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Bioscience, Biotechnology, and Biochemistry Volume 69, 2005 - Issue 12
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Original Articles

Prevention of Intestinal Infection by Glycomacropeptide

Kouhei NAKAJIMAInstitute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo University of Agriculture and Technology
,
Norimitsu TAMURAInstitute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo University of Agriculture and Technology
,
Kazuo KOBAYASHI-HATTORIDivision of Microbiology, The National Institute of Health Sciences
,
Tadashi YOSHIDAInstitute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo University of Agriculture and Technology
,
Yukiko HARA-KUDODivision of Microbiology, The National Institute of Health Sciences
,
Masanari IKEDOEiken Chemical Co., Ltd.
,
Yoshiko SUGITA-KONISHIDivision of Microbiology, The National Institute of Health Sciences
&
Makoto HATTORIInstitute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo University of Agriculture and Technology
 show all
Pages 2294-2301 | Received 21 Apr 2005, Accepted 29 Jul 2005, Published online: 22 May 2014

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Muhammad Umar, Uracha Ruktanonchai, Davids Makararpong & Anil Kumar Anal. (2023) Enhancing Immunity Against Pathogens Through Glycosylated Bovine Colostrum Proteins. Food Reviews International 0:0, pages 1-18.
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Hyun Sun Yun, Younghoon Kim, Mi Ri Park, Sae Hun Kim & Sejong Oh. (2014) Inhibitory effects of the κ-casein macropeptide isolated from milk protein on the biofilm formation and virulence of Listeria monocytogenes. Bioscience, Biotechnology, and Biochemistry 78:3, pages 490-498.
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Wentao Qi, Suhasini Joshi, Christopher R. Weber, Ramesh K. Wali, Hemant K. Roy & Suzana D. Savkovic. (2011) Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia. Gut Microbes 2:5, pages 267-273.
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Geoffrey W. Krissansen. (2007) Emerging Health Properties of Whey Proteins and Their Clinical Implications. Journal of the American College of Nutrition 26:6, pages 713S-723S.
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Articles from other publishers (48)

Rami M. Althnaibat, Heather L. Bruce, Jianping Wu & Michael G. Gänzle. (2024) Bioactive peptides in hydrolysates of bovine and camel milk proteins: A review of studies on peptides that reduce blood pressure, improve glucose homeostasis, and inhibit pathogen adhesion. Food Research International 175, pages 113748.
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Bulei Sheng, Nina A. Poulsen, Maria Glantz, Marie Paulsson, Lotte B. Larsen & Søren D. Nielsen. (2023) Influence of genetic variants and sialylation of purified κ-casein on peptide release during in vitro digestion. Food Chemistry Advances 3, pages 100483.
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Carmen Lammi, Carlotta Bollati, Laura Fiori, Jianqiang Li, Melissa Fanzaga, Lorenza d'Adduzio, Martina Tosi, Alberto Burlina, Gianvincenzo Zuccotti & Elvira Verduci. (2023) Glycomacropeptide (GMP) rescued the oxidative and inflammatory activity of free L-AAs in human Caco-2 cells: New insights that support GMP as a valid and health-promoting product for the dietary management of phenylketonuria (PKU) patients. Food Research International 173, pages 113258.
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Yunyao Qu, Si Hong Park & David C. Dallas. (2023) The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome. Nutrients 15:18, pages 3991.
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Mai Morozumi, Yasuaki Wada, Muneya Tsuda, Fuka Tabata, Tatsuya Ehara, Hirohiko Nakamura & Kazuhiro Miyaji. (2023) Cross-feeding among bifidobacteria on glycomacropeptide. Journal of Functional Foods 103, pages 105463.
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Rami M. Althnaibat, Mandy Koch, Heather L. Bruce, Daniel Wefers & Michael G. Gänzle. (2022) Glycomacropeptide from camel milk inhibits the adhesion of enterotoxigenic Escherichia coli K88 to porcine cells. International Dairy Journal 134, pages 105448.
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Xue Yu, Yan Xing, Hui Liu, Yanmei Chang, Yanxia You, Yuqi Dou, Bin Liu, Qi Wang, Defu Ma, Lijun Chen & Xiaomei Tong. (2022) Effects of a Formula with scGOS/lcFOS (9:1) and Glycomacropeptide (GMP) Supplementation on the Gut Microbiota of Very Preterm Infants. Nutrients 14:9, pages 1901.
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Jeewon Koh, Bum Jin Kim, Yunyao Qu, Honggang Huang & David C Dallas. (2022) Top-Down Glycopeptidomics Reveals Intact Glycomacropeptide Is Digested to a Wide Array of Peptides in Human Jejunum. The Journal of Nutrition 152:2, pages 429-438.
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K.S. Singh, B.P. Singh, N. Rokana, N. Singh, J. Kaur, A. Singh & H. Panwar. (2021) Bio‐therapeutics from human milk: prospects and perspectives. Journal of Applied Microbiology 131:6, pages 2669-2687.
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Zitao Guo, Dalong Yi, Bo Hu, Yi Shi, Yu Xin, Zhenghua Gu, Huaigao Liu & Liang Zhang. (2021) The alteration of gut microbiota by bioactive peptides: a review. Systems Microbiology and Biomanufacturing 1:4, pages 363-377.
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Mathilde Foisy Sauvé, Francis Feldman, Mireille Koudoufio, Nour-El-Houda Ould-Chikh, Lena Ahmarani, Alain Sane, Thierry N’Timbane, Ramy El-Jalbout, Nathalie Patey, Schohraya Spahis, Alain Stintzi, Edgard Delvin & Emile Levy. (2021) Glycomacropeptide for Management of Insulin Resistance and Liver Metabolic Perturbations. Biomedicines 9:9, pages 1140.
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Xiaoyu Bao & Jianping Wu. (2021) Impact of food-derived bioactive peptides on gut function and health. Food Research International 147, pages 110485.
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Pernille G. Wernlund, Christian L. Hvas, Jens F. Dahlerup, Martin I. Bahl, Tine R. Licht, Knud E. B. Knudsen & Jørgen S. Agnholt. (2020) Casein glycomacropeptide is well tolerated in healthy adults and changes neither high-sensitive C-reactive protein, gut microbiota nor faecal butyrate: a restricted randomised trial. British Journal of Nutrition 125:12, pages 1374-1385.
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Sinead T. Morrin, Rachael H. Buck, Michael Farrow & Rita M. Hickey. (2021) Milk-derived anti-infectives and their potential to combat bacterial and viral infection. Journal of Functional Foods 81, pages 104442.
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Mathilde Foisy SauvéSchohraya SpahisEdgard DelvinEmile Levy. (2021) Glycomacropeptide: A Bioactive Milk Derivative to Alleviate Metabolic Syndrome Outcomes. Antioxidants & Redox Signaling 34:3, pages 201-222.
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Erinn M. Quinn, Michelle Kilcoyne, Dan Walsh, Lokesh Joshi & Rita M. Hickey. (2020) A Whey Fraction Rich in Immunoglobulin G Combined with Bifidobacterium longum subsp. infantis ATCC 15697 Exhibits Synergistic Effects against Campylobacter jejuni. International Journal of Molecular Sciences 21:13, pages 4632.
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Daniel Cervantes-García, Armida I. Bahena-Delgado, Mariela Jiménez, Laura E. Córdova-Dávalos, Vanessa Ruiz-Esparza Palacios, Esperanza Sánchez-Alemán, María C. Martínez-Saldaña & Eva Salinas. (2020) Glycomacropeptide Ameliorates Indomethacin-Induced Enteropathy in Rats by Modifying Intestinal Inflammation and Oxidative Stress. Molecules 25:10, pages 2351.
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Tatiane Winkler Marques Machado, Jenifer Mota Rodrigues, Tatiana Rojo Moro, Maria Eugênia Rabello Duarte & Miguel Daniel Noseda. (2020) Marine Microalgae Biomolecules and Their Adhesion Capacity to Salmonella enterica sv. Typhimurium. Applied Sciences 10:7, pages 2239.
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Lane, Calonne, Slattery & Hickey. (2019) Oligosaccharides Isolated from MGO™ Manuka Honey Inhibit the Adhesion of Pseudomonas aeruginosa, Escherichia Coli O157:H7 and Staphylococcus Aureus to Human HT-29 cells. Foods 8:10, pages 446.
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Juan Jauregui-Rincón, Eva Salinas-Miralles, Norma Chávez-Vela & Mariela Jiménez-Vargas. 2019. Whey - Biological Properties and Alternative Uses. Whey - Biological Properties and Alternative Uses.
Shane Feeney, Jared Q. Gerlach, Helen Slattery, Michelle Kilcoyne, Rita M. Hickey & Lokesh Joshi. (2019) Lectin microarray profiling and monosaccharide analysis of bovine milk immunoglobulin G oligosaccharides during the first 10 days of lactation. Food Science & Nutrition 7:5, pages 1564-1572.
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Laura Córdova-Dávalos, Mariela Jiménez & Eva Salinas. (2019) Glycomacropeptide Bioactivity and Health: A Review Highlighting Action Mechanisms and Signaling Pathways. Nutrients 11:3, pages 598.
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Shane Feeney, Lokesh Joshi & Rita M. Hickey. 2018. Novel Proteins for Food, Pharmaceuticals and Agriculture. Novel Proteins for Food, Pharmaceuticals and Agriculture 1 28 .
N. O'Riordan, J. O'Callaghan, L.F. Buttò, M. Kilcoyne, L. Joshi & R.M. Hickey. (2018) Bovine glycomacropeptide promotes the growth of Bifidobacterium longum ssp. infantis and modulates its gene expression. Journal of Dairy Science 101:8, pages 6730-6741.
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Shane Feeney, Joseph Ryan, Michelle Kilcoyne, Lokesh Joshi & Rita Hickey. (2017) Glycomacropeptide Reduces Intestinal Epithelial Cell Barrier Dysfunction and Adhesion of Entero-Hemorrhagic and Entero-Pathogenic Escherichia coli in Vitro. Foods 6:11, pages 93.
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Tereza Volstatova, Jaroslav Havlik, Miroslava Potuckova & Martina Geigerova. (2016) Milk digesta and milk protein fractions influence the adherence of Lactobacillus gasseri R and Lactobacillus casei FMP to human cultured cells. Food & Function 7:8, pages 3531-3538.
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Maria X. Maldonado-Gomez, Hyeyoung Lee, Daniela Barile, Mei Lu & Robert W. Hutkins. (2015) Adherence inhibition of enteric pathogens to epithelial cells by bovine colostrum fractions. International Dairy Journal 40, pages 24-32.
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Da-Yong Zhou, Xian-Na Chang, Sha-Sha Bao, Liang Song, Bei-Wei Zhu, Xiu-Ping Dong, Yuan Zong, Dong-Mei Li, Mao-Mao Zhang, Yu-Xin Liu & Yoshiyuki Murata. (2014) Purification and partial characterisation of a cathepsin L-like proteinase from sea cucumber (Stichopus japonicus) and its tissue distribution in body wall. Food Chemistry 158, pages 192-199.
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A.S. Kvistgaard, J.B. Schroder, E. Jensen, A. Setarehnejad & A. Kanekanian. 2014. Milk and Dairy Products as Functional Foods. Milk and Dairy Products as Functional Foods 198 236 .
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Gemma González-Ortiz, José Francisco Pérez, Rafael Gustavo Hermes, Francesc Molist, Rufino Jiménez-Díaz & Susana María Martín-Orúe. (2013) Screening the ability of natural feed ingredients to interfere with the adherence of enterotoxigenic Escherichia coli (ETEC) K88 to the porcine intestinal mucus . British Journal of Nutrition 111:4, pages 633-642.
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R. Peterson, W. Y. Cheah, J. Grinyer & N. Packer. (2013) Glycoconjugates in human milk: Protecting infants from disease. Glycobiology 23:12, pages 1425-1438.
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Sanjeev Anand, Khanal Som Nath & Marella Chenchaiah. 2013. Milk and Dairy Products in Human Nutrition. Milk and Dairy Products in Human Nutrition 477 497 .
Ana C. Pinheiro, Ana I. Bourbon, António A. Vicente & Mafalda A.C. Quintas. (2013) Transport mechanism of macromolecules on hydrophilic bio-polymeric matrices – Diffusion of protein-based compounds from chitosan films. Journal of Food Engineering 116:3, pages 633-638.
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Rafael Gustavo Hermes, Francesc Molist, José Francisco Pérez, Arantza Gómez de Segura, Mauro Ywazaki, Roger Davin, Miquel Nofrarías, Timo K. Korhonen, Ritva Virkola & Susana María Martín-Orúe. (2012) Casein glycomacropeptide in the diet may reduce Escherichia coli attachment to the intestinal mucosa and increase the intestinal lactobacilli of early weaned piglets after an enterotoxigenic E. coli K88 challenge . British Journal of Nutrition 109:6, pages 1001-1012.
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Neelima, Rajan Sharma, Yudhishthir Singh Rajput & Bimlesh Mann. (2013) Chemical and functional properties of glycomacropeptide (GMP) and its role in the detection of cheese whey adulteration in milk: a review. Dairy Science & Technology 93:1, pages 21-43.
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Rafael G. Hermes, Edgar G. Manzanilla, Susana M. Martín-Orúe, José F. Pérez & Kirk C. Klasing. (2011) Influence of dietary ingredients on in vitro inflammatory response of intestinal porcine epithelial cells challenged by an enterotoxigenic Escherichia coli (K88). Comparative Immunology, Microbiology and Infectious Diseases 34:6, pages 479-488.
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Pilar Requena, Abdelali Daddaoua, Emilia Guadix, Antonio Zarzuelo, María Dolores Suárez, Fermín Sánchez de Medina & Olga Martínez-Augustin. (2009) Bovine glycomacropeptide induces cytokine production in human monocytes through the stimulation of the MAPK and the NF-κB signal transduction pathways. British Journal of Pharmacology 157:7, pages 1232-1240.
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