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Expert Opinion on Therapeutic Patents Volume 19, 2009 - Issue 1
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Muscarinic antagonist-β-adrenergic agonist dual pharmacology molecules as bronchodilators: a patent review

Nicholas C Ray Argenta Discovery Ltd, 8-9 Spire Green Centre, Flex Meadow, Essex CM19 5TR, Harlow, UK +44 0 1279 645645; +44 0 1279 645646; [email protected]
, PhD &
Lilian Alcaraz AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, Leicestershire, UK
, PhD
Pages 1-12 | Published online: 05 Jan 2009

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Peter Norman. (2013) New dual-acting bronchodilator treatments for COPD, muscarinic antagonists and β2 agonists in combination or combined into a single molecule. Expert Opinion on Investigational Drugs 22:12, pages 1569-1580.
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Peter Norman. (2012) Evaluation of WO-2012085582 and WO-2012085583 two identified MABAs: backups to AZD-2115?. Expert Opinion on Therapeutic Patents 22:11, pages 1377-1383.
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Peter Norman. (2012) Novel dihydroquinoline-based MABAs; clues to the identity of LAS-190792: evaluation of WO20111411802. Expert Opinion on Therapeutic Patents 22:2, pages 185-192.
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Maria Prat, Amadeu Gavaldà, Silvia Fonquerna & Montserrat Miralpeix. (2011) Inhaled muscarinic antagonists for respiratory diseases: a review of patents and current developments (2006 – 2010). Expert Opinion on Therapeutic Patents 21:10, pages 1543-1573.
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Peter J Barnes. (2011) Triple inhalers for obstructive airways disease: will they be useful?. Expert Review of Respiratory Medicine 5:3, pages 297-300.
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Boudewijn Van de Maele, Leonardo M. Fabbri, Carmen Martin, Rachael Horton, Michael Dolker & Tim Overend. (2010) Cardiovascular Safety of QVA149, a Combination of Indacaterol and NVA237, in COPD Patients. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:6, pages 418-427.
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Dramane I Lainé. (2010) Long-acting muscarinic antagonists for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology 3:1, pages 43-53.
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Philippe Taupin. (2009) Fourteen compounds and their derivatives for the treatment of diseases and injuries characterized by reduced neurogenesis and neurodegeneration. Expert Opinion on Therapeutic Patents 19:4, pages 541-547.
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Articles from other publishers (19)

Elisa Pasqua, Nicole Hamblin, Christine Edwards, Charles Baker-Glenn & Chris Hurley. (2022) Developing inhaled drugs for respiratory diseases: A medicinal chemistry perspective. Drug Discovery Today 27:1, pages 134-150.
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Britta Bonn & Matthew Perry. 2021. Inhaled Medicines. Inhaled Medicines 13 34 .
Masato Komiyama, Takahiro Itoh & Takumi Takeyasu. (2014) Scalable Ruthenium-Catalyzed Asymmetric Synthesis of a Key Intermediate for the β2-Adrenergic Receptor Agonist. Organic Process Research & Development 19:1, pages 315-319.
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David J. Lewis, Thomas C. Williams & Steven L. Beck. (2014) Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug development. Journal of Applied Toxicology 34:4, pages 319-331.
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Stephen J. Atkinson, Peter E. Soden, Davina C. Angell, Marcus Bantscheff, Chun-wa Chung, Kathryn A. Giblin, Nicholas Smithers, Rebecca C. Furze, Laurie Gordon, Gerard Drewes, Inmaculada Rioja, Jason Witherington, Nigel J. Parr & Rab K. Prinjha. (2014) The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes. MedChemComm 5:3, pages 342-351.
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Peter J. Barnes. 2014. Indacaterol. Indacaterol 129 146 .
Tao Wang, Michelle L. Lamb, Michael H. Block, Audrey Molina Davies, Yongxin Han, Ethan Hoffmann, Stephanos Ioannidis, John A. Josey, Zhong-Ying Liu, Paul D. Lyne, Terry MacIntyre, Peter J. Mohr, Charles A. Omer, Tove Sjögren, Kenneth Thress, Bin Wang, Haiyun Wang, Dingwei Yu & Hai-Jun Zhang. (2012) Discovery of Disubstituted Imidazo[4,5- b ]pyridines and Purines as Potent TrkA Inhibitors . ACS Medicinal Chemistry Letters 3:9, pages 705-709.
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Marc Decramer, Wim Janssens & Marc Miravitlles. (2012) Chronic obstructive pulmonary disease. The Lancet 379:9823, pages 1341-1351.
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Peter J. Barnes. (2012) Severe asthma: Advances in current management and future therapy. Journal of Allergy and Clinical Immunology 129:1, pages 48-59.
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Gary Phillips & Michael Salmon. 2012. Annual Reports in Medicinal Chemistry Volume 47. Annual Reports in Medicinal Chemistry Volume 47 209 221 .
Richard M. Eglen. 2012. Muscarinic Receptors. Muscarinic Receptors 3 28 .
Rachel OsborneNick ClarkePaul GlossopAmy KenyonHao LiuSheena PatelSusan SummerhillLyn H. Jones. (2011) Efficient Conversion of a Nonselective Norepinephrin Reuptake Inhibitor into a Dual Muscarinic Antagonist−β 2 -Agonist for the Treatment of Chronic Obstructive Pulmonary Disease . Journal of Medicinal Chemistry 54:19, pages 6998-7002.
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Matthew D SelbyPieter D de Koning & Dannielle F Roberts. (2011) A perspective on synthetic and solid-form enablement of inhalation candidates. Future Medicinal Chemistry 3:13, pages 1679-1701.
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Lyn H. Jones, Helen Baldock, Mark E. Bunnage, Jane Burrows, Nick Clarke, Michele Coghlan, David Entwistle, David Fairman, Neil Feeder, Craig Fulton, Laura Hilton, Kim James, Rhys M. Jones, Amy S. Kenyon, Stuart Marshall, Sandra D. Newman, Rachel Osborne, Sheena Patel, Matthew D. Selby, Emilio F. Stuart, Michael A. Trevethick, Karen N. Wright & David A. Price. (2011) Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. Bioorganic & Medicinal Chemistry Letters 21:9, pages 2759-2763.
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Laura Hilton, Rachel Osborne, Amy S. Kenyon, Helen Baldock, Mark E. Bunnage, Jane Burrows, Nick Clarke, Michele Coghlan, David Entwistle, David Fairman, Neil Feeder, Kim James, Rhys M. Jones, Nadia Laouar, Graham Lunn, Stuart Marshall, Sandra D. Newman, Sheena Patel, Matthew D. Selby, Fiona Spence, Emilio F. Stuart, Susan Summerhill, Michael A. Trevethick, Karen N. Wright, Michael Yeadon, David A. Price & Lyn H. Jones. (2011) Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm 2:9, pages 870.
Crossref
Peter J. Barnes. 2011. Principles of Immunopharmacology. Principles of Immunopharmacology 321 357 .
Klaus J. Erb, Domnic H. Martyres & Peter Seither. 2003. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
. (2010) Current World Literature. Current Opinion in Pulmonary Medicine 16:1, pages 77-82.
Crossref
Peter J Barnes. (2009) Novel mechanisms and new therapies for chronic obstructive pulmonary disease. Therapy 6:6, pages 795-804.
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