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Original Articles

Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin

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Pages 973-977 | Received 02 Nov 1998, Accepted 05 Feb 1999, Published online: 22 May 2014

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Maaike M. Appeldoorn, Jean-Paul Vincken, Harry Gruppen & Peter C.H. Hollman. (2009) Procyanidin Dimers A1, A2, and B2 Are Absorbed without Conjugation or Methylation from the Small Intestine of Rats. The Journal of Nutrition 139:8, pages 1469-1473.
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Tankred Schewe & Helmut Sies. 2009. Beer in Health and Disease Prevention. Beer in Health and Disease Prevention 803 813 .
H. Xu, W.T. Lui, C.Y. Chu, P.S. Ng, C.C. Wang & M.S. Rogers. (2008) Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model. Human Reproduction 24:3, pages 608-618.
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Maria Gonta, Gheorghe Duca & Diana Porubin. (2008) Establishment of the Antioxidant/Antiradical Activity of the Inhibitors Using the DPPH–Radical. Chemistry Journal of Moldova 3:1, pages 118-126.
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Keiko Unno, Yuichi Ishikawa, Fumiyo Takabayashi, Toru Sasaki, Nina Takamori, Kazuaki Iguchi & Minoru Hoshino. (2009) Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice. BioFactors 34:4, pages 263-271.
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Maria de Lourdes Mata-Bilbao, Cristina Andrés-Lacueva, Elena Roura, Olga Jáuregui, Celina Torre & Rosa Maria Lamuela-Raventós. (2007) A New LC/MS/MS Rapid and Sensitive Method for the Determination of Green Tea Catechins and their Metabolites in Biological Samples. Journal of Agricultural and Food Chemistry 55:22, pages 8857-8863.
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K.O. Chu, C.C. Wang, C.Y. Chu, K.W. Choy, C.P. Pang & M.S. Rogers. (2007) Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Human Reproduction 22:1, pages 280-287.
Crossref
Elisa Tripoli, Maurizio La Guardia, Santo Giammanco, Danila Di Majo & Marco Giammanco. (2007) Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review. Food Chemistry 104:2, pages 466-479.
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Susan E. Pollard, Gunter G.C. Kuhnle, David Vauzour, Katerina Vafeiadou, Xenofon Tzounis, Matthew Whiteman, Catherine Rice-Evans & Jeremy P.E. Spencer. (2006) The reaction of flavonoid metabolites with peroxynitrite. Biochemical and Biophysical Research Communications 350:4, pages 960-968.
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Kai On Chu, Chi Chiu Wang, Ching Yan Chu, Kwok Ping Chan, Michael Scott Rogers, Kwong Wai Choy & Chi Pui Pang. (2006) Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats. Journal of Pharmaceutical Sciences 95:6, pages 1372-1381.
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Silvia Mandel, Tamar Amit, Moussa Youdim & Orly Weinreb. 2005. Molecular Interventions in Lifestyle-Related Diseases. Molecular Interventions in Lifestyle-Related Diseases 155 174 .
Jeremy Spencer. 2005. Nutrition and Cancer Prevention. Nutrition and Cancer Prevention.
Elena Roura, Cristina Andrés-Lacueva, Olga Jáuregui, Eva Badia, Ramon Estruch, Maria Izquierdo-Pulido & Rosa M. Lamuela-Raventós. (2005) Rapid Liquid Chromatography Tandem Mass Spectrometry Assay To Quantify Plasma (−)-Epicatechin Metabolites after Ingestion of a Standard Portion of Cocoa Beverage in Humans. Journal of Agricultural and Food Chemistry 53:16, pages 6190-6194.
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Rosanna M.A. Rahman, Shiva M. Nair, Stephen C. Helps, Odette M. Shaw, Neil R. Sims, Rhonda J. Rosengren & Ian Appleton. (2005) (−)-Epigallocatechin gallate as an intervention for the acute treatment of cerebral ischemia. Neuroscience Letters 382:3, pages 227-230.
Crossref
Salomon L. Abrahamse, Willem J. Kloots & Johan M.M. van Amelsvoort. (2005) Absorption, distribution, and secretion of epicatechin and quercetin in the rat. Nutrition Research 25:3, pages 305-317.
Crossref
Violeta G. RANEVA, Yukiko SHIMIZU & Hiroyuki SHIMASAKI. (2005) Antioxidant Activity in Plasma and Tissues Distribution of (-)-Epigallocatechin Gallate after Oral Administration to Rats. Journal of Oleo Science 54:5, pages 289-298.
Crossref
Li Zhang, Ying Zheng, Moses S.S. Chow & Zhong Zuo. (2004) Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model. International Journal of Pharmaceutics 287:1-2, pages 1-12.
Crossref
Orly Weinreb, Silvia Mandel, Tamar Amit & Moussa B.H. Youdim. (2004) Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. The Journal of Nutritional Biochemistry 15:9, pages 506-516.
Crossref
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Crossref
Morgan, Joseph Rothwell & Andrea Day. 2004. Phytochemicals in Health and Disease. Phytochemicals in Health and Disease 57 76 .
Silvia Mandel, Orly Weinreb, Tamar Amit & Moussa B. H. Youdim. (2004) Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases. Journal of Neurochemistry 88:6, pages 1555-1569.
Crossref
Iman A. Hakim, Robin B. Harris, H-H. Sherry Chow, Michael Dean, Sylvia Brown & Iqbal Unnisa Ali. (2004) Effect of a 4-Month Tea Intervention on Oxidative DNA Damage among Heavy Smokers. Cancer Epidemiology, Biomarkers & Prevention 13:2, pages 242-249.
Crossref
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Crossref
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Kirty S. Solanky, Nigel J. C. Bailey, Elaine Holmes, John C. Lindon, Adrienne L. Davis, Theo P. J. Mulder, John P. M. Van Duynhoven & Jeremy K. Nicholson. (2003) NMR-Based Metabonomic Studies on the Biochemical Effects of Epicatechin in the Rat. Journal of Agricultural and Food Chemistry 51:14, pages 4139-4145.
Crossref
E.F Lhoste, V Ouriet, S Bruel, J.-P Flinois, C Brézillon, J Magdalou, C Chèze & L Nugon-Baudon. (2003) The human colonic microflora influences the alterations of xenobiotic-metabolizing enzymes by catechins in male F344 rats. Food and Chemical Toxicology 41:5, pages 695-702.
Crossref
Midori Natsume, Naomi Osakabe, Makoto Oyama, Motoko Sasaki, Seigo Baba, Yoshimasa Nakamura, Toshihiko Osawa & Junji Terao. (2003) Structures of (−)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (−)-epicatechin: differences between human and rat. Free Radical Biology and Medicine 34:7, pages 840-849.
Crossref
Masaaki Nakai, Masami Harada, Koichi Nakahara, Kengo Akimoto, Hiroshi Shibata, Wataru Miki & Yoshinobu Kiso. (2003) Novel Antioxidative Metabolites in Rat Liver with Ingested Sesamin. Journal of Agricultural and Food Chemistry 51:6, pages 1666-1670.
Crossref
Tianhong Pan, Joseph Jankovic & Weidong Le. (2003) Potential Therapeutic Properties of Green Tea Polyphenols in Parkinson???s Disease. Drugs & Aging 20:10, pages 711-721.
Crossref
Hiroshi KuriharaHarukazu FukamiYoshiko ToyodaNorihiko KageyamaNobuo TsuruokaHiroshi ShibataYoshinobu KisoTakaharu Tanaka. (2003) Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL). Biological and Pharmaceutical Bulletin 26:5, pages 739-742.
Crossref
Maria Wartenberg, Paula Budde, Markus de Mareés, Frank Grünheck, Suk Ying Tsang, Yu Huang, Zhen-Yu Chen, Jürgen Hescheler & Heinrich Sauer. (2003) Inhibition of Tumor-Induced Angiogenesis and Matrix-Metalloproteinase Expression in Confrontation Cultures of Embryoid Bodies and Tumor Spheroids by Plant Ingredients Used in Traditional Chinese Medicine. Laboratory Investigation 83:1, pages 87-98.
Crossref
Manal M Abd El Mohsen, Gunter Kuhnle, Andreas R Rechner, Hagen Schroeter, Sarah Rose, Peter Jenner & Catherine A Rice-Evans. (2002) Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radical Biology and Medicine 33:12, pages 1693-1702.
Crossref
Cécile Cren-OlivéPhilippe HapiotJean PinsonChristian Rolando. (2002) Free Radical Chemistry of Flavan-3-ols:  Determination of Thermodynamic Parameters and of Kinetic Reactivity from Short (ns) to Long (ms) Time Scale. Journal of the American Chemical Society 124:47, pages 14027-14038.
Crossref
Roberta R Holt, Sheryl A Lazarus, M Cameron Sullards, Qin Yan Zhu, Derek D Schramm, John F Hammerstone, Cesar G Fraga, Harold H Schmitz & Carl L Keen. (2002) Procyanidin dimer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa,,. The American Journal of Clinical Nutrition 76:4, pages 798-804.
Crossref
Jaya Bharathi Vaidyanathan & Thomas Walle. (2002) Glucuronidation and Sulfation of the Tea Flavonoid (−)-Epicatechin by the Human and Rat Enzymes. Drug Metabolism and Disposition 30:8, pages 897-903.
Crossref
Fayez E. Kandil, Mary Ann L. Smith, Randy B. Rogers, Marie-France Pépin, Lynda L. Song, John M. Pezzuto & David S. Seigler. (2002) Composition of a Chemopreventive Proanthocyanidin-Rich Fraction from Cranberry Fruits Responsible for the Inhibition of 12- O -Tetradecanoyl Phorbol-13-acetate (TPA)-Induced Ornithine Decarboxylase (ODC) Activity . Journal of Agricultural and Food Chemistry 50:5, pages 1063-1069.
Crossref
K.A. Youdim, J.P.E. Spencer, H. Schroeter & C. Rice-Evans. (2002) Dietary Flavonoids as Potential Neuroprotectants. Biological Chemistry 383:3-4.
Crossref
Qing Feng, Yasuyoshi Torii, Koji Uchida, Yoshimasa Nakamura, Yokihiko Hara & Toshihiko Osawa. (2001) Black Tea Polyphenols, Theaflavins, Prevent Cellular DNA Damage by Inhibiting Oxidative Stress and Suppressing Cytochrome P450 1A1 in Cell Cultures. Journal of Agricultural and Food Chemistry 50:1, pages 213-220.
Crossref
Jeremy P.E. SpencerHagen SchroeterAndreas R. RechnerCatherine Rice-Evans. (2001) Bioavailability of Flavan-3-ols and Procyanidins: Gastrointestinal Tract Influences and Their Relevance to Bioactive Forms In Vivo . Antioxidants & Redox Signaling 3:6, pages 1023-1039.
Crossref
Seigo Baba, Naomi Osakabe, Midori Natsume, Yuko Muto, Toshio Takizawa & Junji Terao. (2001) In Vivo Comparison of the Bioavailability of (+)-Catechin, (−)-Epicatechin and Their Mixture in Orally Administered Rats. The Journal of Nutrition 131:11, pages 2885-2891.
Crossref
Jeremy P.E Spencer, Hagen Schroeter, Andrew J Crossthwaithe, Gunter Kuhnle, Robert J Williams & Catherine Rice-Evans. (2001) Contrasting influences of glucuronidation and O -methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts. Free Radical Biology and Medicine 31:9, pages 1139-1146.
Crossref
Beverly A. Warden, Lametta S. Smith, Gary R. Beecher, Douglas A. Balentine & Beverly A. Clevidence. (2001) Catechins Are Bioavailable in Men and Women Drinking Black Tea throughout the Day. The Journal of Nutrition 131:6, pages 1731-1737.
Crossref
Takuro Koga & Mohsen Meydani. (2001) Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. The American Journal of Clinical Nutrition 73:5, pages 941-948.
Crossref
Shutsung Liao, Yung-Hsi Kao & Richard A Hiipakka. 2001. 1 94 .
Seigo Baba, Naomi Osakabe, Midori Natsume, Akiko Yasuda, Toshio Takizawa, Tetsuo Nakamura & Junji Terao. (2007) Cocoa powder enhances the level of antioxidative activity in rat plasma. British Journal of Nutrition 84:5, pages 673-680.
Crossref
Gunter Kuhnle, Jeremy P.E. Spencer, Hagen Schroeter, Baskar Shenoy, Edward S. Debnam, S.Kaila S. Srai, Catherine Rice-Evans & Ulrich Hahn. (2000) Epicatechin and Catechin are O-Methylated and Glucuronidated in the Small Intestine. Biochemical and Biophysical Research Communications 277:2, pages 507-512.
Crossref
Andrea T. Borchers, Carl L. Keen, Sandra M. Hannum & M. Eric Gershwin. (2000) Cocoa and Chocolate: Composition, Bioavailability, and Health Implications. Journal of Medicinal Food 3:2, pages 77-105.
Crossref
Jeremy P.E. Spencer, Fozia Chaudry, Ananth Sekher Pannala, S.Kaila Srai, Edward Debnam & Catherine Rice-Evans. (2000) Decomposition of Cocoa Procyanidins in the Gastric Milieu. Biochemical and Biophysical Research Communications 272:1, pages 236-241.
Crossref
M Castellari, L Matricardi, G Arfelli, S Galassi & A Amati. (2000) Level of single bioactive phenolics in red wine as a function of the oxygen supplied during storage. Food Chemistry 69:1, pages 61-67.
Crossref
Tomonori Unno, Akio Sugimoto & Takami Kakuda. (2000) Scavenging effect of tea catechins and their epimers on superoxide anion radicals generated by a hypoxanthine and xanthine oxidase system. Journal of the Science of Food and Agriculture 80:5, pages 601-606.
Crossref
Jeremy P.E Spencer, George Chowrimootoo, Ruksana Choudhury, Edward S Debnam, S.Kaila Srai & Catherine Rice-Evans. (1999) The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Letters 458:2, pages 224-230.
Crossref

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