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Original Articles

Redox Molecules and Cancer Prevention: The Importance of Understanding the Role of the Antioxidant Network

Pages 232-240 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Yiqiao Gao, Yixin Zhang, Wei Liu, Nan Zhang, Qinghe Gao, Jingfang Shangguan, Na Li, Ying Zhao & Yanlong Jia. (2023) Danggui Buxue decoction alleviates cyclophosphamide-induced myelosuppression by regulating β-hydroxybutyric acid metabolism and suppressing oxidative stress. Pharmaceutical Biology 61:1, pages 710-721.
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Frazer J. Lowe, Karsta Luettich & Evan O. Gregg. (2013) Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective. Biomarkers 18:3, pages 183-195.
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Leyre Gravina, Fatima Ruiz, Elena Diaz, Jose Antonio Lekue, Aduna Badiola, Jon Irazusta & Susana Maria Gil. (2012) Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players. Journal of the International Society of Sports Nutrition 9:1.
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Christopher P. F. Marinangeli & Peter J. H. Jones. (2010) Functional food ingredients as adjunctive therapies to pharmacotherapy for treating disorders of metabolic syndrome. Annals of Medicine 42:5, pages 317-333.
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JeanM. Feugang, Fei Ye, DavidY. Zhang, Yanhong Yu, Mei Zhong, Sui Zhang & Changping Zou. (2010) Cactus Pear Extracts Induce Reactive Oxygen Species Production and Apoptosis in Ovarian Cancer Cells. Nutrition and Cancer 62:5, pages 692-699.
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Zorabel Cordero, Dagmar Drogan, Cornelia Weikert & Heiner Boeing. (2010) Vitamin E and Risk of Cardiovascular Diseases: A Review of Epidemiologic and Clinical Trial Studies. Critical Reviews in Food Science and Nutrition 50:5, pages 420-440.
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Perumal Subramanian, Kadiyala Babu Dakshayani, Seithikurippu R. Pandi-Perumal, Ilya Trakht & Daniel P. Cardinali. (2008) 24-Hour rhythms in oxidative stress during hepatocarcinogenesis in rats: effect of melatonin or α-ketoglutarate. Redox Report 13:2, pages 78-86.
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Shriram D. Ranade, Shankar G. Alegaon, U. Venkatasubramanian, A. Soundarya Priya, Rohini S. Kavalapure, Jagdish Chand, Sunil S. Jalalpure & D. Vinod. (2023) Design, synthesis, molecular dynamics simulation, MM/GBSA studies and kinesin spindle protein inhibitory evaluation of some 4-aminoquinoline hybrids. Computational Biology and Chemistry 105, pages 107881.
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Marco Alfonso Perrone, Alberto Aimo, Sergio Bernardini & Aldo Clerico. (2023) Inflammageing and Cardiovascular System: Focus on Cardiokines and Cardiac-Specific Biomarkers. International Journal of Molecular Sciences 24:1, pages 844.
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Raphaëlle Varraso, Zhen Li, Annabelle Bedard & Carlos A. Camargo, Jr.. 2023. Asthma in the 21st Century. Asthma in the 21st Century 87 134 .
Elena Genovese, Margherita Mirabile, Sebastiano Rontauroli, Stefano Sartini, Sebastian Fantini, Lara Tavernari, Monica Maccaferri, Paola Guglielmelli, Elisa Bianchi, Sandra Parenti, Chiara Carretta, Selene Mallia, Sara Castellano, Corrado Colasante, Manjola Balliu, Niccolò Bartalucci, Raffaele Palmieri, Tiziana Ottone, Barbara Mora, Leonardo Potenza, Francesco Passamonti, Maria Teresa Voso, Mario Luppi, Alessandro Maria Vannucchi, Enrico Tagliafico & Rossella Manfredini. (2022) The Response to Oxidative Damage Correlates with Driver Mutations and Clinical Outcome in Patients with Myelofibrosis. Antioxidants 11:1, pages 113.
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Khushnuma Wahabi, Ahmad Perwez & Moshahid A. Rizvi. 2022. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects 65 80 .
Khushnuma Wahabi, Ahmad Perwez & Moshahid A. Rizvi. 2021. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Handbook of Oxidative Stress in Cancer: Therapeutic Aspects 1 16 .
Jia Wang, Jingjing Yang, Chen Wang, Zhibai Zhao & Yuan Fan. (2021) Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus. Oxidative Medicine and Cellular Longevity 2021, pages 1-16.
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Mahdieh Abbasalizad Farhangi & Ali Mohammad-Rezaei. (2021) Higher dietary total antioxidant capacity (TAC) reduces the risk of cardio-metabolic risk factors among adults: An updated systematic review and meta-analysis. International Journal for Vitamin and Nutrition Research, pages 1-15.
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Maria Celia B. Hughes, Gail M. Williams, Hervé Pageon, Anny Fourtanier & Adèle C. Green. (2021) Dietary Antioxidant Capacity and Skin Photoaging: A 15-Year Longitudinal Study. Journal of Investigative Dermatology 141:4, pages 1111-1118.e2.
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Rosa Vona, Lucia Pallotta, Martina Cappelletti, Carola Severi & Paola Matarrese. (2021) The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders. Antioxidants 10:2, pages 201.
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Magdalena Jeszka-Skowron, Tomasz Podgórski & Beata Czarczyńska-Goślińska. 2021. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food. Analytical Methods in the Determination of Bioactive Compounds and Elements in Food 263 308 .
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi & Pourya Fathollahi. (2020) Dietary total antioxidant capacity (TAC), general and central obesity indices and serum lipids among adults: An updated systematic review and meta-analysis. International Journal for Vitamin and Nutrition Research, pages 1-17.
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Hinako Nanri, Ikuko Kashino, Takeshi Kochi, Masafumi Eguchi, Shamima Akter, Akiko Nanri, Isamu Kabe & Tetsuya Mizoue. (2020) Cross-Sectional Study on the Association between Dietary Non-Enzymatic Antioxidant Capacity and Serum Liver Enzymes: The Furukawa Nutrition and Health Study. Nutrients 12:7, pages 2051.
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Takako Miki, Masafumi Eguchi, Takeshi Kochi, Shamima Akter, Huan Hu, Ikuko Kashino, Keisuke Kuwahara, Isamu Kabe, Akiko Nanri & Tetsuya Mizoue. (2020) Prospective study on the association between dietary non-enzymatic antioxidant capacity and depressive symptoms. Clinical Nutrition ESPEN 36, pages 91-98.
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Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei & Ali Akbar Moosavi-Movahedi. (2019) Personalizing the safe, appropriate and effective concentration(s) of ozone for a non-diabetic individual and four type II diabetic patients in autohemotherapy through blood hemoglobin analysis. Journal of Translational Medicine 17:1.
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Hyejin Kim, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin & Jeongseon Kim. (2019) Protective Effect of Green Tea Consumption on Colorectal Cancer Varies by Lifestyle Factors. Nutrients 11:11, pages 2612.
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Mohammad Parohan, Alireza Sadeghi, Seyed Reza Khatibi, Morteza Nasiri, Alireza Milajerdi, Mahmoud Khodadost & Omid Sadeghi. (2019) Dietary total antioxidant capacity and risk of cancer: a systematic review and meta-analysis on observational studies. Critical Reviews in Oncology/Hematology 138, pages 70-86.
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Fouad Mehraban, Arefeh Seyedarabi, Zahra Seraj, Shahin Ahmadian, Najmeh Poursasan, Saeed Rayati & Ali Akbar Moosavi-Movahedi. (2018) Molecular insights into the effect of ozone on human hemoglobin in autohemotherapy: Highlighting the importance of the presence of blood antioxidants during ozonation. International Journal of Biological Macromolecules 119, pages 1276-1285.
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Nadia Bastide, Laureen Dartois, Valérie Dyevre, Laure Dossus, Guy Fagherazzi, Mauro Serafini & Marie-Christine Boutron-Ruault. (2016) Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study. European Journal of Nutrition 56:3, pages 1233-1243.
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Ilaria Marrocco, Fabio Altieri & Ilaria Peluso. (2017) Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative Medicine and Cellular Longevity 2017, pages 1-32.
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Aimee L Lucas, Cristina Bosetti, Paolo Boffetta, Eva Negri, Alessandra Tavani, Mauro Serafini, Jerry Polesel, Diego Serraino, Carlo La Vecchia & Marta Rossi. (2016) Dietary total antioxidant capacity and pancreatic cancer risk: an Italian case–control study. British Journal of Cancer 115:1, pages 102-107.
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Nadia Bastide, Sophie Morois, Claire Cadeau, Suvi Kangas, Mauro Serafini, Gaëlle Gusto, Laure Dossus, Fabrice H. Pierre, Françoise Clavel-Chapelon & Marie-Christine Boutron-Ruault. (2016) Heme Iron Intake, Dietary Antioxidant Capacity, and Risk of Colorectal Adenomas in a Large Cohort Study of French Women. Cancer Epidemiology, Biomarkers & Prevention 25:4, pages 640-647.
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Delphine Praud, Maria Parpinel, Mauro Serafini, Rino Bellocco, Alessandra Tavani, Pagona Lagiou, Carlo La Vecchia & Marta Rossi. (2015) Non-enzymatic antioxidant capacity and risk of gastric cancer. Cancer Epidemiology 39:3, pages 340-345.
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N. Bastide, V. Dyevre, L. Dartois, S. Kangas, M. Serafini, F. Clavel-Chapelon & M.-C. Boutron-Ruault. (2014) P240: Capacité antioxydante totale et mortalité toutes causes et cause-spécifique dans la cohorte E3N. Nutrition Clinique et Métabolisme 28, pages S194-S195.
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S. Wachtel-Galor, P.M. Siu & I.F.F. Benzie. 2014. Aging. Aging 81 91 .
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R. Zamora-Ros, M. Serafini, R. Estruch, R.M. Lamuela-Raventós, M.A. Martínez-González, J. Salas-Salvadó, M. Fiol, J. Lapetra, F. Arós, M.I. Covas & C. Andres-Lacueva. (2013) Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: Evidence for a mechanism of antioxidant tuning. Nutrition, Metabolism and Cardiovascular Diseases 23:12, pages 1167-1174.
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Raul Zamora-Ros, Veronika Fedirko, Antonia Trichopoulou, Carlos A. González, Christina Bamia, Elisabeth Trepo, Ute Nöthlings, Talita Duarte-Salles, Mauro Serafini, Lea Bredsdorff, Kim Overvad, Anne Tjønneland, Jytte Halkjaer, Guy Fagherazzi, Florence Perquier, Marie-Christine Boutron-Ruault, Verena Katzke, Annekatrin Lukanova, Anna Floegel, Heiner Boeing, Pagona Lagiou, Dimitrios Trichopoulos, Calogero Saieva, Claudia Agnoli, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H. Bas Bueno-de-Mesquita, Petra H.M. Peeters, Elisabete Weiderpass, Dagrun Engeset, Guri Skeie, Marcial Vicente Argüelles, Esther Molina-Montes, Miren Dorronsoro, María José Tormo, Eva Ardanaz, Ulrika Ericson, Emily Sonestedt, Malin Sund, Rikard Landberg, Kay-Tee Khaw, Nicholas J. Wareham, Francesca L. Crowe, Elio Riboli & Mazda Jenab. (2013) Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study. International Journal of Cancer 133:10, pages 2429-2443.
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Daniele Lettieri-Barbato, Francesco Tomei, Angela Sancini, Giuseppa Morabito & Mauro Serafini. (2013) Effect of plant foods and beverages on plasma non-enzymatic antioxidant capacity in human subjects: a meta-analysis. British Journal of Nutrition 109:9, pages 1544-1556.
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Luísa B. Roseiro, Luís C. Duarte, Diana L. Oliveira, Ricardo Roque, M. Gabriela Bernardo-Gil, Alice I. Martins, Catarina Sepúlveda, Joana Almeida, Margarida Meireles, Francisco M. Gírio & Amélia Pilar Rauter. (2013) Supercritical, ultrasound and conventional extracts from carob (Ceratonia siliqua L.) biomass: Effect on the phenolic profile and antiproliferative activity. Industrial Crops and Products 47, pages 132-138.
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Mauro Serafini, Paula Jakszyn, Leila Luján‐Barroso, Antonio Agudo, H. Bas Bueno‐de‐Mesquita, Fränzel J.B. van Duijnhoven, Mazda Jenab, Carmen Navarro, Domenico Palli, Heiner Boeing, Peter Wallström, Sara Regnér, Mattijs E. Numans, Fatima Carneiro, Marie‐Christine Boutron‐Ruault, Françoise Clavel‐Chapelon, Sophie Morois, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, José Ramon Quirós, Esther Molina‐Montes, Jose M. Huerta Castaño, Aurelio Barricarte, Pilar Amiano, Kay‐Tee Khaw, Nicholas Wareham, Naomi E. Allen, Timothy J. Key, Suzanne M. Jeurnink, Petra H.M. Peeters, Christina Bamia, Elisabeth Valanou, Antonia Trichopoulou, Rudolf Kaaks, Annekatrin Lukanova, Manuela M. Bergmann, Björn Lindkvist, Roger Stenling, Ingegerd Johansson, Christina C. Dahm, Kim Overvad, Majken Jensen, Anja Olsen, Anne Tjonneland, Eiliv Lund, Sabina Rinaldi, Dominique Michaud, Traci Mouw, Elio Riboli & Carlos A. González. (2012) Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study. International Journal of Cancer 131:4.
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Kristýna Joudalová & Zuzana Réblová. (2012) Dietary intake of antioxidants in the Czech RepublicDietary. Czech Journal of Food Sciences 30:3, pages 268-275.
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Hyun Ah Jung, Seong Eun Jin, Ran Joo Choi, Hung Tran Manh, Yeong Shik Kim, Byung-Sun Min, You Kyung Son, Bo Ra Ahn, Byung-Woo Kim, Hee Sook Sohn & Jae Sue Choi. (2011) Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Archives of Pharmacal Research 34:12, pages 2087-2099.
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Peter C.H. Hollman, Aedin Cassidy, Blandine Comte, Marina Heinonen, Myriam Richelle, Elke Richling, Mauro Serafini, Augustin Scalbert, Helmut Sies & Stéphane Vidry. (2011) The Biological Relevance of Direct Antioxidant Effects of Polyphenols for Cardiovascular Health in Humans Is Not Established1–4. The Journal of Nutrition 141:5, pages 989S-1009S.
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Sertan Ergun, Şule Can Troşala, Saman Warnakulasuriya, Sevda Özel, Ayşe Emel Önal, Duygu Ofluoğlu, Yegane Güven & Hakki Tanyeri. (2011) Evaluation of oxidative stress and antioxidant profile in patients with oral lichen planus. Journal of Oral Pathology & Medicine 40:4, pages 286-293.
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Iris F.F. BenzieSissi Wachtel-Galor. (2010) Vegetarian Diets and Public Health: Biomarker and Redox Connections. Antioxidants & Redox Signaling 13:10, pages 1575-1591.
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Mauro Serafini, Ilaria Peluso & Anna Raguzzini. (2010) Flavonoids as anti-inflammatory agents. Proceedings of the Nutrition Society 69:3, pages 273-278.
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Amrit K Sakhi, Kjell M Russnes, Magne Thoresen, Nasser E Bastani, Anette Karlsen, Sigbjørn Smeland & Rune Blomhoff. (2009) Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study. BMC Cancer 9:1.
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Yiqiao Gao, Yixin Zhang, Wei Liu, Nan Zhang, Qinghe Gao, Jingfang Shangguan, Ying Zhao & YanLong Jia. (2022) Studies on the Mechanisms of Danggui Buxue Decoction in Prevention and Treatment of Myelosuppression: Regulating Β-Hydroxybutyric Acid Metabolism and Suppressing Oxidative Stress. SSRN Electronic Journal.
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