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Original Articles

Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli

Pages 168-178 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (22)

Xinhui Huang, Xinyu Zhou, Chunting Wu, Weiqi Li, Yongjie Ma, Qilian He & Fuli Ya. (2023) Sulforaphane attenuates platelet granule secretion through down-regulating glycoprotein VI-mediated p38 MAPK/cPLA2 signaling pathway. CyTA - Journal of Food 21:1, pages 189-197.
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Faye M. A. Langston, Geoff R. Nash & John R. Bows. (2023) The retention and bioavailability of phytochemicals in the manufacturing of baked snacks. Critical Reviews in Food Science and Nutrition 63:14, pages 2141-2177.
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Maia E. W. Morrison, Janine M. Joseph, Susan E. McCann, Li Tang, Hani M. Almohanna & Kirsten B. Moysich. (2020) Cruciferous Vegetable Consumption and Stomach Cancer: A Case-Control Study. Nutrition and Cancer 72:1, pages 52-61.
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Hallie McManus, Kirsten B. Moysich, Li Tang, Janine Joseph & Susan E. McCann. (2018) Usual Cruciferous Vegetable Consumption and Ovarian Cancer: A Case-Control Study. Nutrition and Cancer 70:4, pages 678-683.
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Probo Y. Nugrahedi, Inneke Hantoro, Ruud Verkerk, Matthijs Dekker & Bea Steenbekkers. (2015) Practices and health perception of preparation of Brassica vegetables: translating survey data to technological and nutritional implications. International Journal of Food Sciences and Nutrition 66:6, pages 633-641.
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Probo Y. Nugrahedi, Ruud Verkerk, Budi Widianarko & Matthijs Dekker. (2015) A Mechanistic Perspective on Process-Induced Changes in Glucosinolate Content in Brassica Vegetables: A Review. Critical Reviews in Food Science and Nutrition 55:6, pages 823-838.
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Genevieve Tse & GuyD. Eslick. (2014) Cruciferous Vegetables and Risk of Colorectal Neoplasms: A Systematic Review and Meta-Analysis. Nutrition and Cancer 66:1, pages 128-139.
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Ben Liu, Qiqi Mao, Xiao Wang, Feng Zhou, Jindan Luo, Chaojun Wang, Yiwei Lin, Xiangyi Zheng & Liping Xie. (2013) Cruciferous Vegetables Consumption and Risk of Renal Cell Carcinoma: A Meta-Analysis. Nutrition and Cancer 65:5, pages 668-676.
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Yuesheng Zhang. (2012) The 1,2-Benzenedithiole-Based Cyclocondensation Assay: A Valuable Tool for the Measurement of Chemopreventive Isothiocyanates. Critical Reviews in Food Science and Nutrition 52:6, pages 525-532.
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Evelyn Lamy, Cathy Scholtes, Corinna Herz & Volker Mersch-Sundermann. (2011) Pharmacokinetics and pharmacodynamics of isothiocyanates. Drug Metabolism Reviews 43:3, pages 387-407.
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Eun-Sun Hwang & Hyong Joo Lee. (2010) Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. International Journal of Food Sciences and Nutrition 61:3, pages 324-336.
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Patrizia Riso, Daniela Martini, Francesco Visioli, Antonia Martinetti & Marisa Porrini. (2009) Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers. Nutrition and Cancer 61:2, pages 232-237.
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Patrizia Riso, Antonella Brusamolino, Massimo Moro & Marisa Porrini. (2009) Absorption of bioactive compounds from steamed broccoli and their effect on plasma glutathione S-transferase activity. International Journal of Food Sciences and Nutrition 60:sup1, pages 56-71.
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Daniel R McGrath & Allan D Spigelman. (2008) Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer. Expert Opinion on Therapeutic Targets 12:6, pages 729-738.
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A. Gliszczyńska-Świgło, E. Ciska, K. Pawlak-Lemańska, J. Chmielewski, T. Borkowski & B. Tyrakowska. (2006) Changes in the content of health-promoting compounds and antioxidant activity of broccoli after domestic processing. Food Additives & Contaminants 23:11, pages 1088-1098.
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Franca Bianchini & Harri Vainio. (2004) Isothiocyanates in Cancer Prevention. Drug Metabolism Reviews 36:3-4, pages 655-667.
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Alan R. Kristal & Johanna W. Lampe. (2002) Brassica Vegetables and Prostate Cancer Risk: A Review of the Epidemiological Evidence. Nutrition and Cancer 42:1, pages 1-9.
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Articles from other publishers (237)

Faith A.A. Kwa, Bang V. Bui, Bruce R. Thompson & Lauren N. Ayton. (2023) Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease. Drug Discovery Today 28:9, pages 103718.
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Katie Treasure, James Harris & Gary Williamson. (2023) Exploring the anti‐inflammatory activity of sulforaphane. Immunology & Cell Biology.
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Liang Yan & Yachun Yan. (2023) Therapeutic potential of sulforaphane in liver diseases: a review. Frontiers in Pharmacology 14.
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Hidde P. van Steenwijk, Evi Winter, Edward Knaven, Jos F. Brouwers, Myrthe van Baardwijk, Jasper B. van Dalum, Teus J. C. Luijendijk, Frits H. M. van Osch, Freddy J. Troost, Aalt Bast, Khrystyna O. Semen & Alie de Boer. (2023) The beneficial effect of sulforaphane on platelet responsiveness during caloric load: a single-intake, double-blind, placebo-controlled, crossover trial in healthy participants. Frontiers in Nutrition 10.
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Hidde P. van Steenwijk, Frits H.M. van Osch, Freddy J. Troost, Aalt Bast, Alie de Boer & Khrystyna O. Semen. (2023) Heart rate variability correlates with the effect of sulforaphane on calorie-induced inflammation in healthy participants: a randomized placebo-controlled study. Clinical Nutrition Open Science 49, pages 140-156.
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Xinyu Zhou, Xinhui Huang, Chunting Wu, Yongjie Ma, Weiqi Li, Jinqiu Hu, Rong Li & Fuli Ya. (2023) Sulforaphane attenuates glycoprotein VI-mediated platelet mitochondrial dysfunction through up-regulating the cAMP/PKA signaling pathway in vitro and in vivo . Food & Function 14:8, pages 3613-3629.
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Antonio Costa-Pérez, Vanesa Núñez-Gómez, Nieves Baenas, Giuseppe Di Pede, Mariem Achour, Claudine Manach, Pedro Mena, Daniele Del Rio, Cristina García-Viguera, Diego A. Moreno & Raúl Domínguez-Perles. (2023) Systematic Review on the Metabolic Interest of Glucosinolates and Their Bioactive Derivatives for Human Health. Nutrients 15:6, pages 1424.
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Zhitao Pan, Ziyi Meng, Mei Tan, Hanying Duan, Hosahalli S. Ramaswamy, Xin Qiu & Chao Wang. (2022) Optimization the conversion of glucosinolate to isothiocyanate in yellow mustard seeds (Sinapis alba) by response surface methodology. Applied Food Research 2:2, pages 100207.
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Madhumitha Kedhari Sundaram, Preetha R, Shafiul Haque, Naseem Akhter, Saif Khan, Saheem Ahmad & Arif Hussain. (2022) Dietary isothiocyanates inhibit cancer progression by modulation of epigenome. Seminars in Cancer Biology 83, pages 353-376.
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Dominik Kołodziejski, Izabela Koss-Mikołajczyk, Hansruedi Glatt & Agnieszka Bartoszek. (2022) The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles. Scientific Reports 12:1.
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Zeinab T. Shakour, Naglaa G. Shehab, Ahmed S. Gomaa, Ludger A. Wessjohann & Mohamed A. Farag. (2022) Metabolic and biotransformation effects on dietary glucosinolates, their bioavailability, catabolism and biological effects in different organisms. Biotechnology Advances 54, pages 107784.
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Mirko Marino, Daniela Martini, Samuele Venturi, Massimiliano Tucci, Marisa Porrini, Patrizia Riso & Cristian Del Bo'. (2021) An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation. Frontiers in Nutrition 8.
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Modhi O. Alotaibi, Galal Khamis, Hamada AbdElgawad, Afrah E. Mohammed, Mohamed S. Sheteiwy, Mudawi M. Elobeid & Ahmed M. Saleh. (2021) Lepidium sativum Sprouts Grown under Elevated CO2 Hyperaccumulate Glucosinolates and Antioxidants and Exhibit Enhanced Biological and Reduced Antinutritional Properties. Biomolecules 11:8, pages 1174.
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