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Original Articles

High Methadone Dose Significantly Reduces Cocaine Use in Methadone Maintenance Treatment (MMT) Patients

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Pages 43-50 | Published online: 23 Sep 2008

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Giulio Perugi, Alessandro Pallucchini, Salvatore Rizzato, Pietro De Rossi, Gabriele Sani, Angelo GI Maremmani, Vito Pinzone & Icro Maremmani. (2019) Pharmacotherapeutic strategies for the treatment of attention-deficit hyperactivity (ADHD) disorder with comorbid substance-use disorder (SUD). Expert Opinion on Pharmacotherapy 20:3, pages 343-355.
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Ozietta D. Taylor. (2015) Poly Substance Use in Methadone Maintenance Therapy (MMT) Patients. Journal of Human Behavior in the Social Environment 25:8, pages 822-829.
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Einat Peles, Shaul Schreiber & Miriam Adelson. (2014) Trends in Substance Abuse and Infectious Disease Over 20 Years in a Large Methadone Maintenance Treatment (MMT) Clinic in Israel. Substance Abuse 35:3, pages 226-229.
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Lin Zhao, William L. Holzemer, Jacqueline P. Tulsky, Mallory O. Johnson & Carol Dawson Rose. (2014) Effect of Methadone Dose on Maintenance Treatment and Health Consequences Among Heroin Addicts in South China. Substance Use & Misuse 49:1-2, pages 13-21.
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Marta Rodríguez-Arias, María Asunción Aguilar, Carmen Manzanedo & José Miñarro. (2010) Preclinical evidence of new opioid modulators for the treatment of addiction. Expert Opinion on Investigational Drugs 19:8, pages 977-994.
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Mary Jeanne Kreek, Lisa Borg, Elizabeth Ducat & Brenda Ray. (2010) Pharmacotherapy in the Treatment of Addiction: Methadone. Journal of Addictive Diseases 29:2, pages 200-216.
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Erin Cummins & Francesco Leri. (2009) Animal studies trigger new insights on the use of methadone maintenance. Expert Opinion on Drug Discovery 4:5, pages 577-586.
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Einat Peles, Shirley Linzy, Mary Jeanne Kreek & Miriam Adelson. (2008) One-Year and Cumulative Retention as Predictors of Success in Methadone Maintenance Treatment: A Comparison of Two Clinics in the United States and Israel. Journal of Addictive Diseases 27:4, pages 11-25.
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Mary Jeanne Kreek. (2007) Opioids, dopamine, stress, and the addictions. Dialogues in Clinical Neuroscience 9:4, pages 363-378.
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Articles from other publishers (39)

Eleanor Blair Towers, Daniel A. Shapiro, Jean M. Abel, Anousheh Bakhti-Suroosh, Kristyna Kupkova, David T. Auble, Patrick A. Grant & Wendy J. Lynch. (2023) Transcriptional Profile of Exercise-Induced Protection Against Relapse to Cocaine Seeking in a Rat Model. Biological Psychiatry Global Open Science 3:4, pages 734-745.
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Catarina Cordeiro, Rodrigo Saraiva, Inês Simões, Fátima Ismail & Filipa Novais. (2022) The Hero’s Substitution: Cross Sectional Study about Substitution Therapy for Heroin. Revista Portuguesa de Psiquiatria e Saúde Mental 8:2, pages 77-80.
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Tabitha E Moses, Gary L Rhodes, Emytis Tavakoli, Carl W Christensen, Alireza Amirsadri & Mark K Greenwald. (2022) Predictors of Retention and Drug Use Among Patients With Opioid Use Disorder Transferred to a Specialty “Second Chance” Methadone Program. Substance Abuse: Research and Treatment 16, pages 117822182211383.
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Patrick S. Thomas, Ellen M. Nielsen, Catherine J. Spellicy, Mark J. Harding, An Ye, Michelle Patriquin, Sara C. Hamon, Thomas R. Kosten & David A. Nielsen. (2021) The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatric Genetics 31:3, pages 88-94.
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David A. Gorelick. 2021. Textbook of Addiction Treatment. Textbook of Addiction Treatment 173 186 .
Xiaobin Cao, Chunqing Lin, Changhe Wang & Zunyou Wu. 2020. HIV/AIDS in China. HIV/AIDS in China 177 200 .
Hagit Bonny-Noach. (2019) Harm reduction drug policy in Israel: what has been accomplished and what still needs to be done?. Israel Journal of Health Policy Research 8:1.
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Einat Peles, Orna Levran, Matthew Randesi, Jurg Ott, Mary Jeanne Kreek & Miriam Adelson. (2019) Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction. Journal of Addiction Medicine 13:6, pages 430-435.
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Angelo Maremmani, Matteo Pacini & Icro Maremmani. (2019) What we have learned from the Methadone Maintenance Treatment of Dual Disorder Heroin Use Disorder patients. International Journal of Environmental Research and Public Health 16:3, pages 447.
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Einat Peles, Shaul Schreiber, Anat Sason & Miriam Adelson. (2018) Similarities and changes between 15- and 24-year survival and retention rates of patients in a large medical-affiliated methadone maintenance treatment (MMT) center. Drug and Alcohol Dependence 185, pages 112-119.
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Marcus Herdener, Kenneth M Dürsteler, Erich Seifritz & Carlos Nordt. (2017) Changes in substance use in patients receiving opioid substitution therapy and resulting clinical challenges: a 17-year treatment case register analysis. The Lancet Psychiatry 4:4, pages 302-309.
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Einat Peles, Anat Sason, Shaul Schreiber & Miriam Adelson. (2017) Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial. The American Journal on Addictions 26:2, pages 167-175.
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Perrine Roux, Caroline Lions, Antoine Vilotitch, Laurent Michel, Marion Mora, Gwenaelle Maradan, Fabienne Marcellin, Bruno Spire, Alain Morel & Patrizia M. Carrieri. (2016) Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm Reduction Journal 13:1.
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Yan Zhou, Hilary Briggs & Mary Jeanne Kreek. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 1003 1011 .
Matteo Pacini, Angelo Giovanni Icro Maremmani, Mauro Ceccanti & Icro Maremmani. (2015) Former Heroin-Dependent Alcohol Use Disorder Patients. Prevalence, Addiction History and Clinical Features. Alcohol and Alcoholism 50:4, pages 451-457.
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David A. Gorelick. 2015. Textbook of Addiction Treatment: International Perspectives. Textbook of Addiction Treatment: International Perspectives 381 404 .
Marcus Baumeister, Marc Vogel, Kenneth M Dürsteler-MacFarland, Urs Gerhard, Johannes Strasser, Marc Walter, Gerhard A Wiesbeck & Sylvie A Petitjean. (2014) Association between methadone dose and concomitant cocaine use in methadone maintenance treatment: a register-based study. Substance Abuse Treatment, Prevention, and Policy 9:1.
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Xiaobin Cao, Zunyou Wu, Keming Rou, Li Li, Chunqing Lin, Changhe Wang, Wei Luo, Lin Pang, Wenyuan Yin & Jianhua Li. (2014) Retention and its predictors among methadone maintenance treatment clients in China: A six-year cohort study. Drug and Alcohol Dependence 145, pages 87-93.
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Melissa J. Stewart, Heather G. Fulton & Sean P. Barrett. (2014) Powder and Crack Cocaine Use Among Opioid Users. Journal of Addiction Medicine 8:4, pages 264-270.
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Miriam Adelson, Shaul Schreiber, Anat Sason & Einat Peles. (2014) Are 2 Weeks of “Take-Home” Privileges Beneficial for Patients' Long-term Outcome in a Methadone Maintenance Treatment Program?. Journal of Addiction Medicine 8:3, pages 170-175.
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Jean M. Bidlack. 2014. Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse. Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse 387 418 .
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Mary Jeanne Kreek, Orna Levran, Brian Reed, Stefan D. Schlussman, Yan Zhou & Eduardo R. Butelman. (2012) Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics. Journal of Clinical Investigation 122:10, pages 3387-3393.
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Wim van den Brink. 2012. Essential Evidence-Based Psychopharmacology. Essential Evidence-Based Psychopharmacology 235 261 .
Francesco Leri, Yan Zhou, Brendan Carmichael, Erin Cummins & Mary Jeanne Kreek. (2012) Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression. European Neuropsychopharmacology 22:2, pages 143-152.
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Mary Jeanne Kreek. (2011) Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment. Annals of the New York Academy of Sciences 1231:1, pages 65-72.
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Lei Li, Rassamee Sangthong, Virasakdi Chongsuvivatwong, Edward McNeil & Jianhua Li. (2011) Multiple substance use among heroin-dependent patients before and during attendance at methadone maintenance treatment program, Yunnan, China. Drug and Alcohol Dependence 116:1-3, pages 246-249.
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Yan Zhou, Dmitri Proudnikov, Vadim Yuferov & Mary Jeanne Kreek. (2010) Drug-induced and genetic alterations in stress-responsive systems: Implications for specific addictive diseases. Brain Research 1314, pages 235-252.
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RICHARD SENBANJO, KIM WOLFF, E. JANE MARSHALL & JOHN STRANG. (2009) Persistence of heroin use despite methadone treatment: Poor coping self-efficacy predicts continued heroin use. Drug and Alcohol Review 28:6, pages 608-615.
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Francesco Leri, Yan Zhou, Benjamin Goddard, AnneMarie Levy, Derek Jacklin & Mary Jeanne Kreek. (2009) Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain. European Neuropsychopharmacology 19:4, pages 238-249.
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David H. Epstein, John Schmittner, Annie Umbricht, Jennifer R. Schroeder, Eric T. Moolchan & Kenzie L. Preston. (2009) Promoting abstinence from cocaine and heroin with a methadone dose increase and a novel contingency. Drug and Alcohol Dependence 101:1-2, pages 92-100.
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David A Nielsen, Vadim Yuferov, Sara Hamon, Colin Jackson, Ann Ho, Jurg Ott & Mary Jeanne Kreek. (2008) Increased OPRM1 DNA Methylation in Lymphocytes of Methadone-Maintained Former Heroin Addicts. Neuropsychopharmacology 34:4, pages 867-873.
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Mary Jeanne Kreek, Yan Zhou, Eduardo R Butelman & Orna Levran. (2009) Opiate and cocaine addiction: from bench to clinic and back to the bench. Current Opinion in Pharmacology 9:1, pages 74-80.
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M.J. Kreek, S.D. Schlussman, B. Reed, Y. Zhang, D.A. Nielsen, O. Levran, Y. Zhou & E.R. Butelman. (2009) Bidirectional translational research: Progress in understanding addictive diseases. Neuropharmacology 56, pages 32-43.
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M.J. Kreek, L. Borg, Y. Zhou & I. Kravets. 2009. Hormones, Brain and Behavior. Hormones, Brain and Behavior 3177 3207 .
Francesco Leri, Robert E Sorge, Erin Cummins, David Woehrling, James G Pfaus & Jane Stewart. (2007) High-Dose Methadone Maintenance in Rats: Effects on Cocaine Self-Administration and Behavioral Side Effects. Neuropsychopharmacology 32:11, pages 2290-2300.
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Einat Peles, Gershon Bodner, Mary Jeanne Kreek, Vera Rados & Miriam Adelson. (2006) Corrected‐QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients—a cross‐sectional study. Addiction 102:2, pages 289-300.
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George A Kenna, Darci M Nielsen, Patricia Mello, Alison Schiesl & Robert M Swift. (2007) Pharmacotherapy of Dual Substance Abuse and Dependence. CNS Drugs 21:3, pages 213-237.
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