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Original Articles

A Phase I, Open Label, Four-Way Crossover Study to Compare the Pharmacokinetic Profiles of a Single Dose of 20 mg of a Cannabis Based Medicine Extract (CBME) Administered on 3 Different Areas of the Buccal Mucosa and to Investigate the Pharmacokinetics of CBME per Oral in Healthy Male and Female Volunteers (GWPK0112)

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Pages 79-120 | Published online: 15 Oct 2008

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Ehsan Moazen-Zadeh, Alexandra ChisholmKeren BachiYasmin L. Hurd. (2023) Pharmacokinetics of Cannabidiol: A Systematic Review and Meta-Regression Analysis. Cannabis and Cannabinoid Research.
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Heather Barkholtz & Maia Bates. (2023) Measuring the diversity gap of cannabis clinical trial participants compared to people who report using cannabis. Scientific Reports 13:1.
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Yitong Liu & Robert L. Sprando. (2022) Physiologically based pharmacokinetic modeling and simulation of cannabinoids in human plasma and tissues. Journal of Applied Toxicology 43:4, pages 589-598.
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Mahesh Pattabhiramaiah & Shanthala Mallikarjunaiah. 2023. Medical Cannabis and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases. Medical Cannabis and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases 103 118 .
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C. Austin Zamarripa, Ryan Vandrey & Tory R. Spindle. (2022) Factors that Impact the Pharmacokinetic and Pharmacodynamic Effects of Cannabis: a Review of Human Laboratory Studies. Current Addiction Reports 9:4, pages 608-621.
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Hayley B. Schultz, Adele HosseiniAndrew J. McLachlanStephanie E. Reuter. (2022) Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development. Cannabis and Cannabinoid Research.
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Sultan Mayar, Mina Memarpoor-Yazdi, Ahmad Makky, Romina Eslami Sarokhalil & Nazzareno D'Avanzo. (2022) Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids. Frontiers in Molecular Neuroscience 15.
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Yvonne Bonomo, Amanda Norman, Lisa Collins, Helen O’Neill, Peter Galettis, Jane Trinca, Nigel Strauss, Jennifer Martin & David Castle. (2021) Pharmacokinetics, Safety, and Tolerability of a Medicinal Cannabis Formulation in Patients with Chronic Non-cancer Pain on Long-Term High Dose Opioid Analgesia: A Pilot Study. Pain and Therapy 11:1, pages 171-189.
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Daryl Efron, Kaitlyn Taylor, Jonathan M Payne, Jeremy L Freeman, Noel Cranswick, Melissa Mulraney, Chidambaram Prakash, Katherine J Lee & Katrina Williams. (2020) Does cannabidiol reduce severe behavioural problems in children with intellectual disability? Study protocol for a pilot single-site phase I/II randomised placebo controlled trial. BMJ Open 10:3, pages e034362.
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Marilyn A. Huestis. 2020. Principles of Forensic Toxicology. Principles of Forensic Toxicology 389 448 .
Abigail M. Freeman, Katherine Petrilli, Rachel Lees, Chandni Hindocha, Claire Mokrysz, H. Valerie Curran, Rob Saunders & Tom P. Freeman. (2019) How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review. Neuroscience & Biobehavioral Reviews 107, pages 696-712.
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Benjamin J Whalley, Hong Lin, Lynne Bell, Thomas Hill, Amesha Patel, Roy A Gray, C Elizabeth Roberts, Orrin Devinsky, Michael Bazelot, Claire M Williams & Gary J Stephens. (2018) Species‐specific susceptibility to cannabis‐induced convulsions. British Journal of Pharmacology 176:10, pages 1506-1523.
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Sonja Elsaid, Stefan Kloiber & Bernard Le Foll. 2019. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside 25 75 .
Sophie A. Millar, Nicole L. Stone, Andrew S. Yates & Saoirse E. O'Sullivan. (2018) A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology 9.
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Crossref
Evan C. Rosenberg, Richard W. Tsien, Benjamin J. Whalley & Orrin Devinsky. (2015) Cannabinoids and Epilepsy. Neurotherapeutics 12:4, pages 747-768.
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Orrin Devinsky, Maria Roberta Cilio, Helen Cross, Javier Fernandez-Ruiz, Jacqueline French, Charlotte Hill, Russell Katz, Vincenzo Di Marzo, Didier Jutras-Aswad, William George Notcutt, Jose Martinez-Orgado, Philip J. Robson, Brian G. Rohrback, Elizabeth Thiele, Benjamin Whalley & Daniel Friedman. (2014) Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia 55:6, pages 791-802.
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Yahiya Y. Syed, Kate McKeage & Lesley J. Scott. (2014) Delta-9-Tetrahydrocannabinol/Cannabidiol (Sativex®): A Review of Its Use in Patients with Moderate to Severe Spasticity Due to Multiple Sclerosis. Drugs 74:5, pages 563-578.
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Erin L Karschner, W David Darwin, Robert S Goodwin, Stephen Wright & Marilyn A Huestis. (2011) Plasma Cannabinoid Pharmacokinetics following Controlled Oral Δ9-Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration. Clinical Chemistry 57:1, pages 66-75.
Crossref
Marilyn A. Huestis, Karl B. Scheidweiler, Takeshi Saito, Neil Fortner, Tsadik Abraham, Richard A. Gustafson & Michael L. Smith. (2008) Excretion of Δ9-tetrahydrocannabinol in sweat. Forensic Science International 174:2-3, pages 173-177.
Crossref
Marilyn A. Huestis. (2007) Human Cannabinoid Pharmacokinetics. Chemistry & Biodiversity 4:8, pages 1770-1804.
Crossref
Geoffrey W. Guy & Colin G. Stott. 2005. Cannabinoids as Therapeutics. Cannabinoids as Therapeutics 231 263 .
M. A. Huestis. 2005. Cannabinoids. Cannabinoids 657 690 .
Jonathan S. Berman, Catherine Symonds & Rolfe Birch. (2004) Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Pain 112:3, pages 299-306.
Crossref

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