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Research Article

Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use

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Read on this site (5)

Harry P. Cintineo, Marissa L. Bello, Alexa J. Chandler, Thomas D. Cardaci, Bridget A. McFadden & Shawn M. Arent. (2022) Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial. Journal of the International Society of Sports Nutrition 19:1, pages 543-564.
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Marcos Daou, Julia Montagner Sassi, Matthew W. Miller & Adam M. Gonzalez. (2019) Effects of a Multi-Ingredient Energy Supplement on Cognitive Performance and Cerebral-Cortical Activation. Journal of Dietary Supplements 16:2, pages 129-140.
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Kyle R. Cesareo, Justin R. Mason, Patrick G. Saracino, Margaret C. Morrissey & Michael J. Ormsbee. (2019) The effects of a caffeine-like supplement, TeaCrine®, on muscular strength, endurance and power performance in resistance-trained men. Journal of the International Society of Sports Nutrition 16:1.
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Marissa L. Bello, Alan J. Walker, Bridget A. McFadden, David J. Sanders & Shawn M. Arent. (2019) The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players. Journal of the International Society of Sports Nutrition 16:1.
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Tim N. Ziegenfuss, Scott M. Habowski, Jennifer E. Sandrock, A. William Kedia, Chad M. Kerksick & Hector L. Lopez. (2017) A Two-Part Approach to Examine the Effects of Theacrine (TeaCrine®) Supplementation on Oxygen Consumption, Hemodynamic Responses, and Subjective Measures of Cognitive and Psychometric Parameters. Journal of Dietary Supplements 14:1, pages 9-24.
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Articles from other publishers (18)

Michael D. Roberts, Michael B. La Monica, Betsy Raub, Jennifer E. Sandrock, Tim N. Ziegenfuss, Ryan Smith, Varun B. Dwaraka & Hector L. Lopez. (2023) The Effects of a Multi-Ingredient Supplement Containing Wasabia Japonica Extract, Theacrine, and Copper (I) Niacin Chelate on Peripheral Blood Mononuclear Cell DNA Methylation, Transcriptomics, and Sirtuin Activity. Physiologia 3:2, pages 233-246.
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Henrique Santa Capita Cerqueira, Hugo Tourinho Filho, Marcos Corrêa Junior & Carlos Eduardo Martinelli Junior. (2022) Effects of Theacrine as a Pre-Workout Supplement. International Journal of Environmental Research and Public Health 19:21, pages 14037.
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Goutam Mondal, Yan-Hong Wang, Ryan Yates, Richard Bloomer & Matthew Butawan. (2022) Caffeine and Methylliberine: A Human Pharmacokinetic Interaction Study. Journal of Exercise and Nutrition 5:3.
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Michael D. Roberts, Shelby C. Osburn, Joshua S. Godwin, Bradley A. Ruple, Michael B. La Monica, Betsy Raub, Jennifer E. Sandrock, Tim N. Ziegenfuss & Hector L. Lopez. (2022) Enhance Trial: Effects of NAD3® on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults: A Subset Analysis Focused on Blood Cell NAD+ Concentrations and Lipid Metabolism. Physiologia 2:1, pages 20-31.
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Yu Shi, Shao-Rong Zhang, Kang Sun, Xing-Hua Wang, Jie-ling Jiang, li-Yong Luo & Liang Zeng. (2022) Characterization of bitter taste theacrine in Pu-erh tea. Journal of Food Composition and Analysis 106, pages 104331.
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Joseph J. Knapik, Daniel W. Trone, Ryan A. Steelman, Emily K. Farina & Harris R. Lieberman. (2022) Adverse effects associated with use of specific dietary supplements: The US Military Dietary Supplement Use Study. Food and Chemical Toxicology 161, pages 112840.
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Shuran Zhang, Jiqiang Jin, Jiedan Chen, Sezai Ercisli & Liang Chen. (2022) Purine alkaloids in tea plants: component, biosynthetic mechanism and genetic variation. Beverage Plant Research 2:1, pages 1-9.
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Cian-Fen Jhuo, Yu-Yu Hsu, Wen-Ying Chen & Jason T. C. Tzen. (2021) Attenuation of Tumor Development in Mammary Carcinoma Rats by Theacrine, an Antagonist of Adenosine 2A Receptor. Molecules 26:24, pages 7455.
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Yue-Yue Sheng, Jing Xiang, Ze-Shi Wang, Jing Jin, Ying-Qi Wang, Qing-Sheng Li, Da Li, Zhou-Tao Fang, Jian-Liang Lu, Jian-Hui Ye, Yue-Rong Liang & Xin-Qiang Zheng. (2020) Theacrine From Camellia kucha and Its Health Beneficial Effects. Frontiers in Nutrition 7.
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Wen-Jun Duan, Lei Liang, Ming-Hai Pan, Dan-Hua Lu, Ting-Mei Wang, Shan-Bing Li, Han-Bing Zhong, Xuan-Jun Yang, Yan Cheng, Bo Liu, Wei-Xi Li, Hiroshi Kurihara, Wei Bi, Yi-Fang Li & Rong-Rong He. (2020) Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation. Phytomedicine 77, pages 153281.
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Trisha A. VanDusseldorp, Matthew T. Stratton, Alyssa R. Bailly, Alyssa J. Holmes, Michaela G. Alesi, Yuri Feito, Gerald T. Mangine, Garrett M. Hester, Tiffany A. Esmat, Megan Barcala, Karleena R. Tuggle, Michael Snyder & Andrew S. Modjeski. (2020) Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients 12:3, pages 654.
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Timothy S. Murbach, Róbert Glávits, John R. Endres, Amy E. Clewell, Gábor Hirka, Adél Vértesi, Erzsébet Béres & Ilona Pasics Szakonyiné. (2019) A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of Toxicology 2019, pages 1-25.
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David O. Kennedy. (2019) Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance. Sports Medicine 49:S1, pages 39-58.
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Eliza Oprea, Lavinia L. Ruta & Ileana C. Farcasanu. 2019. Sports and Energy Drinks. Sports and Energy Drinks 65 129 .
Guo-En Wang, Yi-Fang Li, Yu-Jia Zhai, Lian Gong, Jing-Yu Tian, Mo Hong, Nan Yao, Yan-Ping Wu, Hiroshi Kurihara & Rong-Rong He. (2018) Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. Metabolism 85, pages 227-239.
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Hui HeDejian MaLaura Brooks CroneMatthew ButawanBernd MeibohmRichard J. BloomerCharles R. Yates. (2017) Assessment of the Drug–Drug Interaction Potential Between Theacrine and Caffeine in Humans. Journal of Caffeine Research 7:3, pages 95-102.
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Majid S. KoozehchianConrad P. EarnestY. Peter JungP. Blaise CollinsAbigail O'ConnorRyan DaltonSong Yi ShinRyan SowinskiChris RasmussenPeter S. MuranoMike GreenwoodRichard B. Kreider. (2017) Dose Response to One Week of Supplementation of a Multi-Ingredient Preworkout Supplement Containing Caffeine Before Exercise. Journal of Caffeine Research 7:3, pages 81-94.
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Amy Clewell, Gábor Hirka, Róbert Glávits, Philip A. Palmer, John R. Endres, Timothy S. Murbach, Tennille Marx & Ilona Pasics Szakonyiné. (2016) A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. Journal of Toxicology 2016, pages 1-17.
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