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Review

Farnesyltransferase inhibitors: recent advances

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Pages 175-186 | Published online: 02 Mar 2005

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Yue Yang, Dhruva K. Chakravorty & Kenneth M. MerzJr.Jr.. (2010) Finding a Needle in the Haystack: Computational Modeling of Mg 2+ Binding in the Active Site of Protein Farnesyltransferase . Biochemistry 49:44, pages 9658-9666.
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Martin Schlitzer, Regina Ortmann & Mirko Altenkämper. 2009. Drug Design of Zinc‐Enzyme Inhibitors. Drug Design of Zinc‐Enzyme Inhibitors 813 857 .
Sérgio Filipe Sousa, Pedro Alexandrino Fernandes & Maria João Ramos. (2009) Molecular dynamics simulations on the critical states of the farnesyltransferase enzyme. Bioorganic & Medicinal Chemistry 17:9, pages 3369-3378.
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Katja Kohring, Jochen Wiesner, Mirko Altenkämper, Jacek Sakowski, Katrin Silber, Alexander Hillebrecht, Peter Haebel, Hans-Martin Dahse, Regina Ortmann, Hassan Jomaa, Gerhard Klebe & Martin Schlitzer. (2008) Development of Benzophenone-Based Farnesyltransferase Inhibitors as Novel Antimalarials. ChemMedChem 3:8, pages 1217-1231.
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Sérgio F. Sousa, Pedro A. Fernandes & Maria João Ramos. (2008) Enzyme Flexibility and the Catalytic Mechanism of Farnesyltransferase: Targeting the Relation. The Journal of Physical Chemistry B 112:29, pages 8681-8691.
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Devendra S. Puntambekar, Rajani Giridhar & Mange Ram Yadav. (2008) Insights into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models. European Journal of Medicinal Chemistry 43:1, pages 142-154.
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Sérgio Filipe Sousa, Pedro Alexandrino Fernandes & Maria João Ramos. (2006) Theoretical studies on farnesyltransferase: The distances paradox explained. Proteins: Structure, Function, and Bioinformatics 66:1, pages 205-218.
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Sérgio Filipe Sousa, Pedro Alexandrino Fernandes & Maria João Ramos. (2006) Effective tailor-made force field parameterization of the several Zn coordination environments in the puzzling FTase enzyme: opening the door to the full understanding of its elusive catalytic mechanism. Theoretical Chemistry Accounts 117:1, pages 171-181.
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Laura L. Rokosz, Chia-Yu Huang, John C. Reader, Tara M. Stauffer, Daniel Chelsky, Nolan H. Sigal, Ashit K. Ganguly & John J. Baldwin. (2005) Surfing the piperazine core of tricyclic farnesyltransferase inhibitors. Bioorganic & Medicinal Chemistry Letters 15:24, pages 5537-5543.
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Sérgio F. Sousa, Pedro A. Fernandes & Maria João Ramos. (2005) Farnesyltransferase: Theoretical studies on peptide substrate entrance—thiol or thiolate coordination?. Journal of Molecular Structure: THEOCHEM 729:1-2, pages 125-129.
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Sérgio F. Sousa, Pedro A. Fernandes & Maria João Ramos. (2005) Farnesyltransferase—New Insights into the Zinc-Coordination Sphere Paradigm: Evidence for a Carboxylate-Shift Mechanism. Biophysical Journal 88:1, pages 483-494.
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S�rgio Filipe Sousa, Pedro Alexandrino Fernandes & Maria Jo�o Ramos. (2004) Unraveling the mechanism of the farnesyltransferase enzyme. JBIC Journal of Biological Inorganic Chemistry 10:1, pages 3-10.
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