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Expert Opinion on Therapeutic Patents Volume 24, 2014 - Issue 7
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Oligonucleotide delivery: a patent review (2010 – 2013)

Santiago GrijalvoInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), and Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Department of Chemical and Biomolecular Nanotechnology, Jordi Girona 18-26, 08034 Barcelona, Spain+34 934006145; +34 932045904; [email protected]
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Anna AviñóInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), and Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Department of Chemical and Biomolecular Nanotechnology, Jordi Girona 18-26, 08034 Barcelona, Spain+34 934006145; +34 932045904; [email protected]
&
Ramon EritjaInstitute for Advanced Chemistry of Catalonia (IQAC-CSIC), and Networking Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Department of Chemical and Biomolecular Nanotechnology, Jordi Girona 18-26, 08034 Barcelona, Spain+34 934006145; +34 932045904; [email protected]
Pages 801-819 | Published online: 05 May 2014

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Xia He, Da-Fang Wu, Jun Ji, Wen-ping Ling, Xiao-ling Chen & Yue-Xuan Chen. (2016) Ultrasound microbubble-carried PNA targeting to c-myc mRNA inhibits the proliferation of rabbit iliac arterious smooth muscle cells and intimal hyperplasia. Drug Delivery 23:7, pages 2482-2487.
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Zhi Fang, Lin-Yan Wan, Liang-Yin Chu, Yan-Qiong Zhang & Jiang-Feng Wu. (2015) ‘Smart’ nanoparticles as drug delivery systems for applications in tumor therapy. Expert Opinion on Drug Delivery 12:12, pages 1943-1953.
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Marina A Dobrovolskaia & Scott E McNeil. (2015) Strategy for selecting nanotechnology carriers to overcome immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics. Expert Opinion on Drug Delivery 12:7, pages 1163-1175.
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Anna Kaczmarek, Svenja Schneider, Brunhilde Wirth & Markus Riessland. (2015) Investigational therapies for the treatment of spinal muscular atrophy. Expert Opinion on Investigational Drugs 24:7, pages 867-881.
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Paulina Wyrozumska, Justyna Meissner, Monika Toporkiewicz, Marta Szarawarska, Kazimierz Kuliczkowski, Maciej Ugorski, Marta A Walasek & Aleksander F Sikorski. (2015) Liposome-coated lipoplex–based carrier for antisense oligonucleotides. Cancer Biology & Therapy 16:1, pages 66-76.
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Pooja Khairnar, Tejaswini Kolipaka, Giriraj Pandey, Vivek Phatale, Saurabh Shah, Dadi A. Srinivasarao, Shailendra Saraf & Saurabh Srivastava. (2024) Nanosponge-mediated oligonucleotide delivery: A cutting-edge technology towards cancer management. Journal of Drug Delivery Science and Technology 91, pages 105226.
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Dmytro HoncharenkoCristina S.J. Rocha, Karin E. LundinJyotirmoy MaityStefan MiltonUlf TedebarkMerita MurtolaMalgorzata HoncharenkoAndis SlaitasC.I. Edvard SmithRula ZainRoger Strömberg. (2022) 2′- O -( N -(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity . Nucleic Acid Therapeutics 32:3, pages 221-233.
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Maryam Teimouri, Hossein Hosseini, Zahra ArabSadeghabadi, Reyhaneh Babaei-Khorzoughi, Sattar Gorgani-Firuzjaee & Reza Meshkani. (2022) The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications. Journal of Physiology and Biochemistry 78:2, pages 307-322.
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Manuel Hawner & Christian Ducho. (2020) Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules. Molecules 25:24, pages 5963.
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Alexander Batista-Duharte, Luis Sendra, Maria Herrero, Damiana Téllez-Martínez, Iracilda Carlos & Salvador Aliño. (2020) Progress in the Use of Antisense Oligonucleotides for Vaccine Improvement. Biomolecules 10:2, pages 316.
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Anjuman A. Begum, Istvan Toth, Waleed M. Hussein & Peter M. Moyle. (2019) Advances in Targeted Gene Delivery. Current Drug Delivery 16:7, pages 588-608.
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Xin Xia, Zhun Zhou, Chris DeSantis, John J. Rossi & Dennis Bong. (2019) Triplex Hybridization of siRNA with Bifacial Glycopolymer Nucleic Acid Enables Hepatocyte-Targeted Silencing. ACS Chemical Biology 14:6, pages 1310-1318.
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Pedro M.D. Moreno, Ana R. Ferreira, Daniela Salvador, Maria T. Rodrigues, Marília Torrado, Eva D. Carvalho, Ulf Tedebark, Mónica M. Sousa, Isabel F. Amaral, Jesper Wengel & Ana P. Pêgo. (2018) Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury. Molecular Therapy - Nucleic Acids 11, pages 393-406.
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Fumito WadaTsuyoshi YamamotoTetsuya UedaMotoki SawamuraShunsuke WadaMariko Harada-ShibaSatoshi Obika. (2018) Cholesterol–GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides. Nucleic Acid Therapeutics 28:1, pages 50-57.
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Elena Zavyalova & Alexey Kopylov. 2018. Nanostructures for the Engineering of Cells, Tissues and Organs. Nanostructures for the Engineering of Cells, Tissues and Organs 249 290 .
Valentina Sardone, Haiyan Zhou, Francesco Muntoni, Alessandra Ferlini & Maria Falzarano. (2017) Antisense Oligonucleotide-Based Therapy for Neuromuscular Disease. Molecules 22:4, pages 563.
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Peter T. Altenbuchner, Patrick D. L. Werz, Patricia Schöppner, Friederike Adams, Alexander Kronast, Christina Schwarzenböck, Alexander Pöthig, Christian Jandl, Martin Haslbeck & Bernhard Rieger. (2016) Next Generation Multiresponsive Nanocarriers for Targeted Drug Delivery to Cancer Cells. Chemistry - A European Journal 22:41, pages 14576-14584.
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Pınar Akkuş Süt, Melike Belenli, Özlem Şen, Melis Emanet, Mine Altunbek & Mustafa Çulha. 2016. Advanced Surface Engineering Materials. Advanced Surface Engineering Materials 297 347 .
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Shunsuke Wada, Hidenori Yasuhara, Fumito Wada, Motoki Sawamura, Reiko Waki, Tsuyoshi Yamamoto, Mariko Harada-Shiba & Satoshi Obika. (2016) Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides. Journal of Controlled Release 226, pages 57-65.
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Durga Pokharel & Shiyue Fang. (2016) Polymerizable phosphoramidites with an acid-cleavable linker for eco-friendly synthetic oligodeoxynucleotide purification. Green Chemistry 18:4, pages 1125-1136.
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Xiaomeng Huang, Mengzi Zhang, Xinmei Wang, L. James Lee & Robert J. Lee. 2016. Non-Viral Gene Delivery Vectors. Non-Viral Gene Delivery Vectors 201 213 .
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Vivek K Sharma & Jonathan K Watts. (2015) Oligonucleotide therapeutics: chemistry, delivery and clinical progress. Future Medicinal Chemistry 7:16, pages 2221-2242.
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Annabelle Biscans, Sonia Rouanet, Jean-Rémi Bertrand, Jean-Jacques Vasseur, Christelle Dupouy & Françoise Debart. (2015) Synthesis, binding, nuclease resistance and cellular uptake properties of 2′- O -acetalester-modified oligonucleotides containing cationic groups. Bioorganic & Medicinal Chemistry 23:17, pages 5360-5368.
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Zhun Zhou, Xin Xia & Dennis Bong. (2015) Synthetic Polymer Hybridization with DNA and RNA Directs Nanoparticle Loading, Silencing Delivery, and Aptamer Function. Journal of the American Chemical Society 137:28, pages 8920-8923.
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S.D. Wilton, R.N. Veedu & S. Fletcher. (2015) The emperor's new dystrophin: finding sense in the noise. Trends in Molecular Medicine 21:7, pages 417-426.
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Adele Alagia, Montserrat Terrazas & Ramon Eritja. (2015) Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units. Molecules 20:5, pages 7602-7619.
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Sandra Paola Sánchez-Rodríguez, Joana Valeria Enrriquez-Avila, Juan Miguel Soto-Fajardo, Carolina Peña-Montes & Ismael Bustos-Jaimes. (2014) In Vitro Encapsulation of Heterologous dsDNA Into Human Parvovirus B19 Virus-Like Particles. Molecular Biotechnology 57:4, pages 309-317.
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