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Original Article

Pharmacokinetic profile of a 24-hour controlled-release OROS formulation of hydromorphone in the presence of alcohol

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Pages 297-305 | Accepted 12 Nov 2007, Published online: 05 Dec 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Rand Ahmad, Samaneh Alaei & Hamid Omidian. (2018) Safety and performance of current abuse-deterrent formulations. Expert Opinion on Drug Metabolism & Toxicology 14:12, pages 1255-1271.
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Harold W Goforth. (2010) Hydromorphone-OROS formulation. Expert Opinion on Pharmacotherapy 11:7, pages 1207-1214.
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J Turgeon, R Gröning, G Sathyan, J Thipphawong & U Richarz. (2010) The pharmacokinetics of a long-acting OROS hydromorphone formulation. Expert Opinion on Drug Delivery 7:1, pages 137-144.
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Sharon M Weinstein. (2009) A new extended release formulation (OROS) of hydromorphone in the management of pain. Therapeutics and Clinical Risk Management 5, pages 75-80.
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Kaoru Toyama, Naoki Uchida, Hitoshi Ishizuka, Takehiko Sambe & Shinichi Kobayashi. (2015) Single-dose evaluation of safety, tolerability and pharmacokinetics of newly formulated hydromorphone immediate-release and hydrophilic matrix extended-release tablets in healthy Japanese subjects without co-administration of an opioid antagonist. The Journal of Clinical Pharmacology 55:9, pages 975-984.
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N. Jedinger, S. Schrank, S. Mohr, A. Feichtinger, J. Khinast & E. Roblegg. (2015) Alcohol dose dumping: The influence of ethanol on hot-melt extruded pellets comprising solid lipids. European Journal of Pharmaceutics and Biopharmaceutics 92, pages 83-95.
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N. Jedinger, J. Khinast & E. Roblegg. (2014) The design of controlled-release formulations resistant to alcohol-induced dose dumping – A review. European Journal of Pharmaceutics and Biopharmaceutics 87:2, pages 217-226.
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Krishna Devarakonda, Joris Vandenbossche & Ute Richarz. (2013) Complementary pharmacokinetic measures to further define the profile of once-daily OROS hydromorphone ER during single-dose and steady-state dosing. SpringerPlus 2:1.
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Thomas B. Gregory. (2013) Hydromorphone: Evolving to Meet the Challenges of Today’s Health Care Environment. Clinical Therapeutics 35:12, pages 2007-2027.
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Frank Porecca & Tamara KingMellar P Davis. 2012. Analgesics for Cancer Pain. Analgesics for Cancer Pain 42 59 .
William D. Fiske, Janet Jobes, Qinfang Xiang, Sou-Chan Chang & Irma H. Benedek. (2012) The Effects of Ethanol on the Bioavailability of Oxymorphone Extended-Release Tablets and Oxymorphone Crush-Resistant Extended-Release Tablets. The Journal of Pain 13:1, pages 90-99.
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Johann D. Ringe, Susanne Schäfer, Antonie M. Wimmer & Thorsten Giesecke. (2011) Use of OROS® hydromorphone in the treatment of osteoarthritis and osteoporosis: A pooled analysis of three non-interventional studies focusing on different starting dosesAnwendung von OROS® Hydromorphon in der Behandlung von Arthrose- und Osteoporoseschmerzen; eine gepoolte Analyse von drei nicht-interventionellen Studien mit verschiedenen Startdosen. Wiener klinische Wochenschrift 124:1-2, pages 25-31.
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Kenneth Todd Moore, Dominique St-Fleur, Nadia Cardillo Marricco, Jay Ariyawansa, Véronique Pagé, Jayalakshmi Natarajan, Gaetano Morelli & Ute Richarz. (2011) A Randomized Study of the Effects of Food on the Pharmacokinetics of Once-Daily Extended-Release Hydromorphone in Healthy Volunteers. The Journal of Clinical Pharmacology 51:11, pages 1571-1579.
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David R. P. Guay. (2010) Oral Hydromorphone Extended-Release. The Consultant Pharmacist 25:12, pages 816-828.
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Ira Whitten. 2010. The Essence of Analgesia and Analgesics. The Essence of Analgesia and Analgesics 448 451 .
Anjanette P. Smith, Terry W. Moore, Benjamin J. Westenberger & William H. Doub. (2010) In vitro dissolution of oral modified-release tablets and capsules in ethanolic media. International Journal of Pharmaceutics 398:1-2, pages 93-96.
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Robert B. Raffa & Joseph V. PergolizziJrJr. (2010) Opioid Formulations Designed to Resist/Deter Abuse. Drugs 70:13, pages 1657-1675.
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Michael J. Brennan & Steven Stanos. (2010) Strategies to Optimize Pain Management With Opioids While Minimizing Risk of Abuse. PM&R 2:6, pages 544-558.
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David Lussier, Ute Richarz & Gabriele Finco. (2010) Use of Hydromorphone, with Particular Reference to the OROS® Formulation, in the Elderly. Drugs & Aging 27:4, pages 327-335.
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Natalie J. Carter & Gillian M. Keating. (2010) OROS® Hydromorphone Prolonged Release. CNS Drugs 24:4, pages 337-361.
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Jackie Gardner-Nix & Sebastiano Mercadante. (2010) The Role of OROS ® Hydromorphone in the Management of Cancer Pain . Pain Practice 10:1, pages 72-77.
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Magdi Hanna, Alberto Tuca & John Thipphawong. (2009) An open-label, 1-year extension study of the long-term safety and efficacy of once-daily OROS® hydromorphone in patients with chronic cancer pain. BMC Palliative Care 8:1.
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Robert L Barkin, Dean Shirazi & Eric Kinzler. (2009) Effect of Ethanol on the Release of Morphine Sulfate From Oramorph SR Tablets. American Journal of Therapeutics 16:6, pages 482-486.
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Hans Lennernäs. (2009) Ethanol−Drug Absorption Interaction: Potential for a Significant Effect on the Plasma Pharmacokinetics of Ethanol Vulnerable Formulations. Molecular Pharmaceutics 6:5, pages 1429-1440.
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Jay S Grider. (2009) Clinical application of extended-release hydromorphone for pain management. Therapy 6:5, pages 653-656.
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Howard S. Smith. (2009) Enteral Controlled-Release Opioid Delivery Systems. Pain Medicine 10:suppl 1, pages S30-S38.
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Magdi Hanna & John Thipphawong. (2008) A randomized, double-blind comparison of OROS®hydromorphone and controlled-release morphine for the control of chronic cancer pain. BMC Palliative Care 7:1.
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Donna A. Volpe, Ebenezer B. Asafu-Adjaye, Christopher D. Ellison, Suresh Doddapaneni, Ramana S. Uppoor & Mansoor A. Khan. (2008) Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers. The AAPS Journal 10:2, pages 360-362.
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