573
Views
129
CrossRef citations to date
0
Altmetric
Original Articles

Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin

, , , , , , & show all
Pages 973-977 | Received 02 Nov 1998, Accepted 05 Feb 1999, Published online: 22 May 2014

  • 1) Rice-Evans, C. A., Miller, N. J., and Paganga, G., Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biol. Med., 20, 933-956 (1996).
  • 2) Laranjinha, J. A. N., Almeida, L. M., and Madeira, V. M. C., Reactivity of dietary phenolic acids with peroxyl radicals: antioxidant activity upon low density lipoprotein peroxidation. Biochem. Pharmacol., 48, 487-494 (1994).
  • 3) Frankel, E. N., Kanner, J., German, J. B., Parks, E., and Kinsella, J. E., Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet, 341, 454-457 (1993).
  • 4) Hayek, T., Fuhrman, B., Vaya, J., Roseblat, M., Belinky, P., Coleman, R., Elis, A., and Aviram, M., Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler. Thromb. Vasc. Biol., 17, 2744-2752 (1997).
  • 5) Pietta, P. G., Simonetti, P., Gardana, C., Brusamolino, A., Morazzoni, P., and Bombardelli, E., Catechin metabolites after intake of green tea infusions. Biofactors, 8, 111-118 (1998).
  • 6) Lotito, S. B., and Fraga, C. G., (+)-Catechin prevents human plasma oxidation. Free Radical Biol. Med., 24, 435-441 (1998).
  • 7) Silva, E. L. D., Piskula, M., and Terao, J., Enhancement of antioxidative ability of rat plasma by oral administration of (-)-epicatechin. Free Radical Biol. Med., 24, 1209-1216 (1998).
  • 8) Das, N. P., Studies on flavonoid metabolism. Absorption and metabolism of (+)-catechin in man. Biochem. Pharmacol., 20, 3435-3445 (1971).
  • 9) Chen, L., Lee, M. J., Li, H., and Yang, C. S., Absorption, distribution, and elimination of tea polyphenols in rats. Drug Metab. Dispos., 25, 1045-1050 (1997).
  • 10) Piskula, M. K., and Terao, J., Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues. J. Nutr., 128, 1172-1178 (1998).
  • 11) Shaw, I. C., and Griffiths, L. A., Identification of the major biliary metabolite of (+)-catechin in the rat. Xenobiotica, 10, 905-911 (1980).
  • 12) Gott, D. M., and Griffiths, L. A., Effects of antibiotic pretreatments on the metabolism and excretion of [U14C](+)-catechin ([U14C](+)-cyanidanol-3) and its metabolite, 3′-O-methyl-(+)-catechin. Xenobiotica, 17, 423-434 (1987).
  • 13) Hackett, A. M., Griffiths, L. A., and Wermeille, M., The quantitative disposition of 3-O-methyl-(+)-[U14C]catechin in man following oral administration. Xenobiotica, 15, 907-914 (1985).
  • 14) Hackett, A. M., and Griffiths, L. A., The metabolism and excretion of 3-O-methyl-(+)-catechin in the rat, mouse, and marmoset. Drug Metab. Dispos., 9, 54-59 (1981).
  • 15) Das, N. P., and Sothy, S. P., Studies on flavonoid metabolism. Biliary and urinary excretion of metabolites of (+)-[U14C]catechin. Biochem. J., 125, 417-423 (1971).
  • 16) Hatano, T., Edamatsu, R., Hiramatsu, M., Mori, A., Fujita, Y., Yasuhara, T., Yoshida, T., and Okuda, T., Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull., 37, 2016-2021 (1989).
  • 17) Willker, W., Leibfritz, D., Kerssebaum, R., and Bermel, W., Gradient selection in inverse heteronuclear correlation spectroscopy. Magn. Reson. Chem., 31, 287-292 (1993).
  • . 1990. p. 343- 355.
  • . 1994. p. 538- 564.
  • 20) Radominska, A., Little, J.M., Lehman, P. A., Samokyszyn, V., Rios, G. R., King, C. D., Green, M. D., and Tephly, T. R., Glucuronidation of retinoids by rat recombinant UDP: glucuronosyltransferase 1.1 (bilirubin UGT). Drug Metab. Dispos., 25, 889-892 (1997).
  • 21) Iwersen, S., and Schmoldt, A., A specific hydroxysteroid UGT is responsible for the conjugation of aliphatic alcohols in rats: an estimation of the importance of glucuronidation versus oxidation. Alcohol, 15, 185-192 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.