651
Views
61
CrossRef citations to date
0
Altmetric
Original Articles

Inhibition of Increases in Blood Glucose and Serum Neutral Fat by Momordica charantia Saponin Fraction

, , , , , & show all
Pages 735-740 | Received 17 Oct 2006, Accepted 11 Dec 2006, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

  Mahwish, Farhan Saeed, Farhana Nosheen, Qurat-ul -Ain, Bushra Niaz, Muhammad Afzaal, Kashifa Ehsan, Muzzamal Hussain, Muhammad Imran & Entessar Al Jbawi. (2023) Bio-evaluation of alkaloids and saponins from bitter melon: Probing more desirable compound in treating hyperglycemia and hyperlipidemia. Cogent Food & Agriculture 9:1.
Read now
Yifan Zhou & Baojun Xu. (2022) New insights into anti-diabetes effects and molecular mechanisms of dietary saponins. Critical Reviews in Food Science and Nutrition 0:0, pages 1-26.
Read now
Jianhui Su, Hongxin Wang, Chaoyang Ma, Chengxiang Liu, Chuanzhong Gao, Rongjing Nie & Md Ramim Tanver Rahman. (2016) Hypocholesterolaemic mechanism of bitter melon aqueous extracts via inhibition of pancreatic cholesterol esterase and reduction of cholesterol micellar solubility. International Journal of Food Sciences and Nutrition 67:1, pages 20-28.
Read now
Chuncho Han, Qiusha Hui & Yingzi Wang. (2008) Hypoglycaemic activity of saponin fraction extracted from in PEG/salt aqueous two-phase systems. Natural Product Research 22:13, pages 1112-1119.
Read now

Articles from other publishers (57)

Muhammad Umair Afzal, Muhammad Pervaiz, Anam Ejaz, Eisha Bajwa, Sadaf Naz, Zohaib Saeed, Sami Ullah, Syeda Shaista Gillani, Rana Rashad Mehmood Kan & Umer Younas. (2023) A comprehensive study of the sources, extraction methods and structures of the Saponin compounds for its antidiabetic activity. Biocatalysis and Agricultural Biotechnology 54, pages 102913.
Crossref
Cam Thi Hong Tran, Parushi Nargotra, Hoa Thi Cam Pham, Dong My Lieu, Phung Kim Huynh, Hui-Min David Wang, Cheng-Di Dong & Chia-Hung Kuo. (2023) The effect of carboxymethyl cellulose and β-cyclodextrin as debittering agents on bitterness and physicochemical properties of bitter gourd extract. Journal of Food Science and Technology 60:5, pages 1521-1529.
Crossref
Chang-Yi Huang & Su-Der Chen. (2022) Application of High Pressure Processing on Ultrasonically Treated Extract from Wild Bitter Gourd. Processes 10:10, pages 1926.
Crossref
Emine OKUMUŞ & Mehmet Ali TEMİZ. (2022) Saponin Bileşeninin Biyolojik Aktiviteleri, Kullanım Alanları ve EtkileriThe Biological Activities, Applications and Effects of Saponin Component. Van Sağlık Bilimleri Dergisi 15:2, pages 164-173.
Crossref
Ze Fan, Jinnan Li, Di Wu, Chenhui Li, Dingchen Cao, Linghong Miao, Xianping Ge & Liansheng Wang. (2022) Preliminarily curative effectiveness of long-term bitter melon Momordica charantia saponins administration for the glucose homeostasis of juvenile common carp (Cyprinus carpio) fed a high-starch diet. Aquaculture Reports 25, pages 101232.
Crossref
Mahmoud Radwan, Mahmoud Mahrous M. Abbas, Amaal Mohammadein, Jamila S. Al Malki, Said M. A. Elraey & Mohammad Magdy. (2022) Growth Performance, Immune Response, Antioxidative Status, and Antiparasitic and Antibacterial Capacity of the Nile Tilapia (Oreochromis niloticus) After Dietary Supplementation With Bottle Gourd (Lagenaria siceraria, Molina) Seed Powder. Frontiers in Marine Science 9.
Crossref
Chang-Yi Huang, Yu-Huang Cheng & Su-Der Chen. (2022) Hot Air-Assisted Radio Frequency (HARF) Drying on Wild Bitter Gourd Extract. Foods 11:8, pages 1173.
Crossref
F Tedjakusuma & D Lo. (2022) Functional properties of Anredera cordifolia (Ten.) Steenis: a review. IOP Conference Series: Earth and Environmental Science 998:1, pages 012051.
Crossref
Awa Fanny Massounga Bora, Xiaodong Li & Lu Liu. (2021) Physicochemical and Functional Characterization of Newly Designed Biopolymeric-Based Encapsulates with Probiotic Culture and Charantin. Foods 10:11, pages 2677.
Crossref
Amy C. Keller, Kan He, Anne-Marie Brillantes & Edward J. Kennelly. (2021) A characterized saponin-rich fraction of Momordica charantia shows antidiabetic activity in C57BLK/6 mice fed a high fat diet. Phytomedicine Plus 1:4, pages 100134.
Crossref
Marisol Cortez-NavarreteMiriam Méndez-del VillarElsy Janeth Ramos-GonzálezKarina G. Pérez-Rubio. (2021) Momordica Charantia: A Review of Its Effects on Metabolic Diseases and Mechanisms of Action . Journal of Medicinal Food 24:10, pages 1017-1027.
Crossref
Syam P.K. Jeepipalli, Bin Du, Uteuliyev Y. Sabitaliyevich & Baojun Xu. (2020) New insights into potential nutritional effects of dietary saponins in protecting against the development of obesity. Food Chemistry 318, pages 126474.
Crossref
Laksmi Hartajanie, S. Fatimah-Muis, K. Heri-Nugroho HS, Ign Riwanto & M. Sulchan. (2020) Probiotics Fermented Bitter Melon Juice as Promising Complementary Agent for Diabetes Type 2: Study on Animal Model. Journal of Nutrition and Metabolism 2020, pages 1-7.
Crossref
Shuang Jiang, Lei Xu, Yan Xu, Yushan Guo, Lin Wei, Xueting Li & Wu Song. (2020) Antidiabetic effect of Momordica charantia saponins in rats induced by high-fat diet combined with STZ. Electronic Journal of Biotechnology 43, pages 41-47.
Crossref
Man WANG, Bing YU, Jun HE, Jie YU, Yu-heng LUO, Jun-qiu LUO, Xiang-bin MAO & Dai-wen CHEN. (2020) The toxicological effect of dietary excess of saccharicterpenin, the extract of camellia seed meal, in piglets. Journal of Integrative Agriculture 19:1, pages 211-224.
Crossref
Fan, Kim, Choi, Tang & Moon. (2019) The Role of Momordica charantia in Resisting Obesity. International Journal of Environmental Research and Public Health 16:18, pages 3251.
Crossref
Teresa Herrera, Joaquín Navarro del Hierro, Tiziana Fornari, Guillermo Reglero & Diana Martin. (2019) Inhibitory effect of quinoa and fenugreek extracts on pancreatic lipase and α-amylase under in vitro traditional conditions or intestinal simulated conditions. Food Chemistry 270, pages 509-517.
Crossref
Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 177 249 .
Jun Yin, Chang-Seob Seo, In Hwang, Min Lee & Kwang Song. (2018) Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds. Nutrients 10:9, pages 1221.
Crossref
Xiaojuan An, Wenping Li, Yinli Liang, Lan Mu & Tianli Bao. (2017) Fruit quality components of balsam pear (Momordica charantia L.) and soil respiration in response to soil moisture under two soil conditions. Journal of Food Measurement and Characterization 12:2, pages 710-720.
Crossref
John Baptist Nzukizi Mudumbi, Seteno Karabo Obed Ntwampe, Lukhanyo Mekuto, Tandi Matsha & Elie Fereche Itoba-Tombo. (2018) The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies. Environmental Monitoring and Assessment 190:5.
Crossref
Anofi O. T. Ashafa & Mikhail O. Nafiu. (2017) Antidiabetic activity and free radicals modulatory potentials of saponin-rich extract of Cochlospermum planchonii (Hook Fx. Planch) root in vitro. Comparative Clinical Pathology 27:2, pages 313-320.
Crossref
Shoko Nishizono, Atsushi Nomura, Miharu Hidaka, Kaori Senju, Senanayake V.K. Gamarallage, Nobuhiro Fukuda, Chizuru Yukizaki & Keisuke Uryu. (2018) Effects of Bitter Melon (<i>Momordica charantia</i>) Juice Powder on Lipid Metabolism in Ratsニガウリ果汁末のラット脂質代謝に及ぼす影響. Nippon Shokuhin Kagaku Kogaku Kaishi 65:2, pages 45-54.
Crossref
Joaquín Navarro del Hierro, Teresa Herrera, Tiziana Fornari, Guillermo Reglero & Diana Martin. (2018) The gastrointestinal behavior of saponins and its significance for their bioavailability and bioactivities. Journal of Functional Foods 40, pages 484-497.
Crossref
Birten Emre, Ömer Korkmaz, Füsun Temamoğulları, Abuzer Kafar Zonturlu, İsmail Koyuncu, Mustafa Özkaraca & Mehmet Cengiz. (2017) Effect of intrauterine infusion of Momordica charantia L. on oxidative stress and pregnancy rate in infertile cows . Journal of Veterinary Research 61:4, pages 489-496.
Crossref
Narinder P. S. Dhillon, Chung-Cheng Lin, Zhanyong Sun, Peter M. Hanson, Dolores R. Ledesma, Sandra D. Habicht & Ray-Yu Yang. (2016) Varietal and harvesting stage variation in the content of carotenoids, ascorbic acid and tocopherols in the fruit of bitter gourd ( Momordica charantia L.) . Plant Genetic Resources 15:3, pages 248-259.
Crossref
Yuwen LiJongsun ParkYin WuJia CuiNa JiaMiaomiao XiAidong Wen. (2017) Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis : implication in antihyperglycemic and hypolipidemic activities . The Korean Journal of Physiology & Pharmacology 21:3, pages 279.
Crossref
Md. Mamun Or Rashid, Jannatul Ferdous, Sujan Banik, Md. Rabiul Islam, A.H.M. Mazbah Uddin & Fataha Nur Robel. (2016) Anthelmintic activity of silver-extract nanoparticles synthesized from the combination of silver nanoparticles and M. charantia fruit extract. BMC Complementary and Alternative Medicine 16:1.
Crossref
Mariangela Marrelli, Filomena Conforti, Fabrizio Araniti & Giancarlo Statti. (2016) Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules 21:10, pages 1404.
Crossref
Patricia T. Alpert. (2015) Super Foods With Medicinal Properties. Home Health Care Management & Practice 28:2, pages 127-129.
Crossref
Akihiro Ogawa, Toshiya Kobayashi, Fumihiko Sakai, Yukio Kadooka & Yoshihiro Kawasaki. (2015) Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects. Lipids in Health and Disease 14:1.
Crossref
Naglaa Raafat AbdRaboh & Naglaa Ahmed. (2015) Comparative Study of Biochemical Changes in Alloxan Induced Diabetic Mice Treated with Extracts of Spathodea campanulata Flowering Branch and Barks. Research Journal of Medicinal Plant 9:8, pages 395-405.
Crossref
Consuelo Lomas-Soria, Iza F. Pérez-Ramírez, Juan Caballero-Pérez, Ramón G. Guevara-Gonzalez, Lorenzo Guevara-Olvera, Guadalupe Loarca-Piña, Horacio S. Guzman-Maldonado & Rosalía Reynoso-Camacho. (2015) Cooked common beans ( Phaseolus vulgaris L.) modulate renal genes in streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 26:7, pages 761-768.
Crossref
Yuwen Li, Tiejun Zhang, Jia Cui, Na Jia, Yin Wu, Miaomiao Xi & Aidong Wen. (2015) Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects. Journal of Pharmacy and Pharmacology 67:7, pages 997-1007.
Crossref
Olusola Olalekan Elekofehinti. (2015) Saponins: Anti-diabetic principles from medicinal plants – A review. Pathophysiology 22:2, pages 95-103.
Crossref
C.S. Devaki, D. D. Wadikar & P.E. Patki. (2015) Vegetable gourds – guards of human health: a critical appraisal. Nutrition & Food Science 45:1, pages 125-144.
Crossref
Md Ashraful Alam, Riaz Uddin, Nusrat Subhan, Md Mahbubur Rahman, Preeti Jain & Hasan Mahmud Reza. (2015) Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome. Journal of Lipids 2015, pages 1-18.
Crossref
Heping Cao, Kandan Sethumadhavan, Casey C. Grimm & Abul H. J. Ullah. (2014) Characterization of a Soluble Phosphatidic Acid Phosphatase in Bitter Melon (Momordica charantia). PLoS ONE 9:9, pages e106403.
Crossref
Jeom-Sook Lee, Myung-Sook Choi, Kown-Il Seo, Jin Lee, Hae-In Lee, Ju-Hye Lee, Myung-Joo Kim & Mi-Kyung Lee. (2013) Platycodi radix saponin inhibits α-glucosidase in vitro and modulates hepatic glucose-regulating enzyme activities in C57BL/KsJ-db/db mice. Archives of Pharmacal Research 37:6, pages 773-782.
Crossref
Hyun Young Kim, Seung Mi Sin, Sanghyun Lee, Kye Man Cho & Eun Ju Cho. (2013) The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates Oxidative Stress. Preventive Nutrition and Food Science 18:1, pages 18-22.
Crossref
Rosaria Acquaviva, Claudia Di Giacomo, Luca Vanella, Rosa Santangelo, Valeria Sorrenti, Ignazio Barbagallo, Carlo Genovese, Silvana Mastrojeni, Salvatore Ragusa & Liliana Iauk. (2013) Antioxidant Activity of Extracts of Momordica Foetida Schumach. et Thonn.. Molecules 18:3, pages 3241-3249.
Crossref
K. Koga, M. Hisamura, T. Kanetaka, K. Yoshino, Y. Matsuo & T. Tanaka. (2013) Proanthocyanidin Oligomers Isolated from Salacia reticulata leaves potently Inhibit Pancreatic Lipase Activity . Journal of Food Science 78:1, pages H105-H111.
Crossref
Cheow Peng Ooi, Zaitun Yassin & Tengku-Aizan Hamid. (2012) Momordica charantia for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews.
Crossref
Gamarallage V. K. Senanayake, Nobuhiro Fukuda, Shoko Nshizono, Yu-Ming Wang, Koji Nagao, Teruyoshi Yanagita, Masako Iwamoto & Hideaki Ohta. (2012) Mechanisms Underlying Decreased Hepatic Triacylglycerol and Cholesterol by Dietary Bitter Melon Extract in the Rat. Lipids 47:5, pages 495-503.
Crossref
Padmaja Chaturvedi. (2012) Antidiabetic Potentials of Momordica charantia : Multiple Mechanisms Behind the Effects . Journal of Medicinal Food 15:2, pages 101-107.
Crossref
Amy C. Keller, Jun Ma, Adam Kavalier, Kan He, Anne-Marie B. Brillantes & Edward J. Kennelly. (2011) Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 19:1, pages 32-37.
Crossref
Masao Sato, Takatoshi Ueda, Kazuko Nagata, Sawako Shiratake, Hiroko Tomoyori, Mitsuo Kawakami, Yukio Ozaki, Hiroshi Okubo, Bungo Shirouchi & Katsumi Imaizumi. (2011) Dietary kakrol ( Momordica dioica Roxb.) flesh inhibits triacylglycerol absorption and lowers the risk for development of fatty liver in rats . Experimental Biology and Medicine 236:10, pages 1139-1146.
Crossref
Sandra D. Habicht, Veronika Kind, Silvia Rudloff, Christian Borsch, Andreas S. Mueller, Josef Pallauf, Ray-yu Yang & Michael B. Krawinkel. (2011) Quantification of antidiabetic extracts and compounds in bitter gourd varieties. Food Chemistry 126:1, pages 172-176.
Crossref
U Gupta. 2011. What's New About Crop Plants. What's New About Crop Plants 403 427 .
Fabiola Rivera-Ramírez, Gerardo N. Escalona-Cardoso, Leticia Garduño-Siciliano, Carlos Galaviz-Hernández & Norma Paniagua-Castro. (2011) Antiobesity and Hypoglycaemic Effects of Aqueous Extract of Ibervillea sonorae in Mice Fed a High-Fat Diet with Fructose . Journal of Biomedicine and Biotechnology 2011, pages 1-6.
Crossref
Sandra D. Klomann, Andreas S. Mueller, Josef Pallauf & Michael B. Krawinkel. (2010) Antidiabetic effects of bitter gourd extracts in insulin-resistant db/db mice. British Journal of Nutrition 104:11, pages 1613-1620.
Crossref
David G. Popovich, Lu Li & Wei Zhang. (2010) Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food and Chemical Toxicology 48:6, pages 1619-1626.
Crossref
Cheow Peng Ooi, Zaitun Yassin & Tengku-Aizan Hamid. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Edralin A. Lucas, Gerard G. Dumancas, Brenda J. Smith, Stephen L. Clarke & Bahram H. Arjmandi. 2010. Bioactive Foods in Promoting Health. Bioactive Foods in Promoting Health 525 549 .
Cheow Peng Ooi, Zaitun Yassin & Tengku-Aizan Hamid. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Felix O. Omoruyi. (2008) Jamaican Bitter Yam Sapogenin: Potential Mechanisms of Action in Diabetes. Plant Foods for Human Nutrition 63:3, pages 135-140.
Crossref
Miaomiao Xi, Chunxu Hai, Haifeng Tang, Mingsheng Chen, Kunquan Fang & Xin Liang. (2007) Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytotherapy Research 22:2, pages 228-237.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.