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Original Articles

Methadone Dosage and Retention

An Examination of the 60 mg/Day Threshold

, , , , , , & show all
Pages 23-47 | Published online: 17 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (15)

Solmaz Amiri, Robert B. Lutz, Michael G. McDonell, John M. Roll & Ofer Amram. (2020) Spatial access to opioid treatment program and alcohol and cannabis outlets: analysis of missed doses of methadone during the first, second, and third 90 days of treatment. The American Journal of Drug and Alcohol Abuse 46:1, pages 78-87.
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Giulio Perugi, Alessandro Pallucchini, Salvatore Rizzato, Pietro De Rossi, Gabriele Sani, Angelo GI Maremmani, Vito Pinzone & Icro Maremmani. (2019) Pharmacotherapeutic strategies for the treatment of attention-deficit hyperactivity (ADHD) disorder with comorbid substance-use disorder (SUD). Expert Opinion on Pharmacotherapy 20:3, pages 343-355.
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Steven L. Proctor, Philip L. Herschman, Ronnie Lee & Albert M. Kopak. (2019) The Role of Patient Payment Method in Premature Discharge from Methadone Maintenance Treatment. Substance Use & Misuse 54:1, pages 97-105.
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Jing Gu, Huifang Xu, Joseph T.F. Lau, Long Chen, Zixin Wang, Chun Hao & Yuantao Hao. (2014) Situation-specific factors predicting nonadherence to methadone maintenance treatment: a cross-sectional study using the case-crossover design in Guangzhou, China. AIDS Care 26:sup1, pages S107-S112.
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Lin Zhao, William L. Holzemer, Jacqueline P. Tulsky, Mallory O. Johnson & Carol Dawson Rose. (2014) Effect of Methadone Dose on Maintenance Treatment and Health Consequences Among Heroin Addicts in South China. Substance Use & Misuse 49:1-2, pages 13-21.
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Jinma Ren, Zhen Ning, Carl V. Asche, Minghua Zhuang, Carmen S. Kirkness, Xiangyang Ye, Jie Fu & Qichao Pan. (2013) Trends and predictors in methadone maintenance treatment dropout in Shanghai, China: 2005–2011. Current Medical Research and Opinion 29:7, pages 731-738.
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Huang-Chi Lin, Kuei-Ying Chen, Peng-Wei Wang, Cheng-Fang Yen, Hung-Chi Wu, Chia-Nan Yen, Yi-Chun Yeh, Kung-shang Chung & Hsun-Cheng Chang. (2013) Predictors for Dropping-Out From Methadone Maintenance Therapy Programs Among Heroin Users in Southern Taiwan. Substance Use & Misuse 48:1-2, pages 181-191.
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Louise Mullen, Joseph Barry, Jean Long, Eamon Keenan, Deirdre Mulholland, Loretto Grogan & Ide Delargy. (2012) A National Study of the Retention of Irish Opiate Users in Methadone Substitution Treatment. The American Journal of Drug and Alcohol Abuse 38:6, pages 551-558.
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Sebastian Trautmann & Hans-Ulrich Wittchen. (2012) Abstinence Orientation and Treatment Practice: An Analysis of German Settings Providing Opioid Maintenance Therapy. Substance Use & Misuse 47:1, pages 22-30.
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Mary Jeanne Kreek, Lisa Borg, Elizabeth Ducat & Brenda Ray. (2010) Pharmacotherapy in the Treatment of Addiction: Methadone. Journal of Addictive Diseases 29:2, pages 200-216.
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Ayman Fareed, Jennifer Casarella, Richard Amar, Sreedevi Vayalapalli & Karen Drexler. (2010) Methadone Maintenance Dosing Guideline for Opioid Dependence, a Literature Review. Journal of Addictive Diseases 29:1, pages 1-14.
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PeterL. Tenore. (2008) Psychotherapeutic Benefits of Opioid Agonist Therapy. Journal of Addictive Diseases 27:3, pages 49-65.
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Barry Stimmel. (2007) Buprenorphine Misuse, Abuse, and Diversion. Journal of Addictive Diseases 26:3, pages 1-3.
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Richard Hallinan, Richard Hallinan, Andrew Byrne, Richard Hallinan, Andrew Byrne, Gregory J. Dore, Richard Hallinan, Andrew Byrne & Gregory J. Dore. (2007) Harm reduction, hepatitis C and opioid pharmacotherapy: an opportunity for integrated hepatitis C virus-specific harm reduction. Drug and Alcohol Review 26:4, pages 437-443.
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Barry Stimmel. (2005) Maintenance for Opioid Addiction with Buprenorphine and Methadone. Journal of Addictive Diseases 24:3, pages 1-6.
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Articles from other publishers (24)

Icro Maremmani, Matteo Pacini & Angelo G. I. MaremmaniIcro Maremmani, Matteo Pacini & Angelo G. I. Maremmani. 2023. Dual Disorder Heroin Addicts. Dual Disorder Heroin Addicts 39 90 .
Daniel L. Howard. 2020. Effective Prevention and Treatment of Substance Use Disorders for Racial and Ethnic Minorities. Effective Prevention and Treatment of Substance Use Disorders for Racial and Ethnic Minorities.
Solmaz Amiri, Katherine Hirchak, Robert Lutz, Michael G. McDonell, Sterling M. McPherson, John M. Roll & Ofer Amram. (2018) Three-year retention in methadone opioid agonist treatment: A survival analysis of clients by dose, area deprivation, and availability of alcohol and cannabis outlets. Drug and Alcohol Dependence 193, pages 63-68.
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Guang Zhang, Yuecheng Yang, Runhua Ye, Dapeng Zhang, Duo Shan, Yifei Hu, Bing Dai & Zhongfu Liu. (2018) Effect of community-based extension clinics of methadone maintenance therapy for opiate-dependent clients. Medicine 97:47, pages e13323.
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Jemima A. Frimpong, Karen Shiu-Yee & Thomas D'Aunno. (2017) The Role of Program Directors in Treatment Practices: The Case of Methadone Dose Patterns in U.S. Outpatient Opioid Agonist Treatment Programs. Health Services Research 52:5, pages 1881-1907.
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Wan Shakira R. H.Abdullah Sarimah & Bachok Norsa’adah. (2017) Factor Predictive of 1-Year Retention on Methadone Maintenance Therapy Program: A Survival Analysis Study. Addictive Disorders & Their Treatment 16:2, pages 64-69.
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Jacopo V. Bizzarri, Valentina Casetti, Livia Sanna, Angelo Giovanni Icro Maremmani, Luca Rovai, Silvia Bacciardi, Daria Piacentino, Andreas Conca & Icro Maremmani. (2016) The newer Opioid Agonist Treatment with lower substitutive opiate doses is associated with better toxicology outcome than the older Harm Reduction Treatment. Annals of General Psychiatry 15:1.
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C. D. Darker, J. Ho, G. Kelly, L. Whiston & J. Barry. (2015) Demographic and clinical factors predicting retention in methadone maintenance: results from an Irish cohort. Irish Journal of Medical Science (1971 -) 185:2, pages 433-441.
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Omary Ubuguyu, Olivia C. Tran, Robert Douglas Bruce, Frank Masao, Cassian Nyandindi, Norman Sabuni, Sheryl McCurdy, Jessie Mbwambo & Barrot H. Lambdin. (2016) Improvements in health-related quality of life among methadone maintenance clients in Dar es Salaam, Tanzania. International Journal of Drug Policy 30, pages 74-81.
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Olivia C. Tran, Robert Douglas Bruce, Frank Masao, Omary Ubuguyu, Norman Sabuni, Jessie Mbwambo & Barrot H. Lambdin. (2015) Implementation and Operational Research. JAIDS Journal of Acquired Immune Deficiency Syndromes 69:2, pages e43-e48.
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Christine Wilder, Daniel Lewis & Theresa Winhusen. (2015) Medication assisted treatment discontinuation in pregnant and postpartum women with opioid use disorder. Drug and Alcohol Dependence 149, pages 225-231.
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Marcus Baumeister, Marc Vogel, Kenneth M Dürsteler-MacFarland, Urs Gerhard, Johannes Strasser, Marc Walter, Gerhard A Wiesbeck & Sylvie A Petitjean. (2014) Association between methadone dose and concomitant cocaine use in methadone maintenance treatment: a register-based study. Substance Abuse Treatment, Prevention, and Policy 9:1.
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Kaina Zhou & Guihua Zhuang. (2014) Retention in methadone maintenance treatment in mainland China, 2004–2012: A literature review. Addictive Behaviors 39:1, pages 22-29.
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Angelo Giovanni Icro Maremmani, Luca Rovai, Silvia Bacciardi, Fabio Rugani, Matteo Pacini, Pier Paolo Pani, Liliana Dell' Osso, Hagop Akiskal & Icro Maremmani. (2013) The long-term outcomes of heroin dependent-treatment-resistant patients with bipolar 1 comorbidity after admission to enhanced methadone maintenance. Journal of Affective Disorders 151:2, pages 582-589.
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Tony Szu-Hsien Lee, Hsi-Che Shen, Wei-Hsin Wu, Chun-Wei Huang, Muh-Yong Yen, Bo-En Wang, Peing Chuang, Chien-Yu Shih, Ying-Chun Chou & Yi-Lien Liu. (2011) Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan. Substance Abuse Treatment, Prevention, and Policy 6:1.
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Sharon M. Kelly, Kevin E. O’Grady, Shannon Gwin Mitchell, Barry S. Brown & Robert P. Schwartz. (2011) Predictors of methadone treatment retention from a multi-site study: A survival analysis. Drug and Alcohol Dependence 117:2-3, pages 170-175.
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Bohdan Nosyk, David C. Marsh, Huiying Sun, Martin T. Schechter & Aslam H. Anis. (2010) Trends in methadone maintenance treatment participation, retention, and compliance to dosing guidelines in British Columbia, Canada: 1996–2006. Journal of Substance Abuse Treatment 39:1, pages 22-31.
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YANHUA CHE, SAWITRI ASSANANGKORNCHAI, EDWARD MCNEIL, VIRASAKDI CHONGSUVIVATWONG, JIANHUA LI, ALAN GEATER & JING YOU. (2010) Predictors of early dropout in methadone maintenance treatment program in Yunnan province, China. Drug and Alcohol Review 29:3, pages 263-270.
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Gez Bevan. (2009) Problem drug use the public health imperative: what some of the literature says. Substance Abuse Treatment, Prevention, and Policy 4:1.
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Nidal Moukaddam, David V. Herin, Angela Stotts, Anne Hamilton Dougherty, Charles Green, Marc Mooney, Ann Garcia, Richard A. Meisch, Katherine Cowan, Frederick Gerard Moeller, Joy M. Schmitz & John Grabowski. (2009) Comparison of 3 L-α-acetyl-methadol (LAAM) Maintenance Strategies for Heroin Dependence. Addictive Disorders & Their Treatment 8:4, pages 191-200.
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Enwu Liu, Tao Liang, Limei Shen, Huan Zhong, Bing Wang, Zunyou Wu & Roger Detels. (2009) Correlates of methadone client retention: A prospective cohort study in Guizhou province, China. International Journal of Drug Policy 20:4, pages 304-308.
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Caleb J. Banta‐Green, Charles Maynard, Thomas D. Koepsell, Elizabeth A. Wells & Dennis M. Donovan. (2009) Retention in methadone maintenance drug treatment for prescription‐type opioid primary users compared to heroin users. Addiction 104:5, pages 775-783.
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G. L. Dickinson, A. Rostami-Hodjegan, O. Lagundoye, N. Seivewright, P. Pratt & M. S. Lennard. (2006) A six-year evaluation of methadone prescribing practices at a substance misuse treatment centre in the UK. Journal of Clinical Pharmacy and Therapeutics 31:5, pages 477-484.
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Karen D. Ersche, Paul C. Fletcher, Jonathan P. Roiser, Tim D. Fryer, Mervyn London, Trevor W. Robbins & Barbara J. Sahakian. (2006) Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers. Psychopharmacology 188:3, pages 364-373.
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