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Tanshinone derivatives: a patent review (January 2006 – September 2012)

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Pages 19-29 | Published online: 25 Oct 2012

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Amirhossein Sheida, Tarannomsadat Taghavi, Rana Shafabakhsh, Amirreza Ostadian, Zahra Razaghi Bahabadi, Mahmood Khaksary Mahabady, Michael R Hamblin & Hamed Mirzaei. (2023) Potential of natural products in the treatment of myocardial infarction: focus on molecular mechanisms. Critical Reviews in Food Science and Nutrition 63:22, pages 5488-5505.
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Shihao You, Xianghui He, Mei Wang, Lina Mao & Lu Zhang. (2020) Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis. Cancer Management and Research 12, pages 11309-11320.
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Yuee Cai, Wenji Zhang, Zirong Chen, Zhi Shi, Chengwei He & Meiwan Chen. (2016) Recent insights into the biological activities and drug delivery systems of tanshinones. International Journal of Nanomedicine 11, pages 121-130.
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Lin-Wei Zeng, Chang-Xin Zhou, Jia-Dong Liu, Chang-Hong Liu, Jian-Xia Mo, A-Fang Hou, Wei Yao, Zhen-Zhen Wang & Li-She Gan. (2016) Design, synthesis, and antimicrobial activities of new tanshinone IIA esters. Natural Product Research 30:23, pages 2662-2668.
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Maolin Sun, Chaoming Liang, Liming Cao, Yaguo Wang, Jiasheng Yang, Shiyu Hou, Wei Yu, Yueyue Ma, Ruihua Cheng & Jinxing Ye. (2024) Two-step continuous flow process of sodium tanshinone IIA sulfonate using a 3D circular cyclone-type microreactor. Chinese Chemical Letters 35:1, pages 108738.
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Minming Xia, Yifeng Wu, Hui Zhu & Wenbiao Duan. (2023) Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway. Human & Experimental Toxicology 42.
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Zhu Chen, Jiaai Zhao, Siwang Wang & Qiang Li. (2023) Tanshinone IIA attenuates ox‐LDL ‐induced endothelial cell injury by inhibiting NF‐kapaB pathway via circ_0000231/ miR ‐590‐5p/ TXNIP axis . Chemical Biology & Drug Design.
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Nadim Mitri, Kamil Rahme, Giulio Fracasso & Esther Ghanem. (2023) Upgrading gold to green nanoparticles: applications in prostate cancer. Advances in Natural Sciences: Nanoscience and Nanotechnology 14:2, pages 023001.
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Jiaming Li, Hongda Sheng, Yingchao Wang, Zhencheng Lai, Yi Wang & Sunliang Cui. (2023) Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor. Journal of Medicinal Chemistry 66:4, pages 2946-2963.
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Xin-Fang Lv, Ruo-Qing Wen, Kai Liu, Xin-Ke Zhao, Chen-Liang Pan, Xiang Gao, Xue Wu, Xiao-Dong Zhi, Chun-Zhen Ren, Qi-Lin Chen, Wei-Jie Lu, Ting-Yan Bai & Ying-Dong Li. (2022) Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy. Frontiers in Cardiovascular Medicine 9.
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Xing Huang, Lili Jin, Hao Deng, Dan Wu, Qing-kun Shen, Zhe-shan Quan, Chang-hao Zhang & Hong-Yan Guo. (2022) Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications. Frontiers in Pharmacology 13.
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Xing Huang, Hao Deng, Qing-kun Shen & Zhe-Shan Quan. (2022) Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications. Current Medicinal Chemistry 29:11, pages 1959-1989.
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Haiwei Ni, Guojing Ruan, Cheng Sun, Xuan Yang, Zhenyan Miao, Jifei Li, Ying Chen, Hai Qin, Yichen Liu, Lufeng Zheng, Yingying Xing, Tao Xi & Xiaoman Li. (2021) Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. Environmental Toxicology 37:2, pages 192-200.
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Dong XU, Chengli GUI, Haiyan ZHAO & Fengli LIU. (2022) Cryptotanshinone protects hippocampal neurons against oxygen-glucose deprivation-induced injury through the activation of Nrf2/HO-1 signaling pathway. Food Science and Technology 42.
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Wenfeng Zhang, Cun Liu, Jie Li, Yiping Lu, Huayao Li, Jing Zhuang, Xin Ren, Mengmeng Wang & Changgang Sun. (2022) Tanshinone IIA: New Perspective on the Anti-Tumor Mechanism of A Traditional Natural Medicine. The American Journal of Chinese Medicine 50:01, pages 209-239.
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Zhangyang Bi, Yayun Wang & Wei Zhang. (2021) A comprehensive review of tanshinone IIA and its derivatives in fibrosis treatment. Biomedicine & Pharmacotherapy 137, pages 111404.
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Zhencheng Lai, Jixiao He, Changxin Zhou, Huajun Zhao & Sunliang Cui. (2021) Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years. Current Medicinal Chemistry 28:14, pages 2807-2827.
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Ying-Shih Su, Min Zhan Kuo, Yi Ting Kuo, Shu-Wei Huang, Chia-Jung Lee, Zheng-Yuan Su, Yu-Hui Ni, Dian-Kun Li & Tien-Yuan Wu. (2021) Diterpenoid anthraquinones as chemopreventive agents altered microRNA and transcriptome expressions in cancer cells. Biomedicine & Pharmacotherapy 136, pages 111260.
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Heng Zou, Yanli Li, Xiaomin Liu, Zong Wu, Jingjing Li & Zhongliang Ma. (2020) Roles of plant‐derived bioactive compounds and related microRNAs in cancer therapy . Phytotherapy Research 35:3, pages 1176-1186.
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Jun Shi, Jianhui Lai, Yujian Lin, Xiaoqi Xu, Siyi Guo, Hui Wang, Fang Wang & Yuyi Mai. (2020) Tanshinone IIA down-regulated p-Smad3 signaling to inhibit TGF-β1-mediated fibroblast proliferation via lncRNA-HSRL/SNX9. The International Journal of Biochemistry & Cell Biology 129, pages 105863.
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He Huang, Chuanjun Song & Junbiao Chang. (2020) Synthesis and Biological Activity Study of Tanshinone Derivatives: A Literature and Patent Review. Current Topics in Medicinal Chemistry 20:28, pages 2520-2534.
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Lei Wang, Xiaoxing Xiong, Xu Zhang, Yingze Ye, Zhihong Jian, Wenwei Gao & Lijuan Gu. (2020) Sodium Tanshinone IIA Sulfonate Protects Against Cerebral Ischemia–reperfusion Injury by Inhibiting Autophagy and Inflammation. Neuroscience 441, pages 46-57.
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Tengfei Li, Duo Li, Xinyu Xu, Yantong Zhu, Margaret Phiri, Shunli Ji, Chang Shu & Li Ding. (2020) A simple injectable peptide-based hydrogel of tanshinone ⅡA for antioxidant and anticoagulation. Journal of Drug Delivery Science and Technology 58, pages 101532.
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He Huang, Chuanjun Song, Zhen Wang, Mengyang Li & Junbiao Chang. (2020) Total synthesis of tanshinone IIA. Tetrahedron Letters 61:28, pages 152102.
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Yujie Wang & Diancai Zhang. (2019) Tanshinol inhibits growth of malignant melanoma cells via regulating miR-1207-5p/CHPF pathway. Archives of Dermatological Research 312:5, pages 373-383.
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Wenjuan Tong, Jianghong Guo & Chunfen Yang. (2020) Tanshinone II A enhances pyroptosis and represses cell proliferation of HeLa cells by regulating miR-145/GSDMD signaling pathway. Bioscience Reports 40:4.
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Shangguan Jian, Liang Chen, Lian Minxue, Che Hongmin, Tang Ronghua, Fan Xiaoxuan, Zhang Binbin & Guo Shiwen. (2020) Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. International Journal of Molecular Medicine.
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Zhong-Yan Zhou, Wai-Rong Zhao, Jing Zhang, Xin-Lin Chen & Jing-Yi Tang. (2019) Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics. Biomedicine & Pharmacotherapy 118, pages 109362.
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Cristina Ribas Fürstenau, Izabel Cristina Custódio de Souza & Marcos Roberto de Oliveira. (2019) Tanshinone I Induces Mitochondrial Protection by a Mechanism Involving the Nrf2/GSH Axis in the Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal. Neurotoxicity Research 36:3, pages 491-502.
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Yu-En Shih, Chao-Hsiang Chen, Nan-Hei Lin & Jason T.C. Tzen. (2019) Development of Indirect Competitive ELISA for Lithospermic Acid B of Salvia miltiorrhiza with Its Specific Antibodies Generated via Artificial Oil Bodies. Molecules 24:10, pages 1952.
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Wenna Chen, Ximing Li, Shengnan Guo, Nan Song, Junyan Wang, Lianqun Jia & Aisong Zhu. (2019) Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis. International Immunopharmacology 70, pages 486-497.
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Choongho Lee. (2018) Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway. Oxidative Medicine and Cellular Longevity 2018, pages 1-26.
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Yingfeng Weng, Jixian Lin, Hui Liu, Hui Wu, Zhimin Yan & Jing Zhao. (2017) AMPK activation by Tanshinone IIA protects neuronal cells from oxygen-glucose deprivation. Oncotarget 9:4, pages 4511-4521.
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Zhiqiang Wang, Seung Hwan Hwang, Guanglei Zuo, Set Byeol Kim & Soon Sung Lim. (2018) An in vitro affinity-based method for studying herb–drug interactions for direct identification of cytochrome P450 1A2, 3A4, and 2C9 specific ligands from herbal extracts using ultrafiltration-high performance liquid chromatography . RSC Advances 8:16, pages 8944-8949.
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Marcos Roberto de Oliveira, Cristina Ribas Fürstenau, Izabel Cristina Custódio de Souza & Gustavo da Costa Ferreira. (2016) Tanshinone I Attenuates the Effects of a Challenge with H2O2 on the Functions of Tricarboxylic Acid Cycle and Respiratory Chain in SH-SY5Y Cells. Molecular Neurobiology 54:10, pages 7858-7868.
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Ji Zhu, Yingling Xu, Guangyan Ren, Xiao Hu, Cui Wang, Zhen Yang, Zhuoyu Li, Wei Mao & Dezhao Lu. (2017) Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1. European Journal of Pharmacology 815, pages 427-436.
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Biying Ji, Fei Zhou, Lijuan Han, Jun Yang, Haijian Fan, Shanshan Li, Jingwei Li, Xin Zhang, Xiaoying Wang, Xiangyan Chen & Yun Xu. (2017) Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage. Translational Stroke Research 8:4, pages 334-340.
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Marcos Roberto de Oliveira, Patrícia Fernanda Schuck & Simone Morelo Dal Bosco. (2016) Tanshinone I Induces Mitochondrial Protection through an Nrf2-Dependent Mechanism in Paraquat-TreatedHuman Neuroblastoma SH-SY5Y Cells. Molecular Neurobiology 54:6, pages 4597-4608.
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Dongdong Wang, Chunbo Lu, Feifei Sun, Mingxu Cui, Haibo Mu, Jinyou Duan & Huiling Geng. (2017) A tanshinone I derivative enhances the activities of antibiotics against Staphylococcus aureus in vitro and in vivo. Research in Microbiology 168:1, pages 46-54.
Crossref
Ching-Fen Wu & Thomas Efferth. 2017. Salvia Biotechnology. Salvia Biotechnology 179 207 .
Sana Javed, Ameema Tariq, Touqeer Ahmed, Barbara Budzyńska, Silvia Tejada, Maria Daglia, Seyed Fazel NabaviEduardo Sobarzo-Sánchez & Seyed Mohammad Nabavi. (2016) Tanshinones and mental diseases: from chemistry to medicine. Reviews in the Neurosciences 27:8, pages 777-791.
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Zhijie Zhu, Yang Zhao, Junbo Li, Li Tao, Peiliang Shi, Zhonghong Wei, Xiaobo Sheng, Dandan Shen, Zhaoguo Liu, Liang Zhou, Chao Tian, Fangtian Fan, Cunsi Shen, Pingting Zhu, Aiyun Wang, Wenxing Chen, Qingshun Zhao & Yin Lu. (2015) Cryptotanshinone, a novel tumor angiogenesis inhibitor, destabilizes tumor necrosis factor‐α mRNA via decreasing nuclear–cytoplasmic translocation of RNA‐binding protein HuR. Molecular Carcinogenesis 55:10, pages 1399-1410.
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MING SHU, XIAO-RONG HU, ZUO-AN HUNG, DAM-DAN HUANG & SHUN ZHANG. (2016) Effects of tanshinone IIA on fibrosis in a rat model of cirrhosis through heme oxygenase-1, inflammation, oxidative stress and apoptosis. Molecular Medicine Reports 13:4, pages 3036-3042.
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Oriana Tabarrini, Jenny Desantis & Serena Massari. (2016) Recent advances in the identification of Tat-mediated transactivation inhibitors: progressing toward a functional cure of HIV. Future Medicinal Chemistry 8:4, pages 421-442.
Crossref
Hyou-Ju Jin & Chun-Guang Li. (2016) Molecular Mechanisms of Cardioprotective Actions of Tanshinones. Journal of Chemistry 2016, pages 1-14.
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Ting ChenJunhui Yang, Lihua Chen, Xiaocui QianQin Zheng, Tingming FuHongzhi QiaoJunsong LiLiuqing Di. (2016) Use of ordered mesoporous silica-loaded phyto-phospholipid complex for BCS IV class plant drug to enhance oral bioavailability: a case report of tanshinone II A . RSC Advances 6:116, pages 115010-115020.
Crossref
Feng Feng, Ying Feng, Zhen Liu, Wei-Hua Li, Wen-Cong Wang, Zhong-Dao Wu & Zhiyue Lv. (2015) Effects of albendazole combined with TSII-A (a Chinese herb compound) on optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice. Parasites & Vectors 8:1.
Crossref
Jun Tang, Chao Zhu, Zhi-hong Li, Xiao-yu Liu, Shu-kai Sun, Ting Zhang, Zhuo-jing Luo, Hui Zhang & Wei-yan Li. (2015) Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain. Journal of Neuroinflammation 12:1.
Crossref
Suyou Liu, Lijun Long, Duoduo Xie, Lijun Liu & Dayou Ma. (2015) The iodine-mediated highly regioselective synthesis of angular and linear naphthofuroquinones. Tetrahedron Letters 56:48, pages 6730-6733.
Crossref
Vito Giuseppe D’Agostino, Preet Lal, Barbara Mantelli, Christopher Tiedje, Chiara Zucal, Natthakan Thongon, Matthias Gaestel, Elisa Latorre, Luciana Marinelli, Pierfausto Seneci, Marialaura Amadio & Alessandro Provenzani. (2015) Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function. Scientific Reports 5:1.
Crossref
Fenglai Xiao, Bo Yan, Lei Chen & Dong Zhou. (2015) Review of the use of botanicals for epilepsy in complementary medical systems — Traditional Chinese Medicine. Epilepsy & Behavior 52, pages 281-289.
Crossref
Dongdong Wang, Wuxia Zhang, Tingting Wang, Na Li, Haibo Mu, Jiwen Zhang & Jinyou Duan. (2015) Unveiling the Mode of Action of Two Antibacterial Tanshinone Derivatives. International Journal of Molecular Sciences 16:8, pages 17668-17681.
Crossref
Haiying Tang, Huanyu He, Hong Ji, Lili Gao, Jingwei Mao, Jia Liu, Hongli Lin & Taihua Wu. (2015) Tanshinone IIA ameliorates bleomycin-induced pulmonary fibrosis and inhibits transforming growth factor-beta-β–dependent epithelial to mesenchymal transition. Journal of Surgical Research 197:1, pages 167-175.
Crossref
Jude S. MortonAnita QuonPo-Yin CheungTatsuya Sawamura & Sandra T. Davidge. (2015) Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308:3, pages R163-R172.
Crossref
Jinming Zhang, Yingbo Li, Xiefan Fang, Demin Zhou, Yitao Wang & Meiwan Chen. (2014) TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy. International Journal of Pharmaceutics 476:1-2, pages 185-198.
Crossref
Hong-Sheng Zhang, Xin-Yu Chen, Tong-Chao Wu & Feng-Juan Zhang. (2014) Tanshinone II A Inhibits Tat-Induced HIV-1 Transactivation Through Redox-Regulated AMPK/Nampt Pathway. Journal of Cellular Physiology 229:9, pages 1193-1201.
Crossref
JIAN ZHANG, JU WANG, JIU-YANG JIANG, SHANG-DIAN LIU, KAI FU & HONG-YU LIU. (2014) Tanshinone IIA induces cytochrome c-mediated caspase cascade apoptosis in A549 human lung cancer cells via the JNK pathway. International Journal of Oncology 45:2, pages 683-690.
Crossref
Andrey Marchev, Christiane Haas, Sibylle Schulz, Vasil Georgiev, Juliane Steingroewer, Thomas Bley & Atanas Pavlov. (2013) Sage in vitro cultures: a promising tool for the production of bioactive terpenes and phenolic substances. Biotechnology Letters 36:2, pages 211-221.
Crossref
Olivia Erin Buenafe, Adriana Orellana-Paucar, Jan Maes, Hao Huang, Xuhui Ying, Wim De Borggraeve, Alexander D. Crawford, Walter Luyten, Camila V. Esguerra & Peter de Witte. (2013) Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models. ACS Chemical Neuroscience 4:11, pages 1479-1487.
Crossref
Tao Liu, Gui Feng Zhang, Hui Yin, Xiao Bao Jin & Jia Yong Zhu. (2013) Electrospray Ionization Mass Spectral Characteristics and Fragmentation Mechanisms of Tanshinones in <i>Radix Salvia miltiorrhiza</i>. Advanced Materials Research 781-784, pages 1027-1031.
Crossref

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