Citations (62)
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Simona Collina, Emanuele Bignardi, Marta Rui, Daniela Rossi, Raffaella Gaggeri, Alice Zamagni, Michela Cortesi & Anna Tesei. (2017) Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016). Expert Opinion on Therapeutic Patents 27:5, pages 565-578.
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Bahar Guler, Huseyin Akbulut, Caner Geyik, F. Baris Barlas, Dilek Odaci Demirkol, Hakan Coskunol, Suna Timur & Yusuf Yagci. (2016) Functional poly(p-phenylene)s as targeting and drug carrier materials. International Journal of Polymeric Materials and Polymeric Biomaterials 65:13, pages 653-659.
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Colin G. Rousseaux & Stephanie F. Greene. (2016) Sigma receptors [σRs]: biology in normal and diseased states. Journal of Receptors and Signal Transduction 36:4, pages 327-388.
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José Miguel Vela, Manuel Merlos & Carmen Almansa. (2015) Investigational sigma-1 receptor antagonists for the treatment of pain. Expert Opinion on Investigational Drugs 24:7, pages 883-896.
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Articles from other publishers (58)
Elisabetta Teodori, Laura Braconi, Dina Manetti, Maria Novella Romanelli & Silvia Dei. (2022) The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that
Act as Multidrug Resistance (MDR) Reversers. Current Topics in Medicinal Chemistry 22:31, pages 2535-2569.
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Giordano Novak Rossi, Lorena T. L. Guerra, Glen B. Baker, Serdar M. Dursun, José Carlos Bouso Saiz, Jaime E. C. Hallak & Rafael G. dos Santos. (2022) Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant. Biomolecules 12:11, pages 1618.
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Steven A. Barker. (2022) Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. Psychopharmacology 239:6, pages 1749-1763.
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Catharina Holtschulte, Frederik Börgel, Stefanie Westphälinger, Dirk Schepmann, Gianluca Civenni, Erik Laurini, Domenico Marson, Carlo V. Catapano, Sabrina Pricl & Bernhard Wünsch. (2022)
Synthesis of Aminoethyl‐Substituted Piperidine Derivatives as σ
1
Receptor Ligands with Antiproliferative Properties
. ChemMedChem 17:7.
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Elena Bechthold, Julian A. Schreiber, Nadine Ritter, Lucie Grey, Dirk Schepmann, Constantin Daniliuc, Rafael González-Cano, Francisco Rafael Nieto, Guiscard Seebohm & Bernhard Wünsch. (2022) Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity. European Journal of Medicinal Chemistry 230, pages 114113.
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Giacomo Rossino, Marta Rui, Pasquale Linciano, Daniela Rossi, Massimo Boiocchi, Marco Peviani, Elena Poggio, Daniela Curti, Dirk Schepmann, Bernhard Wünsch, Mariela González-Avendaño, Ariela Vergara-Jaque, Julio Caballero & Simona Collina. (2021) Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization. Journal of Medicinal Chemistry 64:20, pages 14997-15016.
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Nicole Kopp, Gianluca Civenni, Domenico Marson, Erik Laurini, Sabrina Pricl, Carlo V. Catapano, Hans-Ulrich Humpf, Carmen Almansa, Francisco Rafael Nieto, Dirk Schepmann & Bernhard Wünsch. (2021) Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity. European Journal of Medicinal Chemistry 219, pages 113443.
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Abhilash Rana & Seema Bhatnagar. (2021) Advancements in folate receptor targeting for anti-cancer therapy: A small molecule-drug conjugate approach. Bioorganic Chemistry 112, pages 104946.
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Héctor Torres-Gómez, Constantin Daniliuc, Dirk Schepmann, Erik Laurini, Sabrina Pricl & Bernhard Wünsch. (2021) Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity. International Journal of Molecular Sciences 22:11, pages 5685.
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Elisabeth Kronenberg, Frauke Weber, Dirk Schepmann & Bernhard Wünsch. (2021)
Synthesis and
σ
receptor affinity of spiro[[2]benzopyran-1,1′-cyclohexanes] with an exocyclic amino moiety in the 3′-position
. RSC Medicinal Chemistry 12:2, pages 237-244.
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Nicole Kopp, Catharina Holtschulte, Frederik Börgel, Kirstin Lehmkuhl, Kristina Friedland, Gianluca Civenni, Erik Laurini, Carlo V. Catapano, Sabrina Pricl, Hans-Ulrich Humpf, Dirk Schepmann & Bernhard Wünsch. (2021) Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes. European Journal of Medicinal Chemistry 210, pages 112950.
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Roberta Listro, Silvia Stotani, Giacomo Rossino, Marta Rui, Alessio Malacrida, Guido Cavaletti, Michela Cortesi, Chiara Arienti, Anna Tesei, Daniela Rossi, Marcello Di Giacomo, Mariarosaria Miloso & Simona Collina. (2020) Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents. Frontiers in Chemistry 8.
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Pasquale Linciano, Giacomo Rossino, Roberta Listro, Daniela Rossi & Simona Collina. (2020) Sigma-1 receptor antagonists: promising players in fighting neuropathic pain. Pharmaceutical Patent Analyst 9:3, pages 77-85.
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Maria Revi. 2020. GeNeDis 2018. GeNeDis 2018
105
116
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Marta Rui, Giacomo Rossino, Daniela Rossi & Simona Collina. 2019. Emerging Drugs and Targets for Multiple Sclerosis. Emerging Drugs and Targets for Multiple Sclerosis
264
284
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Yukari Matsushima, Kazuki Terada, Chiaki Kamei & Yumi Sugimoto. (2019) Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor. European Journal of Pharmacology 853, pages 129-135.
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Hongmei Jia, Ying Zhang & Yiyun Huang. (2019) Imaging sigma receptors in the brain: New opportunities for diagnosis of Alzheimer’s disease and therapeutic development. Neuroscience Letters 691, pages 3-10.
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María Rodríguez-Muñoz, Yara Onetti, Elsa Cortés-Montero, Javier Garzón & Pilar Sánchez-Blázquez. (2018) Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Molecular Brain 11:1.
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Marta Rui, Giacomo Rossino, Stefania Coniglio, Stefania Monteleone, Arianna Scuteri, Alessio Malacrida, Daniela Rossi, Laura Catenacci, Milena Sorrenti, Mayra Paolillo, Daniela Curti, Letizia Venturini, Dirk Schepmann, Bernhard Wünsch, Klaus R. Liedl, Guido Cavaletti, Vittorio Pace, Ernst Urban & Simona Collina. (2018) Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. European Journal of Medicinal Chemistry 158, pages 353-370.
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Steven A. Barker. (2018) N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function. Frontiers in Neuroscience 12.
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Anna Tesei, Michela Cortesi, Alice Zamagni, Chiara Arienti, Sara Pignatta, Michele Zanoni, Mayra Paolillo, Daniela Curti, Marta Rui, Daniela Rossi & Simona Collina. (2018) Sigma Receptors as Endoplasmic Reticulum Stress “Gatekeepers” and their Modulators as Emerging New Weapons in the Fight Against Cancer. Frontiers in Pharmacology 9.
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Danielle O. Sambo, Joseph J. Lebowitz & Habibeh Khoshbouei. (2018) The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Pharmacology & Therapeutics 186, pages 152-167.
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Héctor Torres-Gómez, Constantin Daniliuc, Dirk Schepmann & Bernhard Wünsch. (2018) Synthesis of 3-aza[4.4.3]propellanes with high σ1 receptor affinity. Bioorganic & Medicinal Chemistry 26:8, pages 1705-1712.
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Emanuele Amata, Antonio Rescifina, Orazio Prezzavento, Emanuela Arena, Maria Dichiara, Valeria Pittalà, Ángeles Montilla-García, Francesco Punzo, Pedro Merino, Enrique J. Cobos & Agostino Marrazzo. (2017)
(+)-Methyl (1
R
,2
S
)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties
. Journal of Medicinal Chemistry 61:1, pages 372-384.
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Silvia Franchini, Claudia Sorbi, Umberto Maria Battisti, Annalisa Tait, Leda Ivanova Bencheva, Elena Cichero, Paola Fossa, Antonio Cilia, Orazio Prezzavento, Simone Ronsisvalle, Giuseppina Aricò, Luisa Benassi, Cristina Vaschieri, Paola Azzoni, Cristina Magnoni & Livio Brasili. (2017)
Structure-Activity Relationships within a Series of σ
1
and σ
2
Receptor Ligands: Identification of a σ
2
Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma
. ChemMedChem 12:22, pages 1893-1905.
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Simona Collina, Marta Rui, Silvia Stotani, Emanuele Bignardi, Daniela Rossi, Daniela Curti, Fabrizio Giordanetto, Alessio Malacrida, Arianna Scuteri & Guido Cavaletti. (2017) Are sigma receptor modulators a weapon against multiple sclerosis disease?. Future Medicinal Chemistry 9:17, pages 2029-2051.
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Daniela Rossi, Rita Nasti, Simona Collina, Giuseppe Mazzeo, Simone Ghidinelli, Giovanna Longhi, Maurizio Memo & Sergio Abbate. (2017) The role of chirality in a set of key intermediates of pharmaceutical interest, 3-aryl-substituted-γ-butyrolactones, evidenced by chiral HPLC separation and by chiroptical spectroscopies. Journal of Pharmaceutical and Biomedical Analysis 144, pages 41-51.
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Lena Fanter, Christoph Müller, Dirk Schepmann, Franz Bracher & Bernhard Wünsch. (2017) Chiral-pool synthesis of 1,2,4-trisubstituted 1,4-diazepanes as novel σ1 receptor ligands. Bioorganic & Medicinal Chemistry 25:17, pages 4778-4799.
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Tao Bai, Shuai Wang, Yipu Zhao, Rongtao Zhu, Weijie Wang & Yuling Sun. (2017) Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications 491:4, pages 919-925.
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Timur A. Mavlyutov, Huan Yang, Miles L. Epstein, Arnold E. Ruoho, Jay Yang & Lian-Wang Guo. (2017) APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum. Oncotarget 8:31, pages 51317-51330.
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Giacomo Rossino, Marta Rui, Marcello Di Giacomo, Daniela Rossi & Simona Collina. (2017) Synthesis of a drug discovery library for the identification of sigma receptors modulators. BioDiscovery 20, pages e14958.
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Simona Collina, Marta Rui, Giacomo Rossino, Serena Della Volpe, Daniela Rossi, Arianna Scuteri, Alessio Malacrida & Guido Cavaletti. (2017) Sigma 1 receptor modulators as a new weapon against multiple sclerosis. BioDiscovery 20, pages e14565.
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Ramesh Kandimalla & P. Hemachandra Reddy. (2017) Therapeutics of Neurotransmitters in Alzheimer’s Disease. Journal of Alzheimer's Disease 57:4, pages 1049-1069.
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Tetsuya Ezawa, Yuya Kawashima, Takuya Noguchi, Seunghee Jung & Nobuyuki Imai. (2017) Convenient synthesis of memantine analogues containing a chiral cyclopropane skeleton as a sigma-1 receptor agonist. Tetrahedron: Asymmetry 28:2, pages 266-281.
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Daniela Rossi, Marta Rui, Marcello Di Giacomo, Dirk Schepmann, Bernhard Wünsch, Stefania Monteleone, Klaus R. Liedl & Simona Collina. (2017) Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines. Bioorganic & Medicinal Chemistry 25:1, pages 11-19.
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J. M. Entrena, C. Sánchez-Fernández, F. R. Nieto, R. González-Cano, S. Yeste, E. J. Cobos & J. M. Baeyens. (2016) Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin. Scientific Reports 6:1.
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Huilin Liu, Jiaojiao Chen, Xingyan Jiang, Tao Wang, Xiaoyuan Xie, Hui Hu, Fang Yu, Xingzhi Wang & Handong Fan. (2016) Apoptotic signal pathways and regulatory mechanisms of cancer cells induced by IL-24. Wuhan University Journal of Natural Sciences 21:6, pages 519-530.
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Marta Rui, Daniela Rossi, Annamaria Marra, Mayra Paolillo, Sergio Schinelli, Daniela Curti, Anna Tesei, Michela Cortesi, Alice Zamagni, Erik Laurini, Sabrina Pricl, Dirk Schepmann, Bernhard Wűnsch, Ernst Urban, Vittorio Pace & Simona Collina. (2016) Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents. European Journal of Medicinal Chemistry 124, pages 649-665.
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Marta Rui, Annamaria Marra, Vittorio Pace, Markus Juza, Daniela Rossi & Simona Collina. (2016) Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment. Molecules 21:9, pages 1210.
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Theresa M. Carbonaro & Michael B. Gatch. (2016) Neuropharmacology of N,N-dimethyltryptamine. Brain Research Bulletin 126, pages 74-88.
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Annamaria Marra, Daniela Rossi, Lauretta Maggi, Federica Corana, Barbara Mannucci, Marco Peviani, Daniela Curti & Simona Collina. (2016)
Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for
in vivo
analysis of sigma1 receptor agonists
. Biomedical Chromatography 30:4, pages 645-651.
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Annamaria Marra, Daniela Rossi, Luca Pignataro, Chiara Bigogno, Annalisa Canta, Norberto Oggioni, Alessio Malacrida, Massimo Corbo, Guido Cavaletti, Marco Peviani, Daniela Curti, Giulio Dondio & Simona Collina. (2016)
Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (
R
)-RC-33, a promising Sigma1 receptor agonist
. Future Medicinal Chemistry 8:3, pages 287-295.
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Daniela Rossi, Annamaria Marra, Marta Rui, Stefania Brambilla, Markus Juza & Simona Collina. (2016) “Fit-for-purpose” development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ 1 receptor agonist. Journal of Pharmaceutical and Biomedical Analysis 118, pages 363-369.
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Anil Kumar, Arti Singh & Ekavali. (2015) A review on Alzheimer's disease pathophysiology and its management: an update. Pharmacological Reports 67:2, pages 195-203.
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Daniela Rossi, Annamaria Marra, Marta Rui, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl, Dirk Schepmann, Bernhard Wuensch, Marco Peviani, Daniela Curti & Simona Collina. (2015) A step forward in the sigma enigma: a role for chirality in the sigma1 receptor–ligand interaction?. MedChemComm 6:1, pages 138-146.
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Madhura Manohar, Samuel D. Banister, Corinne Beinat, James O'Brien-Brown & Michael Kassiou. (2015) Recent Advances in the Development of Sigma-1 Receptor Ligands. Australian Journal of Chemistry 68:4, pages 600.
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Mireille Happy, Jordan Dejoie, Cynthia K. Zajac, Briseida Cortez, Karabi Chakraborty, Joseph Aderemi & Moira Sauane. (2015) Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation. Biochemical and Biophysical Research Communications 456:2, pages 683-688.
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Luisa Quesada-Romero, Karel Mena-Ulecia, Matias Zuñiga, Pedro De-la-Torre, Daniela Rossi, William Tiznado, Simona Collina & Julio Caballero. (2015)
Optimal graph-based and Simplified Molecular Input Line Entry System-based descriptors for quantitative structure-activity relationship analysis of arylalkylaminoalcohols, arylalkenylamines, and arylalkylamines as σ
1
receptor ligands
. Journal of Chemometrics 29:1, pages 13-20.
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E.I. Solntseva, N.A. Kapai, O.V. Popova, P.D. Rogozin & V.G. Skrebitsky. (2014) The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide. Brain Research Bulletin 106, pages 56-61.
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Peer Hasebein, Bastian Frehland, Dirk Schepmann & Bernhard Wünsch. (2014) Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5-Phenylsulfanyl- and 5-Benzyl-Substituted Tetrahydro-2-benzazepines. ChemMedChem, pages n/a-n/a.
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Carmen Almansa & José Miguel Vela. (2014) Selective sigma-1 receptor antagonists for the treatment of pain. Future Medicinal Chemistry 6:10, pages 1179-1199.
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S. Brune, D. Schepmann, K.-H. Klempnauer, D. Marson, V. Dal Col, E. Laurini, M. Fermeglia, B. Wünsch & S. Pricl. (2014)
The Sigma Enigma:
In Vitro
/
in Silico
Site-Directed Mutagenesis Studies Unveil σ
1
Receptor Ligand Binding
. Biochemistry 53:18, pages 2993-3003.
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DONG-AN SU, RI-YUE JIANG, NING LIU, LIANG-CAI DING, DA-MING WANG, HAI-YING YU, EN-SHI YAN, MEI-HUA ZHU & BIN ZHU. (2014) Effects of BD1047, a σ1 receptor antagonist, on the expression of mTOR, Camk2γ and GSK-3β in fluvoxamine-treated N2a cells. Experimental and Therapeutic Medicine 7:2, pages 435-438.
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R. Anand, Kiran Dip Gill & Abbas Ali Mahdi. (2014) Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology 76, pages 27-50.
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Mauro Niso, Carmen Abate, Marialessandra Contino, Savina Ferorelli, Amalia Azzariti, Roberto Perrone, Nicola Antonio Colabufo & Francesco Berardi. (2013) Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity. ChemMedChem 8:12, pages 2026-2035.
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Daniela Rossi, Alice Pedrali, Annamaria Marra, Luca Pignataro, Dirk Schepmann, Bernhard Wünsch, Lian Ye, Kristina Leuner, Marco Peviani, Daniela Curti, Ornella Azzolina & Simona Collina. (2013) Studies on the Enantiomers of as Neuroprotective Agents: Isolation, Configurational Assignment, and Preliminary Biological Profile. Chirality 25:11, pages 814-822.
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Winchie Do, Cynthia Herrera, Jason Mighty, Maria Shumskaya, Stephen M. Redenti & Moira Sauane. (2013) Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis. Biochemical and Biophysical Research Communications 439:2, pages 215-220.
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Ede Frecska, Attila Szabo, Michael J. Winkelman, Luis E. Luna & Dennis J. McKenna. (2013) A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity. Journal of Neural Transmission 120:9, pages 1295-1303.
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