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Calpain inhibitors as potential treatment for stroke and other neurodegenerative diseases: recent trends and developments

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Pages 1707-1727 | Published online: 25 Feb 2005

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Levente Endre Dókus, Mo’ath Yousef & Zoltán Bánóczi. (2020) Modulators of calpain activity: inhibitors and activators as potential drugs. Expert Opinion on Drug Discovery 15:4, pages 471-486.
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Jesse S. Dondapati, Sudhakar Godi & Ajay P. Babu. (2008) QSAR studies on peptide α-ketoamides and α-ketohydroxamate derivatives as calpain I inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 23:6, pages 757-762.
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Rodney Guttmann. (2007) Recent developments in the therapeutic targeting of calpains in neurodegeneration. Expert Opinion on Therapeutic Patents 17:10, pages 1203-1213.
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Articles from other publishers (32)

Dhira Joshi, Jennifer C. Milligan, Theresa U. Zeisner, Nicola O'Reilly, John F. X. Diffley & George Papageorgiou. (2021) An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques. RSC Advances 11:33, pages 20457-20464.
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Omid Reza Tamtaji, Naghmeh Mirhosseini, Russel J. Reiter, Abolfazl Azami & Zatollah Asemi. (2018) Melatonin, a calpain inhibitor in the central nervous system: Current status and future perspectives. Journal of Cellular Physiology 234:2, pages 1001-1007.
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Ashok D. Pehere, Steven Nguyen, Sarah K. Garlick, Danny W. Wilson, Irene Hudson, Matthew J. Sykes, James D. Morton & Andrew D. Abell. (2019) Tripeptide analogues of MG132 as protease inhibitors. Bioorganic & Medicinal Chemistry 27:2, pages 436-441.
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Fany BlancLaetitia FurioDorothée MoisyHui-Ling YenMichel ChignardEmmanuel LetavernierNadia NaffakhChris Ka Pun MokMustapha Si-Tahar. (2016) Targeting host calpain proteases decreases influenza A virus infection. American Journal of Physiology-Lung Cellular and Molecular Physiology 310:7, pages L689-L699.
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Jing Fan, Clare M. Gladding, Liang Wang, Lily Y.J. Zhang, Alexandra M. Kaufman, Austen J. Milnerwood & Lynn A. Raymond. (2012) P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiology of Disease 45:3, pages 999-1009.
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Donald J. AbrahamPhilippe G. Nantermet, Evan F. Shalen, Shankar Venkatraman, Hong Zhu & Robert J. Mark. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 447 828 .
Jian Xu, Pradeep Kurup, Yongfang Zhang, Susan M. Goebel-Goody, Peter H. Wu, Ammar H. Hawasli, Matthew L. Baum, James A. Bibb & Paul J. Lombroso. (2009) Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP. The Journal of Neuroscience 29:29, pages 9330-9343.
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José Pfizer, Irmgard Assfalg-Machleidt, Werner Machleidt & Norbert Schaschke. (2008) Inhibition of human μ-calpain by conformationally constrained calpastatin peptides. bchm 389:1, pages 83-90.
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Yoshihisa ShirasakiMasazumi YamaguchiHiroyuki Miyashita. (2006) Retinal Penetration of Calpain Inhibitors in Rats After Oral Administration. Journal of Ocular Pharmacology and Therapeutics 22:6, pages 417-424.
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Yoshihisa Shirasaki, Hiroyuki Miyashita & Masazumi Yamaguchi. (2006) Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety. Bioorganic & Medicinal Chemistry 14:16, pages 5691-5698.
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Yoshihisa Shirasaki, Masayuki Nakamura, Masazumi Yamaguchi, Hiroyuki Miyashita, Osamu Sakai & Jun Inoue. (2006) Exploration of Orally Available Calpain Inhibitors 2:  Peptidyl Hemiacetal Derivatives. Journal of Medicinal Chemistry 49:13, pages 3926-3932.
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M. Lee Sanders & Isaac O. Donkor. (2006) A novel series of urea-based peptidomimetic calpain inhibitors. Bioorganic & Medicinal Chemistry Letters 16:7, pages 1965-1968.
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Cyrille Lescop, Holger Herzner, Hervé Siendt, Reto Bolliger, Marco Henneböhle, Philipp Weyermann, Alexandre Briguet, Isabelle Courdier-Fruh, Michael Erb, Mark Foster, Thomas Meier, Josef P. Magyar & Andreas von Sprecher. (2005) Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy. Bioorganic & Medicinal Chemistry Letters 15:23, pages 5176-5181.
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M. Windisch, B. Hutter-Paier, E. Grygar, E. Doppler & H. Moessler. (2005) N-PEP-12 – a novel peptide compound that protects cortical neurons in culture against different age and disease associated lesions. Journal of Neural Transmission 112:10, pages 1331-1343.
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Yoshihisa Shirasaki, Hiroyuki Miyashita, Masazumi Yamaguchi, Jun Inoue & Masayuki Nakamura. (2005) Exploration of orally available calpain inhibitors: Peptidyl α-ketoamides containing an amphiphile at P3 site. Bioorganic & Medicinal Chemistry 13:14, pages 4473-4484.
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Mayana Zatz & Alessandra Starling. (2005) Calpains and Disease. New England Journal of Medicine 352:23, pages 2413-2423.
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Yibin Zeng, Qingshan Li, Robert P. Hanzlik & Jeffrey Aubé. (2005) Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorganic & Medicinal Chemistry Letters 15:12, pages 3034-3038.
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Ron Bihovsky, Ming Tao, John P. Mallamo & Gregory J. Wells. (2004) 1,2-Benzothiazine 1,1-dioxide α-ketoamide analogues as potent calpain I inhibitors. Bioorganic & Medicinal Chemistry Letters 14:4, pages 1035-1038.
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Isaac O. Donkor, Jie Han & Xiaozhang Zheng. (2003) Design, Synthesis, Molecular Modeling Studies, and Calpain Inhibitory Activity of Novel α-Ketoamides Incorporating Polar Residues at the P 1 ‘-Position . Journal of Medicinal Chemistry 47:1, pages 72-79.
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DARREL E. GOLL, VALERY F. THOMPSON, HONGQI LI, WEI WEI & JINYANG CONG. (2003) The Calpain System. Physiological Reviews 83:3, pages 731-801.
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Wilfried Lubisch, Edith Beckenbach, Sabina Bopp, Hans-Peter Hofmann, Arzu Kartal, Claudia Kästel, Tanja Lindner, Marion Metz-Garrecht, Jutta Reeb, Ferdinand Regner, Michael Vierling & Achim Möller. (2003) Benzoylalanine-Derived Ketoamides Carrying Vinylbenzyl Amino Residues:  Discovery of Potent Water-Soluble Calpain Inhibitors with Oral Bioavailability. Journal of Medicinal Chemistry 46:12, pages 2404-2412.
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Isaac O. Donkor, Rajani Korukonda, Tien L. Huang & Louis LeCourJr.Jr.. (2003) Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics. Bioorganic & Medicinal Chemistry Letters 13:5, pages 783-784.
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W. Lubisch & A. Möller. (2002) Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors. Bioorganic & Medicinal Chemistry Letters 12:10, pages 1335-1338.
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Gregory J. Wells, Ming Tao, Kurt A. Josef & Ron Bihovsky. (2001) 1,2-Benzothiazine 1,1-Dioxide P 2 −P 3 Peptide Mimetic Aldehyde Calpain I Inhibitors . Journal of Medicinal Chemistry 44:21, pages 3488-3503.
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Kurt A Josef, Frederick W Kauer & Ron Bihovsky. (2001) Potent peptide α-Ketohydroxamate inhibitors of recombinant human calpain I. Bioorganic & Medicinal Chemistry Letters 11:19, pages 2615-2617.
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Isaac O. Donkor, Xiaozhang Zheng, Jie Han, Calvin Lacy & Duane D. Miller. (2001) Significance of Hydrogen Bonding at the S1′ Subsite of Calpain I. Bioorganic & Medicinal Chemistry Letters 11:13, pages 1753-1755.
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Donald L. Mykles. 2001. Apoptosis. Apoptosis 247 287 .
Marc R. Del Bigio. (2000) Calcium-Mediated Proteolytic Damage in White Matter of Hydrocephalic Rats?. Journal of Neuropathology & Experimental Neurology 59:11, pages 946-954.
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Isaac O Donkor, Xiaozhang Zheng & Duane D Miller. (2000) Synthesis and calpain inhibitory activity of α-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position. Bioorganic & Medicinal Chemistry Letters 10:22, pages 2497-2500.
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Rabindranath Tripathy, Mark A. Ator & John P. Mallamo. (2000) Calpain inhibitors based on the quiescent affinity label concept: high rates of calpain inactivation with leaving groups derived from N-hydroxy peptide coupling reagents. Bioorganic & Medicinal Chemistry Letters 10:20, pages 2315-2319.
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W. Lubisch, H.P. Hofmann, H.J. Treiber & A. Möller. (2000) Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors. Bioorganic & Medicinal Chemistry Letters 10:19, pages 2187-2191.
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Norton P. Peet, Hwa-Ok Kim, Angela L. Marquart, Michael R. Angelastro, Thaddeus R. Nieduzak, Julie N. White, Dirk Friedrich, Gary A. Flynn, Mark E. Webster, Roy J. Vaz, Matthew D. Linnik, Jack R. Koehl, Shujaath Mehdi, Philippe Bey, Bart Emary & Kin-Kai Hwang. (1999) Hydroxyoxazolidines as α-aminoacetaldehyde equivalents: Novel inhibitors of calpain. Bioorganic & Medicinal Chemistry Letters 9:16, pages 2365-2370.
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