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Original Articles

Promotion by Collagen Tripeptide of Type I Collagen Gene Expression in Human Osteoblastic Cells and Fracture Healing of Rat Femur

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Pages 2680-2687 | Received 11 May 2007, Accepted 02 Aug 2007, Published online: 22 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Yu Fu, Margrethe Therkildsen, Rotimi E. Aluko & René Lametsch. (2019) Exploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges. Critical Reviews in Food Science and Nutrition 59:13, pages 2011-2027.
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Shoko Yamamoto, Fumitaka Hayasaka, Kisaburo Deguchi, Toshimitsu Okudera, Toshitake Furusawa & Yasuo Sakai. (2015) Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats. Bioscience, Biotechnology, and Biochemistry 79:12, pages 2026-2033.
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Masashi Kusubata, Yoh-ichi Koyama, Chisa Tometsuka, Yasutaka Shigemura & Kenji Sato. (2015) Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic contact dermatitis-affected mouse ear. Bioscience, Biotechnology, and Biochemistry 79:8, pages 1356-1361.
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Kang Hyun Leem, Sanga KimJunsik LimHae Jeong ParkYong Chul ShinJoong Su Lee. (2023) Hydrolyzed Collagen Tripeptide Promotes Longitudinal Bone Growth in Childhood Rats via Increases in Insulin-Like Growth Factor-1 and Bone Morphogenetic Proteins. Journal of Medicinal Food 26:11, pages 809-819.
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Jianing Wang, Bing Zhang, Weipeng Lu, Junli Liu, Weijie Zhang, Yihu Wang, Ming Ma, Xiaofeng Cao & Yanchuan Guo. (2020) Cell Proliferation Stimulation Ability and Osteogenic Activity of Low Molecular Weight Peptides Derived from Bovine Gelatin Hydrolysates. Journal of Agricultural and Food Chemistry 68:29, pages 7630-7640.
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Jeevithan Elango, Jeyashakila Robinson, Jingyi Zhang, Bin Bao, Nan Ma, José Eduardo Maté Sánchez de Val & Wenhui Wu. (2019) Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK- Runx2. Cells 8:5, pages 446.
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Yuki Taga, Masashi Kusubata, Kiyoko Ogawa-Goto, Shunji Hattori & Noriko Funato. (2018) Collagen-derived X-Hyp-Gly-type tripeptides promote differentiation of MC3T3-E1 pre-osteoblasts. Journal of Functional Foods 46, pages 456-462.
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Ming Lu & Xin-Huai Zhao. (2018) The Growth Proliferation, Apoptotic Prevention, and Differentiation Induction of the Gelatin Hydrolysates from Three Sources to Human Fetal Osteoblasts (hFOB 1.19 Cells). Molecules 23:6, pages 1287.
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Amiko Hakuta, Yukie Yamaguchi, Tomoko Okawa, Shoko Yamamoto, Yasuo Sakai & Michiko Aihara. (2017) Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. Journal of Dermatological Science 88:3, pages 357-364.
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Keita Kamikura, Tsutomu Minatoya, Michiko Terada-Nakaishi, Shoko Yamamoto, Yasuo Sakai, Toshitake Furusawa, Yuta Matsushima & Hidero Unuma. (2017) Enhanced bone formation in the vicinity of porous β-TCP scaffolds exhibiting slow release of collagen-derived tripeptides. Journal of Materials Science: Materials in Medicine 28:9.
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Bo Fan, Xiao Wang, Hang Zhang, Peng Gao, Haoqiang Zhang, Xiaokang Li, Hai Huang, Xin Xiao, Dong Liu, Qin Lian, Zheng Guo & Zhen Wang. (2016) Improving the osteogenesis and degradability of biomimetic hybrid materials using a combination of bioglass and collagen I. Materials & Design 112, pages 67-79.
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Sneha B. Sontakke, Jin-hee Jung, Zhe Piao & Hye Jin Chung. (2016) Orally Available Collagen Tripeptide: Enzymatic Stability, Intestinal Permeability, and Absorption of Gly-Pro-Hyp and Pro-Hyp. Journal of Agricultural and Food Chemistry 64:38, pages 7127-7133.
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Xiao-Wen Pan & Xin-Huai Zhao. (2015) In Vitro Proliferation and Anti-Apoptosis of the Papain-Generated Casein and Soy Protein Hydrolysates towards Osteoblastic Cells (hFOB1.19). International Journal of Molecular Sciences 16:12, pages 13908-13920.
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Lihua Tang, Yasuo Sakai, Yoshimichi Ueda & Shogo Katsuda. (2015) Effects of oral administration of tripeptides derived from type I collagen (collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits. Journal of Bioscience and Bioengineering 119:5, pages 558-563.
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Takuya Naraoka, Yasuyuki Ishibashi, Eiichi Tsuda, Yuji Yamamoto, Tomomi Kusumi & Satoshi Toh. (2013) Periodic knee injections of collagen tripeptide delay cartilage degeneration in rabbit experimental osteoarthritis. Arthritis Research & Therapy 15:1, pages R32.
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Yu Fu & Xin-Huai Zhao. (2013) In vitro responses of hFOB1.19 cells towards chum salmon (Oncorhynchus keta) skin gelatin hydrolysates in cell proliferation, cycle progression and apoptosis. Journal of Functional Foods 5:1, pages 279-288.
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Hee-Bong Pyun, Minji Kim, Jieun Park, Yasuo Sakai, Noriaki Numata, Jin-Yeong Shin, Hyun-Jung Shin, Do-Un Kim & Jae-Kwan Hwang. (2012) Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice. Preventive Nutrition and Food Science 17:4, pages 245-253.
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Se-Kwon KimKenji Sato & Yasutaka Shigemura. 2011. Marine Cosmeceuticals. Marine Cosmeceuticals 125 132 .
Yasutaka Shigemura, Saeko Akaba, Eriko Kawashima, Eun Young Park, Yasushi Nakamura & Kenji Sato. (2011) Identification of a novel food-derived collagen peptide, hydroxyprolyl-glycine, in human peripheral blood by pre-column derivatisation with phenyl isothiocyanate. Food Chemistry 129:3, pages 1019-1024.
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Sung-Hee Han, Yuki Uzawa, Tatsuya Moriyama & Yukio Kawamura. (2011) Effect of collagen and collagen peptides from bluefin tuna abdominal skin on cancer cells. Health 03:03, pages 129-134.
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Xiang-Hong Xu, Shan-Shan Dong, Yan Guo, Tie-Lin Yang, Shu-Feng Lei, Christopher J. Papasian, Ming Zhao & Hong-Wen Deng. (2010) Molecular Genetic Studies of Gene Identification for Osteoporosis: The 2009 Update. Endocrine Reviews 31:4, pages 447-505.
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Yasutaka Shigemura, Koji Iwai, Fumiki Morimatsu, Takaaki Iwamoto, Toshio Mori, Chikako Oda, Toshio Taira, Eun Young Park, Yasusi Nakamura & Kenji Sato. (2009) Effect of Prolyl-hydroxyproline (Pro-Hyp), a Food-Derived Collagen Peptide in Human Blood, on Growth of Fibroblasts from Mouse Skin. Journal of Agricultural and Food Chemistry 57:2, pages 444-449.
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Saya Hata, Tohru Hayakawa, Hiroyuki Okada, Kazuhiko Hayashi, Yoshiaki Akimoto & Hirotsugu Yamamoto. (2008) Effect of Oral Administration of High Advanced-Collagen Tripeptide (HACP) on Bone Healing Process in Rat. Journal of Hard Tissue Biology 17:1, pages 17-22.
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