Citations (78)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Vidhi Bhatt & Anand Krishna Tiwari. (2022)
Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases. International Journal of Neuroscience 0:0, pages 1-26.
Read now
Read now
Fabricio F Costa. (2010) Epigenomics in cancer management. Cancer Management and Research 2, pages 255-265.
Read now
Read now
Articles from other publishers (76)
Anna Fedorczak, Andrzej Lewiński & Renata Stawerska. (2023) Involvement of Sirtuin 1 in the Growth Hormone/Insulin-like Growth Factor 1 Signal Transduction and Its Impact on Growth Processes in Children. International Journal of Molecular Sciences 24:20, pages 15406.
Crossref
Crossref
Klaudia Jomova, Renata Raptova, Suliman Y. Alomar, Saleh H. Alwasel, Eugenie Nepovimova, Kamil Kuca & Marian Valko. (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Archives of Toxicology 97:10, pages 2499-2574.
Crossref
Crossref
Dan Zhang, Jifa Zhang, Yuxi Wang, Guan Wang, Pan Tang, Yun Liu, Yiwen Zhang & Liang Ouyang. (2023) Targeting epigenetic modifications in Parkinson's disease therapy. Medicinal Research Reviews 43:5, pages 1748-1777.
Crossref
Crossref
Youheng Wang, Rusheng Zhao, Chengyan Wu, Xuefei Liang, Lei He, Libo Wang & Xuehui Wang. (2023) Activation of the sirtuin silent information regulator 1 pathway inhibits pathological myocardial remodeling. Frontiers in Pharmacology 14.
Crossref
Crossref
Zhang Fan & Li Bin. (2022) Will Sirtuin 2 Be a Promising Target for Neuroinflammatory Disorders?. Frontiers in Cellular Neuroscience 16.
Crossref
Crossref
Arzu Keskin-Aktan, Kazime Gonca Akbulut, Samira Abdi & Hakan Akbulut. (2021) SIRT2 and FOXO3a expressions in the cerebral cortex and hippocampus of young and aged male rats: antioxidant and anti-apoptotic effects of melatonin. Biologia Futura 73:1, pages 71-85.
Crossref
Crossref
Zahra Hajializadeh & Mohammad Khaksari. (2021) The protective effects of 17-β estradiol and SIRT1 against cardiac hypertrophy: a review. Heart Failure Reviews 27:2, pages 725-738.
Crossref
Crossref
Tae Hoon Kim, Steven L Young, Tsutomu Sasaki, Jeffrey L Deaton, David P Schammel, Wilder Alberto Palomino, Jae-Wook Jeong & Bruce A Lessey. (2022) Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium. The Journal of Clinical Endocrinology & Metabolism 107:3, pages 788-800.
Crossref
Crossref
Xiuqi Chen, Wenmei Lu & Danhong Wu. (2021) Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders. Frontiers in Neuroscience 15.
Crossref
Crossref
Semih Yagci, Mahmut Gozelle, Selen Gozde Kaya, Yesim Ozkan, Ahmet Bugra Aksel, Filiz Bakar-Ates, Yasemin Dundar & Gokcen Eren. (2021) Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT. Bioorganic & Medicinal Chemistry 30, pages 115961.
Crossref
Crossref
Fang Wang & Hou-Zao Chen. (2020) Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases. Frontiers in Pharmacology 11.
Crossref
Crossref
Lincy Edatt, Aswini Poyyakkara, Grace R. Raji, Vishnu Ramachandran, S. Sharath Shankar & V. B. Sameer Kumar. (2020) Role of Sirtuins in Tumor Angiogenesis. Frontiers in Oncology 9.
Crossref
Crossref
Bo Bin Lee, Yujin Kim, Dongho Kim, Eun Yoon Cho, Joungho Han, Hong Kwan Kim, Young Mog Shim & Duk‐Hwan Kim. (2019) Metformin and tenovin‐6 synergistically induces apoptosis through LKB1‐independent SIRT1 down‐regulation in non‐small cell lung cancer cells. Journal of Cellular and Molecular Medicine 23:4, pages 2872-2889.
Crossref
Crossref
Shang Yao, Zimam Mahmud, Nikoleta Sachini, Sathid Aimjongjun, Paula Saavedra-García & Eric W-F Lam. 2019. FOXO Transcription Factors. FOXO Transcription Factors
77
90
.
Yumeng Guo & Yu Wang. 2018. Endothelial Dysfunction - Old Concepts and New Challenges. Endothelial Dysfunction - Old Concepts and New Challenges.
Tongxin Wang, Weilei Yao, Ji Li, Qiongyu He, Yafei Shao & Feiruo Huang. (2018) Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysis. American Journal of Physiology-Endocrinology and Metabolism 315:4, pages E496-E510.
Crossref
Crossref
Jalal Choupani, Sima Mansoori Derakhshan, Sahar Bayat, Mohammad Reza Alivand & Mahmoud Shekari Khaniani. (2018) Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial-mesenchymal transition in cancer cells. Journal of Cellular Physiology 233:6, pages 4443-4457.
Crossref
Crossref
Sakineh Dadashpour & Saeed Emami. (2018) Indole in the target-based design of anticancer agents: A versatile scaffold with diverse mechanisms. European Journal of Medicinal Chemistry 150, pages 9-29.
Crossref
Crossref
Gebremedhin S. Hailu, Dina Robaa, Mariantonietta Forgione, Wolfgang Sippl, Dante Rotili & Antonello Mai. (2017) Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. Journal of Medicinal Chemistry 60:12, pages 4780-4804.
Crossref
Crossref
Luca Giovannini & Sara Bianchi. (2017) Role of nutraceutical SIRT1 modulators in AMPK and mTOR pathway: Evidence of a synergistic effect. Nutrition 34, pages 82-96.
Crossref
Crossref
Zhenyue He, Jun Yi, Li Jin, Banzhou Pan, Longbang Chen & Haizhu Song. (2015) Overexpression of Sirtuin-1 is associated with poor clinical outcome in esophageal squamous cell carcinoma. Tumor Biology 37:6, pages 7139-7148.
Crossref
Crossref
Mateusz Wątroba & Dariusz Szukiewicz. (2016) The role of sirtuins in aging and age-related diseases. Advances in Medical Sciences 61:1, pages 52-62.
Crossref
Crossref
Li Qiang, Ning Kon, Wenhui Zhao, Le Jiang, Colette M. Knight, Carrie Welch, Utpal Pajvani, Wei Gu & Domenico Accili. (2015) Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. Cell Reports 11:11, pages 1797-1808.
Crossref
Crossref
Jakeer Pasha, Bhaskar Kandagatla, Saikat Sen, Guru Pavan Kumar Seerapu, Sushmitha Bujji, Devyani Haldar, Srinivas Nanduri & Srinivas Oruganti. (2015) Amberlyst-15 catalyzed Povarov reaction of N-arylidene-1H-indazol-6-amines and indoles: a greener approach to the synthesis of exo-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinolines as potential sirtuin inhibitors. Tetrahedron Letters 56:18, pages 2289-2292.
Crossref
Crossref
Alvaro Martin, Cosmin A. Tegla, Cornelia D. Cudrici, Adam M. Kruszewski, Philippe Azimzadeh, Dallas Boodhoo, Armugam P. Mekala, Violeta Rus & Horea Rus. (2014) Role of SIRT1 in autoimmune demyelination and neurodegeneration. Immunologic Research 61:3, pages 187-197.
Crossref
Crossref
Lina Ma & Yun Li. (2015) SIRT1: Role in cardiovascular biology. Clinica Chimica Acta 440, pages 8-15.
Crossref
Crossref
Alexander Lo, Melissa Serravallo & Jared Jagdeo. 2015. Epigenetics and Dermatology. Epigenetics and Dermatology
137
175
.
Christina A. Vivelo & Anthony K. L. Leung. (2014) Proteomics approaches to identify mono‐(ADP‐ribosyl)ated and poly(ADP‐ribosyl)ated proteins. PROTEOMICS 15:2-3, pages 203-217.
Crossref
Crossref
Tomohiro Kozako, Takayoshi Suzuki, Makoto Yoshimitsu, Naomichi Arima, Shin-ichiro Honda & Shinji Soeda. (2014) Anticancer Agents Targeted to Sirtuins. Molecules 19:12, pages 20295-20313.
Crossref
Crossref
Qi Zhang, Xiang Zhou, RuiZhi Wu, Amber Mosley, Shelya X Zeng, Zhen Xing & Hua Lu. (2014) The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress. eLife 3.
Crossref
Crossref
Kedar Prasad. 2014. Neurodegenerative Disease and Micronutrients. Neurodegenerative Disease and Micronutrients
91
132
.
Ling Li, Tereza Osdal, Yinwei Ho, Sookhee Chun, Tinisha McDonald, Puneet Agarwal, Allen Lin, Su Chu, Jing Qi, Liang Li, Yao-Te Hsieh, Cedric Dos Santos, Hongfeng Yuan, Trung-Quang Ha, Mihaela Popa, Randi Hovland, Øystein Bruserud, Bjørn Tore Gjertsen, Ya-Huei Kuo, Wenyong Chen, Sonia Lain, Emmet McCormack & Ravi Bhatia. (2014) SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells. Cell Stem Cell 15:4, pages 431-446.
Crossref
Crossref
William OldsJonathan Wisor. 2014. Sleep, Circadian Rhythms, and Metabolism. Sleep, Circadian Rhythms, and Metabolism
217
236
.
Sachiko Hirai, Shinji Endo, Rie Saito, Mitsuaki Hirose, Takunori Ueno, Hideo Suzuki, Kenji Yamato, Masato Abei & Ichinosuke Hyodo. (2014) Antitumor Effects of a Sirtuin Inhibitor, Tenovin-6, against Gastric Cancer Cells via Death Receptor 5 Up-Regulation. PLoS ONE 9:7, pages e102831.
Crossref
Crossref
Antje Weseler & Aalt Bast. 2014. Hormesis in Health and Disease. Hormesis in Health and Disease
43
76
.
Takunori Ueno, Shinji Endo, Rie Saito, Mitsuaki Hirose, Sachiko Hirai, Hideo Suzuki, Kenji Yamato & Ichinosuke Hyodo. (2014) The Sirtuin Inhibitor Tenovin-6 Upregulates Death Receptor 5 and Enhances Cytotoxic Effects of 5-Fluorouracil and Oxaliplatin in Colon Cancer Cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 21:3, pages 155-164.
Crossref
Crossref
Bin He, Jing Hu, Xiaoyu Zhang & Hening Lin. (2014) Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org. Biomol. Chem. 12:38, pages 7498-7502.
Crossref
Crossref
Eric W.-F. Lam, Kyle W. Muir & Chuay-Yeng Koo. 2015. Molecular Oncology. Molecular Oncology
328
335
.
Subhajit Dasgupta & Mausumi Bandyopadhyay. (2013) Neuroprotective mode of action of resveratrol in central nervous system. PharmaNutrition 1:3, pages 90-97.
Crossref
Crossref
You Hee Choi, Hangun Kim, Sung Ho Lee, Yun-Hye Jin & Kwang Youl Lee. (2013) ERK1/2 regulates SIRT2 deacetylase activity. Biochemical and Biophysical Research Communications 437:2, pages 245-249.
Crossref
Crossref
Melissa Serravallo, Jared Jagdeo, Sharon A. Glick, Daniel M. Siegel & Neil I. Brody. (2013) Sirtuins in dermatology: applications for future research and therapeutics. Archives of Dermatological Research 305:4, pages 269-282.
Crossref
Crossref
Javier R. Revollo & Xiaoling Li. (2013) The ways and means that fine tune Sirt1 activity. Trends in Biochemical Sciences 38:3, pages 160-167.
Crossref
Crossref
Iva B Zovkic & J David Sweatt. (2012) Epigenetic Mechanisms in Learned Fear: Implications for PTSD. Neuropsychopharmacology 38:1, pages 77-93.
Crossref
Crossref
Jun Xie, Xiaoming Zhang & Li Zhang. (2013) Negative regulation of inflammation by SIRT1. Pharmacological Research 67:1, pages 60-67.
Crossref
Crossref
Yu Wang, Cheng Xu, Yan Liang & Paul M. Vanhoutte. (2012) SIRT1 in metabolic syndrome: Where to target matters. Pharmacology & Therapeutics 136:3, pages 305-318.
Crossref
Crossref
Angela Nebbioso, Vincenzo Carafa, Rosaria Benedetti & Lucia Altucci. (2012) Trials with ‘epigenetic’ drugs: An update. Molecular Oncology 6:6, pages 657-682.
Crossref
Crossref
Lisa Pirrie, Anna R. McCarthy, Louise L. Major, Vaida Morkūnaitė, Asta Zubrienė, Daumantas Matulis, Sonia Lain, Tomas Lebl & Nicholas J. Westwood. (2012) Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a 1H-NMR Method to Assess Deacetylase Activity. Molecules 17:10, pages 12206-12224.
Crossref
Crossref
Ubaldina Galli, Ornella Mesenzani, Camilla Coppo, Giovanni Sorba, Pier Luigi Canonico, Gian Cesare Tron & Armando A. Genazzani. (2012) Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. European Journal of Medicinal Chemistry 55, pages 58-66.
Crossref
Crossref
José M. Villalba & Francisco J. Alcaín. (2012) Sirtuin activators and inhibitors. BioFactors 38:5, pages 349-359.
Crossref
Crossref
Daniel M. Fass, Melissa M. Kemp, Frederick A. Schroeder, Florence F. Wagner, Qiu Wang & Edward B. Holson. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Qi Zhang, Shelya X. Zeng, Yu Zhang, Yiwei Zhang, Derong Ding, Qizhuang Ye, Samy O. Meroueh & Hua Lu. (2012) A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Molecular Medicine 4:4, pages 298-312.
Crossref
Crossref
Blair C. R. Dancy, Shonoi A. Ming, Romeo Papazyan, Christine A. Jelinek, Ananya Majumdar, Yan Sun, Beverley M. Dancy, William J. DruryIIIIII, Robert J. Cotter, Sean D. Taverna & Philip A. Cole. (2012) Azalysine Analogues as Probes for Protein Lysine Deacetylation and Demethylation. Journal of the American Chemical Society 134:11, pages 5138-5148.
Crossref
Crossref
Kristofer S. Fritz, James J. Galligan, Matthew D. Hirschey, Eric Verdin & Dennis R. Petersen. (2012) Mitochondrial Acetylome Analysis in a Mouse Model of Alcohol-Induced Liver Injury Utilizing SIRT3 Knockout Mice. Journal of Proteome Research 11:3, pages 1633-1643.
Crossref
Crossref
Florian Thaler. (2012) Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications. Pharmaceutical Patent Analyst 1:1, pages 75-90.
Crossref
Crossref
Anna R. McCarthy, Lisa Pirrie, Jonathan J. Hollick, Sebastien Ronseaux, Johanna Campbell, Maureen Higgins, Oliver D. Staples, Fanny Tran, Alexandra M.Z. Slawin, Sonia Lain & Nicholas J. Westwood. (2012) Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins. Bioorganic & Medicinal Chemistry 20:5, pages 1779-1793.
Crossref
Crossref
Katherine T Andrews, Ashraful Haque & Malcolm K Jones. (2011) HDAC inhibitors in parasitic diseases. Immunology & Cell Biology 90:1, pages 66-77.
Crossref
Crossref
Carine Robert & Feyruz V. Rassool. 2012. Histone Deacetylase Inhibitors as Cancer Therapeutics. Histone Deacetylase Inhibitors as Cancer Therapeutics
87
129
.
Jonathan P. Wisor. (2011) A metabolic–transcriptional network links sleep and cellular energetics in the brain. Pflügers Archiv - European Journal of Physiology 463:1, pages 15-22.
Crossref
Crossref
Chi-Hsien Peng, Jong-Yuh Cherng, Guang-Yuh Chiou, Yu-Chih Chen, Chen-Hsiu Chien, Chung-Lan Kao, Yuh-Lih Chang, Yueh Chien, Liang-Kung Chen, Jorn-hon Liu, Shih-Jen Chen & Shih-Hwa Chiou. (2011) Delivery of Oct4 and SirT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium. Biomaterials 32:34, pages 9077-9088.
Crossref
Crossref
Jan Škrha. 2011. Oxidative Stress in Vertebrates and Invertebrates. Oxidative Stress in Vertebrates and Invertebrates
83
102
.
Tero Huhtiniemi, Heikki S. Salo, Tiina Suuronen, Antti Poso, Antero Salminen, Jukka Leppänen, Elina Jarho & Maija Lahtela-Kakkonen. (2011) Structure-Based Design of Pseudopeptidic Inhibitors for SIRT1 and SIRT2. Journal of Medicinal Chemistry 54:19, pages 6456-6468.
Crossref
Crossref
Kilian Huber & Giulio Superti-Furga. (2011) After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorganic & Medicinal Chemistry 19:12, pages 3616-3624.
Crossref
Crossref
Kristofer S. Fritz, James J. Galligan, Rebecca L. Smathers, James R. Roede, Colin T. Shearn, Philip Reigan & Dennis R. Petersen. (2011) 4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification. Chemical Research in Toxicology 24:5, pages 651-662.
Crossref
Crossref
Stephen S. MyattJan J. BrosensEric W.-F. Lam. (2011) Sense and Sensitivity: FOXO and ROS in Cancer Development and Treatment. Antioxidants & Redox Signaling 14:4, pages 675-687.
Crossref
Crossref
Charles A. Blum, James L. Ellis, Christine Loh, Pui Yee Ng, Robert B. Perni & Ross L. Stein. (2010) SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging. Journal of Medicinal Chemistry 54:2, pages 417-432.
Crossref
Crossref
Federico Medda, Thomas L. Joseph, Lisa Pirrie, Maureen Higgins, Alexandra M. Z. Slawin, Sonia Lain, Chandra Verma & Nicholas J. Westwood. (2011) N1-Benzyl substituted cambinol analogues as isozyme selective inhibitors of the sirtuin family of protein deacetylases. MedChemComm 2:7, pages 611.
Crossref
Crossref
Brett M. Hirsch & Weiping Zheng. (2011) Sirtuin mechanism and inhibition: explored with Nε-acetyl-lysine analogs. Mol. BioSyst. 7:1, pages 16-28.
Crossref
Crossref
Nicholas A. McGrath, Joshua R. Binner, Georgios Markopoulos, Matthew Brichacek & Jon T. Njardarson. (2011) An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products. Chem. Commun. 47:1, pages 209-211.
Crossref
Crossref
Won Keun Oh, Kyoung Bin Cho, Tran Thi Hien, Tae Hyung Kim, Hyung Sik Kim, Trong Tuan Dao, Hyo-Kyung Han, Seong-Min Kwon, Sang-Gun Ahn, Jung-Hoon Yoon, Tae Hyun Kim, Yoon Gyoon Kim & Keon Wook Kang. (2010) Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1. Molecular Pharmacology 78:5, pages 855-864.
Crossref
Crossref
Kedar Prasad. 2010. Micronutrients in Health and Disease. Micronutrients in Health and Disease
197
220
.
Yechun Wang, Hui Chen & Oliver Yu. (2010) Metabolic engineering of resveratrol and other longevity boosting compounds. BioFactors 36:5, pages 394-400.
Crossref
Crossref
Tero Huhtiniemi, Tiina Suuronen, Maija Lahtela-Kakkonen, Tanja Bruijn, Sanna Jääskeläinen, Antti Poso, Antero Salminen, Jukka Leppänen & Elina Jarho. (2010) Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2. Bioorganic & Medicinal Chemistry 18:15, pages 5616-5625.
Crossref
Crossref
Jingjie Yi & Jianyuan Luo. (2010) SIRT1 and p53, effect on cancer, senescence and beyond. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:8, pages 1684-1689.
Crossref
Crossref
Euan W. Baxter & Jo Milner. (2009) p53 regulates LIF expression in human medulloblastoma cells. Journal of Neuro-Oncology 97:3, pages 373-382.
Crossref
Crossref
Barrie Peck, Chun-Yuan Chen, Ka-Kei Ho, Paolo Di Fruscia, Stephen S. Myatt, R. Charles Coombes, Matthew J. Fuchter, Chwan-Deng Hsiao & Eric W.-F. Lam. (2010) SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2. Molecular Cancer Therapeutics 9:4, pages 844-855.
Crossref
Crossref
Brett M. Hirsch, Caroline A. Gallo, Zhanwen Du, Zhenghe Wang & Weiping Zheng. (2010) Discovery of potent, proteolytically stable, and cell permeable human sirtuin peptidomimetic inhibitors containing Nε-thioacetyl-lysine. MedChemComm 1:3, pages 233.
Crossref
Crossref