194
Views
54
CrossRef citations to date
0
Altmetric
Original Articles

Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters: Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to…

, , &
Pages 705-710 | Received 23 Jul 2001, Accepted 04 Dec 2001, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Li Yuan, Jinjin Cheng, Qian Chu, Xiu Ji, Jianjun Yuan, Fayun Feng, Ruichang Gao & Xiangyang Yu. (2019) Di-n-butyl phthalate degrading endophytic bacterium Bacillus amyloliquefaciens subsp. strain JR20 isolated from garlic chive and its colonization in a leafy vegetable. Journal of Environmental Science and Health, Part B 54:8, pages 693-701.
Read now
Munawar Saeed Qureshi, Abdull Rahim bin Mohd Yusoff, Mohd Dzul Hakim Wirzal, Jiri Barek, Hassan Imran Afridi & Zafer Üstündag. (2016) Methods for the Determination of Endocrine-Disrupting Phthalate Esters. Critical Reviews in Analytical Chemistry 46:2, pages 146-159.
Read now
Katsumi SHIBATA, Rina KONDO, Mitsue SANO & Tsutomu FUKUWATARI. (2013) Increased Conversion of Tryptophan to Nicotinamide in Rats by Dietary Valproate. Bioscience, Biotechnology, and Biochemistry 77:2, pages 295-300.
Read now
Zhaojiang Wang, Kefu Chen, Jun Li & Lihuan Mo. (2011) The decontamination of bleaching effluent by pilot‐scale solar Fenton process. Environmental Technology 32:7, pages 721-730.
Read now
Katsumi SHIBATA, Miki YASUI, Mitsue SANO & Tsutomu FUKUWATARI. (2011) Fluorometric Determination of 2-Oxoadipic Acid, a Common Metabolite of Tryptophan and Lysine, by High-Performance Liquid Chromatography with Pre-Chemical Derivatization. Bioscience, Biotechnology, and Biochemistry 75:1, pages 185-187.
Read now
Stephanie Ringeissen, Susan C. Connor, H. Roger Brown, Brian C. Sweatman, Mark P. Hodson, Steve P. Kenny, Richard I. Haworth, Paul Mcgill, Mark A. Price, Mike C. Aylott, Derek J. Nunez, John N. Haselden & Catherine J. Waterfield. (2003) Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography. Biomarkers 8:3-4, pages 240-271.
Read now
Tsutomu FUKUWATARI, Yuko SUZUKI, Etsuro SUGIMOTO & Katsumi SHIBATA. (2002) Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters: Time-dependent Increase in Quinolinic Acid and Its Metabolites in…. Bioscience, Biotechnology, and Biochemistry 66:12, pages 2687-2691.
Read now

Articles from other publishers (46)

Suzanne Ducroq, Eric Duplus, Lucille Penalva-Mousset, Francesca Trivelloni, Aurore L’honoré, Caroline Chabat-Courrède, Ivan Nemazanyy, Valérie Grange-Messent, Isabelle Petropoulos & Sakina Mhaouty-Kodja. (2023) Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture. Environmental Health Perspectives 131:7.
Crossref
Suzanne Ducroq, Eric Duplus, Valérie Grange-Messent, Francesca Trivelloni, Lucille Penalva-Mousset, Isabelle Petropoulos & Sakina Mhaouty-Kodja. (2023) Cognitive and hippocampal effects of adult male mice exposure to environmentally relevant doses of phthalates. Environmental Pollution 323, pages 121341.
Crossref
Br. Yundi Zhang, Mingyu Cui, Yidong Zhang, Wei Xu, Min Wang, Rong Shao & Jianfei Ding. (2023) Nanocrystalline HZSM‐5prepared by supercritical hydrothermal synthesis and its catalytic esterification performances. ChemistrySelect 8:9.
Crossref
Huu-Tuan Tran, Minh-Ky Nguyen, Hong-Giang Hoang, Justin M. Hutchison & Chi Thanh Vu. (2022) Composting and green technologies for remediation of phthalate (PAE)-contaminated soil: Current status and future perspectives. Chemosphere 307, pages 135989.
Crossref
Kei Zaitsu, Tomomi Asano, Daisuke Kawakami, Jiarui Chang, Kazuaki Hisatsune, Masaru Taniguchi & Akira Iguchi. (2022) Metabolomics and Data-Driven Bioinformatics Revealed Key Maternal Metabolites Related to Fetal Lethality via Di(2-ethylhexyl)phthalate Exposure in Pregnant Mice. ACS Omega 7:27, pages 23717-23726.
Crossref
Dekai Liu, Yirui Shen, Phyu Thin Wai, Haryono Agus, Pingbo Zhang, Pingping Jiang, Zhixin Nie, Guoqiang Jiang, Huihang Zhao & Minzhong Zhao. (2020) An efficient plasticizer based on waste cooking oil: Structure and application. Journal of Applied Polymer Science 138:13, pages 50128.
Crossref
Dekai Liu, Yirui Shen, Pingping Jiang, Phyu Thin Wai, Zheming Zhang, Pingbo Zhang, Haryono Agus, Zhixin Nie, Minzhong Zhao & Huihang Zhao. (2021) An efficient cold-resistant strategy: Synthesis and application of green cold-resistant bio-based plasticizer for poly(vinyl chloride). European Polymer Journal 142, pages 110154.
Crossref
Dekai Liu, Pingping Jiang, Zhixin Nie, Hanying Wang, Zhuding Dai, Jianneng Deng & Zhiliang Cao. (2020) Synthesis of an efficient bio-based plasticizer derived from waste cooking oil and its performance testing in PVC. Polymer Testing 90, pages 106625.
Crossref
Simin Cheng, Wenbo Cao, Xu Zhao, Ningxi Li, Zheng Ouyang, Qiang Ma & Xiaoxiao Ma. (2019) Fast screening of prohibited chemicals in plastic toys using ambient ionization mass spectrometry. International Journal of Mass Spectrometry 444, pages 116176.
Crossref
Jiao Tang, Taicheng An, Jukun Xiong & Guiying Li. (2017) The evolution of pollution profile and health risk assessment for three groups SVOCs pollutants along with Beijiang River, China. Environmental Geochemistry and Health 39:6, pages 1487-1499.
Crossref
Leo Nollet. 2017. Chromatographic Analysis of the Environment. Chromatographic Analysis of the Environment 491 513 .
Kankan Li, Dong Ma, Juan Wu, Chao Chai & Yanxi Shi. (2016) Distribution of phthalate esters in agricultural soil with plastic film mulching in Shandong Peninsula, East China. Chemosphere 164, pages 314-321.
Crossref
Hermann AM Mucke. (2016) Patent highlights: February–March 2016. Pharmaceutical Patent Analyst 5:4, pages 203-209.
Crossref
Jun Wang, Luji Bo, Lina Li, Dejian Wang, Gangcai Chen, Peter Christie & Ying Teng. (2014) Occurrence of phthalate esters in river sediments in areas with different land use patterns. Science of The Total Environment 500-501, pages 113-119.
Crossref
Katsumi ShibataJunko HiroseTsutomu Fukuwatari. (2014) Relationship between Urinary Concentrations of Nine Water-soluble Vitamins and their Vitamin Intakes in Japanese Adult Males. Nutrition and Metabolic Insights 7, pages NMI.S17245.
Crossref
萍 王. (2014) Research Progress on the Determination Methods for the Phthalic Acid Ester Compounds in Food. Advances in Analytical Chemistry 04:01, pages 1-6.
Crossref
Xiaofang Wang, Yuanjin Yang, Liping Zhang, Yanbo Ma, Jian Han, Lihua Yang & Bingsheng Zhou. (2013) Endocrine disruption by di-(2-ethylhexyl)-phthalate in Chinese rare minnow ( Gobiocypris rarus ) . Environmental Toxicology and Chemistry 32:8, pages 1846-1854.
Crossref
De-Yin Huang, Shun-Gui Zhou, Wei Hong, Wei-Feng Feng & Liang Tao. (2013) Pollution characteristics of volatile organic compounds, polycyclic aromatic hydrocarbons and phthalate esters emitted from plastic wastes recycling granulation plants in Xingtan Town, South China. Atmospheric Environment 71, pages 327-334.
Crossref
Katsumi Shibata. (2013) Studies on Creation of a New Method for Evaluating Vitamin Nutrition Using Human Urine Samplesヒト尿を用いる新しいビタミン栄養状態の創成. Nippon Eiyo Shokuryo Gakkaishi 66:1, pages 3-8.
Crossref
Katsumi ShibataTomiko TsujiTsutomu Fukuwatari. (2013) Intake and Urinary Amounts of Biotin in Japanese Elementary School Children, College Students, and Elderly Persons. Nutrition and Metabolic Insights 6, pages NMI.S12922.
Crossref
De Dong SunXiao Xu Yan & Wen Ping Xue. (2012) Oxidative Degradation of Dimethyl Phthalate (DMP) by Persulfate Catalyzed by Ag<sup>+</sup> Combined with Microwave Irradiation. Advanced Materials Research 610-613, pages 1209-1212.
Crossref
Katsumi Shibata & Tsutomu Fukuwatari. (2012) The Metabolites in the Tryptophan Degradation Pathway Might Be Useful to Determine the Tolerable Upper Intake Level of Tryptophan Intake in Rats. The Journal of Nutrition 142:12, pages 2227S-2230S.
Crossref
GUANXING HUANG, JICHAO SUN, ZONGYU CHEN, XI CHEN, JIHONG JING, JINGTAO LIU & YUXI ZHANG. (2012) Levels and sources of phthalate esters in shallow groundwater and surface water of Dongguan city, South China. GEOCHEMICAL JOURNAL 46:5, pages 421-428.
Crossref
Qing Lan, Kunyan Cui, Feng Zeng, Fang Zhu, Hong Liu, Hongli Chen, Yongqing Ma, Jiaxin Wen, Tiangang Luan, Guoquan Sun & Zunxiang Zeng. (2011) Characteristics and assessment of phthalate esters in urban dusts in Guangzhou city, China. Environmental Monitoring and Assessment 184:8, pages 4921-4929.
Crossref
Na Wang, Deyang Kong, Zhengjun Shan, Lili Shi, Daoji Cai, Yanzhong Cao, Yongming Liu & Guofang Pang. (2012) Simultaneous determination of pesticides, polycyclic aromatic hydrocarbons, polychlorinated biphenyls and phthalate esters in human adipose tissue by gas chromatography?tandem mass spectrometry. Journal of Chromatography B 898, pages 38-52.
Crossref
Zhaojiang Wang, Kefu Chen, Jun Li, Lihuan Mo & Qiang Wang. (2011) The removal of COD from bleaching effluents by Fenton's reagent: Effect of system parameters and kinetic study. Environmental Progress & Sustainable Energy 30:2, pages 168-176.
Crossref
Tugba Olmez-Hanci, Ceren Imren, Işık Kabdaşlı, Olcay Tünay & Idil Arslan-Alaton. (2020) Application of the UV-C photo-assisted peroxymonosulfate oxidation for the mineralization of dimethyl phthalate in aqueous solutions. Photochemical & Photobiological Sciences 10:3, pages 408-413.
Crossref
Jiping Zhu, Rong Wang, Yong‐Lai Feng & Xu‐Liang Cao. 2010. Analysis of Endocrine Disrupting Compounds in Food. Analysis of Endocrine Disrupting Compounds in Food 255 268 .
Malene Boas, Hanne Frederiksen, Ulla Feldt-Rasmussen, Niels E. Skakkebæk, Laszlo Hegedüs, Linda Hilsted, Anders Juul & Katharina M. Main. (2010) Childhood Exposure to Phthalates: Associations with Thyroid Function, Insulin-like Growth Factor I, and Growth. Environmental Health Perspectives 118:10, pages 1458-1464.
Crossref
Roger M. Smith. 2010. Handbook of Sample Preparation. Handbook of Sample Preparation 181 189 .
Jiping Zhu, Susan Phillips & Xu-Liang Cao. 2010. Safety Analysis of Foods of Animal Origin. Safety Analysis of Foods of Animal Origin 907 928 .
Hui Liu, Ying Liang, Dan Zhang, Cheng Wang, Hecheng Liang & Hesheng Cai. (2010) Impact of MSW landfill on the environmental contamination of phthalate esters. Waste Management 30:8-9, pages 1569-1576.
Crossref
Feng Zeng, Yujun Lin, Kunyan Cui, Jiaxin Wen, Yongqin Ma, Hongli Chen, Fang Zhu, Zhiling Ma & Zunxiang Zeng. (2010) Atmospheric deposition of phthalate esters in a subtropical city. Atmospheric Environment 44:6, pages 834-840.
Crossref
Fukuwatari Tsutomu. (2010) Importance of the Tryptophan-nicotinamide Conversion Pathway for Niacin Nutrition. Nippon Eiyo Shokuryo Gakkaishi 63:4, pages 135-141.
Crossref
Hui Liu, Hecheng Liang, Ying Liang, Dan Zhang, Cheng Wang, Hesheng Cai & Stepan. L. Shvartsev. (2010) Distribution of phthalate esters in alluvial sediment: A case study at JiangHan Plain, Central China. Chemosphere 78:4, pages 382-388.
Crossref
Bin Xu, Nai-yun Gao, Hefa Cheng, Sheng-ji Xia, Min Rui & Dan-dan Zhao. (2009) Oxidative degradation of dimethyl phthalate (DMP) by UV/H2O2 process. Journal of Hazardous Materials 162:2-3, pages 954-959.
Crossref
Dan Zhang, Hui Liu, Ying Liang, Cheng Wang, Hecheng Liang & Hesheng Cai. (2009) Distribution of phthalate esters in the groundwater of Jianghan plain, Hubei, China. Frontiers of Earth Science in China 3:1, pages 73-79.
Crossref
Dan Zhang, Hui Liu, Ying Liang, Cheng Wang, Hecheng Liang & Hesheng Cai. (2008) Concentration and Composition of Phthalate Esters in the Groundwater of Jianghan Plain, HuBei, China. Concentration and Composition of Phthalate Esters in the Groundwater of Jianghan Plain, HuBei, China.
Feng Zeng, Kunyan Cui, Zhiyong Xie, Lina Wu, Min Liu, Guoquan Sun, Yujun Lin, Danling Luo & Zunxiang Zeng. (2008) Phthalate esters (PAEs): Emerging organic contaminants in agricultural soils in peri-urban areas around Guangzhou, China. Environmental Pollution 156:2, pages 425-434.
Crossref
Feng Zeng, Kunyan Cui, Zhiyong Xie, Min Liu, Yangjie Li, Yujun Lin, Zunxiang Zeng & Fangbai Li. (2008) Occurrence of phthalate esters in water and sediment of urban lakes in a subtropical city, Guangzhou, South China. Environment International 34:3, pages 372-380.
Crossref
Jane Delaney, Mark P. Hodson, Hansa Thakkar, Susan C. Connor, Brian C. Sweatman, Steve P. Kenny, Paul J. McGill, Julie C. Holder, Kathryn A. Hutton, John N. Haselden & Catherine J. Waterfield. (2004) Tryptophan?NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation. Archives of Toxicology 79:4, pages 208-223.
Crossref
Giuseppe Latini, Claudio De Felice & Alberto Verrotti. (2004) Plasticizers, infant nutrition and reproductive health. Reproductive Toxicology 19:1, pages 27-33.
Crossref
Tsutomu Fukuwatari, Mari Ohta, Etsuro Sugimoto, Ryuzo Sasaki & Katsumi Shibata. (2004) Effects of dietary di(2-ethylhexyl)phthalate, a putative endocrine disrupter, on enzyme activities involved in the metabolism of tryptophan to niacin in rats. Biochimica et Biophysica Acta (BBA) - General Subjects 1672:2, pages 67-75.
Crossref
Tsutomu FUKUWATARI, Mai TORIOCHI, Mari OHTA, Ryuzo SASAKI & Katsumi SHIBATA. (2004) Metabolic Disturbance of Tryptophan-Nicotinamide Conversion Pathway by Putative Endocrine Disruptors, Bisphenol A and Styrene Monomer. Journal of the Food Hygienic Society of Japan (Shokuhin Eiseigaku Zasshi) 45:1, pages 1-7.
Crossref
Mari OHTA, Junko KITAMURA, Tsutomu FUKUWATARI, Ryuzo SASAKI & Katsumi SHIBATA. (2004) Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Mice. Experimental Animals 53:1, pages 57-60.
Crossref
Katsumi Shibata, Tsutomu Fukuwatari, Mayumi Murakami & Ryuzo Sasaki. 2003. Developments in Tryptophan and Serotonin Metabolism. Developments in Tryptophan and Serotonin Metabolism 435 441 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.