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Original Article

Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe–statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia

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Pages 249-259 | Accepted 30 Oct 2007, Published online: 30 Nov 2007

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Read on this site (6)

Alberico Catapano, Peter P Toth, Joanne E Tomassini & Andrew M Tershakovec. (2013) The efficacy and safety of ezetimibe coadministered with statin therapy in various patient groups. Clinical Lipidology 8:1, pages 13-41.
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Nkechinyere Ijioma & Jennifer G Robinson. (2011) Lipid-lowering effects of ezetimibe and simvastatin in combination. Expert Review of Cardiovascular Therapy 9:2, pages 131-145.
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Alberico L. Catapano. (2009) Perspectives on low-density lipoprotein cholesterol goal achievement. Current Medical Research and Opinion 25:2, pages 431-447.
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Wendy Jessup, Arnold Herman & John Chapman. (2008) Phytosterols in cardiovascular disease:innocuous dietary components,or accelerators of atherosclerosis?. Future Lipidology 3:3, pages 301-310.
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Harold E Bays, David Neff, Joanne E Tomassini & Andrew M Tershakovec. (2008) Ezetimibe: cholesterol lowering and beyond. Expert Review of Cardiovascular Therapy 6:4, pages 447-470.
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Articles from other publishers (41)

Mengmeng Wang, Min Yu, Amel Thanina Amrouche, Fan Jie, Shengyang Ji & Baiyi Lu. (2023) Human intestinal Caco-2 cell model to evaluate the absorption of 7-ketophytosterols and their effects on cholesterol transport. Food Science and Human Wellness 12:5, pages 1701-1707.
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Panagiotis Anagnostis, Vasileios Kotsis, Maciej Banach & Dimitri P. Mikhailidis. (2023) Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?. Metabolites 13:2, pages 145.
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Eder Carlos Rocha Quintão. (2020) Plasma Non-cholesterol Sterols as Markers of Cholesterol Synthesis and Intestinal Absorption: A Critical Review. Current Pharmaceutical Design 26:40, pages 5152-5162.
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Pooja Malhotra, Ravinder K. Gill, Seema Saksena & Waddah A. Alrefai. (2020) Disturbances in Cholesterol Homeostasis and Non-alcoholic Fatty Liver Diseases. Frontiers in Medicine 7.
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Shinji Koba. (2020) Noncholesterol Sterols and Sitosterolemia in Clinical Practice. Journal of Atherosclerosis and Thrombosis 27:5, pages 406-408.
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Eric J. Brandt, Lane B. Benes, Linda Lee, Thomas D. Dayspring, Matthew Sorrentino & Michael Davidson. (2018) The Effect of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition on Sterol Absorption Markers in a Cohort of Real-World Patients. Journal of Cardiovascular Pharmacology and Therapeutics 24:1, pages 54-61.
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Peter J H Jones, Maryam Shamloo, Dylan S MacKay, Todd C Rideout, Semone B Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J Baer, Kara L Calkins, Harry R Davis, P Barton Duell, Henry Ginsberg, Helena Gylling, David Jenkins, Dieter Lütjohann, Mohammad Moghadasian, Robert A Moreau, David Mymin, Richard E OstlundJrJr, Rouyanne T Ras, Javier Ochoa Reparaz, Elke A Trautwein, Stephen Turley, Tim Vanmierlo & Oliver Weingärtner. (2018) Progress and perspectives in plant sterol and plant stanol research. Nutrition Reviews 76:10, pages 725-746.
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Shanqun Jiang, Scott A. Venners, Kang Li, Yi-Hsiang Hsu, Justin Weinstock, Yanfeng Zou, Faming Pan & Xiping Xu. (2017) Effect modification by region in the associations of LEP G2548A and LEPR Q223R polymorphisms with statin-induced CK elevation . Oncotarget 8:64, pages 107565-107576.
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Kang Li, Yanhong Liu, Scott A. Venners, Yi-Hsiang Hsu, Shanqun Jiang, Justin Weinstock, Yiyang Sun, Binyan Wang & Xiping Xu. (2016) Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia. Clinical and Applied Thrombosis/Hemostasis 23:4, pages 336-344.
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Matthew Peach, Ren Xu, Dan Fitzpatrick, Lisa Hamilton, Ransi Somaratne, Robert Scott, Scott M. Wasserman & C. Stephen Djedjos. (2016) Effect of evolocumab on cholesterol synthesis and absorption. Journal of Lipid Research 57:12, pages 2217-2224.
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Daniela M.T. Malina, Francisco A. Fonseca, Sílvio A. Barbosa, Soraia H. Kasmas, Valéria A. Machado, Carolina N. França, Ney C. Borges, Ronilson A. Moreno & Maria C. Izar. (2015) Additive effects of plant sterols supplementation in addition to different lipid-lowering regimens. Journal of Clinical Lipidology 9:4, pages 542-552.
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Olivier Descamps, Joanne E. Tomassini, Jianxin Lin, Adam B. Polis, Arvind Shah, Philippe Brudi, Mary E. Hanson & Andrew M. Tershakovec. (2015) Variability of the LDL-C lowering response to ezetimibe and ezetimibe + statin therapy in hypercholesterolemic patients. Atherosclerosis 240:2, pages 482-489.
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Pere Leyes, Esteban Martínez, María Larrousse, Montserrat Cofán, Joan Trabal, Ana María Pérez-Heras, María T Forga & Emilio Ros. (2014) Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial. BMC Infectious Diseases 14:1.
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Dylan S. Mackay, Peter J.H. Jones, Semone B. Myrie, Jogchum Plat & Dieter Lütjohann. (2014) Methodological considerations for the harmonization of non-cholesterol sterol bio-analysis. Journal of Chromatography B 957, pages 116-122.
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Naoko Kumagai, Shin-ichiro Miura, Bo Zhang, Keita Noda & Keijiro Saku. (2013) Effects of ezetimibe on hypercholesterolemia in the lipid profile in patients with metabolic syndrome: Zenith Trial. IJC Metabolic & Endocrine 1, pages 7-12.
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Michael H. Davidson, Jason Voogt, Jayraz Luchoomun, Julie Decaris, Salena Killion, Drina Boban, Alexander Glass, Hussein Mohammad, Yun Lu, Deona Villegas, Richard Neese, Marc Hellerstein, David Neff, Thomas Musliner, Joanne E. Tomassini & Scott Turner. (2013) Inhibition of intestinal cholesterol absorption with ezetimibe increases components of reverse cholesterol transport in humans. Atherosclerosis 230:2, pages 322-329.
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Simone P. Barbosa, Lívia C. Lins, Francisco A. Fonseca, Lívia N. Matos, Ana C. Aguirre, Henrique T. Bianco, Jonatas B. Amaral, Carolina N. França, Jose M. Santana & Maria C. Izar. (2013) Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. Life Sciences 92:14-16, pages 845-851.
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Scott M. Grundy. (2013) Plasma noncholesterol sterols as indicators of cholesterol absorption. Journal of Lipid Research 54:4, pages 873-875.
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Sung-Woo Park. (2013) Intestinal and Hepatic Niemann-Pick C1-Like 1. Diabetes & Metabolism Journal 37:4, pages 240.
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Thomas R. Fleming. 2013. Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials. Proceedings of the Fourth Seattle Symposium in Biostatistics: Clinical Trials 137 156 .
A. J. Taylor, T. C. Villines & E. J. Stanek. (2012) Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe. European Heart Journal 33:23, pages 2939-2945.
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Nuntakorn Thongtang, Jianxin Lin, Ernst J. Schaefer, Robert S. Lowe, Joanne E. Tomassini, Arvind K. Shah & Andrew M. Tershakovec. (2012) Effects of ezetimibe added to statin therapy on markers of cholesterol absorption and synthesis and LDL-C lowering in hyperlipidemic patients. Atherosclerosis 225:2, pages 388-396.
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S.H. Kasmas, M.C. Izar, C.N. França, S.C. Ramos, F.T. Moreira, T. Helfenstein, R.A. Moreno, N.C. Borges, A.M. Figueiredo-Neto & F.A. Fonseca. (2012) Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies. Brazilian Journal of Medical and Biological Research 45:11, pages 1095-1101.
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Tamio Teramoto, Atsunori Kashiwagi, Shun Ishibashi & Hiroyuki Daida. (2012) Cross-Sectional Survey to Assess the Status of Lipid Management in High-Risk Patients With Dyslipidemia: Clinical Impact of Combination Therapy With Ezetimibe. Current Therapeutic Research 73:1-2, pages 1-15.
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Silvia C Ramos, Francisco A Fonseca, Soraia H Kasmas, Flávio T Moreira, Tatiana Helfenstein, Ney C Borges, Ronilson A Moreno, Vinicius M Rezende, Fernanda C Silva & Maria C Izar. (2011) The role of soluble fiber intake in patients under highly effective lipid-lowering therapy. Nutrition Journal 10:1.
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Eric J. Niesor, Evelyne Chaput, Andreas Staempfli, Denise Blum, Michael Derks & David Kallend. (2011) Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. Atherosclerosis 219:2, pages 761-767.
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Allen J. Taylor. (2011) Another clinical evidence straw on the $4 billion ezetimibe camel's back. Atherosclerosis 218:1, pages 23-25.
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Olivier S. Descamps, Johan De Sutter, Michel Guillaume & Luc Missault. (2011) Where does the interplay between cholesterol absorption and synthesis in the context of statin and/or ezetimibe treatment stand today?. Atherosclerosis 217:2, pages 308-321.
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H.A.W. Neil, U. Ceglarek, J. Thiery, S. Paul, A. Farmer & R.R. Holman. (2010) Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: A randomised placebo controlled factorial trial. Atherosclerosis 213:2, pages 512-517.
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Timo E. Strandberg, Helena Gylling, Reijo S. Tilvis & Tatu A. Miettinen. (2010) Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. Atherosclerosis 210:1, pages 282-287.
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Susan G. Lakoski, Fang Xu, Gloria L. Vega, Scott M. Grundy, Manisha Chandalia, Chun Lam, Robert S. Lowe, Michael E. Stepanavage, Thomas A. Musliner, Jonathan C. Cohen & Helen H. Hobbs. (2010) Indices of Cholesterol Metabolism and Relative Responsiveness to Ezetimibe and Simvastatin. The Journal of Clinical Endocrinology & Metabolism 95:2, pages 800-809.
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Thomas Sudhop, Michael Reber, Diane Tribble, Aditi Sapre, William Taggart, Patrice Gibbons, Thomas Musliner, Klaus von Bergmann & Dieter Lütjohann. (2009) Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men. Journal of Lipid Research 50:10, pages 2117-2123.
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