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Expert Opinion on Therapeutic Patents Volume 19, 2009 - Issue 11
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Aptamers: from bench side research towards patented molecules with therapeutic applications

Paromita Majumder Professor, Universidade de São Paulo, Instituto de Quimica, Departamento de Bioquímica, São Paulo, SP, CEP 05508-900, Brazil +55 11 3091 3810 ext 223; +55 11 3815 5579; [email protected]; Venetian Institute of Molecular Medicine, Foundation for Advanced Biomedical Research, Via G. Orus 2, 35129 Padova, Italy
, PhD,
Katia N Gomes Professor, Universidade de São Paulo, Instituto de Quimica, Departamento de Bioquímica, São Paulo, SP, CEP 05508-900, Brazil +55 11 3091 3810 ext 223; +55 11 3815 5579; [email protected]
, MSc &
Henning Ulrich Professor, Universidade de São Paulo, Instituto de Quimica, Departamento de Bioquímica, São Paulo, SP, CEP 05508-900, Brazil +55 11 3091 3810 ext 223; +55 11 3815 5579; [email protected]
, PhD
Pages 1603-1613 | Published online: 26 Oct 2009

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Sepideh Zununi Vahed, Nazanin Fathi, Mohammad Samiei, Solmaz Maleki Dizaj & Simin Sharifi. (2019) Targeted cancer drug delivery with aptamer-functionalized polymeric nanoparticles. Journal of Drug Targeting 27:3, pages 292-299.
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Roberto Gambari. (2014) Peptide nucleic acids: a review on recent patents and technology transfer. Expert Opinion on Therapeutic Patents 24:3, pages 267-294.
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Jagat R. Kanwar, Kislay Roy & Rupinder K. Kanwar. (2011) Chimeric aptamers in cancer cell-targeted drug delivery. Critical Reviews in Biochemistry and Molecular Biology 46:6, pages 459-477.
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Articles from other publishers (20)

Dali Wang, Yang Li, Xiaoran Deng, Matthew Torre, Zipei Zhang, Xiyu Li, Wei Zhang, Kathleen Cullion, Daniel S. Kohane & Christopher B. Weldon. (2023) An aptamer-based depot system for sustained release of small molecule therapeutics. Nature Communications 14:1.
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Shuwen Qian, Dingran Chang, Sisi He & Yingfu Li. (2022) Aptamers from random sequence space: Accomplishments, gaps and future considerations. Analytica Chimica Acta 1196, pages 339511.
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Arghya Sett. 2021. Theranostics - An Old Concept in New Clothing [Working Title]. Theranostics - An Old Concept in New Clothing [Working Title].
Youli Zu. (2020) Aptamer technology: a new approach to treat lymphoma?. Blood Science 2:1, pages 11-15.
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Sohameh Mohebbi, Nahid Bakhtiari, Fahimeh Charbgoo & Zeinab Shirvani-Farsani. (2019) RNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers. MEDICAL SCIENCES JOURNAL 29:4, pages 275-283.
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Qiang Zhang, Hongbin Qiu, Fangqiang Tang, Ye Tao, Baosheng Guan, Xuechen Li & Wei Yang. (2016) Aptamer-based Dry-reagent Strip Biosensor for Detection of Small Molecule ATP. Chemistry Letters 45:3, pages 289-290.
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Graziella El Khoury, Basmah Khogeer, Chen Chen, Kheng T Ng, Shaleem I Jacob & Christopher R Lowe. (2015) Bespoke affinity ligands for the purification of therapeutic proteins. Pharmaceutical Bioprocessing 3:2, pages 139-152.
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Christopher Oelkrug, Ulrich Sack, Andreas Boldt, Isis C. Nascimento, Henning Ulrich & Stephan Fricke. (2015) Antibody- and aptamer-strategies for GvHD prevention. Journal of Cellular and Molecular Medicine 19:1, pages 11-20.
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S Detchokul, E D Williams, M W Parker & A G Frauman. (2014) Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies. British Journal of Pharmacology 171:24, pages 5462-5490.
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Yu Gao, Jingjing Xie, Haijun Chen, Songen Gu, Rongli Zhao, Jingwei Shao & Lee Jia. (2014) Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology Advances 32:4, pages 761-777.
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XIAOYU PEI, JUN ZHANG & JIE LIU. (2014) Clinical applications of nucleic acid aptamers in cancer. Molecular and Clinical Oncology 2:3, pages 341-348.
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Tracy L. Nero, Craig J. Morton, Jessica K. Holien, Jerome Wielens & Michael W. Parker. (2014) Oncogenic protein interfaces: small molecules, big challenges. Nature Reviews Cancer 14:4, pages 248-262.
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Tina Šmuc, Il-Young Ahn & Henning Ulrich. (2013) Nucleic acid aptamers as high affinity ligands in biotechnology and biosensorics. Journal of Pharmaceutical and Biomedical Analysis 81-82, pages 210-217.
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Michiko Kimoto, Rie Yamashige, Ken-ichiro Matsunaga, Shigeyuki Yokoyama & Ichiro Hirao. (2013) Generation of high-affinity DNA aptamers using an expanded genetic alphabet. Nature Biotechnology 31:5, pages 453-457.
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Ka-To Shum & John J. Rossi. 2013. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 395 423 .
Ka-To Shum & John J. Rossi. 2013. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases. DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases 395 423 .
Na Sun, Susanne Aileen Funke & Dieter Willbold. (2012) Mirror image phage display – Generating stable therapeutically and diagnostically active peptides with biotechnological means. Journal of Biotechnology 161:2, pages 121-125.
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Fred Reynolds & Kimberly A. Kelly. (2011) Techniques for Molecular Imaging Probe Design. Molecular Imaging 10:6, pages 7290.2011.00003.
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Yamei Liu, Victor G Stepanov, Ulrich Strych, Richard C Willson, George W Jackson & George E Fox. (2010) DNAzyme-mediated recovery of small recombinant RNAs from a 5S rRNA-derived chimera expressed in Escherichia coli. BMC Biotechnology 10:1.
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Bieke Van Dorst, Jaytry Mehta, Karen Bekaert, Elsa Rouah-Martin, Wim De Coen, Peter Dubruel, Ronny Blust & Johan Robbens. (2010) Recent advances in recognition elements of food and environmental biosensors: A review. Biosensors and Bioelectronics 26:4, pages 1178-1194.
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