Publication Cover
Redox Report
Communications in Free Radical Research
Volume 5, 2000 - Issue 1
422
Views
47
CrossRef citations to date
0
Altmetric
Miscellany

The antihypertensive hydralazine is an efficient scavenger of acrolein

, &
Pages 47-49 | Published online: 19 Jul 2013

REFERENCES

  • Marnett LJ. Health effects of aldehydes and alcohols in mobile source emissions. In: The Health Effects Institute. Air Pollution, the Automobile, and Public Health. Washington, DC: National Academy Press, 1988; 579-603.
  • Russo A, Mitchell JB, DeGraff Wet al. Depletion of cellular glutathione by exogenous spermine in V79 cells: implications for spermine-induced hyperthermic sensitization. Cancer Res 1985; 45: 4910–4914.
  • Uchida K, Kanematsu M, Moimitsu Y et al. Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidised low density lipoproteins. J Biol Chem 1998; 273: 16058–16066.
  • Burcham PC. Internal hazards: baseline DNA damage by endogenous products of normal metabolism. Mutat Res 1999; 443: 11–36.
  • Uchida K, Kanematsu M, Sakai K et al. Protein-bound acrolein: potential markers of oxidative stress. Proc Natl Acad Sci USA 1998; 95: 4882–4887.
  • Calingasan NY, Uchida K, Gibson GE. Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease. J Neurochem 1999; 72: 751–756.
  • Al-Abed Y, Bucala R. Efficient scavenging of fatty acid oxidation products by aminoguanidine. Chem Res Toxicol 1997; 10: 875–879.
  • Hipkiss AR, Worthington VC, Himsworth DT et al. Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite. Biochim Biophys Acta 1998; 1380: 46–54.
  • Reece PA. Hydralazine and related compounds: chemistry, metabolism, and mode of action. Med Res Rev 1981; 1: 73–96.
  • O'Donnell JP, Proveaux WJ, Ma JK. High-performance liquid chromatographic studies of reaction of hydralazine with biogenic aldehydes and ketones. J Pharm Sci 1979; 68: 1524–1526.
  • Burcham PC, Kuhan YT. Introduction of carbonyl groups into proteins by the lipid peroxidation product, malondialdehyde. Biochem Biophys Res Commit 1996; 220: 996–1001.
  • Burcham PC, Harman AW. Paracetamol-induced stimulation of glycogenolysis in isolated mouse hepatocytes is not directly associated with cell death. Biochem Pharmacol 1989; 38: 2357–2362.
  • Lalich JJ, Paik WC. Influence of hydralazine consumption on allylamine induced myocardial fibrosis and hypertrophy in rats. Exp Mol Pathol 1974; 21: 29–39.
  • Johnson P, Wei Y, Huentelman Mt et al. Hydralazine, but not captopril, decreases free radical production and apoptosis in neurons and thymocytes. Free Radic Res 1998; 28: 393–402.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.