, Michael Kahle & Ian V. J. Murray. (2010) Hydralazine Modifies Aβ Fibril Formation and Prevents Modification by Lipids in Vitro . Biochemistry 49:49, pages 10371-10380.
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Kristin Hamann & Riyi Shi. (2009) Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury. Journal of Neurochemistry 111:6, pages 1348-1356.
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Kristin Hamann, Abigail Durkes, Hui Ouyang, Koji Uchida, Amber Pond & Riyi Shi. (2008) Critical role of acrolein in secondary injury following ex vivo spinal cord trauma . Journal of Neurochemistry 107:3, pages 712-721.
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Philip C. Burcham. (2008) Potentialities and Pitfalls Accompanying Chemico-Pharmacological Strategies against Endogenous Electrophiles and Carbonyl Stress. Chemical Research in Toxicology 21:4, pages 779-786.
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A Negre-Salvayre, C Coatrieux, C Ingueneau & R Salvayre. (2008) Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. British Journal of Pharmacology 153:1, pages 6-20.
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Kristin Hamann, Genevieve Nehrt, Hui Ouyang, Brad Duerstock & Riyi Shi. (2007) Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cord. Journal of Neurochemistry 0:0, pages 071108171001006-???.
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Giancarlo Aldini, Isabella Dalle‐Donne, Roberto Maffei Facino, Aldo Milzani & Marina Carini. (2006) Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls. Medicinal Research Reviews 27:6, pages 817-868.
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Elizabeth M. Ellis. (2007) Reactive carbonyls and oxidative stress: Potential for therapeutic intervention. Pharmacology & Therapeutics 115:1, pages 13-24.
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Lisa M. Kaminskas, Simon M. Pyke & Philip C. Burcham. (2007) Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs. Rapid Communications in Mass Spectrometry 21:7, pages 1155-1164.
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Giancarlo Aldini, Isabella Dalle‐Donne, Roberto Colombo, Roberto Maffei Facino, Aldo Milzani & Marina Carini. (2006) Lipoxidation‐Derived Reactive Carbonyl Species as Potential Drug Targets in Preventing Protein Carbonylation and Related Cellular Dysfunction. ChemMedChem 1:10, pages 1045-1058.
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Peishan Liu-Snyder, Richard Ben Borgens & Riyi Shi. (2006) Hydralazine rescues PC12 cells from acrolein-mediated death. Journal of Neuroscience Research 84:1, pages 219-227.
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Leopoldo Raij, Eugene G. DeMaster & Edgar A. Jaimes. (2001) Cigarette smoke-induced endothelium dysfunction: role of superoxide anion. Journal of Hypertension 19:5, pages 891-897.
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