Citations (69)
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Laith Q Al-Mawsawi, Rasha I Al-Safi & Nouri Neamati. (2008) Anti-infectives Clinical progress of HIV-1 integrase inhibitors. Expert Opinion on Emerging Drugs 13:2, pages 213-225.
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Christine Fossey, Anh-Hoang Vu, Anamaria Vidu, Irina Zarafu, Daniel Laduree, Sylvie Schmidt, Geraldine Laumond & Anne-Marie Aubertin. (2007) Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker. Journal of Enzyme Inhibition and Medicinal Chemistry 22:5, pages 591-607.
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Andrea Savarino. (2006) A historical sketch of the discovery and development of HIV-1 integrase inhibitors. Expert Opinion on Investigational Drugs 15:12, pages 1507-1522.
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Jim A Turpin. (2003) The next generation of HIV/AIDS drugs: novel and developmental antiHIV drugs and targets. Expert Review of Anti-infective Therapy 1:1, pages 97-128.
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Nouri Neamati. (2003) Dipyrimidine-based inhibitors of HIV-1 integrase. Expert Opinion on Investigational Drugs 12:2, pages 289-292.
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Articles from other publishers (64)
Takushi Kanazu, Junto Tamada, Susumu Kume & Tohru Mizutare. (2023) Cross-species drug metabolism and impact of metabolic stability testing under anaerobic condition on predicting pharmacokinetics of keto-enol containing compound in humans. Drug Metabolism and Pharmacokinetics, pages 100538.
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Moktar Aburzeza & Khaled AlFalous. (2020) Utilization derivatives of 4 - [4-(acetylamino)phenyl]-2 - (3,5 dimethyl - 1 H-pyrzol -1-yl)-3-hydroxy-4-oxobutanoic acid in Heterocyclic Synthesis and Study of Their Biological Activities. مجلة الجامعة الأسمرية: العلوم التطبيقية 5:2, pages 23-34.
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Mahdieh Safakish, Zahra Hajimahdi, Mohammad R. Aghasadeghi, Rouhollah Vahabpour & Afshin Zarghi. (2020) Design, Synthesis, Molecular Modeling and Anti-HIV Assay of Novel Quinazolinone Incorporated Coumarin Derivatives. Current HIV Research 18:1, pages 41-51.
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Salvatore Bongarzone, Marta Nadal, Zuzanna Kaczmarska, Cristina Machón, Mercedes Álvarez, Fernando Albericio & Miquel Coll. (2018) Structure-Driven Discovery of α,γ-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase. ACS Omega 3:8, pages 8497-8505.
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Maher A. El-Hashash & Sameh A. Rizk. (2016) Regioselective Diastereomeric Michael Adducts as Building Blocks in Heterocyclic Synthesis. Journal of Heterocyclic Chemistry 53:4, pages 1236-1240.
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Dominga Rogolino, Mauro Carcelli, Mario Sechi & Nouri Neamati. (2012) Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design. Coordination Chemistry Reviews 256:23-24, pages 3063-3086.
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Kaiqing Ma, Penghui Wang, Wei Fu, Xiaolong Wan, Lu Zhou, Yong Chu & Deyong Ye. (2011) Rational design of 2-pyrrolinones as inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters 21:22, pages 6724-6727.
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Sheo B. Singh. 2011. HIV‐1 Integrase. HIV‐1 Integrase
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Mario Sechi, Mauro Carcelli, Dominga Rogolino & Nouri Neamati. 2011. HIV‐1 Integrase. HIV‐1 Integrase
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Mark G Lewis, Sandro Norelli, Matt Collins, Maria Letizia Barreca, Nunzio Iraci, Barbara Chirullo, Jake Yalley-Ogunro, Jack Greenhouse, Fausto Titti, Enrico Garaci & Andrea Savarino. (2010) Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology 7:1.
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Julianne A. Hunt. 2010. Modern Drug Synthesis. Modern Drug Synthesis
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Chenzhong Liao, Christophe Marchand, Terrence R Burke Jr, Yves Pommier & Marc C Nicklaus. (2010) Authentic HIV-1 integrase inhibitors. Future Medicinal Chemistry 2:7, pages 1107-1122.
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Veerasamy Ravichandran, Sivadasan Shalini, Karupiah Sundram & Arumugam Dhanaraj Sokkalingam. (2010) QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors. European Journal of Medicinal Chemistry 45:7, pages 2791-2797.
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Zi-Guo Jiao, Hong-Qiu He, Cheng-Chu Zeng, Jian-Jun Tan, Li-Ming Hu & Cun-Xin Wang. (2010) Design, Synthesis and Anti-HIV Integrase Evaluation of N-(5-Chloro-8-Hydroxy-2-Styrylquinolin-7-yl)Benzenesulfonamide Derivatives. Molecules 15:3, pages 1903-1917.
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Mario Sechi, Mauro Carcelli, Dominga Rogolino & Nouri Neamati. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors
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Jia ZENG, Xiuhua LÜ, Chengchu ZENG, Liming HU & Rugang ZHONG. (2009) Design, Synthesis and Anti‐HIV Integrase Evaluation of 1,2,3‐ Triazol‐4‐yl‐substituted 1,4‐Dihydro‐4‐oxo‐1,5‐napthyridine‐ 3‐carboxylic Acids. Chinese Journal of Chemistry 27:5, pages 953-962.
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Mario Sechi, Fabrizio Carta, Luciano Sannia, Roberto Dallocchio, Alessandro Dessì, Rasha I. Al-Safi & Nouri Neamati. (2009) Design, synthesis, molecular modeling, and anti-HIV-1 integrase activity of a series of photoactivatable diketo acid-containing inhibitors as affinity probes. Antiviral Research 81:3, pages 267-276.
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Mario Sechi, Ugo Azzena, Maria Paola Delussu, Roberto Dallocchio, Alessandro Dessì, Alessia Cosseddu, Nicolino Pala & Nouri Neamati. (2008) Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors. Molecules 13:10, pages 2442-2461.
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Kavya Ramkumar, Konstantin V. Tambov, Rambabu Gundla, Alexandr V. Manaev, Vladimir Yarovenko, Valery F. Traven & Nouri Neamati. (2008) Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase Inhibitors. Bioorganic & Medicinal Chemistry 16:19, pages 8988-8998.
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Ira B. Dicker, Brian Terry, Zeyu Lin, Zhufang Li, Sagarika Bollini, Himadri K. Samanta, Volodymyr Gali, Michael A. Walker & Mark R. Krystal. (2008) Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors. Journal of Biological Chemistry 283:35, pages 23599-23609.
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Antonio Garofalo, Fedora Grande, Antonella Brizzi, Francesca Aiello, Raveendra Dayam & Nouri Neamati. (2008) Naphthoxazepine Inhibitors of HIV-1 Integrase: Synthesis and Biological Evaluation. ChemMedChem 3:6, pages 986-990.
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Raveendra Dayam, Laith Q. Al-Mawsawi, Zahrah Zawahir, Myriam Witvrouw, Zeger Debyser & Nouri Neamati. (2008) Quinolone 3-Carboxylic Acid Pharmacophore: Design of Second Generation HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry 51:5, pages 1136-1144.
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Raveendra Dayam, Rambabu Gundla, Laith Q. Al‐Mawsawi & Nouri Neamati. (2007) HIV‐1 integrase inhibitors: 2005–2006 update. Medicinal Research Reviews 28:1, pages 118-154.
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Raveendra Dayam, Laith Q. Al-Mawsawi & Nouri Neamati. (2007) Substituted 2-pyrrolinone inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters 17:22, pages 6155-6159.
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Ira B. Dicker, Himadri K. Samanta, Zhufang Li, Yang Hong, Yuan Tian, Jacques Banville, Roger R. Remillard, Michael A. Walker, David R. Langley & Mark Krystal. (2007) Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors. Journal of Biological Chemistry 282:43, pages 31186-31196.
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Vinod Uchil, Byung Seo & Vasu Nair. (2007) A Novel Strategy to Assemble the β-Diketo Acid Pharmacophore of HIV Integrase Inhibitors on Purine Nucleobase Scaffolds. The Journal of Organic Chemistry 72:22, pages 8577-8579.
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Laith Q. Al-Mawsawi & Nouri Neamati. (2007) Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy. Trends in Pharmacological Sciences 28:10, pages 526-535.
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Sonal Dubey, Y.D. Satyanarayana & Harshita Lavania. (2007) Development of integrase inhibitors for treatment of AIDS: An overview. European Journal of Medicinal Chemistry 42:9, pages 1159-1168.
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Kamlesh Kumar Sahu, Veerasamy Ravichandran, Vishnu Kant Mourya & Ram Kishore Agrawal. (2007) QSAR analysis of caffeoyl naphthalene sulfonamide derivatives as HIV-1 integrase inhibitors. Medicinal Chemistry Research 15:7-8, pages 418-430.
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Cheng‐Chu Zeng, Xue‐Mei Li, Hong Yan & Ru‐Gang Zhong. (2007)
Design and Synthesis of
p
/
m
‐[
p
‐(un)Substituted Phenylsulfonamido]phenyl
β
‐Diketo Acids and Quinoxalone Derivatives
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Laith Q. Al-Mawsawi, Mario Sechi & Nouri Neamati. (2007) Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity. FEBS Letters 581:6, pages 1151-1156.
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Raveendra Dayam, Laith Q Al-Mawsawi & Nouri Neamati. (2007) HIV-1 Integrase Inhibitors. Drugs in R & D 8:3, pages 155-168.
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Chih-Chia Chiang, Jean-François Mouscadet, Hou-Jen Tsai, Chi-Tsan Liu & Ling-Yih Hsu. (2007) Synthesis and HIV-1 Integrase Inhibition of Novel Bis- or Tetra-Coumarin Analogues. Chemical and Pharmaceutical Bulletin 55:12, pages 1740-1743.
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Yi-Sheng Xu, Cheng-Chu Zeng, Xue-Mei Li, Ru-Gang Zhong & Yi Zeng. (2006) Design, Synthesis and Cu2+ Recognition ofβ-Diketoacid and Quinoxalone Derivatives Bearing Caffeoyl or Galloyl Moieties Linked by Arylamide as Potential HIV Integrase Inhibitors. Chinese Journal of Chemistry 24:8, pages 1086-1094.
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Mario SechiAlessia BacchiMauro CarcelliCarlotta CompariElenia DuceEmilia FisicaroDominga RogolinoPaul GatesMarco DerudasLaith Q. Al-MawsawiNouri Neamati. (2006) From Ligand to Complexes: Inhibition of Human Immunodeficiency Virus Type 1 Integrase by β-Diketo Acid Metal Complexes. Journal of Medicinal Chemistry 49:14, pages 4248-4260.
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Jinxia Deng, James A. Kelley, Joseph J. Barchi, Tino Sanchez, Raveendra Dayam, Yves Pommier & Nouri Neamati. (2006) Mining the NCI antiviral compounds for HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry 14:11, pages 3785-3792.
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Cédric Maurin, Fabrice Bailly, Gladys Mbemba, Jean François Mouscadet & Philippe Cotelle. (2006) Design, synthesis, and anti-integrase activity of catechol–DKA hybrids. Bioorganic & Medicinal Chemistry 14:9, pages 2978-2984.
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Raveendra Dayam, Jinxia Deng & Nouri Neamati. (2006) HIV-1 integrase inhibitors: 2003–2004 update. Medicinal Research Reviews 26:3, pages 271-309.
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Allison A. Johnson, Webster Santos, Godwin C.G. Pais, Christophe Marchand, Ronak Amin, Terrence R. BurkeJr.Jr., Gregory Verdine & Yves Pommier. (2006) Integration Requires a Specific Interaction of the Donor DNA Terminal 5′-Cytosine with Glutamine 148 of the HIV-1 Integrase Flexible Loop. Journal of Biological Chemistry 281:1, pages 461-467.
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Raveendra Dayam, Tino Sanchez & Nouri Neamati. (2005) Diketo Acid Pharmacophore. 2. Discovery of Structurally Diverse Inhibitors of HIV-1 Integrase. Journal of Medicinal Chemistry 48:25, pages 8009-8015.
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D. Christopher Meadows, Timothy B. Mathews, Thomas W. North, Michael J. Hadd, Chih Lin Kuo, Nouri Neamati & Jacquelyn Gervay-Hague. (2005) Synthesis and Biological Evaluation of Geminal Disulfones as HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry 48:14, pages 4526-4534.
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Yves Pommier, Allison A. Johnson & Christophe Marchand. (2005) Integrase inhibitors to treat HIV/Aids. Nature Reviews Drug Discovery 4:3, pages 236-248.
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Wim G. Verschueren, Inge Dierynck, Katie I. E. Amssoms, Lili Hu, Paul M. J. G. Boonants, Geert M. E. Pille, Frits F. D. Daeyaert, Kurt Hertogs, Dominique L. N. G. Surleraux & Piet B. T. P. Wigerinck. (2004) Design and Optimization of Tricyclic Phtalimide Analogues as Novel Inhibitors of HIV-1 Integrase. Journal of Medicinal Chemistry 48:6, pages 1930-1940.
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Mario Sechi, Luciano Sannia, Fabrizio Carta, Michele Palomba, Roberto Dallocchio, Alessandro Dessì, Massimiliano Derudas, Zahrah Zawahir & Nouri Neamati. (2016) Design of Novel Bioisosteres of β-Diketo Acid Inhibitors of HIV-1 Integrase. Antiviral Chemistry and Chemotherapy 16:1, pages 41-61.
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Raveendra Dayam, Tino Sanchez, Omoshile Clement, Robert Shoemaker, Shizuko Sei & Nouri Neamati. (2004) β-Diketo Acid Pharmacophore Hypothesis. 1. Discovery of a Novel Class of HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry 48:1, pages 111-120.
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Hongbin Yuan & Abby Parrill. (2005) Cluster analysis and three-dimensional QSAR studies of HIV-1 integrase inhibitors. Journal of Molecular Graphics and Modelling 23:4, pages 317-328.
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Raveendra Dayam & Nouri Neamati. (2004) Active site binding modes of the β-diketoacids: a multi-active site approach in HIV-1 integrase inhibitor design. Bioorganic & Medicinal Chemistry 12:24, pages 6371-6381.
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Rajeshri G. Karki, Yun Tang, Terrence R. BurkeJrJr & Marc C. Nicklaus. (2005) Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design. Journal of Computer-Aided Molecular Design 18:12, pages 739-760.
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Mario SechiMassimiliano DerudasRoberto DallocchioAlessandro DessìAlessia BacchiLuciano SanniaFabrizio CartaMichele PalombaOmar RagabCarney ChanRobert ShoemakerShizuko SeiRaveendra DayamNouri Neamati. (2004) Design and Synthesis of Novel Indole β-Diketo Acid Derivatives as HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry 47:21, pages 5298-5310.
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Daria J. Hazuda, Neville J. Anthony, Robert P. Gomez, Samson M. Jolly, John S. Wai, Linghang Zhuang, Thorsten E. Fisher, Mark Embrey, James P. GuareJr.Jr., Melissa S. Egbertson, Joseph P. Vacca, Joel R. Huff, Peter J. Felock, Marc V. Witmer, Kara A. Stillmock, Robert Danovich, Jay Grobler, Michael D. Miller, Amy S. Espeseth, Lixia Jin, I-Wu Chen, Jiunn H. Lin, Kelem Kassahun, Joan D. Ellis, Bradley K. Wong, Wei Xu, Paul G. Pearson, William A. Schleif, Riccardo Cortese, Emilio Emini, Vincenzo Summa, M. Katharine Holloway & Steven D. Young. (2004) A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proceedings of the National Academy of Sciences 101:31, pages 11233-11238.
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Francesca Aiello, Antonella Brizzi, Antonio Garofalo, Fedora Grande, Gaetano Ragno, Raveendra Dayam & Nouri Neamati. (2004) Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry 12:16, pages 4459-4466.
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Maria Letizia Barreca, Angela Rao, Laura De Luca, Maria Zappalà, Cristina Gurnari, Pietro Monforte, Erik De Clercq, Bénédicte Van Maele, Zeger Debyser, Myriam Witvrouw, James M. Briggs & Alba Chimirri. (2004) Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors. Journal of Chemical Information and Computer Sciences 44:4, pages 1450-1455.
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Cédric Maurin, Fabrice Bailly & Philippe Cotelle. (2004) Improved preparation and structural investigation of 4-aryl-4-oxo-2-hydroxy-2-butenoic acids and methyl esters. Tetrahedron 60:31, pages 6479-6486.
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Zdzislaw Brzozowski, Franciszek Saczewski, Tino Sanchez, Chih-Ling Kuo, Maria Gdaniec & Nouri Neamati. (2004) Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines. Bioorganic & Medicinal Chemistry 12:13, pages 3663-3672.
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Kithsiri B. Herath, Hiranthi Jayasuriya, Gerald F. Bills, Jon D. Polishook, Anne W. Dombrowski, Ziqiang Guan, Peter J. Felock, Daria J. Hazuda & Sheo B. Singh. (2004) Isolation, Structure, Absolute Stereochemistry, and HIV-1 Integrase Inhibitory Activity of Integrasone, a Novel Fungal Polyketide. Journal of Natural Products 67:5, pages 872-874.
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Ya-Qiu Long, Xiao-Hua Jiang, Raveendra Dayam, Tino Sanchez, Robert Shoemaker, Shizuko Sei & Nouri Neamati. (2004) Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase. Journal of Medicinal Chemistry 47:10, pages 2561-2573.
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Mario Sechi, Gianfranco Angotzi, Roberto Dallocchio, Alessandro Dessì, Fabrizio Carta, Luciano Sannia, Alberto Mariani, Stefano Fiori, Tino Sanchez, Leah Movsessian, Carmen Plasencia & Nouri Neamati. (2016) Design and Synthesis of Novel Dihydroxyindole-2-Carboxylic Acids as HIV-1 Integrase Inhibitors. Antiviral Chemistry and Chemotherapy 15:2, pages 67-81.
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M.Jane Cox Rosemond, Lisa St. John-Williams, Toshiro Yamaguchi, Toshio Fujishita & John S Walsh. (2004) Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases. Chemico-Biological Interactions 147:2, pages 129-139.
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Chih-Ling Kuo, Haregewein Assefa, Shantaram Kamath, Zdzialaw Brzozowski, Jaroslaw Slawinski, Franciszek Saczewski, John K. Buolamwini & Nouri Neamati. (2003) Application of CoMFA and CoMSIA 3D-QSAR and Docking Studies in Optimization of Mercaptobenzenesulfonamides as HIV-1 Integrase Inhibitors. Journal of Medicinal Chemistry 47:2, pages 385-399.
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Mario Sechi, Luciano Sannia, Maria Orecchioni, Fabrizio Carta, Giuseppe Paglietti & Nouri Neamati. (2009)
Structural investigation of 3,5‐disubstituted isoxazoles by
1
H‐nuclear magnetic resonance
. Journal of Heterocyclic Chemistry 40:6, pages 1097-1102.
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Sheo B. Singh, Deborah L. Zink, Ziqiang Guan, Javier Collado, Fernando Pelaez, Peter J. Felock & Daria J. Hazuda. (2003)
Isolation, Structure, and HIV‐1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by
Penicillium chrysogenum
. Helvetica Chimica Acta 86:10, pages 3380-3385.
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Christophe Marchand, Allison A. Johnson, Rajeshri G. Karki, Godwin C. G. Pais, Xuechun Zhang, Kiriana Cowansage, Tapan A. Patel, Marc C. Nicklaus, Terrence R. BurkeJr.Jr. & Yves Pommier. (2003) Metal-Dependent Inhibition of HIV-1 Integrase by β-Diketo Acids and Resistance of the Soluble Double-Mutant (F185K/C280S). Molecular Pharmacology 64:3, pages 600-609.
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Xuechun Zhang, Godwin C.G Pais, Evguenia S Svarovskaia, Christophe Marchand, Allison A Johnson, Rajeshri G Karki, Marc C Nicklaus, Vinay K Pathak, Yves Pommier & Terrence R BurkeJr.Jr.. (2003) Azido-Containing aryl β-Diketo acid HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters 13:6, pages 1215-1219.
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Nouri Neamati, Zhaiwei Lin, Rajeshri G. Karki, Ann Orr, Kiriana Cowansage, Dirk Strumberg, Godwin C. G. Pais, Johannes H. Voigt, Marc C. Nicklaus, Heather E. Winslow, He Zhao, Jim A. Turpin, Jizu Yi, Anna Marie Skalka, Terrence R. Burke, & Yves Pommier. (2002) Metal-Dependent Inhibition of HIV-1 Integrase. Journal of Medicinal Chemistry 45:26, pages 5661-5670.
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