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Original Articles

Baicalein, a Novel Apoptotic Agent for Hepatoma Cell Lines:A Potential Medicine for Hepatoma

Pages 287-295 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Wanjun Yan, Xingcong Ma, Xiaoyao Zhao & Shuqun Zhang. (2018) Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro. Drug Design, Development and Therapy 12, pages 3961-3972.
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Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li & Jin Huang. (2016) 2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 98-105.
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Articles from other publishers (40)

Jung-Min Oh, Yujin Kang, Jumi Park, Yubin Sung, Dayoung Kim, Yuri Seo, Eun A Lee, Jae Sun Ra, Enkhzul Amarsanaa, Young-Un Park, Seon Young Lee, Jung Me Hwang, Hongtae Kim, Orlando Schärer, Seung Woo Cho, Changwook Lee, Kei-ichi Takata, Ja Yil Lee & Kyungjae Myung. (2023) MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1. Nucleic Acids Research 51:11, pages 5584-5602.
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Juhi Rais, Habiba Khan & Mohd. Arshad. (2023) The Role of Phytochemicals in Cancer Prevention: A Review with Emphasis on Baicalein, Fisetin, and Biochanin A. Current Topics in Medicinal Chemistry 23:12, pages 1123-1135.
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Arshad Husain Rahmani, Ahmad Almatroudi, Amjad Ali Khan, Ali Yousif Babiker, Malak Alanezi & Khaled S. Allemailem. (2022) The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways. Molecules 27:22, pages 8023.
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Fanfan Hou, Zhenyuan Yu, YaHsin Cheng, Yang Liu, Shuang Liang & Fang Zhang. (2022) Deciphering the pharmacological mechanisms of Scutellaria baicalensis Georgi on oral leukoplakia by combining network pharmacology, molecular docking and experimental evaluations. Phytomedicine 103, pages 154195.
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Elika Verma, Aviral Kumar, Uzini Devi Daimary, Dey Parama, Sosmitha Girisa, Gautam Sethi & Ajaikumar B. Kunnumakkara. (2021) Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review. Journal of Functional Foods 86, pages 104660.
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Jasmine Baby, Aswathy R. Devan, Ayana R. Kumar, Jaggaiah N. Gorantla, Bhagyalakshmi Nair, Thanatharayil Sathian Aishwarya & Lekshmi R. Nath. (2021) Cogent role of flavonoids as key orchestrators of chemoprevention of hepatocellular carcinoma: A review. Journal of Food Biochemistry 45:7.
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Danhui Ma, Sinuo Chen, Heming Wang, Jiayi Wei, Hao Wu, Hong Gao, Xinlai Cheng, Taotao Liu, Shi-Hua Luo, Yicheng Zhao & Guangqi Song. (2021) Baicalein Induces Apoptosis of Pancreatic Cancer Cells by Regulating the Expression of miR-139-3p and miR-196b-5p. Frontiers in Oncology 11.
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Dan Qiao, Jingchun Jin, Jian Xing, Yingying Zhang, Nailing Jia, Xiangshan Ren, Zhenhua Lin, Ningyi Jin, Liyan Chen & Yingshi Piao. (2021) Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling. The American Journal of Chinese Medicine 49:02, pages 525-541.
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Zhe Ma, Bing Zhang, Yuqi Fan, Meng Wang, Dereje Kebebe, Jiawei Li & Zhidong Liu. (2019) Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. Biomedicine & Pharmacotherapy 117, pages 109128.
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Chongyang Ma, Tian Xu, Xiaoguang Sun, Shuang Zhang, Shuling Liu, Shuning Fan, Chaofang Lei, Feifei Tang, Changming Zhai, Changxiang Li, Juan Luo, Qingguo Wang, Wei Wei, Xueqian Wang & Fafeng Cheng. (2019) Network Pharmacology and Bioinformatics Approach Reveals the Therapeutic Mechanism of Action of Baicalein in Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-15.
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Ye Tian, Liang Zhen, Jian’an Bai, Yumei Mei, Zheng Li, Aihua Lin & Xueliang Li. (2017) Anticancer Effects of Baicalein in Pancreatic Neuroendocrine Tumors In Vitro and In Vivo. Pancreas 46:8, pages 1076-1081.
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Beibei Bie, Jin Sun, Ying Guo, Jun Li, Wei Jiang, Jun Yang, Chen Huang & Zongfang Li. (2017) Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma. Biomedicine & Pharmacotherapy 93, pages 1285-1291.
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Linh Thi Thao Nguyen, Yeon Woo Song & Somi Kim Cho. (2016) Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells. Molecules and Cells 39:12, pages 909-914.
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Kai-Chih Hung, Hui-Ju Huang, Yi-Ting Wang & Anya Maan-Yuh Lin. (2016) Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo. Journal of Ethnopharmacology 194, pages 522-529.
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Ying Gao, Shane A. Snyder, Jaclyn N. Smith & Yi Charlie Chen. (2016) Anticancer properties of baicalein: a review. Medicinal Chemistry Research 25:8, pages 1515-1523.
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Yongliang Zhang, Jennifer T. Fox, Young-Un Park, Gene Elliott, Ganesha Rai, Mengli Cai, Srilatha Sakamuru, Ruili Huang, Menghang Xia, Kyeryoung Lee, Min Ho Jeon, Bijoy P. Mathew, Hee Dong Park, Winfried Edelmann, Chan Young Park, Sung You Hong, David Maloney & Kyungjae Myung. (2016) A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies. Cancer Research 76:14, pages 4183-4191.
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Ga Bin Park, Yeong Seok Kim, Hyun-Kyung Lee, Jae Wook Yang, Daejin Kim & Dae Young Hur. (2015) ASK1/JNK-mediated TAp63 activation controls the cell survival signal of baicalein-treated EBV-transformed B cells. Molecular and Cellular Biochemistry 412:1-2, pages 247-258.
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Shixuan Zhang, Yongming Bao, Xiulan Ju, Kangjian Li, Haiyan Shang, Lisha Ha, Yuan Qian, Liang Zou, Xiaodan Sun, Jing Li, Qianru Wang & Qingyu Fan. (2015) BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS. Scientific Reports 5:1.
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Yung-Kai Huang, Ting-Chen Chang, Joen-Rong Sheu, Kuo-Hsuan Wen & Duen-Suey Chou. (2014) Comparison of free radical formation induced by baicalein and pentamethyl-hydroxychromane in human promyelocytic leukemia cells using electron spin resonance. Journal of Food and Drug Analysis 22:3, pages 379-390.
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Kunlun Chen, Shu Zhang, Yuanyuan Ji, Jun Li, Peng An, Hongtao Ren, Rongrui Liang, Jun Yang & Zongfang Li. (2013) Baicalein Inhibits the Invasion and Metastatic Capabilities of Hepatocellular Carcinoma Cells via Down-Regulation of the ERK Pathway. PLoS ONE 8:9, pages e72927.
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HONG-BO ZHANG, PING LU, QING-YIN GUO, ZHEN-HUA ZHANG & XIANG-YU MENG. (2013) Baicalein induces apoptosis in esophageal squamous cell carcinoma cells through modulation of the PI3K/Akt pathway. Oncology Letters 5:2, pages 722-728.
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HONG-LIANG LI, SHU ZHANG, YUAN WANG, RONG-RUI LIANG, JUN LI, PENG AN, ZI-MING WANG, JUN YANG & ZONG-FANG LI. (2013) Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells. Molecular Medicine Reports 7:1, pages 266-270.
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Ji Luo, Yinglong Ren, Hao Gu, Yi Wu & Yun Wang. (2013) dTGS: Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-9.
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Yun-Ju Chen, Chieh-Shan Wu, Jeng-Jer Shieh, Jyh-Horng Wu, Hsing-Yu Chen, Ting-Wen Chung, Yu-Kuo Chen & Chi-Chen Lin. (2013) Baicalein Triggers Mitochondria-Mediated Apoptosis and Enhances the Antileukemic Effect of Vincristine in Childhood Acute Lymphoblastic Leukemia CCRF-CEM Cells. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-19.
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Nam Il Park, Hui Xu, Xiaohua Li, Young Seon Kim, Mi Young Lee & Sang Un Park. (2012) Overexpression of phenylalanine ammonia-lyase improves flavones production in transgenic hairy root cultures of Scutellaria baicalensis. Process Biochemistry 47:12, pages 2575-2580.
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RONG-RUI LIANG, SHU ZHANG, JUN-AN QI, ZHI-DONG WANG, JUN LI, PEI-JUN LIU, CHEN HUANG, XIAO-FENG LE, JUN YANG & ZONG-FANG LI. (2012) Preferential inhibition of hepatocellular carcinoma by the flavonoid Baicalein through blocking MEK-ERK signaling. International Journal of Oncology 41:3, pages 969-978.
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Jennifer T. Fox, Srilatha SakamuruRuili HuangNedelina Teneva, Steven O. Simmons, Menghang XiaRaymond R. Tice, Christopher P. AustinKyungjae Myung. (2012) High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proceedings of the National Academy of Sciences 109:14, pages 5423-5428.
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Yung-Wei Chiu, Tseng-Hsi Lin, Wen-Shih Huang, Chun-Yuh Teng, Yi-Sheng Liou, Wu-Hsien Kuo, Wea-Lung Lin, Hai-I Huang, Jai-Nien Tung, Chih-Yang Huang, Jer-Yuh Liu, Wen-Hung Wang, Jin-Ming Hwang & Hsing-Chun Kuo. (2011) Baicalein inhibits the migration and invasive properties of human hepatoma cells. Toxicology and Applied Pharmacology 255:3, pages 316-326.
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Yun Ling, Yan Chen, Pu Chen, Hui Hui, Xiuming Song, Zhijian Lu, Chenglin Li, Na Lu & Qinglong Guo. (2011) Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest. Experimental Biology and Medicine 236:7, pages 851-858.
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Xiuqiong He, Lixia Pei, Henry H. Y. Tong & Ying Zheng. (2010) Comparison of Spray Freeze Drying and the Solvent Evaporation Method for Preparing Solid Dispersions of Baicalein with Pluronic F68 to Improve Dissolution and Oral Bioavailability. AAPS PharmSciTech 12:1, pages 104-113.
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Ren-Huei Jiang, Wen-Chi Su, Huei-Fang Liu, Hou-Syun Huang & Jui-I Chao. (2010) Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death. Journal of Cellular Biochemistry 111:2, pages 274-283.
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Jui-I Chao, Wen-Chi Su & Huei-Fang Liu. (2007) Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Molecular Cancer Therapeutics 6:11, pages 3039-3048.
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Henry W.C. Leung, W.H. Yang, M.Y. Lai, C.J. Lin & H.Z. Lee. (2007) Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. Food and Chemical Toxicology 45:3, pages 403-411.
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M. Kampa, A.-P. Nifli, G. Notas & E. Castanas. 2007. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 79 113 .
Min-Ho ChaIl-Chul KimBong-Hee LeeYoosik Yoon. (2006) Baicalein Inhibits Adipocyte Differentiation by Enhancing COX-2 Expression. Journal of Medicinal Food 9:2, pages 145-153.
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Pei-Wen Zheng, Lien-Chai Chiang & Chun-Ching Lin. (2005) Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sciences 76:12, pages 1367-1379.
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Den-En Shieh, Yuan-Ying Chen, Ming-Hong Yen, Lien-Chai Chiang & Chun-Ching Lin. (2004) Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells. Life Sciences 74:18, pages 2279-2290.
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Martina Kovaříková, Jiřina Hofmanová, Karel Souček & Alois Kozubík. (2004) The effects of TNF-α and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status. Differentiation 72:1, pages 23-31.
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Neeru Khanna, Sudip Sen, Himani Sharma & Neeta Singh. (2003) S29 ribosomal protein induces apoptosis in H520 cells and sensitizes them to chemotherapy. Biochemical and Biophysical Research Communications 304:1, pages 26-35.
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Chang-Min Shan & Juan Li. (2002) Study of apoptosis in human liver cancers. World Journal of Gastroenterology 8:2, pages 247.
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