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Original Articles

The in Vivo and in Vitro Stimulatory Effects of Cordycepin on Mouse Leydig Cell Steroidogenesis

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Pages 723-731 | Received 01 Dec 2010, Accepted 05 Jan 2011, Published online: 22 May 2014

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Jian Wang, Chen Chen, Zhihui Jiang, Meng Wang, Hai Jiang & Xiaoying Zhang. (2016) Protective effect of Cordyceps militaris extract against bisphenol A induced reproductive damage. Systems Biology in Reproductive Medicine 62:4, pages 249-257.
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Articles from other publishers (34)

Chong Li, Ling Zhu, Jun-Xia Liu, Jing Guo, Juan Xie, Chun-Meng Shi, Qing-Yuan Sun, Guo-Ning Huang & Jing-Yu Li. (2023) Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression. Cellular and Molecular Life Sciences 80:12.
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Sanjukta Sen, Dipanjan Karati, Rosy Priyadarshini, Tarun Kumar Dua, Paramita Paul, Ranabir Sahu & Gouranga Nandi. (2023) Cordyceps sinensis (yarsagumba): Pharmacological properties of a mushroom. Pharmacological Research - Modern Chinese Medicine 8, pages 100294.
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Kazuaki Iguchi, Koji Nagashima, Jun Mochizuki, Hiroyuki Yamamoto, Keiko Unno & Noriyuki Miyoshi. (2023) Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models. Nutrients 15:9, pages 2142.
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Mai Xuan Bach, Truong Ngoc Minh, Dao Thi Ngoc Anh, Ho Ngoc Anh, Le Viet Anh, Nguyen Quang Trung, Bui Quang Minh & Tran Dang Xuan. (2022) Protection and Rehabilitation Effects of Cordyceps militaris Fruit Body Extract and Possible Roles of Cordycepin and Adenosine. Compounds 2:4, pages 388-403.
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Yan Liu, Zhi-Jian Guo & Xuan-Wei Zhou. (2022) Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism—A Review. Molecules 27:19, pages 6576.
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Shao-An Hsieh, Tien-Huang Lin, Jen-Shu Wang, Jian-Jung Chen, Wen-Kuang Hsu, Li-Chih Ying & Zeng-Chin Liang. (2022) The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients: A pilot study. Pharmacological Research - Modern Chinese Medicine 4, pages 100143.
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Abdulmohsin J. Alamoudi, Sami A. Alessi, Waleed Y. Rizg, Abdulmajeed M. Jali, Awaji Y. Safhi, Fahad Y. Sabei, Sameer Alshehri, Khaled M. Hosny & Ashraf B. Abdel-Naim. (2022) Cordycepin Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats via Modulation of AMPK and AKT Activation. Pharmaceutics 14:8, pages 1652.
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Karol Jerzy Jędrejko, Jan Lazur & Bożena Muszyńska. (2021) Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. Foods 10:11, pages 2634.
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Masar Radhi, Sadaf Ashraf, Steven Lawrence, Asta Arendt Tranholm, Peter Arthur David Wellham, Abdul Hafeez, Ammar Sabah Khamis, Robert Thomas, Daniel McWilliams & Cornelia Huiberdina de Moor. (2021) A Systematic Review of the Biological Effects of Cordycepin. Molecules 26:19, pages 5886.
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Yu-Ying Chen, Chun-Hsien Chen, Wei-Chen Lin, Chih-Wei Tung, Yung-Chia Chen, Shang-Hsun Yang, Bu-Miin Huang & Rong-Jane Chen. (2021) The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin. Molecules 26:16, pages 4954.
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Toan Van Nguyen, Pramote Chumnanpuen, Kongphop Parunyakul, Krittika Srisuksai & Wirasak Fungfuang. (2021) A study of the aphrodisiac properties of Cordyceps militaris in streptozotocin-induced diabetic male rats. Veterinary World 14:2, pages 537-544.
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Gitishree Das, Han-Seung Shin, Gerardo Leyva-Gómez, María L. Del Prado-Audelo, Hernán Cortes, Yengkhom Disco Singh, Manasa Kumar Panda, Abhay Prakash Mishra, Manisha Nigam, Sarla Saklani, Praveen Kumar Chaturi, Miquel Martorell, Natália Cruz-Martins, Vineet Sharma, Neha Garg, Rohit Sharma & Jayanta Kumar Patra. (2021) Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Frontiers in Pharmacology 11.
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炜乾 黄. (2021) Research Progress of Cordycepin on Improving Reproduction and Mechanism in Male Animals. Bioprocess 11:04, pages 146-154.
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Fatma A. Abo Nouh, Sara A. Gezaf, Hebatallah H. Abo Nahas, Yousef H. Abo Nahas, Celia Vargas-De-La-Cruz, Richard Andi Solorzano Acosta & Ahmed M. Abdel-Azeem. 2021. Industrially Important Fungi for Sustainable Development. Industrially Important Fungi for Sustainable Development 207 236 .
Vikas Kaushik, Amanvir Singh, Aditi Arya, Sangeeta Chahal Sindhu, Anil Sindhu & Ajay Singh. (2020) Enhanced production of cordycepin in Ophiocordyceps sinensis using growth supplements under submerged conditions. Biotechnology Reports 28, pages e00557.
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Xin Jiang, Pei-Chen Tang, Qin Chen, Xin Zhang, Yi-Yun Fan, Bo-Cheng Yu, Xin-Xia Gu, Ying Sun, Xiao-Qun Ge & Xiao-Ling Zhang. (2019) Cordycepin Exerts Neuroprotective Effects via an Anti-Apoptotic Mechanism based on the Mitochondrial Pathway in a Rotenone-Induced Parkinsonism Rat Model. CNS & Neurological Disorders - Drug Targets 18:8, pages 609-620.
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Ho, Wu, Lin, Wu, Chiu, Yeh, Huang & Wang. (2019) Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest. International Journal of Molecular Sciences 20:21, pages 5366.
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Ming‐Min Chang, Bo‐Syong Pan, Chia‐Yih Wang & Bu‐Miin Huang. (2019) Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells. Cancer Medicine 8:8, pages 3949-3964.
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Shuang Gu, Xiangyang Wang, Rong Zhou & Jianying Huang. (2019) Isolation and identification of nucleosides/nucleotides raising testosterone and NO levels of mice serum from Chinese chive ( Allium tuberosum ) leaves . Andrologia 51:2, pages e13191.
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Rahul Chaubey, Jitendra Singh, Mohammed Muzeruddin Baig & Amit Kumar. 2019. Recent Advancement in White Biotechnology Through Fungi. Recent Advancement in White Biotechnology Through Fungi 441 474 .
Guihong Qi, Yue Zhou, Xiaopo Zhang, Jiaqi Yu, Xin Li, Xiaoxue Cao, Chongming Wu & Peng Guo. (2018) Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway. Acta Pharmaceutica Sinica B.
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Jong Bong Lee, Cecilia Adrower, Chaolong Qin, Peter M. Fischer, Cornelia H. de Moor & Pavel Gershkovich. (2017) Development of Cordycepin Formulations for Preclinical and Clinical Studies. AAPS PharmSciTech 18:8, pages 3219-3226.
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FY Fung & YC Linn. (2017) Steroids in traditional Chinese medicine: what is the evidence?. Singapore Medical Journal 58:3, pages 115-120.
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Yung-Chia Chen, Ying-Hui Chen, Bo-Syong Pan, Ming-Min Chang & Bu-Miin Huang. (2017) Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Journal of Food and Drug Analysis 25:1, pages 197-205.
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Jin Xu, Ying Huang, Xiang-Xiang Chen, Shuai-Chao Zheng, Peng Chen & Ming-He Mo. (2016) The Mechanisms of Pharmacological Activities of Ophiocordyceps sinensis Fungi . Phytotherapy Research 30:10, pages 1572-1583.
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Bo-Syong Pan, Yang-Kao Wang, Meng-Shao Lai, Yi-Fen Mu & Bu-Miin Huang. (2015) Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Scientific Reports 5:1.
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Yi Liu, Jihui Wang, Wei Wang, Hanyue Zhang, Xuelan Zhang & Chunchao Han. (2015) The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis . Evidence-Based Complementary and Alternative Medicine 2015, pages 1-12.
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Mei Ling Jin, Sun Young Park, Young Hun Kim, Jeong-Il Oh, Sang Joon Lee & Geuntae Park. (2014) The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells. NeuroToxicology 41, pages 102-111.
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M.G. Shashidhar, P. Giridhar, K. Udaya Sankar & B. Manohar. (2013) Bioactive principles from Cordyceps sinensis: A potent food supplement – A review. Journal of Functional Foods 5:3, pages 1013-1030.
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Tsung-Teng Huang, Kowit-Yu Chong, David M. Ojcius, Yi-Hui Wu, Yun-Fei Ko, Cheng-Yeu Wu, Jan Martel, Chia-Chen Lu, Hsin-Chih Lai & John D. Young. (2013) Hirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes. Scientific Reports 3:1.
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Hui-Chen Lo, Chienyan Hsieh, Fang-Yi Lin & Tai-Hao Hsu. (2013) A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients. Journal of Traditional and Complementary Medicine 3:1, pages 16-32.
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Hsiang-Yin Pao, Bo-Syong Pan, Sew-Fen Leu & Bu-Miin Huang. (2012) Cordycepin Stimulated Steroidogenesis in MA-10 Mouse Leydig Tumor Cells through the Protein Kinase C Pathway. Journal of Agricultural and Food Chemistry 60:19, pages 4905-4913.
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Ying-Hui Chen, Sew-Fen Leu, Chun-Yi Jen & Bu-Miin Huang. (2011) Effects of Sesamol on Apoptosis and Steroidogenesis in MA-10 Mouse Leydig Tumor Cells. Journal of Agricultural and Food Chemistry 59:18, pages 9885-9891.
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Bo-Syong Pan, Chun-Yu Lin & Bu-Miin Huang. (2011) The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-14.
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