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Current Medical Research and Opinion Volume 25, 2009 - Issue 7
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Original Article

5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study

Ralf Baron Division of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, GermanyCorrespondence[email protected]
,
Victor Mayoral Clínica del Dolor, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, Spain
,
Göran Leijon Department of Clinical and Experimental Medicine, Division of Neurology, University Hospital, Linköping, Sweden
,
Andreas Binder Division of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, Germany
,
Ilona Steigerwald Grünenthal GmbH, Aachen, Germany
&
Michael Serpell Pain Clinic, Gartnavel General Hospital, University of Glasgow, Glasgow, UK
Pages 1663-1676 | Accepted 05 May 2009, Published online: 01 Jun 2009

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Frank G Preston, David R Riley, Shazli Azmi & Uazman Alam. (2023) Painful Diabetic Peripheral Neuropathy: Practical Guidance and Challenges for Clinical Management. Diabetes, Metabolic Syndrome and Obesity 16, pages 1595-1612.
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Xiding Yang, Ronghua Zhu, Jing Zhang, Zaihua Hou, Lingfeng Yang, Xiao Fan, Qiangyong Yan, Jingjing Li, Zhiguang Zhou & Pingfei Fang. (2023) First-in-human phase I studies of YJ001 spray applied to local skin in healthy subjects and patients with diabetic neuropathic pain. Expert Opinion on Investigational Drugs 32:6, pages 553-562.
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Mengmeng Wang, Zepeng Zhang, Jia Mi, Guoqiang Wang, Lulu Tian, Yunyun Zhao, Xiaomin Li, Xiangyan Li & Xiuge Wang. (2021) Interventional Clinical Trials on Diabetic Peripheral Neuropathy: A Retrospective Analysis. Journal of Pain Research 14, pages 2651-2664.
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Marion Voute, Véronique Morel & Gisèle Pickering. (2021) Topical Lidocaine for Chronic Pain Treatment. Drug Design, Development and Therapy 15, pages 4091-4103.
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Ahmed R. Elsayed, Mohamed A. Elharty & Ahmed S. Elgebaly. (2021) Efficacy and Safety of Lidocaine Patch 5% Supplementation to Intra-articular Bupivacaine Dexmedetomidine after Knee Arthroscopy under General Anesthesia: A Randomized Controlled Study. Egyptian Journal of Anaesthesia 37:1, pages 69-76.
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Pablo Katz, Valeria Pegoraro & Hiltrud Liedgens. (2017) Characteristics, resource utilization and safety profile of patients prescribed with neuropathic pain treatments: a real-world evidence study on general practices in Europe – the role of the lidocaine 5% medicated plaster. Current Medical Research and Opinion 33:8, pages 1481-1489.
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Rainer Sabatowski, Irmgard Bösl, Simone König, Bettina Buchheister, Torsten Meier & Ralf Baron. (2017) Treatment of postherpetic neuralgia with 5% lidocaine medicated plaster in elderly patients – subgroup analyses from three European clinical trials. Current Medical Research and Opinion 33:3, pages 595-603.
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Oscar A de León-Casasola & Victor Mayoral. (2016) The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence. Journal of Pain Research 9, pages 67-79.
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Mark S. Juhn, Bruce Parsons, Roxanna Varvara & Alesia Sadosky. (2015) Pregabalin for painful diabetic peripheral neuropathy: strategies for dosing, monotherapy vs. combination therapy, treatment-refractory patients, and adverse events. Current Medical Research and Opinion 31:5, pages 1017-1026.
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Roberto Casale & Consalvo Mattia. (2014) Building a diagnostic algorithm on localized neuropathic pain (LNP) and targeted topical treatment: focus on 5% lidocaine-medicated plaster. Therapeutics and Clinical Risk Management 10, pages 259-268.
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Roberto Casale, Maria Di Matteo, Cristina E Minella, Guido Fanelli & Massimo Allegri. (2014) Reduction of painful area as new possible therapeutic target in post-herpetic neuropathic pain treated with 5% lidocaine medicated plaster: a case series. Journal of Pain Research 7, pages 353-357.
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Patricia Bruckenthal & Robert L Barkin. (2013) Options for treating postherpetic neuralgia in the medically complicated patient. Therapeutics and Clinical Risk Management 9, pages 329-340.
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Srinivas Nalamachu, Matthew Wieman, Leah Bednarek & Surya Chitra. (2013) Influence of anatomic location of lidocaine patch 5% on effectiveness and tolerability for postherpetic neuralgia. Patient Preference and Adherence 7, pages 551-557.
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Kai-Uwe Kern, Srinivas Nalamachu, Louis Brasseur & Joanna M Zakrzewska. (2013) Can treatment success with 5% lidocaine medicated plaster be predicted in cancer pain with neuropathic components or trigeminal neuropathic pain?. Journal of Pain Research 6, pages 261-280.
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Hiltrud Liedgens, Marko Obradovic & Mark Nuijten. (2013) Health economic evidence of 5% lidocaine medicated plaster in post-herpetic neuralgia. ClinicoEconomics and Outcomes Research 5, pages 597-609.
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Tina Khadem & Vanessa Stevens. (2013) Therapeutic Options for the Treatment of Postherpetic Neuralgia: A Systematic Review. Journal of Pain & Palliative Care Pharmacotherapy 27:3, pages 268-283.
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Rudolf Likar, Ingo Kager, Michael Obmann, Wolfgang Pipam & Reinhard Sittl. (2012) Treatment of localized neuropathic pain after disk herniation with 5% lidocaine medicated plaster. International Journal of General Medicine 5, pages 689-692.
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Gérard Mick & Gerardo Correa-Illanes. (2012) Topical pain management with the 5% lidocaine medicated plaster – a review. Current Medical Research and Opinion 28:6, pages 937-951.
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Michael A. Überall & Gerhard H.H. Müller-Schwefe. (2012) Patient perceptions associated with the 5% lidocaine medicated plaster in daily practice. Current Medical Research and Opinion 28:6, pages 901-909.
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Cory Toth. (2012) Drug safety evaluation of pregabalin . Expert Opinion on Drug Safety 11:3, pages 487-502.
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Andrew Nicolaou, Bruce Nicholson, Guy Hans & Louis Brasseur. (2011) Outcome predictors for treatment success with 5% lidocaine medicated plaster in low back pain with neuropathic components and neuropathic pain after surgical and nonsurgical trauma. Journal of Pain Research 4, pages 25-38.
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Jayadave Shakher & Martin J Stevens. (2011) Update on the management of diabetic polyneuropathies. Diabetes, Metabolic Syndrome and Obesity 4, pages 289-305.
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Burkhard Gustorff, David Hauer, Johannes Thaler, Astrid Seis & Julia Draxler. (2011) Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models – two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers. Expert Opinion on Pharmacotherapy 12:18, pages 2781-2790.
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Robert L. Barkin, Stacy J. Barkin, Gordon A. Irving & Allan Gordon. (2011) Management of Chronic Noncancer Pain in Depressed Patients. Postgraduate Medicine 123:5, pages 143-154.
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Charles E. Argoff. (2011) Review of Current Guidelines on the Care of Postherpetic Neuralgia. Postgraduate Medicine 123:5, pages 134-142.
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Abd A Tahrani, Trevor Askwith & Martin J Stevens. (2010) Emerging drugs for diabetic neuropathy. Expert Opinion on Emerging Drugs 15:4, pages 661-683.
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Stefanie Rehm, Andreas Binder & Ralf Baron. (2010) Post-herpetic neuralgia: 5% lidocaine medicated plaster, pregabalin, or a combination of both? A randomized, open, clinical effectiveness study. Current Medical Research and Opinion 26:7, pages 1607-1619.
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Zorba Paster & Charlene M. Morris. (2010) Treatment of the Localized Pain of Postherpetic Neuralgia. Postgraduate Medicine 122:1, pages 91-107.
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