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Bioscience, Biotechnology, and Biochemistry Volume 72, 2008 - Issue 10
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Original Articles

Robust and Systematic Drug Screening Method Using Chemical Arrays and the Protein Library: Identification of Novel Inhibitors of Carbonic Anhydrase II

Isao MIYAZAKIAntibiotics Laboratory and Chemical Biology Department, RIKEN
,
Siro SIMIZUAntibiotics Laboratory and Chemical Biology Department, RIKEN
,
Harumi ICHIMIYAAntibiotics Laboratory and Chemical Biology Department, RIKEN
,
Makoto KAWATANIAntibiotics Laboratory and Chemical Biology Department, RIKEN
&
Hiroyuki OSADAAntibiotics Laboratory and Chemical Biology Department, RIKEN
Pages 2739-2749 | Received 06 Jun 2008, Accepted 08 Jul 2008, Published online: 22 May 2014

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Makoto Kawatani, Yukako Fukushima, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Yoshiki Yamaguchi, Naoyuki Taniguchi & Hiroyuki Osada. (2015) Identification of matrix metalloproteinase inhibitors by chemical arrays. Bioscience, Biotechnology, and Biochemistry 79:10, pages 1597-1602.
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Articles from other publishers (32)

Ken-ichi Takayama, Seiji Matsuoka, Shungo Adachi, Teruki Honma, Masahito Yoshida, Takayuki Doi, Kazuo Shin-ya, Minoru Yoshida, Hiroyuki Osada & Satoshi Inoue. (2023) Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment. PNAS Nexus 2:6.
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Marco Bürger, Kaori Honda, Yasumitsu Kondoh, Sharon Hong, Nobumoto Watanabe, Hiroyuki Osada & Joanne Chory. (2022) Crystal structure of Arabidopsis DWARF14‐LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture . Plant Direct 6:9.
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Ken-ichi Takayama, Teruki Honma, Takashi Suzuki, Yasumitsu Kondoh, Hiroyuki Osada, Yutaka Suzuki, Minoru Yoshida & Satoshi Inoue. (2021) Targeting Epigenetic and Posttranscriptional Gene Regulation by PSF Impairs Hormone Therapy–Refractory Cancer Growth. Cancer Research 81:13, pages 3495-3508.
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Hayoto Mizuta, Kenta Kuga, Takehiro Suzuki, Yuki Niwa, Naoshi Dohmae & Siro Simizu. (2019) C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells. International Journal of Oncology.
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Yue Hu, Xiao J. Zhang, Xiao T. Yang, Ying Y. Tang, Lin Y. Hu & Dong Zhu. 2019. Heat Shock Protein 90 in Human Diseases and Disorders. Heat Shock Protein 90 in Human Diseases and Disorders 411 439 .
Manabu Kaneko, Yushi Futamura, Senko Tsukuda, Yasumitsu Kondoh, Tomomi Sekine, Hiroyuki Hirano, Kento Fukano, Hirofumi Ohashi, Wakana Saso, Ryo Morishita, Satoko Matsunaga, Fumihiro Kawai, Akihide Ryo, Sam-Yong Park, Ryosuke Suzuki, Hideki Aizaki, Naoko Ohtani, Camille Sureau, Takaji Wakita, Hiroyuki Osada & Koichi Watashi. (2018) Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide. Scientific Reports 8:1.
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Taro NoguchiTaro Noguchi. 2018. Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products. Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products 1 9 .
Taro Noguchi, Hiroyuki Ishiba, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Hiroaki Ohno, Nobutaka Fujii & Shinya Oishi. (2017) Synthesis of Grb2 SH2 Domain Proteins for Mirror-Image Screening Systems. Bioconjugate Chemistry 28:2, pages 609-619.
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Hiroyuki Osada. 2017. Bioprobes. Bioprobes 1 10 .
Tatsuro Kawamura, Makoto Kawatani, Makoto Muroi, Yasumitsu Kondoh, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda & Hiroyuki Osada. (2016) Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. Scientific Reports 6:1.
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Yoshiyuki Soeda, Misato Yoshikawa, Osborne F. X. Almeida, Akio Sumioka, Sumihiro Maeda, Hiroyuki Osada, Yasumitsu Kondoh, Akiko Saito, Tomohiro Miyasaka, Tetsuya Kimura, Masaaki Suzuki, Hiroko Koyama, Yuji Yoshiike, Hachiro Sugimoto, Yasuo Ihara & Akihiko Takashima. (2015) Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature Communications 6:1.
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Takuya Ito, Yasumitsu Kondoh, Kazuko Yoshida, Taishi Umezawa, Takeshi Shimizu, Kazuo Shinozaki & Hiroyuki Osada. (2015) Novel Abscisic Acid Antagonists Identified with Chemical Array Screening. ChemBioChem 16:17, pages 2471-2478.
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Yasumitsu Kondoh, Kaori Honda & Hiroyuki Osada. 2015. Chemical Biology. Chemical Biology 29 41 .
Makoto Kawatani & Hiroyuki Osada. (2014) Affinity-based target identification for bioactive small molecules. MedChemComm 5:3, pages 277-287.
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Thota Ganesh, Jianxiong Jiang, Rangaiah Shashidharamurthy & Ray Dingledine. (2013) Discovery and Characterization of Carbamothioylacrylamides As EP2 Selective Antagonists. ACS Medicinal Chemistry Letters 4:7, pages 616-621.
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Taro Noguchi, Shinya Oishi, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Tatsuhiko Kubo, Masato Kaneda, Hiroaki Ohno, Hiroyuki Osada & Nobutaka Fujii. (2013) Affinity-based screening of MDM2/MDMX–p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors. Bioorganic & Medicinal Chemistry Letters 23:13, pages 3802-3805.
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Marco Bürger, Tobias J. Zimmermann, Yasumitsu Kondoh, Patricia Stege, Nobumoto Watanabe, Hiroyuki Osada, Herbert Waldmann & Ingrid R. Vetter. (2012) Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. Journal of Lipid Research 53:1, pages 43-50.
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Hiroyuki Osada & Siro Simizu. 2013. Chembiomolecular Science. Chembiomolecular Science 103 111 .
Shun Minagawa, Yasumitsu Kondoh, Keigo Sueoka, Hiroyuki Osada & Hitoshi Nakamoto. (2011) Cyclic lipopeptide antibiotics bind to the N-terminal domain of the prokaryotic Hsp90 to inhibit the chaperone activity. Biochemical Journal 435:1, pages 237-246.
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Maola M. G. Khan, Siro Simizu, Ngit Shin Lai, Makoto Kawatani, Takeshi Shimizu & Hiroyuki Osada. (2011) Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120. ACS Chemical Biology 6:3, pages 245-251.
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Konstanty Wierzba, Makoto Muroi & Hiroyuki Osada. (2011) Proteomics accelerating the identification of the target molecule of bioactive small molecules. Current Opinion in Chemical Biology 15:1, pages 57-65.
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Nami Miyanishi, Yukino Suzuki, Siro Simizu, Yoshiko Kuwabara, Kouji Banno & Kazuo Umezawa. (2010) Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion. Biochemical and Biophysical Research Communications 403:1, pages 154-159.
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Kyoji Hagiwara, Tomoyuki Murakami, Guangai Xue, Yasuo Shimizu, Eri Takeda, Yoshie Hashimoto, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Yasuko Tsunetsugu-Yokota & Yoko Aida. (2010) Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array. Biochemical and Biophysical Research Communications 403:1, pages 40-45.
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Isao Miyazaki, Siro Simizu, Hideo Okumura, Satoshi Takagi & Hiroyuki Osada. (2010) A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nature Chemical Biology 6:9, pages 667-673.
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Kyoji Hagiwara, Yasumitsu Kondoh, Atsushi Ueda, Kazunori Yamada, Hideo Goto, Toshiki Watanabe, Tadashi Nakata, Hiroyuki Osada & Yoko Aida. (2010) Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays. Biochemical and Biophysical Research Communications 394:3, pages 721-727.
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Naoki Kanoh. (2010) Organic Chemistry at the Interface of Complex Bioactive Natural Product and Chemical Biology. Journal of Synthetic Organic Chemistry, Japan 68:9, pages 939-950.
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Isao Miyazaki, Siro Simizu & Hiroyuki Osada. 2010. Small Molecule Microarrays. Small Molecule Microarrays 95 107 .
Makoto Kawatani & Hiroyuki Osada. (2009) Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases. Cancer Science 100:11, pages 1999-2005.
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Siro Simizu, Takayuki Teruya, Toshihiko Nogawa, Harumi Aono, Masashi Ueki, Masakazu Uramoto, Yuichi Kobayashi & Hiroyuki Osada. (2009) Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells. Biochemical and Biophysical Research Communications 383:4, pages 406-410.
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Isao Miyazaki, Hideo Okumura, Siro Simizu, Yoshikazu Takahashi, Naoki Kanoh , Yasuhiko Muraoka, Yoshiaki Nonomura & Hiroyuki Osada. (2009) Structure-Affinity Relationship Study of Bleomycins and Sh ble Protein by Use of a Chemical Array . ChemBioChem 10:5, pages 845-852.
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Isao Miyazaki, Siro Simizu, Keisuke Ishida & Hiroyuki Osada. (2009) On-Chip Fragment-Based Approach for Discovery of High-Affinity Bivalent Inhibitors. ChemBioChem 10:5, pages 838-843.
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Hiroyuki Osada. (2009) Development of Agrochemicals and Chemical Biology. Journal of Pesticide Science 34:3, pages 215-220.
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