Advanced search
Publication Cover
Bioscience, Biotechnology, and Biochemistry Volume 66, 2002 - Issue 11
Journal homepage
393
Views
70
CrossRef citations to date
0
Altmetric
Original Articles

Cloned Cytosine Deaminase Gene Expression of Bifidobacterium longum and Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors

Toshiyuki NAKAMURADepartment of Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
,
Takayuki SASAKIDepartment of Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
,
Minoru FUJIMORIDepartment of Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
,
Kazuyuki YAZAWADepartment of Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
,
Yasunobu KANODepartment of Molecular Genetics, Institute of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University 1 Shichono-cho, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
,
Jun AMANODepartment of Surgery, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
&
Shun'ichiro TANIGUCHIDepartment of Molecular Oncology and Angiology, Angio-Aging Research Division, Research Center on Aging and Adaptation, Shinshu University School of Medicine 3-1-1 Asahi, Matsumoto 390-8621, Japan
show all
Pages 2362-2366 | Received 07 May 2002, Accepted 27 Jun 2002, Published online: 22 May 2014

Citations (70)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Lejaniya Abdul Kalam Saleena, Sui Kiat Chang, Khanom Simarani, Kantha Deivi Arunachalam, Rarinthorn Thammakulkrajang, Yu Hsuan How & Liew Phing Pui. (2023) A comprehensive review of Bifidobacterium spp: as a probiotic, application in the food and therapeutic, and forthcoming trends. Critical Reviews in Microbiology 0:0, pages 1-17.
Read now
Vincenzo F. Brancaccio, Daria S. Zhurina & Christian U. Riedel. (2013) Tough nuts to crack. Bioengineered 4:4, pages 197-202.
Read now
Chwanrow K. Baban, Michelle Cronin, Deirdre O’Hanlon, Gerald C. O’Sullivan & Mark Tangney. (2010) Bacteria as vectors for gene therapy of cancer . Bioengineered Bugs 1:6, pages 385-394.
Read now
Ayumi HIDAKA, Yoshinori HAMAJI, Takayuki SASAKI, Shun’ichiro TANIGUCHI & Minoru FUJIMORI. (2007) Exogeneous Cytosine Deaminase Gene Expression in Bifidobacterium breve I-53-8w for Tumor-Targeting Enzyme/Prodrug Therapy. Bioscience, Biotechnology, and Biochemistry 71:12, pages 2921-2926.
Read now
Yoshinori HAMAJI, Minoru FUJIMORI, Takayuki SASAKI, Hitomi MATSUHASHI, Keiichi MATSUI-SEKI, Yuko SHIMATANI-SHIBATA, Yasunobu KANO, Jun AMANO & Shun’ichiro TANIGUCHI. (2007) Strong Enhancement of Recombinant Cytosine Deaminase Activity in Bifidobacterium longum for Tumor-Targeting Enzyme/Prodrug Therapy. Bioscience, Biotechnology, and Biochemistry 71:4, pages 874-883.
Read now

Articles from other publishers (65)

Ziqing Lin, Yanqing Tang, Zerong Chen, Simin Li, Xueyan Xu, Xufeng Hou, Zhenhui Chen, Junjie Wen, Weisen Zeng, Xiaojing Meng & Hongying Fan. (2023) Soluble CD80 oral delivery by recombinant Lactococcus suppresses tumor growth by enhancing antitumor immunity . Bioengineering & Translational Medicine 8:4.
Crossref
Shoko Nomura, Erike W. Sukowati, Yuko Shigeno, Maiko Takahashi, Akari Kato, Yoshimi Benno, Fumiyoshi Yamashita & Hidefumi Mukai. (2023) Blautia coccoides JCM1395T Achieved Intratumoral Growth with Minimal Inflammation: Evidence for Live Bacterial Therapeutic Potential by an Optimized Sample Preparation and Colony PCR Method. Pharmaceutics 15:3, pages 989.
Crossref
Zerong Chen, Haibo Zhang, Jialiang Hui, Yaodong Jiang, Zehai Huang, Zhuangfei Chen & Weisen Zeng. (2023) Tim3scFv-Transforming Lactobacillus Inhibits Transplanted Tumor of Renal-Cell Carcinoma. Urologia Internationalis 107:2, pages 202-213.
Crossref
Ankita Punetha & Arun Kumar Punetha. 2023. Microbiome Therapeutics. Microbiome Therapeutics 197 230 .
Leon M. T. Dicks & Wian Vermeulen. (2022) Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?. Microorganisms 10:9, pages 1733.
Crossref
Aoife M. Brennan, Anna Sokolovska, Ning Li & Vincent M. Isabella. 2022. Engineering Technologies and Clinical Translation. Engineering Technologies and Clinical Translation 33 62 .
Saumya Darshana Patra, Aryashree Arunima & Mrutyunjay Suar. 2022. Microbial Engineering for Therapeutics. Microbial Engineering for Therapeutics 3 40 .
Meiyang Yang, Fuwei Yang, Weijun Chen, Shenhuan Liu, Lipeng Qiu & Jinghua Chen. (2021) Bacteria-mediated cancer therapies: opportunities and challenges. Biomaterials Science 9:17, pages 5732-5744.
Crossref
Shun’ichiro Taniguchi. (2021) In Situ Delivery and Production System (iDPS) of Anti-Cancer Molecules with Gene-Engineered Bifidobacterium. Journal of Personalized Medicine 11:6, pages 566.
Crossref
Michael S. Johns & Nicholas J. Petrelli. (2021) Microbiome and colorectal cancer: A review of the past, present, and future. Surgical Oncology 37, pages 101560.
Crossref
Koichiro Shioya, Tomio Matsumura, Yuji Seki, Hitomi Shimizu, Takaaki Nakamura & Shun'ichiro Taniguchi. (2021) Potentiated antitumor effects of APS001F/5-FC combined with anti-PD-1 antibody in a CT26 syngeneic mouse model. Bioscience, Biotechnology, and Biochemistry 85:2, pages 324-331.
Crossref
Swapnil C. Kamble, Farhan F. Shaikh & Joyita Sarkar. 2021. Nanotechnology for Advances in Medical Microbiology. Nanotechnology for Advances in Medical Microbiology 331 347 .
Vince W. Kelly, Benjamin K. Liang & Shannon J. Sirk. (2020) Living Therapeutics: The Next Frontier of Precision Medicine. ACS Synthetic Biology 9:12, pages 3184-3201.
Crossref
Fanglei Zuo, Shangwu Chen & Harold Marcotte. (2020) Engineer probiotic bifidobacteria for food and biomedical applications - Current status and future prospective. Biotechnology Advances 45, pages 107654.
Crossref
Noura S. Dosoky, Linda S. May-Zhang & Sean S. Davies. (2020) Engineering the gut microbiota to treat chronic diseases. Applied Microbiology and Biotechnology 104:18, pages 7657-7671.
Crossref
Atieh Yaghoubi, Majid Khazaei, Saba Jalili, Seyed Mahdi Hasanian, Amir Avan, Saman Soleimanpour & William C. Cho. (2020) Bacteria as a double-action sword in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188388.
Crossref
Mark R. Charbonneau, Vincent M. Isabella, Ning Li & Caroline B. Kurtz. (2020) Developing a new class of engineered live bacterial therapeutics to treat human diseases. Nature Communications 11:1.
Crossref
Atieh Yaghoubi, Majid Khazaei, Seyed Hasanian, Amir Avan, William C. Cho & Saman Soleimanpour. (2019) Bacteriotherapy in Breast Cancer. International Journal of Molecular Sciences 20:23, pages 5880.
Crossref
Nealie Ngo, Khalil Choucair, Justin F Creeden, Hanan Qaqish, Krupa Bhavsar, Chantal Murphy, Kendra Lian, Mary T Albrethsen, Laura Stanbery, Richard C Phinney, F Charles Brunicardi, Lance Dworkin & John Nemunaitis. (2019) Bifidobacterium spp : the promising Trojan Horse in the era of precision oncology . Future Oncology 15:33, pages 3861-3876.
Crossref
Hongyun Wei, Linlin Chen, Guanghui Lian, Junwen Yang, Fujun Li, Yiyou Zou, Fanggen Lu & Yani Yin. (2018) Antitumor mechanisms of bifidobacteria (Review). Oncology Letters.
Crossref
Mengge Liu, Shiyu Li, Qian Zhang, Zhenrui Xu, Jiajia Wang & Hanxiao Sun. (2018) Oral engineered Bifidobacterium longum expressing rhMnSOD to suppress experimental colitis. International Immunopharmacology 57, pages 25-32.
Crossref
Panos Lehouritis, Glenn Hogan & Mark Tangney. (2017) Designer bacteria as intratumoural enzyme biofactories. Advanced Drug Delivery Reviews 118, pages 8-23.
Crossref
Minyu Song, Won Seo Park, Jayeon Yoo & Jun-Sang Ham. (2017) A Review on Bifidobacteria for Human Health. Journal of Milk Science and Biotechnology 35:2, pages 73-83.
Crossref
Silvia Arboleya, Claire Watkins, Catherine Stanton & R. Paul Ross. (2016) Gut Bifidobacteria Populations in Human Health and Aging. Frontiers in Microbiology 7.
Crossref
Shun’ichiro Taniguchi, Yuko Shimatani & Minoru Fujimori. 2016. Bacterial Therapy of Cancer. Bacterial Therapy of Cancer 49 60 .
Ivan Lin, Thi Van & Peter Smooker. (2015) Live-Attenuated Bacterial Vectors: Tools for Vaccine and Therapeutic Agent Delivery. Vaccines 3:4, pages 940-972.
Crossref
Annika Osswald, Christina Westermann, Zhongke Sun & Christian U. Riedel. (2015) A Phytase-Based Reporter System for Identification of Functional Secretion Signals in Bifidobacteria. PLOS ONE 10:6, pages e0128802.
Crossref
Miguel Martín, Fernando Carmona, Rafael Cuesta, Deyanira Rondón, Natividad Gálvez & José M. Domínguez‐Vera. (2014) Artificial Magnetic Bacteria: Living Magnets at Room Temperature. Advanced Functional Materials 24:23, pages 3489-3493.
Crossref
Muneaki Takahata, Hidehiro Toh, Akiyo Nakano, Misako Takagi, Masaru Murakami, Yasuo Ishii, Tatsuya Takizawa, Soichi Tanabe & Hidetoshi Morita. (2014) Complete sequence analysis of two cryptic plasmids from Bifidobacterium kashiwanohense  JCM 15439 (type strain) isolated from healthy infant feces . Animal Science Journal 85:2, pages 158-163.
Crossref
Shun'ichiro Taniguchi. (2014) <b>Challenge to Solid Cancer Treatment Using </b><b><i>Bifidobacterium </i></b>. Japanese Journal of Lactic Acid Bacteria 25:1, pages 18-23.
Crossref
Panos Lehouritis, Caroline Springer & Mark Tangney. (2013) Bacterial-directed enzyme prodrug therapy. Journal of Controlled Release 170:1, pages 120-131.
Crossref
S. Guglielmetti, B. Mayo & P. Álvarez-Martín. (2013) Mobilome and genetic modification of bifidobacteria. Beneficial Microbes 4:2, pages 143-166.
Crossref
M Cronin, R M Stanton, K P Francis & M Tangney. (2012) Bacterial vectors for imaging and cancer gene therapy: a review. Cancer Gene Therapy 19:11, pages 731-740.
Crossref
Zhongke Sun, Annika Baur, Daria Zhurina, Jing Yuan & Christian U. Riedel. (2012) Accessing the Inaccessible: Molecular Tools for Bifidobacteria. Applied and Environmental Microbiology 78:15, pages 5035-5042.
Crossref
Yasufumi Kaneda. (2012) Virosome: A novel vector to enable multi-modal strategies for cancer therapy. Advanced Drug Delivery Reviews 64:8, pages 730-738.
Crossref
YAN YIN, LEI KOU, JIAN-JUN WANG & GEN-XING XU. (2012) Therapeutic efficacy of Bifidobacterium longum-mediated human interleukin-2 with endostatin or TRAIL in transplanted tumors in mice. Experimental and Therapeutic Medicine 3:3, pages 481-486.
Crossref
Satoru FUKIYA, Yosuke HIRAYAMA, Mikiyasu SAKANAKA, Yasunobu KANO & Atsushi YOKOTA. (2012) Technological Advances in Bifidobacterial Molecular Genetics: Application to Functional Genomics and Medical Treatments. Bioscience of Microbiota, Food and Health 31:2, pages 15-25.
Crossref
Michelle Cronin, Marco Ventura, Gerald F. Fitzgerald & Douwe van Sinderen. (2011) Progress in genomics, metabolism and biotechnology of bifidobacteria. International Journal of Food Microbiology 149:1, pages 4-18.
Crossref
Shinji Fukuda, Hidehiro Toh, Koji Hase, Kenshiro Oshima, Yumiko Nakanishi, Kazutoshi Yoshimura, Toru Tobe, Julie M. Clarke, David L. Topping, Tohru Suzuki, Todd D. Taylor, Kikuji Itoh, Jun Kikuchi, Hidetoshi Morita, Masahira Hattori & Hiroshi Ohno. (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:7331, pages 543-547.
Crossref
Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley & Caroline J. Springer. 2010. Prodrugs and Targeted Delivery. Prodrugs and Targeted Delivery 271 344 .
Ju-Hoon Lee & Daniel J. O'Sullivan. (2010) Genomic Insights into Bifidobacteria. Microbiology and Molecular Biology Reviews 74:3, pages 378-416.
Crossref
Shun’ichiro Taniguchi, Minoru Fujimori, Takayuki Sasaki, Hiroko Tsutsui, Yuko Shimatani, Keiichi Seki & Jun Amano. (2010) Targeting solid tumors with non-pathogenic obligate anaerobic bacteria. Cancer Science 101:9, pages 1925-1932.
Crossref
Geng‐Feng Fu, Yan Yin, Bi Hu & Gen‐Xing Xu. 2010. Emerging Cancer Therapy. Emerging Cancer Therapy 99 117 .
Michelle Cronin, David Morrissey, Simon Rajendran, Shereen M El Mashad, Douwe van Sinderen, Gerald C O'Sullivan & Mark Tangney. (2010) Orally Administered Bifidobacteria as Vehicles for Delivery of Agents to Systemic Tumors. Molecular Therapy 18:7, pages 1397-1407.
Crossref
R T Long, W S Zeng, L Y Chen, J Guo, Y Z Lin, Q S Huang & S Q Luo. (2010) Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice. International Journal of Obesity 34:4, pages 712-719.
Crossref
CHEN LI, XU CHEN, LEI KOU, BI HU, LI-PING ZHU, YAN-RONG FAN, ZHI-WEI WU, JIAN-JUN WANG & GEN-XING XU. (2010) Selenium-Bifidobacterium longum as a delivery system of endostatin for inhibition of pathogenic bacteria and selective regression of solid tumor. Experimental and Therapeutic Medicine 1:1, pages 129-135.
Crossref
B Hu, L Kou, C Li, L-P Zhu, Y-R Fan, Z-W Wu, J-J Wang & G-X Xu. (2009) Bifidobacterium longum as a delivery system of TRAIL and endostatin cooperates with chemotherapeutic drugs to inhibit hypoxic tumor growth. Cancer Gene Therapy 16:8, pages 655-663.
Crossref
Shinae Kizaka-Kondoh, Shotaro Tanaka, Hiroshi Harada & Masahiro Hiraoka. (2009) The HIF-1-active microenvironment: An environmental target for cancer therapy. Advanced Drug Delivery Reviews 61:7-8, pages 623-632.
Crossref
Li-Jun Jia & Zi-Chun Hua. 2009. Gene Therapy of Cancer. Gene Therapy of Cancer 131 154 .
Koji Nomoto, Mayumi Kiwaki & Hirokazu Tsuji. 2008. Handbook of Probiotics and Prebiotics. Handbook of Probiotics and Prebiotics 189 255 .
Shie-Chau Liu, G-One Ahn, Mitomu Kioi, Mary-Jo Dorie, Adam V. Patterson & J. Martin Brown. (2008) Optimized Clostridium -Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA Cross-Linking Agent PR-104 . Cancer Research 68:19, pages 7995-8003.
Crossref
Lorenzo Nissen, Luca Pasini, Bruno Biavati & Barbara Sgorbati. (2008) Cloning and detection of serpin-like protein encoding gene inBifidobacterium longum strains. Annals of Microbiology 58:1, pages 127-131.
Crossref
Minoru Fujimori. (2008) Anaerobic bacteria as a gene delivery system for cancer therapy. Drug Delivery System 23:5, pages 560-566.
Crossref
Michelle Cronin, Moritz Knobel, Mary O'Connell-Motherway, Gerald F. Fitzgerald & Douwe van Sinderen. (2007) Molecular Dissection of a Bifidobacterial Replicon. Applied and Environmental Microbiology 73:24, pages 7858-7866.
Crossref
Douglas Hedley, Lesley Ogilvie & Caroline Springer. (2007) Carboxypeptidase G2-based gene-directed enzyme–prodrug therapy: a new weapon in the GDEPT armoury. Nature Reviews Cancer 7:11, pages 870-879.
Crossref
A. Sangrador-Vegas, C. Stanton, D. van Sinderen, G.F. Fitzgerald & R.P. Ross. (2007) Characterization of plasmid pASV479 from Bifidobacterium pseudolongum subsp. globosum and its use for expression vector construction. Plasmid 58:2, pages 140-147.
Crossref
Y-F Xu, L-P Zhu, B Hu, G-F Fu, H-Y Zhang, J-J Wang & G-X Xu. (2006) A new expression plasmid in Bifidobacterium longum as a delivery system of endostatin for cancer gene therapy. Cancer Gene Therapy 14:2, pages 151-157.
Crossref
Douglas W. Grosenbach, Jarett Feldman, Jeffrey Schlom & Scott I. Abrams. 2007. General Principles of Tumor Immunotherapy. General Principles of Tumor Immunotherapy 217 250 .
Tetsuo Takata, Toshiro Shirakawa, Yoshiko Kawasaki, Shohiro Kinoshita, Akinobu Gotoh, Yasunobu Kano & Masato Kawabata. (2006) Genetically engineered Bifidobacterium animalis expressing the Salmonella flagellin gene for the mucosal immunization in a mouse model . The Journal of Gene Medicine 8:11, pages 1341-1346.
Crossref
Takayuki Sasaki, Minoru Fujimori, Yoshinori Hamaji, Yoshihisa Hama, Ken-ichi Ito, Jun Amano & Shun'ichiro Taniguchi. (2006) Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats. Cancer Science 97:7, pages 649-657.
Crossref
Minoru Fujimori. (2006) Genetically engineeredbifidobacterium as a drug delivery system for systemic therapy of metastatic breast cancer patients. Breast Cancer 13:1, pages 27-31.
Crossref
Ju-Hoon Lee & Daniel J. O’Sullivan. (2006) Sequence Analysis of Two Cryptic Plasmids from Bifidobacterium longum DJO10A and Construction of a Shuttle Cloning Vector . Applied and Environmental Microbiology 72:1, pages 527-535.
Crossref
Adrianne Klijn, Annick Mercenier & Fabrizio Arigoni. (2005) Lessons from the genomes of bifidobacteria. FEMS Microbiology Reviews 29:3, pages 491-509.
Crossref
Cheng Yi, Ying Huang, Zhi-ying Guo & Shu-ren Wang. (2005) Antitumor effect of cytosine deaminase/5-fluorocytosine suicide gene therapy system mediated by Bifidobacterium infantis on melanoma. Acta Pharmacologica Sinica 26:5, pages 629-634.
Crossref
Ross Crittenden. 2004. Lactic Acid Bacteria. Lactic Acid Bacteria.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.