102
Views
65
CrossRef citations to date
0
Altmetric
Original Articles

Genistein-Induced Cell Cycle Arrest and Apoptosis in a Head and Neck Squamous Cell Carcinoma Cell Line

Pages 12-19 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Tayyaba Nawaz, Sundus Nawaz, Waseem Khalid & Khalid Abdelsamea Mohamedahmed. (2023) Dietary phytochemicals beneficial to obesity and cancer management: a review. International Journal of Food Properties 26:1, pages 2006-2024.
Read now
Susanne Andres, Klaus Abraham, Klaus Erich Appel & Alfonso Lampen. (2011) Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 41:6, pages 463-506.
Read now
Rui Zhao, Nong Xiang, FredrickE. Domann & Weixiong Zhong. (2009) Effects of Selenite and Genistein on G2/M Cell Cycle Arrest and Apoptosis in Human Prostate Cancer Cells. Nutrition and Cancer 61:3, pages 397-407.
Read now
Fazlul H. Sarkar & Yiwei Li. (2003) Soy Isoflavones and Cancer Prevention. Cancer Investigation 21:5, pages 744-757.
Read now

Articles from other publishers (61)

Keighley N. Reisenauer, Jaquelin Aroujo, Yongfeng Tao, Santhalakshmi Ranganathan, Daniel Romo & Joseph H. Taube. (2023) Therapeutic vulnerabilities of cancer stem cells and effects of natural products. Natural Product Reports 40:8, pages 1432-1456.
Crossref
Alesia Ivashkevich. (2023) The role of isoflavones in augmenting the effects of radiotherapy. Frontiers in Oncology 12.
Crossref
Hana R. BajesSawsan A. OranYasser K. Bustanji. (2021) Chemical Composition and Antiproliferative and Antioxidant Activities of Methanolic Extract of Alcea setosa A. Malvaceae. Research Journal of Pharmacy and Technology, pages 6447-6454.
Crossref
Maryam Valizadeh, Farnoosh Alimohammadi, Ali Azarm, Zeynab Pourtaghi, Mohammad moein Derakhshan barjoei, Hamoun Sabri, Aryan Jafari, Zahra Arabpour, Pouyan Razavi, Melika Mokhtari & Niloofar Deravi. (2021) Uses of soybean isoflavonoids in dentistry: A literature review. Journal of Dental Sciences.
Crossref
Pei-Ling Hsieh, Yi-Wen Liao, Chang-Wei Hsieh, Pei-Ni Chen & Cheng-Chia Yu. (2020) Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating miR-34a/RTCB Axis. Nutrients 12:7, pages 1924.
Crossref
Zhengguo Ji, Chunyue Huo & Peiqian Yang. (2020) Genistein inhibited the proliferation of kidney cancer cells via CDKN2a hypomethylation: role of abnormal apoptosis. International Urology and Nephrology 52:6, pages 1049-1055.
Crossref
Sanya Haiaty, Mohammad‐Reza Rashidi, Maryam Akbarzadeh, Nazila F. Maroufi, Bahman Yousefi & Mohammad Nouri. (2020) Targeting vasculogenic mimicry by phytochemicals: A potential opportunity for cancer therapy. IUBMB Life 72:5, pages 825-841.
Crossref
Ana Isabel Barbosa, Ana Joyce Coutinho, Sofia A. Costa Lima & Salette Reis. (2019) Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field. Marine Drugs 17:12, pages 654.
Crossref
Alok Ranjan, Sharavan Ramachandran, Nehal Gupta, Itishree Kaushik, Stephen Wright, Suyash Srivastava, Hiranmoy Das, Sangeeta Srivastava, Sahdeo Prasad & Sanjay K. Srivastava. (2019) Role of Phytochemicals in Cancer Prevention. International Journal of Molecular Sciences 20:20, pages 4981.
Crossref
Rahul L. Gajbhiye, Sanjit K. Mahato, Anushree Achari, Parasuraman Jaisankar & V. Ravichandiran. 2019. Bioactive Natural Products for the Management of Cancer: from Bench to Bedside. Bioactive Natural Products for the Management of Cancer: from Bench to Bedside 91 109 .
Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Thomas H. Y. Leung & Hextan Y. S. Ngan. (2018) Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell International 18:1.
Crossref
Krzysztof Siemianowicz, Wirginia Likus, Mariola Dorecka, Renata Wilk, Włodzimierz Dziubdziela & Jarosław Markowski. (2018) Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?. BioMed Research International 2018, pages 1-15.
Crossref
Kurataka Otsuka, Yusuke Yamamoto, Ryosuke Matsuoka & Takahiro Ochiya. (2018) Maintaining good miRNAs in the body keeps the doctor away?: Perspectives on the relationship between food-derived natural products and microRNAs in relation to exosomes/extracellular vesicles. Molecular Nutrition & Food Research 62:1, pages 1700080.
Crossref
Chloe Matovina, Andrew C. Birkeland, Suzanna Zick & Andrew G. Shuman. (2016) Integrative Medicine in Head and Neck Cancer. Otolaryngology–Head and Neck Surgery 156:2, pages 228-237.
Crossref
Marcos Roberto de Oliveira. (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29, pages 35-44.
Crossref
Tarek Baati, Bochra Bejaoui Kefi, Aicha Aouane, Leila Njim, Florence Chaspoul, Vasile Heresanu, Abdelhamid Kerkeni, Fadoua Neffati & Mohamed Hammami. (2016) Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines. RSC Advances 6:103, pages 101688-101696.
Crossref
Xianyong Ma, Zongyong Jiang, Jian Zhang, Youjun Hu, Kaiguo Gao, Li Wang & Xuefen Yang. (2015) Isoflavone Ameliorates H<sub>2</sub>O<sub>2</sub> Induced Injury by Activating the Antioxidant System of Sow Mammary Gland Cell. Natural Science 07:12, pages 571-580.
Crossref
Satoru Matsuda, Akari Minami, Yuna Ono & Yasuko Kitagishi. 2015. Diet and Nutrition in Dementia and Cognitive Decline. Diet and Nutrition in Dementia and Cognitive Decline 1003 1010 .
IN GYU KIM, JIN SIK KIM, JAE HA LEE & EUN WIE CHO. (2014) Genistein decreases cellular redox potential, partially suppresses cell growth in HL-60 leukemia cells and sensitizes cells to γ-radiation-induced cell death. Molecular Medicine Reports 10:6, pages 2786-2792.
Crossref
James Kumi Diaka. (2014) Pyroelectrically Generated Very Low Dose Ionizing Radiation Enhances chemopreventive and Chemotherapeutic Effects of Genistein Isoflavone in Human Prostate Cancer Cells. Journal of Cancer Prevention & Current Research 1:2.
Crossref
Jimmy Pham, Bill Brownlow & Tamer Elbayoumi. (2013) Mitochondria-Specific Pro-Apoptotic Activity of Genistein Lipidic Nanocarriers. Molecular Pharmaceutics 10:10, pages 3789-3800.
Crossref
Ganji Purnachandra Nagaraju, Syed F Zafar & Bassel F El-Rayes. (2013) Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases. Nutrition Reviews 71:8, pages 562-572.
Crossref
Yiwei LiDejuan KongAamir AhmadBin BaoFazlul H. Sarkar. (2013) Antioxidant Function of Isoflavone and 3,3′-Diindolylmethane: Are They Important for Cancer Prevention and Therapy?. Antioxidants & Redox Signaling 19:2, pages 139-150.
Crossref
Sanjeev Banerjee & Paulraj Rajamani. 2013. Natural Products. Natural Products 2175 2254 .
Huili Wang & Suqin Han. (2012) Determination of Genistein by Flow‐injection Chemiluminescence Method Based on Ferricyanide Oxidation Sensitized by Rhodamine 6G. Journal of the Chinese Chemical Society 59:9, pages 1130-1136.
Crossref
Simon Mahoney, Frank Arfuso, Pierra Rogers, Susan Hisheh, David Brown, Michael Millward & Arun Dharmarajan. (2012) Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines. Journal of Biosciences 37:1, pages 73-84.
Crossref
Mariano Bizzarri, Simona Dinicola & Cesare Manetti. 2012. Systems Biology in Cancer Research and Drug Discovery. Systems Biology in Cancer Research and Drug Discovery 3 37 .
T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 730 741 .
Hisae Nakamura, Yuwei Wang, Takeshi Kurita, Hans Adomat, Gerald R. Cunha & Yuzhuo Wang. (2011) Genistein Increases Epidermal Growth Factor Receptor Signaling and Promotes Tumor Progression in Advanced Human Prostate Cancer. PLoS ONE 6:5, pages e20034.
Crossref
Janet M. Pavese, Rebecca L. Farmer & Raymond C. Bergan. (2010) Inhibition of cancer cell invasion and metastasis by genistein. Cancer and Metastasis Reviews 29:3, pages 465-482.
Crossref
Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad & Bharat B. Aggarwal. (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer and Metastasis Reviews 29:3, pages 405-434.
Crossref
X. Yang, S. Yang, C. McKimmey, B. Liu, S. M. Edgerton, W. Bales, L. T. Archer & A. D. Thor. (2010) Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation. Carcinogenesis 31:4, pages 695-702.
Crossref
Jamie L. McCall, Rebekah A. Burich & Philip C. Mack. (2010) GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines. Leukemia Research 34:1, pages 69-76.
Crossref
Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng & Bin Wang. (2009) Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells. Journal of Experimental & Clinical Cancer Research 28:1.
Crossref
K. Benthami, S. Ait Lyazidi, M. Haddad, M. Choukrad, B. Bennetau & S. Shinkaruk. (2009) Photophysics of Genistein isoflavone: Solvent and concentration effects studied by UV–visible spectroscopy and theoretical simulation. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 74:2, pages 385-390.
Crossref
Shashwati Basak, Deepa Pookot, Emily J. Noonan & Rajvir Dahiya. (2008) Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Molecular Cancer Therapeutics 7:10, pages 3195-3202.
Crossref
J. Katz, E. Blake, T.A. Medrano, Y. Sun & K.T. Shiverick. (2008) Isoflavones and gamma irradiation inhibit cell growth in human salivary gland cells. Cancer Letters 270:1, pages 87-94.
Crossref
Sanjeev Banerjee, Yiwei Li, Zhiwei Wang & Fazlul H. Sarkar. (2008) Multi-targeted therapy of cancer by genistein. Cancer Letters 269:2, pages 226-242.
Crossref
Rui Fang, Peter J. Houghton & Peter J. Hylands. (2008) Cytotoxic effects of compounds from Iris tectorum on human cancer cell lines. Journal of Ethnopharmacology 118:2, pages 257-263.
Crossref
Hye-Young Shim, Jong-Hwa Park, Hyun-Dong Paik, Seung-Yeol Nah, Darrick S.H.L. Kim & Ye Sun Han. (2007) Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain–caspase and apoptosis signaling kinase 1–p38 mitogen-activated protein kinase activation cascades. Anti-Cancer Drugs 18:6, pages 649-657.
Crossref
Sonia Ramos. (2007) Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. The Journal of Nutritional Biochemistry 18:7, pages 427-442.
Crossref
Sanjeev Banerjee, Yuxiang Zhang, Zhiwei Wang, Mingxin Che, Paul J Chiao, James L Abbruzzese & Fazlul H. Sarkar. (2007) Retracted: In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer . International Journal of Cancer 120:4, pages 906-917.
Crossref
Julian J Raffoul, Yu Wang, Omer Kucuk, Jeffrey D Forman, Fazlul H Sarkar & Gilda G Hillman. (2006) Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 6:1.
Crossref
Vivek Barve, Fakhara Ahmed, Shreelekha Adsule, Sanjeev Banerjee, Sudhir Kulkarni, Prashant Katiyar, Christopher E. Anson, Annie K. Powell, Subhash Padhye & Fazlul H. Sarkar. (2006) Synthesis, Molecular Characterization, and Biological Activity of Novel Synthetic Derivatives of Chromen-4-one in Human Cancer Cells. Journal of Medicinal Chemistry 49:13, pages 3800-3808.
Crossref
Sanjeev Banerjee, Yuxiang Zhang, Shadan Ali, Mohammad Bhuiyan, Zhiwei Wang, Paul J. Chiao, Philip A. Philip, James Abbruzzese & Fazlul H. Sarkar. (2005) Molecular Evidence for Increased Antitumor Activity of Gemcitabine by Genistein In vitro and In vivo Using an Orthotopic Model of Pancreatic Cancer . Cancer Research 65:19, pages 9064-9072.
Crossref
Yiwei Li & Fazlul Sarkar. 2005. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention.
Sung-Shin Park, Yong-Nyun Kim, Yoon Kyung Jeon, Young A Kim, Ji Eun Kim, Heejung Kim & Chul Woo Kim. (2005) Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. Cancer Chemotherapy and Pharmacology 56:3, pages 271-278.
Crossref
Martin F. Aguero, Maria M. Facchinetti, Zhanna Sheleg & Adrian M. Senderowicz. (2005) Phenoxodiol, a Novel Isoflavone, Induces G1 Arrest by Specific Loss in Cyclin-Dependent Kinase 2 Activity by p53-Independent Induction of p21WAF1/CIP1. Cancer Research 65:8, pages 3364-3373.
Crossref
Yan Gu. (2005) Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis. World Journal of Gastroenterology 11:41, pages 6512.
Crossref
Gilda G. Hillman, Yu Wang, Omer Kucuk, Mingxin Che, Daniel R. Doerge, Mark Yudelev, Michael C. Joiner, Brian Marples, Jeffrey D. Forman & Fazlul H. Sarkar. (2004) Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Molecular Cancer Therapeutics 3:10, pages 1271-1279.
Crossref
Fumiaki Nozawa, Atsushi Itami, Murat Saruc, Min Kim, Jens Standop, Kathleen S. Picha, Kenneth H. Cowan & Parviz M. Pour. (2004) The Combination of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL/Apo2L) and Genistein Is Effective in Inhibiting Pancreatic Cancer Growth. Pancreas 29:1, pages 45-52.
Crossref
Fei Ye, Josephine Wu, Trish Dunn, Jizu Yi, Xiaodi Tong & David Zhang. (2004) Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Cancer Letters 211:1, pages 39-46.
Crossref
Omer Kucuk. 2004. Head and Neck Cancer. Head and Neck Cancer 61 83 .
Zhongmin Tian, Mingxi Wan, Zenglu Wang & Bo Wang. (2003) The preparation of genistein and LC‐MS/MS on‐line analysis. Drug Development Research 61:1, pages 6-12.
Crossref
Lijie Gong, Yiwei Li, Ana Nedeljkovic-Kurepa & Fazlul H Sarkar. (2003) Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene 22:30, pages 4702-4709.
Crossref
Omer Kucuk & Ananda Prasad. 2003. Head and Neck Cancer. Head and Neck Cancer 201 211 .
Anna Wu, Lilian Thompson, Wendy Ward, Maurice Bennink, Elizabeth Rondini, Charles Wood a, Stephen Barnes b, Mark Cline a & Andreas Constantinou. 2002. Phytoestrogens and Health. Phytoestrogens and Health.
M. López-Lázaro, M. Gálvez, C. Martín-Cordero & M.J. Ayuso. 2002. Bioactive Natural Products (Part H). Bioactive Natural Products (Part H) 891 932 .
John Milner, Sharon McDonald, Darrell Anderson & Peter Greenwald. (2001) Molecular Targets for Nutrients Involved with Cancer Prevention. Nutrition and Cancer 41:1, pages 1-16.
Crossref
Laszlo G. Boros, Sara Bassilian, Shu Lim & Wai-Nang Paul Lee. (2001) Genistein Inhibits Nonoxidative Ribose Synthesis in MIA Pancreatic Adenocarcinoma Cells: A New Mechanism of Controlling Tumor Growth. Pancreas 22:1, pages 1-7.
Crossref
Lai K. Leung & Thomas T. Wang. (2000) Bcl-2 Is Not Reduced in the Death of MCF-7 Cells at Low Genistein Concentration. The Journal of Nutrition 130:12, pages 2922-2926.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.