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Expert Opinion on Therapeutic Patents Volume 23, 2013 - Issue 11
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β-Lactamase inhibitors: a review of the patent literature (2010 – 2013)

John D BuynakSouthern Methodist University, Department of Chemistry, Dallas, TX 75275, [email protected]
Pages 1469-1481 | Published online: 23 Aug 2013

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Shazi Shakil, Syed M. Danish Rizvi & Nigel H. Greig. (2023) In depth molecular interaction analyses of the complex of a proposed CTXM-inhibitor bound to the bacterial enzyme. Journal of Biomolecular Structure and Dynamics 41:17, pages 8362-8372.
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Elsa Denakpo, Thierry Naas & Bogdan I. Iorga. (2023) An updated patent review of metallo-β-lactamase inhibitors (2020–2023). Expert Opinion on Therapeutic Patents 33:7-8, pages 523-538.
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Elsa Denakpo, Guillaume Arlet, Alain Philippon & Bogdan I. Iorga. 2024. Metalloenzymes. Metalloenzymes 157 184 .
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Pierre-Alexandre Paquet-Côté, Lorea Alejaldre, Camille Lapointe Verreault, Sophie M.C. Gobeil, Rosalie Lamoureux, Laurie Bédard, Charles-Olivier Normandeau, Claudèle Lemay-St-Denis, Joelle N. Pelletier & Normand Voyer. (2021) Development of sulfahydantoin derivatives as β-lactamase inhibitors. Bioorganic & Medicinal Chemistry Letters 35, pages 127781.
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Ajmer Singh Grewal, Komal Thapa, Neelam Sharma & Sukhbir Singh. (2020) New Delhi metallo-β-lactamase-1 inhibitors for combating antibiotic drug resistance: recent developments. Medicinal Chemistry Research 29:8, pages 1301-1320.
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Raquel Ferrer-Espada, Susana Sánchez-Gómez, Betsey Pitts, Philip S. Stewart & Guillermo Martínez-de-Tejada. (2020) Permeability enhancers sensitize β-lactamase-expressing Enterobacteriaceae and Pseudomonas aeruginosa to β-lactamase inhibitors, thereby restoring their β-lactam susceptibility. International Journal of Antimicrobial Agents 56:1, pages 105986.
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Anete Parkova, Anka Lucic, Alen Krajnc, Jürgen Brem, Karina Calvopiña, Gareth W. Langley, Michael A. McDonough, Peteris Trapencieris & Christopher J. Schofield. (2019) Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. ACS Infectious Diseases 6:6, pages 1398-1404.
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Laure Peilleron & Kevin Cariou. (2020) Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors. Organic & Biomolecular Chemistry 18:5, pages 830-844.
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En Zhang, Ming-Ming Wang, Shu-Chao Huang, Shuai-Min Xu, De-Yun Cui, Yuan-Li Bo, Peng-Yan Bai, Yong-Gang Hua, Chun-Ling Xiao & Shangshang Qin. (2018) NOTA analogue: A first dithiocarbamate inhibitor of metallo-β-lactamases. Bioorganic & Medicinal Chemistry Letters 28:2, pages 214-221.
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Kamaleddin Haj Mohammad Ebrahim Tehrani & Nathaniel I. Martin. (2017) Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem. ACS Infectious Diseases 3:10, pages 711-717.
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Jian Zhang, Sanshan Wang, Qi Wei, Qianqian Guo, Yingjie Bai, Shaoqiang Yang, Fuhang Song, Lixin Zhang & Xiaoguang Lei. (2017) Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance. Bioorganic & Medicinal Chemistry 25:19, pages 5133-5141.
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Prarthana Devi & Peter J. Rutledge. (2017) Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?. ChemBioChem 18:4, pages 338-351.
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Paul W Groundwater, Sophia Xu, Felcia Lai, Linda Váradi, Jinlong Tan, John D Perry & David E Hibbs. (2016) New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers. Future Medicinal Chemistry 8:9, pages 993-1012.
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Ilaria Pettinati, Jürgen Brem, Sook Y. Lee, Peter J. McHugh & Christopher J. Schofield. (2016) The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins. Trends in Biochemical Sciences 41:4, pages 338-355.
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Daohong Liao, Shaoqiang Yang, Jianyu Wang, Jian Zhang, Benke Hong, Fan Wu & Xiaoguang Lei. (2016) Total Synthesis and Structural Reassignment of Aspergillomarasmine A. Angewandte Chemie International Edition 55:13, pages 4291-4295.
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Daohong Liao, Shaoqiang Yang, Jianyu Wang, Jian Zhang, Benke Hong, Fan Wu & Xiaoguang Lei. (2016) Total Synthesis and Structural Reassignment of Aspergillomarasmine A. Angewandte Chemie 128:13, pages 4363-4367.
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Jürgen Brem, Sander S. van Berkel, David Zollman, Sook Y. Lee, Opher Gileadi, Peter J. McHugh, Timothy R. Walsh, Michael A. McDonough & Christopher J. Schofield. (2016) Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers. Antimicrobial Agents and Chemotherapy 60:1, pages 142-150.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 573 643 .
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I. Pettinati, J. Brem, M. A. McDonough & C. J. Schofield. (2015) Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Human Molecular Genetics 24:9, pages 2458-2469.
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Francisco José Pérez-Llarena, Laura Zamorano, Frédéric Kerff, Alejandro Beceiro, Patricia García, Elisenda Miró, Nieves Larrosa, Frederic Gómez-Bertomeu, José Antonio Méndez, Juan José González-López, Antonio Oliver, Moreno Galleni, Ferran Navarro & Germán Bou. (2014) Genetic and Kinetic Characterization of the Novel AmpC β-Lactamases DHA-6 and DHA-7. Antimicrobial Agents and Chemotherapy 58:11, pages 6544-6549.
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Andrew M. King, Sarah A. Reid-Yu, Wenliang Wang, Dustin T. King, Gianfranco De Pascale, Natalie C. Strynadka, Timothy R. Walsh, Brian K. Coombes & Gerard D. Wright. (2014) Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance. Nature 510:7506, pages 503-506.
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Sarah M. Drawz, Krisztina M. Papp-Wallace & Robert A. Bonomo. (2014) New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World. Antimicrobial Agents and Chemotherapy 58:4, pages 1835-1846.
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