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Original Article

Innovative pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: a large observational study under conditions of daily practice

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Pages 1377-1387 | Accepted 18 Mar 2010, Published online: 09 Apr 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (23)

Gineke Koopmans-Klein, Joeri Van Op den Bosch, Yvonne van Megen, Hans Prenen, Frank Huygen & Isabelle Mancini. (2017) Prolonged release oxycodone and naloxone treatment counteracts opioid-induced constipation in patients with severe pain compared to previous analgesic treatment. Current Medical Research and Opinion 33:12, pages 2217-2227.
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Emiliano Petrò, Elena Ruffini, Melania Cappuccio, Valeria Guerini, Gloria Belotti, Sara Fascendini, Cristina Licini & Claudio Marcassa. (2016) Low-dose oral prolonged-release oxycodone/naloxone for chronic pain in elderly patients with cognitive impairment: an efficacy–tolerability pilot study. Neuropsychiatric Disease and Treatment 12, pages 559-569.
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Michael A Ueberall, Alice Eberhardt & Gerhard HH Mueller-Schwefe. (2016) Quality of life under oxycodone/naloxone, oxycodone, or morphine treatment for chronic low back pain in routine clinical practice. International Journal of General Medicine 9, pages 39-51.
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Fabio Guerriero, Anna Roberto, Maria Teresa Greco, Carmelo Sgarlata, Marco Rollone & Oscar Corli. (2016) Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study. Drug Design, Development and Therapy 10, pages 1515-1523.
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Marzia Lazzari, Claudio Marcassa, Silvia Natoli, Roberta Carpenedo, Clarissa Caldarulo, Maria B Silvi & Mario Dauri. (2016) Switching to low-dose oral prolonged-release oxycodone/naloxone from WHO-Step I drugs in elderly patients with chronic pain at high risk of early opioid discontinuation. Clinical Interventions in Aging 11, pages 641-649.
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Amir Rumman, Zane R. Gallinger & Louis W. C. Liu. (2016) Opioid induced constipation in cancer patients: pathophysiology, diagnosis and treatment. Expert Review of Quality of Life in Cancer Care 1:1, pages 25-35.
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Marzia Lazzari, Maria Teresa Greco, Claudio Marcassa, Simona Finocchi, Clarissa Caldarulo & Oscar Corli. (2015) Efficacy and tolerability of oral oxycodone and oxycodone/naloxone combination in opioid-naïve cancer patients: a propensity analysis. Drug Design, Development and Therapy 9, pages 5863-5872.
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Wojciech Leppert. (2015) Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction. Drug Design, Development and Therapy 9, pages 2215-2231.
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Fabio Guerriero, Carmelo Sgarlata, Claudio Marcassa, Giovanni Ricevuti & Marco Rollone. (2015) Efficacy and tolerability of low-dose oral prolonged-release oxycodone/naloxone for chronic nononcological pain in older patients. Clinical Interventions in Aging 10, pages 1-11.
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Sabine Hesselbarth, Kai Hermanns & Petra Oepen. (2015) Prolonged-release oxycodone/naloxone in opioid-naïve patients – subgroup analysis of a prospective observational study. Expert Opinion on Pharmacotherapy 16:4, pages 457-464.
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Thomas Nolte, Ulf Schutter & Oliver Loewenstein. (2014) Cancer pain therapy with a fixed combination of prolonged-release oxycodone/naloxone: results from a non-interventional study. Pragmatic and Observational Research 5, pages 1-13.
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Gineke Koopmans, Karen Simpson, Javier De Andrés, Eberhard Albert Lux, Michel Wagemans & Yvonne Van Megen. (2014) Fixed ratio (2:1) prolonged-release oxycodone/naloxone combination improves bowel function in patients with moderate-to-severe pain and opioid-induced constipation refractory to at least two classes of laxatives. Current Medical Research and Opinion 30:11, pages 2389-2396.
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M. Lazzari, A. F. Sabato, C. Caldarulo, M. Casali, P. Gafforio, C. Marcassa & F. Leonardis. (2014) Effectiveness and tolerability of low-dose oral oxycodone/naloxone added to anticonvulsant therapy for noncancer neuropathic pain: an observational analysis. Current Medical Research and Opinion 30:4, pages 555-564.
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Mellar Davis, Harold W Goforth & Pam Gamier. (2013) Oxycodone combined with opioid receptor antagonists: efficacy and safety. Expert Opinion on Drug Safety 12:3, pages 389-402.
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Sebastiano Mercadante & Antonello Giarratano. (2013) Combined oral prolonged-release oxycodone and naloxone in chronic pain management. Expert Opinion on Investigational Drugs 22:1, pages 161-166.
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Gill E Mundin, Kevin J Smith, Jana Mysicka, Gerhard Heun, Mathias Krämer, Udo Hahn & Christian Leuner. (2012) Validated in vitro/in vivo correlation of prolonged-release oxycodone/naloxone with differing dissolution rates in relation to gastrointestinal transit times. Expert Opinion on Drug Metabolism & Toxicology 8:12, pages 1495-1503.
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Philippe Ducrotté & Christian Caussé. (2012) The Bowel Function Index: a new validated scale for assessing opioid-induced constipation. Current Medical Research and Opinion 28:3, pages 457-466.
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Kai Hermanns, Uwe Junker & Thomas Nolte. (2012) Prolonged-release oxycodone/naloxone in the treatment of neuropathic pain – results from a large observational study. Expert Opinion on Pharmacotherapy 13:3, pages 299-311.
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Benoît Coffin & Christian Caussé. (2011) Constipation assessment scales in adults: a literature review including the new Bowel Function Index. Expert Review of Gastroenterology & Hepatology 5:5, pages 601-613.
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V. Andresen, G. Becker, T. Frieling, M. Goebel-Stengel, F. Gundling, A. Herold, M. Karaus, J. Keller, M. Kim, P. Klose, H. Krammer, M. E. Kreis, R. Kuhlbusch-Zicklam, J. Langhorst, P. Layer, R. Lenzen-Großimlinghaus, A. Madisch, H. Mönnikes, S. Müller-Lissner, D. Rubin, M. Schemann, J. Schwille-Kiuntke, A. Stengel, M. Storr, I. van der Voort, W. Voderholzer, T. Wedel, S. Wirz, H. Witzigmann & C. Pehl. (2022) Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019. Zeitschrift für Gastroenterologie 60:10, pages 1528-1572.
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Grace J. Lee, Shin Ae Kim, Yea Jin Kim & Seog Bae Oh. (2021) Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain. Brain Research 1762, pages 147445.
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Toshiki Mimura. 2021. Pelvic Floor Disorders. Pelvic Floor Disorders 741 752 .
Bart J. Morlion, Stefan A. Mueller‐Lissner, Renato Vellucci, Wojciech Leppert, Benoît C. Coffin, Sara L. Dickerson & Tony O'Brien. (2017) Oral Prolonged‐Release Oxycodone/Naloxone for Managing Pain and Opioid‐Induced Constipation: A Review of the Evidence. Pain Practice 18:5, pages 647-665.
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Esther S. Kim. (2017) Oxycodone/Naloxone Prolonged Release: A Review in Severe Chronic Pain. Clinical Drug Investigation 37:12, pages 1191-1201.
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Jeannine Brant, Lisa Keller, Karen McLeod, Chao Hsing Yeh & Linda Eaton. (2017) Chronic and Refractory Pain: A Systematic Review of Pharmacologic Management in Oncology
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Magdalena Kocot-KępskaRenata ZajączkowskaAnna Przeklasa-MuszyńskaJan Dobrogowski. (2017) The role of oxycodone/naloxone in pain management. BÓL 17:4, pages 26-40.
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Stefan Müller-Lissner, Gabrio Bassotti, Benoit Coffin, Asbjørn Mohr Drewes, Harald Breivik, Elon Eisenberg, Anton Emmanuel, Françoise Laroche, Winfried Meissner & Bart Morlion. (2016) Opioid-Induced Constipation and Bowel Dysfunction: A Clinical Guideline. Pain Medicine, pages pnw255.
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MA Ueberall. (2015) Differential Gastrointestinal Effects of Who-Step III Opioids in Low Back Pain Patients with vs. Without Constipation: Post-Hoc Analysis of Data from a 12-Week Prospective, Open-Label Blinded Endpoint Streamlined Study. Global Journal of Anesthesiology, pages 037-051.
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Ignacio Velázquez Rivera, Modesto García Escobar, Jorge Juan Moya Riera, Javier Manuel del Saz de la Torre, Pedro Fenollosa Vázquez, José Manuel González Mesa, Alfonso Casado, Mayte Martín Fuentes & Javier de Andrés Ares. (2015) Changes in Quality of Life after 3 months of Usual Care in a Large Sample of Patients with Noncancer Pain: The “QOOL: Quality of Life and Pain” Study. Pain Practice 15:7, pages 633-642.
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Jan Poelaert, Gineke Koopmans-Klein, Alioune Dioh, Frédéric Louis, Mayken Gorissen, David Logé, Joeri Van Op den bosch & Yvonne J.B. van Megen. (2015) Treatment With Prolonged-Release Oxycodone/Naloxone Improves Pain Relief and Opioid-Induced Constipation Compared With Prolonged-Release Oxycodone in Patients With Chronic Severe Pain and Laxative-Refractory Constipation. Clinical Therapeutics 37:4, pages 784-792.
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Manuel Heim. (2015) Noninterventional Study of Transdermal Fentanyl (Fentavera) Matrix Patches in Chronic Pain Patients: Analgesic and Quality of Life Effects. Pain Research and Treatment 2015, pages 1-9.
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Bart Morlion, Katri Elina Clemens & Will Dunlop. (2014) Quality of Life and Healthcare Resource in Patients Receiving Opioids for Chronic Pain: A Review of the Place of Oxycodone/Naloxone. Clinical Drug Investigation 35:1, pages 1-11.
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Arturo Cuomo, Gennaro Russo, Gennaro Esposito, Cira Antonietta Forte, Marianna Connola & Claudio Marcassa. (2013) Efficacy and Gastrointestinal Tolerability of Oral Oxycodone/Naloxone Combination for Chronic Pain in Outpatients With Cancer. American Journal of Hospice and Palliative Medicine® 31:8, pages 867-876.
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V. C. P. C. Dongen, P. J. L. Vanelderen, G. Koopmans‐Klein, Y. J. B. Megen, J. Van Zundert & F. J. P. M. Huygen. (2014) Patient preference with respect to QoL and reduction in opioid‐induced constipation ( OIC ) after treatment with prolonged‐release ( PR ) oxycodone/naloxone compared with previous analgesic therapy [ PREFER study] . International Journal of Clinical Practice 68:11, pages 1364-1375.
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Anne Z. DePriest & Katie Miller. (2014) Oxycodone/Naloxone: Role in Chronic Pain Management, Opioid-Induced Constipation, and Abuse Deterrence. Pain and Therapy 3:1, pages 1-15.
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Sabine Hesselbarth, Oliver Löwenstein & Thomas Cegla. (2014) Effects of prolonged-release oxycodone/naloxone on pain control, bowel function and quality of life: A prospective observational study. Scandinavian Journal of Pain 5:2, pages 75-81.
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Celeste B. Burness & Gillian M. Keating. (2014) Oxycodone/Naloxone Prolonged-Release: A Review of Its Use in the Management of Chronic Pain While Counteracting Opioid-Induced Constipation. Drugs 74:3, pages 353-375.
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Antonio Gatti, Manuela Casali, Marzia Lazzari, Giuseppe Tufaro, Paolo Gafforio, Claudia Silvestri, Claudio Marcassa & Alessandro F. Sabato. (2012) Prolonged-Release Oxycodone/Naloxone in Nonmalignant Pain: Single-Center Study in Patients with Constipation. Advances in Therapy 30:1, pages 41-59.
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S. Bader, M. Weber & G. Becker. (2013) Ist die pharmakologische Therapie der Obstipation in der Palliativmedizin evidenzbasiert?Is the pharmacological treatment of constipation in palliative care evidence based?. Der Schmerz 26:5, pages 568-586.
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Christian Compagnone, Fernanda Tagliaferri & Andrea Ramelli. (2011) Some concerns about the article: "High doses of oxycodone–naloxone combination may provide poor analgesia.". Supportive Care in Cancer 20:5, pages 889-890.
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Gálvez Rafael, Provencio Mariano, Sanz-Ortiz Jaime, Ribera Ma Victoria, Esteban Emilio, Collado Francisco, Vara Francisco, Díaz Pilar, Rocafort Javier, Cobo Manuel, Traseira Susana & Brosa Max. (2013) Análisis económico de oxicodona LP/ naloxona LP en el manejo del dolor intenso y el estreñimiento asociado al tratamiento con opioides en España. PharmacoEconomics Spanish Research Articles 9:1, pages 23-34.
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Sam H Ahmedzai, Friedemann Nauck, Gil Bar-Sela, Björn Bosse, Petra Leyendecker & Michael Hopp. (2011) A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain. Palliative Medicine 26:1, pages 50-60.
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Marie-Louise Navez, Florentin Clère, Youlia Kirova, Claire Josse, Bertrand Chuberre & Christian Caussé. (2011) Caractéristiques cliniques des douleurs cancéreuses sévères chez les patients traités par oxycodone. Cohorte OCS2. Douleurs : Evaluation - Diagnostic - Traitement 12:3, pages 110-122.
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