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Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

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Pages 573-584 | Published online: 24 Apr 2009

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Crossref
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Crossref
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Crossref
Rajiv R Ratan. (2009) Epigenetics and the nervous system: epiphenomenon or missing piece of the neurotherapeutic puzzle?. The Lancet Neurology 8:11, pages 975-977.
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