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Tony Taldone, Hardik J Patel, Alexander Bolaender, Maulik R Patel & Gabriela Chiosis. (2014) Protein chaperones: a composition of matter review (2008 – 2013). Expert Opinion on Therapeutic Patents 24:5, pages 501-518.
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Ghassan Abu Sheikha, Mahmoud A. Al-Sha’er & Mutasem O. Taha. (2011) Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. Journal of Enzyme Inhibition and Medicinal Chemistry 26:5, pages 603-609.
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Jennifer S Isaacs. (2005) Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?. Expert Opinion on Investigational Drugs 14:6, pages 569-589.
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P. Workman. (2004) Drug Discovery Strategies: Technologies to Accelerate Translation from Target to Drug. Journal of Chemotherapy 16:sup4, pages 13-15.
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Articles from other publishers (40)
Yiming Xu, Dewang Jing, Dong Zhao, Yongji Wu, Lu Xing, Haroon ur Rashid, Haodong Wang, Lisheng Wang & Huiling Cao. (2020) New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment. Bioorganic & Medicinal Chemistry 28:4, pages 115305.
Crossref
Crossref
Jianhua Liu, Yumei Wang, Hao Guo & Songjie Fan. (2019) DFT study of the solvation effect on an antiangiogenic deguelin analogue's structure and properties. Chemical Data Collections 20, pages 100185.
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Crossref
Ludger A. Wessjohann, Richard Bartelt & Wolfgang Brandt. 2017. Practical Medicinal Chemistry with Macrocycles. Practical Medicinal Chemistry with Macrocycles
77
100
.
Xin Chen & Jian Jin. 2017. The Molecular Basis of Human Cancer. The Molecular Basis of Human Cancer
771
795
.
Shengquan Duan, Sripathy Venkatraman, Xuechuan Hong, Kenneth Huang, Luckner Ulysse, Bingidimi I. Mobele, Alexander Smith, Lawrence Lawless, Andrew Locke & Ravi Garigipati. (2012) Process Development and Scale-Up of an Hsp90 Inhibitor. Organic Process Research & Development 16:11, pages 1787-1793.
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Crossref
Mahmoud A. Al-Sha’er & Mutasem O. Taha. (2012) Application of docking-based comparative intermolecular contacts analysis to validate Hsp90α docking studies and subsequent in silico screening for inhibitors. Journal of Molecular Modeling 18:11, pages 4843-4863.
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Crossref
Kenneth H. Huang, Thomas E. Barta, John W. Rice, Emilie D. Smith, Andy J. Ommen, Wei Ma, James M. Veal, R. Patrick Fadden, Amy F. Barabasz, Briana E. Foley, Philip F. Hughes, Gunnar J. Hanson, Christopher J. Markworth, Melanie Silinski, Jeffrey M. Partridge, Paul M. Steed & Steven E. Hall. (2012) Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90. Bioorganic & Medicinal Chemistry Letters 22:7, pages 2550-2554.
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Crossref
Marco A. Biamonte, Ryan Van de Water, Joseph W. Arndt, Robert H. Scannevin, Daniel Perret & Wen-Cherng Lee. (2009) Heat Shock Protein 90: Inhibitors in Clinical Trials. Journal of Medicinal Chemistry 53:1, pages 3-17.
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Paul A. BroughXavier BarrilJenifer BorgognoniPatrick Chene, Nicholas G. M. DaviesBen DavisMartin J. DrysdaleBrian DymockSuzanne A. EcclesCarlos Garcia-Echeverria, Christophe FromontAngela HayesRoderick E. HubbardAllan M. JordanMichael Rugaard Jensen, Andrew MasseyAngela MerrettAntony PadfieldRachel ParsonsThomas Radimerski, Florence I. RaynaudAlan RobertsonStephen D. RoughleyJoseph Schoepfer, Heather SimmoniteSwee Y. SharpAllan SurgenorMelanie ValentiSteven WallsPaul WebbMike WoodPaul WorkmanLisa Wright. (2009)
Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-
d
]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
. Journal of Medicinal Chemistry 52:15, pages 4794-4809.
Crossref
Crossref
Martin Spichty, Antoine Taly, Franz Hagn, Horst Kessler, Sofia Barluenga, Nicolas Winssinger & Martin Karplus. (2009) The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts. Biophysical Chemistry 143:3, pages 111-123.
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Kenneth H. Huang, James M. Veal, R. Patrick Fadden, John W. Rice, Jeron Eaves, Jon-Paul Strachan, Amy F. Barabasz, Briana E. Foley, Thomas E. Barta, Wei Ma, Melanie A. Silinski, Mei Hu, Jeffrey M. Partridge, Anisa Scott, Laura G. DuBois, Tiffany Freed, Paul M. Steed, Andy J. Ommen, Emilie D. Smith, Philip F. Hughes, Angela R. Woodward, Gunnar J. Hanson, W. Stephen McCall, Christopher J. Markworth, Lindsay Hinkley, Matthew Jenks, Lifeng Geng, Meredith Lewis, James Otto, Bert Pronk, Katleen Verleysen & Steven E. Hall. (2009) Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents. Journal of Medicinal Chemistry 52:14, pages 4288-4305.
Crossref
Crossref
Antonino Lauria, Mario Ippolito & Anna Maria Almerico. (2009) Inside the Hsp90 inhibitors binding mode through induced fit docking. Journal of Molecular Graphics and Modelling 27:6, pages 712-722.
Crossref
Crossref
Inga Cikotiene, Egidijus Kazlauskas, Jurgita Matuliene, Vilma Michailoviene, Jolanta Torresan, Jelena Jachno & Daumantas Matulis. (2009) 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone. Bioorganic & Medicinal Chemistry Letters 19:4, pages 1089-1092.
Crossref
Crossref
Massimiliano Meli & Giorgio Colombo. 2009. Peptide Microarrays. Peptide Microarrays
77
153
.
C Garcia-Echeverria & W R Sellers. (2008) Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 27:41, pages 5511-5526.
Crossref
Crossref
Xiaoguang Lei & Samuel J. Danishefsky. (2008) Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Advanced Synthesis & Catalysis 350:11-12, pages 1677-1681.
Crossref
Crossref
Jeffrey S. Johnston, Mitch A. Phelps, Kristie A. Blum, William Blum, Michael R. Grever, Katherine L. Farley & James T. Dalton. (2008) Development and validation of a rapid and sensitive high-performance liquid chromatography–mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma. Journal of Chromatography B 871:1, pages 15-21.
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Crossref
Thomas Hesterkamp & Mark Whittaker. (2008) Fragment-based activity space: smaller is better. Current Opinion in Chemical Biology 12:3, pages 260-268.
Crossref
Crossref
Miriam Sgobba, Gianluca Degliesposti, Anna Maria Ferrari & Giulio Rastelli. (2008) Structural Models and Binding Site Prediction of the C-terminal Domain of Human Hsp90: A New Target for Anticancer Drugs. Chemical Biology & Drug Design 71:5, pages 420-433.
Crossref
Crossref
Paul A. BroughWynne AherneXavier BarrilJenifer BorgognoniKathy BoxallJulie E. CansfieldKwai-Ming J. CheungIan CollinsNicholas G. M. DaviesMartin J. DrysdaleBrian DymockSuzanne A. EcclesHarry FinchAlexandra FinkAngela HayesRobert HowesRoderick E. HubbardKaren JamesAllan M. JordanAndrea LockieVanessa MartinsAndrew MasseyThomas P. MatthewsEdward McDonaldChristopher J. NorthfieldLaurence H. PearlChrisostomos ProdromouStuart RayFlorence I. RaynaudStephen D. RoughleySwee Y. SharpAllan SurgenorD. Lee WalmsleyPaul WebbMike WoodPaul WorkmanLisa Wright. (2007) 4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer. Journal of Medicinal Chemistry 51:2, pages 196-218.
Crossref
Crossref
Srinivas R. Kasibhatla, Kevin Hong, Marco A. Biamonte, David J. Busch, Patricia L. Karjian, John L. Sensintaffar, Adeela Kamal, Rachel E. Lough, John Brekken, Karen Lundgren, Roy Grecko, Gregg A. Timony, Yingqing Ran, Robert Mansfield, Lawrence C. Fritz, Edgar Ulm, Francis J. Burrows & Marcus F. Boehm. (2007) Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity. Journal of Medicinal Chemistry 50:12, pages 2767-2778.
Crossref
Crossref
Nicola F. Smith, Florence I. Raynaud & Paul Workman. (2007) The application of cassette dosing for pharmacokinetic screening in small-molecule cancer drug discovery. Molecular Cancer Therapeutics 6:2, pages 428-440.
Crossref
Crossref
Carlos Garcia-Echeverria. 2007. Cancer. Cancer
169
206
.
Steven E. Hall. (2006) Chemoproteomics-driven drug discovery: addressing high attrition rates. Drug Discovery Today 11:11-12, pages 495-502.
Crossref
Crossref
Nivedita Sain, Bhavani Krishnan, Michael G. Ormerod, Assunta De Rienzo, Wai M. Liu, Stanley B. Kaye, Paul Workman & Ann L. Jackman. (2006) Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Molecular Cancer Therapeutics 5:5, pages 1197-1208.
Crossref
Crossref
Swee Sharp & Paul Workman. 2006.
323
348
.
S. Pacey, U. Banerj, I. Judson & P. Workman. 2006. Molecular Chaperones in Health and Disease. Molecular Chaperones in Health and Disease
331
358
.
Yves L. Janin. (2005) Heat Shock Protein 90 Inhibitors. A Text Book Example of Medicinal Chemistry?. Journal of Medicinal Chemistry 48:24, pages 7503-7512.
Crossref
Crossref
Xavier Barril, Paul Brough, Martin Drysdale, Roderick E. Hubbard, Andrew Massey, Allan Surgenor & Lisa Wright. (2005) Structure-based discovery of a new class of Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters 15:23, pages 5187-5191.
Crossref
Crossref
Paul A. Brough, Xavier Barril, Mandy Beswick, Brian W. Dymock, Martin J. Drysdale, Lisa Wright, Kate Grant, Andrew Massey, Allan Surgenor & Paul Workman. (2005) 3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone. Bioorganic & Medicinal Chemistry Letters 15:23, pages 5197-5201.
Crossref
Crossref
Luke Whitesell & Susan L. Lindquist. (2005) HSP90 and the chaperoning of cancer. Nature Reviews Cancer 5:10, pages 761-772.
Crossref
Crossref
Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, Martin G. Rowlands, Katherine J. Boxall, Swee Y. Sharp, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, G. Wynne Aherne, Edward McDonald & Paul Workman. (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters 15:14, pages 3338-3343.
Crossref
Crossref
Udai Banerji, Anne O'Donnell, Michelle Scurr, Simon Pacey, Sarah Stapleton, Yasmin Asad, Laura Simmons, Alison Maloney, Florence Raynaud, Maeli Campbell, Michael Walton, Sunil Lakhani, Stanley Kaye, Paul Workman & Ian Judson. (2005) Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies. Journal of Clinical Oncology 23:18, pages 4152-4161.
Crossref
Crossref
Anthea HardcastleKathy BoxallJuliet RichardsPeter TomlinSwee SharpPaul ClarkePaul WorkmanWynne Aherne. (2005) Solid-Phase Immunoassays in Mechanism-Based Drug Discovery: Their Application in the Development of Inhibitors of the Molecular Chaperone Heat-Shock Protein 90. ASSAY and Drug Development Technologies 3:3, pages 273-285.
Crossref
Crossref
Brian W. DymockXavier BarrilPaul A. BroughJulie E. CansfieldAndrew MasseyEdward McDonaldRoderick E. HubbardAllan SurgenorStephen D. RoughleyPaul WebbPaul WorkmanLisa WrightMartin J. Drysdale. (2005) Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design. Journal of Medicinal Chemistry 48:13, pages 4212-4215.
Crossref
Crossref
Emilie Moulin, Vincent Zoete, Sofia Barluenga, Martin Karplus & Nicolas Winssinger. (2005) Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues. Journal of the American Chemical Society 127:19, pages 6999-7004.
Crossref
Crossref
P. WORKMAN. (2005) Drugging the Cancer Kinome: Progress and Challenges in Developing Personalized Molecular Cancer Therapeutics. Cold Spring Harbor Symposia on Quantitative Biology 70:0, pages 499-515.
Crossref
Crossref
Paul Workman. (2005) Genomics and the second golden era of cancer drug development. Molecular BioSystems 1:1, pages 17.
Crossref
Crossref
Marco A. Biamonte, Jiandong Shi, David Hurst, Kevin Hong, Marcus F. Boehm & Srinivas R. Kasibhatla. (2004) Preparation of 8-(Arylsulfanyl)adenines with Diazonium Salts under Mild, Aerobic Conditions. The Journal of Organic Chemistry 70:2, pages 717-720.
Crossref
Crossref
Ann L. Jackman, Stanley Kaye & Paul Workman. (2004) The combination of cytotoxic and molecularly targeted therapies – can it be done?. Drug Discovery Today: Therapeutic Strategies 1:4, pages 445-454.
Crossref
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