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Original Articles

Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters: Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to…

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Pages 705-710 | Received 23 Jul 2001, Accepted 04 Dec 2001, Published online: 22 May 2014

  • 1) Giam, C. S., Atlas, E., Powers, M. A., and Leonad, J. E., Phthalic acids esters. In O. Hutzinger (ed.), The Handbook of Environmental Chemistry, Springer, Berlin, Germany, pp. 67-142 (1994).
  • 2) Koizumi, M., Ema, M., Hirose, A., and Hasegawa, R., Recent studies on toxic effects of phthalate esters on reproduction and development: Focus on Di(2-ethylhexyl)phthalate and Di-n-butyl phthalate. Jpn. J. Food Chem., 7, 65-73 (2000).
  • 3) Koizumi, M., Ema, M., Hirose, A., Kurokawa, Y., and Hasegawa, R., No observed adverse effect levels of phthalate esters on reproductive and developmental toxicity, the differences with age and species in testicular toxicity, and tolerable daily intake of DEHP. Jpn. J. Food Chem., 8, 1-10 (2001).
  • 4) Shibata, K., Motooka, K., Murata, K., and Iwai, K., Increase in growth rate and activity of the tryptophan-NAD pathway caused by di-n-butylphthalate in rats fed on a tryptophan-limited diet. J. Nutr. Sci. Vitaminol., 28, 173-177 (1982).
  • 5) Shibata, K., Fukuwatari, T., Enomoto, A., and Sugimoto, E., Increased conversion ratio of tryptophan to niacin by dietary di-n-butylphthalate. J. Nutr. Sci. Vitaminol., 47, 263-266 (2001).
  • 6) Howarth, J. A., Price, S. C., Dobrota, M., Kentish, P. A., and Hinton, R. H., Effects on male rats of di-(2-ethylhexyl) phthalate and di-n-hexylphthalate administered alone or in combination. Toxicol. Lett., 121, 35-43 (2001).
  • 7) Pullman, M. E. and Colowick, S. P., Preparation of 2- and 6-pyridones of N 1-methylnicotinamide. J. Biol. Chem., 206, 121-127 (1954).
  • 8) Shibata, K., Kawada, T., and Iwai, K., Simultaneous micro-determination of nicotinamide and its major metabolites, N 1-methyl-2-pyridone-5-carboxamide and N 1-methyl-3-pyridone-4-carboxamide, by high-performance liquid chromatography. J. Chromatogr., 424, 23-28 (1988).
  • 9) Shibata, K. and Murata, K., Blood NAD as an index of niacin nutrition. Nutr. Int., 2, 177-181 (1986).
  • 10) Shibata, K., Ultramicro-determination of N 1-methylnicotinamide in urine by high-performance liquid chromatography. Vitamins, 61, 599-604 (1987).
  • 11) Shibata, K., Fluorimetric micro-determination of kynurenic acid, as endogenous blocker of neurotoxicity, by high-performance liquid chromatography. J. Chromatogr., 430, 376-380 (1988).
  • 12) Shibata, K. and Onodera, M., Simultaneous high-performance liquid chromatographic measurement of xanthurenic acid and 3-hydroxyanthranilic acid in urine. Biosci. Biotechnol. Biochem., 56, 974 (1992).
  • 13) Shibata, K. and Onodera, M., Measurement of 3-hydroxyanthranilic acid and anthranilic acid in urine by high-performance liquid chromatography. Agric. Biol. Chem., 55, 143-148 (1991).
  • 14) Shibata, K. and Tanaka, K., Simple measurement of blood NADP and blood levels of NAD and NADP in humans. Agric. Biol. Chem., 50, 2941-2942 (1986).
  • 15) Hayaishi, O., Studies on the biosynthesis of NAD from tryptophan. Vitamins (Japan), 31, 107-114 (1965).
  • 16) Ghafoorunissa and Rao, B. S., Effect of protein level in the diet on quinolinate phosphoribosyltransferase of rat liver. Life Sci., 15, 1597-1602 (1974).
  • 17) Sanada, H., Alteration of tryptophan-niacin metabolism by hormones and nutrients. Vitamins (Japan), 61, 549-562 (1987).
  • 18) Shibata, K. and Toda, S., Effect of thyroxine on the conversion ratio of tryptophan to nicotinamide in rats. Biosci. Biotechnol. Biochem., 58, 1757-1762 (1994).
  • 19) Shibata, K., Effects of protein-amino acids, lipid, and carbohydrate on the conversion ratio of tryptophan to niacin. Vitamins (Japan), 70, 369-382 (1996).
  • 20) Okamoto, H., Okada, F., and Hayaishi, O., Kynurenine metabolism in hyperthyroidism. A biochemical basis for the low NAD(P) level in hyperthyroid rat liver. J. Biol. Chem., 246, 7759-7763 (1971).
  • 21) Sanada, H., Alteration of tryptophan-niacin metabolism by hormones and nutrients. Vitamins (Japan), 61, 549-562 (1987).
  • 22) Shibata, K., Blood pyridine nucleotide levels reflect niacin equivalent intake in humans. J. Clin. Biochem. Nutr., 3, 37-45 (1987).
  • 23) Shibata, K. and Matsuo, H., Effect of dietary tryptophan levels on the urinary excretion of nicotinamide and its metabolites in rats fed a niacin-free diet or a constant total protein level. J. Nutr., 120, 1191-1197 (1990).
  • 24) Knip, M., Douek, I. F., Moore, W. P., Gillmor, H. A., Bingley, P. J., and Gale, E. A., Safety of high-dose nicotinamide: a review. Diabetologia, 43, 1337-1345 (2000).
  • 25) Handler, P. and Dann, W. J., The inhibition of rat growth by nicotinamide. J. Biol. Chem., 146, 357-368 (1942).
  • 26) Shibata, K. and Tanaka. K., Effect of supplementation of excessive nicotinic acid, nicotinamide, quinolinic acid, trigonelline or N 1-methylnicotinamide on the metabolism of niacin in rats. The Bulletin of Teikoku-Gakuen, 12, 1-9 (1986).
  • 27) Shibata K., Fate of excess nicotinamide and nicotinic acid differs in rats. J. Nutr., 119, 892-895 (1989).

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