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Pakhuri Mehta, Shubham Srivastava, Bhanwar Singh Choudhary, Manish Sharma & Ruchi Malik. (2017) Probing voltage sensing domain of KCNQ2 channel as a potential target to combat epilepsy: a comparative study. Journal of Receptors and Signal Transduction 37:6, pages 578-589.
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Ruchi Malik, Pakhuri Mehta, Shubham Srivastava, Bhanwar Singh Choudhary & Manish Sharma. (2017) Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents. Journal of Receptors and Signal Transduction 37:3, pages 259-266.
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Wayne E Childers, Adam M Gilbert, Jeffrey D Kennedy & Garth T Whiteside. (2008) Advances in the development of novel analgesics. Expert Opinion on Therapeutic Patents 18:9, pages 1027-1067.
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Articles from other publishers (28)
Petra Bloms-Funke, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, Caroline Nothdurfter, Gregor Bahrenberg, Thomas Christoph, Christopher Habermann, Christa Kneip, Wolfgang Schröder, Thomas M. Tzschentke & Derek Saunders. (2022) A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration. European Journal of Pharmacology 923, pages 174935.
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Elva Martin-Batista, Rían W. Manville, Belinda Rivero-Pérez, David Bartolomé-Martín, Diego Alvarez de la Rosa, Geoffrey W. Abbott & Teresa Giraldez. (2021) Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Frontiers in Molecular Neuroscience 14.
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Shaoning Yang, Dingqiang Lu & Pingkai Ouyang. (2018) Design, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents. Bioorganic & Medicinal Chemistry Letters 28:10, pages 1731-1735.
Crossref
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Gummalla Prasanthi, Kvsrg Prasad & Koganti Bharathi. (2018) Synthesis, evaluation, and molecular properties prediction of substituted cinnamoylpiperazine derivatives as potential antinociceptive and anticonvulsive agents. Medicinal Chemistry Research 27:6, pages 1599-1608.
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Jiaqi Zhang, Qingzhong Jia, Jinlong Qi, Hailin Zhang, Yaru Wu & Xiaowei Shi. (2018) Exploring in vivo metabolism and excretion of QO-58L using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry. European Journal of Pharmaceutical Sciences 117, pages 379-391.
Crossref
Crossref
Jorge Vicente-Baz, Jose A. Lopez-Garcia & Ivan Rivera-Arconada. (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109, pages 131-138.
Crossref
Crossref
Hiroki Hayashi, Masashi Iwata, Noboru Tsuchimori & Tatsumi Matsumoto. (2014) Activation of Peripheral KCNQ Channels Attenuates Inflammatory Pain. Molecular Pain 10, pages 1744-8069-10-15.
Crossref
Crossref
H. Zhang, Y. Liu, J. Xu, F. Zhang, H. Liang, X. Du & H. Zhang. (2013) Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents. Neuroscience 254, pages 70-79.
Crossref
Crossref
Yiu-Yin Cheung, Haibo Yu, Kaiping Xu, Beiyan Zou, Meng Wu, Owen B. McManus, Min Li, Craig W. Lindsley & Corey R. Hopkins. (2012)
Discovery of a Series of 2-Phenyl-
N
-(2-(pyrrolidin-1-yl)phenyl)acetamides as Novel Molecular Switches that Modulate Modes of K
v
7.2 (KCNQ2) Channel Pharmacology: Identification of (
S
)-2-Phenyl-
N
-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a Potent, Brain Penetrant K
v
7.2 Channel Inhibitor
. Journal of Medicinal Chemistry 55:15, pages 6975-6979.
Crossref
Crossref
Haibo Yu, Meng Wu, Steven D. Townsend, Beiyan Zou, Shunyou Long, J. Scott Daniels, Owen B. McManus, Min Li, Craig W. Lindsley & Corey R. Hopkins. (2011)
Discovery, Synthesis, and Structure–Activity Relationship of a Series of
N
-Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener
. ACS Chemical Neuroscience 2:10, pages 572-577.
Crossref
Crossref
Martin J. Brodie, Athanasios Covanis, Antonio Gil-Nagel, Holger Lerche, Emilio Perucca, Graeme J. Sills & H. Steve White. (2011) Antiepileptic drug therapy: Does mechanism of action matter?. Epilepsy & Behavior 21:4, pages 331-341.
Crossref
Crossref
Di Zhang, Rama Thimmapaya, Xu-Feng Zhang, David J. Anderson, John L. Baranowski, Marc Scanio, Arturo Perez-Medrano, Sridhar Peddi, Zhi Wang, Jyoti R. Patel, David A. DeGoey, Murali Gopalakrishnan, Prisca Honore, Betty B. Yao & Carol S. Surowy. (2011) KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels. Journal of Neuroscience Methods 200:1, pages 54-62.
Crossref
Crossref
George Amato, Rosemarie Roeloffs, Greg C. Rigdon, Brett Antonio, Theresa Mersch, Grant McNaughton-Smith, Alan D. Wickenden, Paul Fritch & Mark J. Suto. (2011)
N
-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy
. ACS Medicinal Chemistry Letters 2:6, pages 481-484.
Crossref
Crossref
Jinlong Qi, Fan Zhang, Yi Mi, Yan Fu, Wen Xu, Diqun Zhang, Yibing Wu, Xiaona Du, Qingzhong Jia, Kewei Wang & Hailin Zhang. (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. European Journal of Medicinal Chemistry 46:3, pages 934-943.
Crossref
Crossref
Rebecca Riblet, Amanpreet Kaur, Harleen Kaur & Mark D. Womble. (2010) The Anticonvulsant Drug Retigabine Enhances M-current and Reduces Neuronal Excitability in Bullfrog Sympathetic Neurons. BIOS 81:2, pages 55-61.
Crossref
Crossref
Paul C. Fritch, Grant McNaughton-Smith, George S. Amato, James F. Burns, C. Wesley Eargle, Rosemarie Roeloffs, William Harrison, Leslie Jones & Alan D. Wickenden. (2009) Novel KCNQ2/Q3 Agonists as Potential Therapeutics for Epilepsy and Neuropathic Pain. Journal of Medicinal Chemistry 53:2, pages 887-896.
Crossref
Crossref
Heike Wulff, Neil A. Castle & Luis A. Pardo. (2009) Voltage-gated potassium channels as therapeutic targets. Nature Reviews Drug Discovery 8:12, pages 982-1001.
Crossref
Crossref
Iain A Greenwood & Susumu Ohya. (2009) New tricks for old dogs: KCNQ expression and role in smooth muscle. British Journal of Pharmacology 156:8, pages 1196-1203.
Crossref
Crossref
YogendraSinh H. Raol, David A. Lapides, Jeffery G. Keating, Amy R. Brooks-Kayal & Edward C. Cooper. (2009) A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Annals of Neurology 65:3, pages 326-336.
Crossref
Crossref
Rosemarie Roeloffs, Alan D. Wickenden, Christopher Crean, Stephen Werness, Grant McNaughton-Smith, James Stables, James O. McNamara, Neil Ghodadra & Greg C. Rigdon. (2008)
In Vivo Profile of ICA-27243 [
N
-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a Potent and Selective KCNQ2/Q3 (Kv7.2/Kv7.3) Activator in Rodent Anticonvulsant Models
. Journal of Pharmacology and Experimental Therapeutics 326:3, pages 818-828.
Crossref
Crossref
A. D. Wickenden, J. L. Krajewski, B. London, P. K. Wagoner, W. A. Wilson, S. Clark, R. Roeloffs, G. McNaughton-Smith & G. C. Rigdon. (2008)
N
-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
. Molecular Pharmacology 73:3, pages 977-986.
Crossref
Crossref
Francesco Miceli, Maria Virginia Soldovieri, Maria Martire & Maurizio Taglialatela. (2008) Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs. Current Opinion in Pharmacology 8:1, pages 65-74.
Crossref
Crossref
Douglas S. Krafte, Jeff Krajewski, Aaron Gerlach & Mark Suto. 2008. Ion Channels. Ion Channels
27
54
.
Gordon Munro & William Dalby-Brown. (2007)
K
v
7 (KCNQ) Channel Modulators and Neuropathic Pain
. Journal of Medicinal Chemistry 50:11, pages 2576-2582.
Crossref
Crossref
Walter Zieglgänsberger, Achim Berthele & Thomas R. Tölle. (2014) Understanding Neuropathic Pain. CNS Spectrums 10:4, pages 298-308.
Crossref
Crossref
G. Blackburn-Munro, W. Dalby-Brown, N. R. Mirza, J. D. Mikkelsen & R. E. Blackburn-Munro. (2006) Retigabine: Chemical Synthesis to Clinical Application. CNS Drug Reviews 11:1, pages 1-20.
Crossref
Crossref
Alexandre L’Heureux, Alain Martel, Huan He, Jie Chen, Li-Qiang Sun, John E. Starrett, Joanne Natale, Steven I. Dworetzky, Ronald J. Knox, David G. Harden, David Weaver, Mark W. Thompson & Yong-Jin Wu. (2005) (S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity. Bioorganic & Medicinal Chemistry Letters 15:2, pages 363-366.
Crossref
Crossref
Yong-Jin Wu, Li-Qiang Sun, Huan He, Jie Chen, John E StarrettJr.Jr., Pierre Dextraze, Jean-Paul Daris, Christopher G Boissard, Rick L Pieschl, Valentin K Gribkoff, Joanne Natale, Ronald J Knox, David G Harden, Mark W Thompson, William Fitzpatrick, David Weaver, Dedong Wu, Qi Gao & Steven I Dworetzky. (2004) Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides. Bioorganic & Medicinal Chemistry Letters 14:17, pages 4533-4537.
Crossref
Crossref