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Original Articles

Pharmacokinetics of Saquinavir-SGC in HIV-Infected Pregnant Women

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Pages 460-465 | Published online: 02 Feb 2015

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Read on this site (5)

A. Fang, S.R. Valluri, M-J. O’Sullivan, R. Maupin, T. Jones, I. Delke & P. Clax. (2012) Safety and Pharmacokinetics of Nelfinavir During the Second and Third Trimesters of Pregnancy and Postpartum. HIV Clinical Trials 13:1, pages 46-59.
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Tai L. Guo, Dori R. Germolec, Denise M. Roesh & Kimber L. White$suffix/text()$suffix/text(). (2010) Immunomodulation in female B6C3F1 mice following treatment with the HIV protease inhibitor saquinavir for 28 days by gavage. Journal of Immunotoxicology 7:4, pages 289-297.
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Gail D Anderson. (2006) Using pharmacokinetics to predict the effects of pregnancy and maternal–infant transfer of drugs during lactation. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 947-960.
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Articles from other publishers (40)

Jeremiah D. Momper & Brookie M. Best. 2022. Clinical Pharmacology During Pregnancy. Clinical Pharmacology During Pregnancy 177 202 .
Manoranjenni Chetty, Michael P. Danckwerts & Andrea Julsing. (2020) Prediction of the exposure to a 400-mg daily dose of efavirenz in pregnancy: is this dose adequate in extensive metabolisers of CYP2B6?. European Journal of Clinical Pharmacology 76:8, pages 1143-1150.
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Mohammed Lamorde, Jonathan M. Schapiro, David Burger & David J. Back. (2014) Antiretroviral drugs for prevention of mother-to-child transmission. AIDS 28:17, pages 2551-2563.
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Shelley A. McCormack & Brookie M. Best. (2014) Protecting the Fetus Against HIV Infection: A Systematic Review of Placental Transfer of Antiretrovirals. Clinical Pharmacokinetics 53:11, pages 989-1004.
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Anders Helldén & Parvaz Madadi. (2013) Pregnancy and pharmacogenomics in the context of drug metabolism and response. Pharmacogenomics 14:14, pages 1779-1791.
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Nisha Andany & Mona R. Loutfy. (2013) HIV Protease Inhibitors in Pregnancy. Drugs 73:3, pages 229-247.
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Brookie M. Best. 2013. Clinical Pharmacology During Pregnancy. Clinical Pharmacology During Pregnancy 173 199 .
Kajal Buckoreelall, Tim R. Cressey & Jennifer R. King. (2012) Pharmacokinetic Optimization of Antiretroviral Therapy in Pregnancy. Clinical Pharmacokinetics 51:10, pages 639-659.
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Maria Martinez-Rebollar, Montserrat Lonca, Iñaki Perez, Dolors Soy, Mercè Brunet, Rosa Martin, Oriol Coll, Sandra Hernandez, Montserrat Laguno, Ana Milinkovic, Maria Larrousse, Marta Calvo, Jose L Blanco, Esteban Martínez, Jose M Gatell & Josep Mallolas. (2011) Pharmacokinetic Study of Saquinavir 500 mg Plus Ritonavir (1000/100 mg Twice a Day) in HIV-Positive Pregnant Women. Therapeutic Drug Monitoring 33:6, pages 772-777.
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F Conradie, C Zorrilla, D Josipovic, M Botes, O Osiyemi, E Vandeloise, T Eley, M Child, R Bertz, W Hu, V Wirtz & D McGrath. (2011) Safety and exposure of once-daily ritonavir-boosted atazanavir in HIV-infected pregnant women. HIV Medicine 12:9, pages 570-579.
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Mark Mirochnick, Brookie M. Best & Diana F. Clarke. (2010) Antiretroviral Pharmacology: Special Issues Regarding Pregnant Women and Neonates. Clinics in Perinatology 37:4, pages 907-927.
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Mohammed Lamorde, Pauline Byakika-Kibwika, Violet Okaba-Kayom, John P Flaherty, Marta Boffito, Rhoda Namakula, Mairin Ryan, Clemensia Nakabiito, David J Back, Saye Khoo, Concepta Merry & Kimberly K Scarsi. (2010) Suboptimal Nevirapine Steady-State Pharmacokinetics During Intrapartum Compared With Postpartum in HIV-1-Seropositive Ugandan Women. JAIDS Journal of Acquired Immune Deficiency Syndromes 55:3, pages 345-350.
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Huixia Zhang, Xiaohui Wu, Suresh Babu Naraharisetti, Francisco Chung, Dale Whittington, Ahmad Mirfazaelian & Jashvant D. Unadkat. (2009) Pregnancy Does Not Increase CYP3A or P-Glycoprotein Activity in the Non-Human Primate, Macaca nemestrina . Journal of Pharmacology and Experimental Therapeutics 330:2, pages 586-595.
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Abhishek Gulati & Phillip M. Gerk. (2009) Role of placental ATP-binding cassette (ABC) transporters in antiretroviral therapy during pregnancy. Journal of Pharmaceutical Sciences 98:7, pages 2317-2335.
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Huixia Zhang, Xiaohui Wu, Francisco Chung, Suresh Babu Naraharisetti, Dale Whittington, Ahmad Mirfazaelian & Jashvant D. Unadkat. (2009) As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina . Journal of Pharmacology and Experimental Therapeutics 329:3, pages 1016-1022.
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Arlene D. Bardeguez. 2009. HIV/AIDS in U.S. Communities of Color. HIV/AIDS in U.S. Communities of Color 103 132 .
Nils von Hentig, Gabi Nisius, Tessa Lennemann, Pavel Khaykin, Christoph Stephan, Errol Babacan, Schlomo Staszewski, Michael Kurowski, Sebastian Harder & Annette Haberl. (2008) Pharmacokinetics, Safety and Efficacy of Saquinavir/ Ritonavir 1,000/100 Mg Twice Daily as HIV Type-1 Therapy and Transmission Prophylaxis in Pregnancy. Antiviral Therapy 13:8, pages 1039-1046.
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Silvia Baroncelli, Paola Villani, Marco Floridia, Maria F Pirillo, Clementina M Galluzzo, Maria Cusato, Roberta Amici, Carmela Pinnetti, Francesca Sabbatini, Atim Molinari, Enrica Tamburrini & Mario Regazzi. (2008) Trough Concentrations of Lopinavir, Nelfinavir, and Nevirapine With Standard Dosing in Human Immunodeficiency Virus-Infected Pregnant Women Receiving 3-Drug Combination Regimens. Therapeutic Drug Monitoring 30:5, pages 604-610.
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Matthieu Roustit, Malik Jlaiel, Pascale Leclercq & Françoise Stanke-Labesque. (2008) Pharmacokinetics and therapeutic drug monitoring of antiretrovirals in pregnant women. British Journal of Clinical Pharmacology 66:2, pages 179-195.
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Arlene D Bardeguez, Jane C Lindsey, Maureen Shannon, Ruth E Tuomala, Susan E Cohn, Elizabeth Smith, Alice Stek, Shelly Buschur, Amanda Cotter, Linda Bettica & Jennifer S Read. (2008) Adherence to Antiretrovirals Among US Women During and After Pregnancy. JAIDS Journal of Acquired Immune Deficiency Syndromes 48:4, pages 408-417.
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Brookie M Best & Edmund V Capparelli. (2008) Implications of gender and pregnancy for antiretroviral drug dosing. Current Opinion in HIV and AIDS 3:3, pages 277-282.
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EV Capparelli, F Aweeka, J Hitti, A Stek, C Hu, SK Burchett, B Best, E Smith, JS Read, H Watts, S Nachman, EM Thorpe, SA Spector, E Jimenez, WT Shearer, M Foca & M Mirochnick. (2008) Chronic administration of nevirapine during pregnancy: impact of pregnancy on pharmacokinetics. HIV Medicine 9:4, pages 214-220.
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Carmen D. Zorrilla, Russell Van Dyke, Arlene Bardeguez, Edward P. Acosta, Betsy Smith, Michael D. Hughes, Sharon Huang, D. Heather Watts, Barbara Heckman, Eleanor Jiménez, George McSherry & Lynne Mofenson. (2007) Clinical Response and Tolerability to and Safety of Saquinavir with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Mothers and Their Infants. Antimicrobial Agents and Chemotherapy 51:6, pages 2208-2210.
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Luis F Lopez-Cortes, Rosa Ruiz-Valderas, Antonio Rivero, Angela Camacho, Manuel Marquez-Solero, Jesus Santos, Milagros García-Lazaro, Pompeyo Viciana, Jesus Rodriguez-Baños & Antonio Ocampo. (2007) Efficacy of Low-Dose Boosted Saquinavir Once Daily Plus Nucleoside Reverse Transcriptase Inhibitors in Pregnant HIV-1-Infected Women With a Therapeutic Drug Monitoring Strategy. Therapeutic Drug Monitoring 29:2, pages 171-176.
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Alice M Stek, Mark Mirochnick, Edmund Capparelli, Brookie M Best, Chengcheng Hu, Sandra K Burchett, Carol Elgie, Diane T Holland, Elizabeth Smith, Ruth Tuomala, Amanda Cotter & Jennifer S Read. (2006) Reduced lopinavir exposure during pregnancy. AIDS 20:15, pages 1931-1939.
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Andrea Gingelmaier, Michael Kurowski, Ralph Kästner, Josef Eberle, Ioannis Mylonas, Bernd H Belohradsky, Klaus Friese & Thomas A Grubert. (2006) Placental transfer and pharmacokinetics of lopinavir and other protease inhibitors in combination with nevirapine at delivery. AIDS 20:13, pages 1737-1743.
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Anita A. Mathias, Lillian Maggio-Price, Yurong Lai, Anshul Gupta & Jashvant D. Unadkat. (2006) Changes in Pharmacokinetics of Anti-HIV Protease Inhibitors during Pregnancy: The Role of CYP3A and P-glycoprotein. Journal of Pharmacology and Experimental Therapeutics 316:3, pages 1202-1209.
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D Heather Watts. (2006) Treating HIV During Pregnancy. Drug Safety 29:6, pages 467-490.
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Susan Cu-Uvin, Arlene Bardeguez & Carla Chibwesha. 2006. Reverse Transcriptase Inhibitors in HIV/AIDS Therapy. Reverse Transcriptase Inhibitors in HIV/AIDS Therapy 425 470 .
Esteve Ribera, Luis Fernando López-Cortés, Vicente Soriano, José Luis Casado & Josep Mallolas. (2005) Therapeutic drug monitoring and the inhibitory quotient of antiretroviral drugs: can they be applied to the current situation?. Enfermedades Infecciosas y Microbiología Clínica 23, pages 55-67.
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Esteve Ribera, Luis Fernando López-Cortés, Vicente Soriano, José Luis Casado & Josep Mallolas. (2005) Monitorización terapéutica y cociente inhibitorio de los fármacos antirretrovirales: ¿son aplicables a nuestra realidad?. Enfermedades Infecciosas y Microbiología Clínica 23, pages 41-54.
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Jennifer J. Kiser, Peter L. Anderson & John G. Gerber. (2005) Therapeutic drug monitoring: Pharmacologic considerations for antiretroviral drugs. Current HIV/AIDS Reports 2:2, pages 61-67.
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Edmund Capparelli, Natella Rakhmanina & Mark Mirochnick. (2005) Pharmacotherapy of perinatal HIV. Seminars in Fetal and Neonatal Medicine 10:2, pages 161-175.
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Gail D Anderson. (2005) Pregnancy-Induced Changes in Pharmacokinetics. Clinical Pharmacokinetics 44:10, pages 989-1008.
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Gail D. Anderson. (2005) Sex and Racial Differences in Pharmacological Response: Where Is the Evidence? Pharmacogenetics, Pharmacokinetics, and Pharmacodynamics. Journal of Women's Health 14:1, pages 19-29.
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J. F. J. B. Nellen, I. Schillevoort, F. W. N. M. Wit, A. S. Bergshoeff, M. H. Godfried, K. Boer, J. M. A. Lange, D. M. Burger & J. M. Prins. (2004) Nelfinavir Plasma Concentrations Are Low during Pregnancy. Clinical Infectious Diseases 39:5, pages 736-740.
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Hélène Chappuy, Jean-Marc Tréluyer, Elisabeth Rey, Jérôme Dimet, Maria Fouché, RN, Ghislaine Firtion, Gérard Pons & Laurent Mandelbrot. (2004) Maternal-fetal transfer and amniotic fluid accumulation of protease inhibitors in pregnant women who are infected with human immunodeficiency virus. American Journal of Obstetrics and Gynecology 191:2, pages 558-562.
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Edward P. Acosta, Arlene Bardeguez, Carmen D. Zorrilla, Russell Van Dyke, Michael D. Hughes, Sharon Huang, Lisa Pompeo, Alice M. Stek, Jane Pitt, D. Heather Watts, Elizabeth Smith, Eleanor Jiménez & Lynne Mofenson. (2004) Pharmacokinetics of Saquinavir plus Low-Dose Ritonavir in Human Immunodeficiency Virus-Infected Pregnant Women. Antimicrobial Agents and Chemotherapy 48:2, pages 430-436.
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Mark Mirochnick & Edmund Capparelli. (2004) Pharmacokinetics of Antiretrovirals in Pregnant Women. Clinical Pharmacokinetics 43:15, pages 1071-1087.
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Bradley W Kosel, Karen P Beckerman, Sandra Hayashi, Masato Homma & Francesca T Aweeka. (2003) Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant women. AIDS 17:8, pages 1195-1199.
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