503
Views
61
CrossRef citations to date
0
Altmetric
Reviews

Targeting IL-6 in the treatment of inflammatory and autoimmune diseases

, MD, , PhD, , MD & , MD
Pages 1457-1466 | Published online: 28 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Nguyen Phuong Thao, Bui Thi Thuy Luyen, Jung Eun Koo, Sohyun Kim, Young Sang Koh, Nguyen Van Thanh, Nguyen Xuan Cuong, Phan Van Kiem, Chau Van Minh & Young Ho Kim. (2016) In vitro anti-inflammatory components isolated from the carnivorous plant Nepenthes mirabilis (Lour.) Rafarin. Pharmaceutical Biology 54:4, pages 588-594.
Read now
Hong-Yu Yuan, Xiao-Lan Zhang, Xue-Hui Zhang, Ling Meng & Ji-Fu Wei. (2015) Analysis of patents on anti-rheumatoid arthritis therapies issued in China. Expert Opinion on Therapeutic Patents 25:8, pages 909-930.
Read now
Thanh-Huyen Tran & Mansoor M Amiji. (2015) Targeted delivery systems for biological therapies of inflammatory diseases. Expert Opinion on Drug Delivery 12:3, pages 393-414.
Read now
Ian P Salt & Timothy M Palmer. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs 21:8, pages 1155-1167.
Read now

Articles from other publishers (57)

Júlia Leão Batista Simões, Geórgia de Carvalho Braga, Tamíres Hillesheim Mittelmann & Margarete Dulce Bagatini. (2024) Current Pharmacology and Modulation of the Purinergic System in Takotsubo Syndrome Triggered by Cytokine Storm. Current Problems in Cardiology 49:1, pages 102019.
Crossref
Mariarita Brancaccio, Alfonsina Milito, Carla Alexandra Viegas, Anna Palumbo, Dina Costa Simes & Immacolata Castellano. (2022) First evidence of dermo-protective activity of marine sulfur-containing histidine compounds. Free Radical Biology and Medicine 192, pages 224-234.
Crossref
Chieh Liu, Yi-Fen Shih & Chun-Jen Liu. (2022) Immunopathogenesis of Acute Flare of Chronic Hepatitis B: With Emphasis on the Role of Cytokines and Chemokines. International Journal of Molecular Sciences 23:3, pages 1407.
Crossref
Haojie Chen, Hao Ji, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin & Da Sun. (2021) Bacterial Ghosts-Based Vaccine and Drug Delivery Systems. Pharmaceutics 13:11, pages 1892.
Crossref
Jung-Soon Han. (2021) Nutritional Value and Anti-inflammation Activity of Misutkaru with Added Gryllus bimaculatus Powder. Asian Journal of Beauty and Cosmetology 19:3, pages 467-476.
Crossref
Chiara Galeaz, Cristina Totis & Alessandra Bisio. (2021) Radiation Resistance: A Matter of Transcription Factors. Frontiers in Oncology 11.
Crossref
Bradley G. Phillips, Ye Wang, Suresh Ambati, Ping Ma & Richard B. Meagher. (2020) Airways therapy of obstructive sleep apnea dramatically improves aberrant levels of soluble cytokines involved in autoimmune disease. Clinical Immunology 221, pages 108601.
Crossref
Jin A Hyun, Ji Hye Lee, Eun Bin Kang, Hyun Jeong Kim, Dong In Kim, Ga Eun Park, Ki Sung Kwak & Bong Jeon An. (2020) Validation of pharmacological activity and anti-pollution effect of ethanol extract of Azadirachta indica leaf. Korean Journal of Food Preservation 27:3, pages 393-406.
Crossref
Koth-Bong-Woo-Ri Kim, So-Mi Jeong, Da-Hyun Jeong, Min-Ji Kim & Dong-Hyun Ahn. (2020) Anti-inflammatory Effects of Sargachromanol I, Sargachromanol G, and Saringosterol from Hexane Fraction of Myagropsis myagroides. Biotechnology and Bioprocess Engineering 25:1, pages 16-21.
Crossref
Lauren M. Osborne, Gayane Yenokyan, Kezhen Fei, Thomas Kraus, Thomas Moran, Catherine Monk & Rhoda Sperling. (2019) Innate immune activation and depressive and anxious symptoms across the peripartum: An exploratory study. Psychoneuroendocrinology 99, pages 80-86.
Crossref
Man-ka Zhang, Hui-min Ma, Jian Zhang, Xin-cheng Song, Xiao-hui Ye, Yu-feng Li, Yi-fan Zhang, Ling-ling He, Hong-shan Wei & Xin Li. (2018) Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A. Cellular Immunology 331, pages 9-15.
Crossref
Dong In Kim, Hyun Jung Kim, Ji Hye Lee, So Jung Han, Ha Eun Kim, Kang Soo Park, Hyo Jin Kim, Jeong Hee Nam, Gyeong Yup Chi & Bong Jeun An. (2018) Anti-inflammation effect of hardy kiwifruit (Actinidia arguta) extract in lipopolysaccharide-stimulated macrophages by suppressing NF-kappaB pathway. Korean Journal of Food Preservation 25:5, pages 564-573.
Crossref
Dong In Kim, Hyun Jung Kim, Jong Moon Yun, Ji Hye Lee, So Jung Han, Ha Eun Kim, Min Jung Jang & Bong Jeun An. (2018) Anti-inflammation effect of blueberry (Vaccinium ashei) leaf extract on RAW 264.7 macrophages stimulated by lipopolysaccharide. Korean Journal of Food Preservation 25:1, pages 107-116.
Crossref
Bangxing YuGuoxing ZhangYi AnWen Wang. (2018) Morroniside on anti-inflammation activities in rats following acute myocardial infarction. The Korean Journal of Physiology & Pharmacology 22:1, pages 17.
Crossref
Srinath Kasturirangan, G. Jonah Rainey, Linda Xu, Xinwei Wang, Alyse Portnoff, Tracy Chen, Christine Fazenbaker, Helen Zhong, Jared Bee, Zhutian Zeng, Craig Jenne, Herren Wu & Changshou Gao. (2017) Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody. Journal of Biological Chemistry 292:10, pages 4361-4370.
Crossref
Dilyara Akberova, Andrei P. Kiassov & Diana Abdulganieva. (2017) Serum Cytokine Levels and Their Relation to Clinical Features in Patients with Autoimmune Liver Diseases. Journal of Immunology Research 2017, pages 1-7.
Crossref
Jae-Myo Yu, Jae-Yoon Jang, Hyeon-Jeong Kim, Yong-Hun Cho, Dong-in Kim, O-jun Kwon, Yeong-Je Cho & Bong-Jeun An. (2016) Antioxidant capacity and Raw 264.7 macrophage anti-inflammatory effect of the Tenebrio Molitor. Korean Journal of Food Preservation 23:6, pages 890-898.
Crossref
Zi-Jian Zhao, Chang Zhao, Jing Xiao & Jian-Cheng Wang. (2016) Transdermal Permeation and Anti-Inflammation Activities of Novel Sinomenine Derivatives. Molecules 21:11, pages 1520.
Crossref
Su-Gyeong Lee & Moon-Moo Kim. (2015) Anti-inflammatory Effect of Scopoletin in RAW264.7 Macrophages. Journal of Life Science 25:12, pages 1377-1383.
Crossref
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Jung Eun Koo, Sohyun Kim, Young Sang Koh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, Young Ho Kim & Chau Van Minh. (2015) Anti-inflammatory components of the Vietnamese starfish Protoreaster nodosus. Biological Research 48:1.
Crossref
Weon-Jong Yoon, Sang Mok Song, Young-Min Ham, Dae-Ju Oh, Chang-Sik Ko, Sun-A Yoon, Yong-Bum Lee, Dae Won Park, Yong Joon Jeong, Jung Eun Kwon, Young-Mi Cho, Ju-Hyun Cho, Chang-Sook Kim & Se Chan Kang. (2015) Anti-osteoarthritis Effects on Fruit Extract of Litsea japonica. Korean Journal of Plant Resources 28:5, pages 591-599.
Crossref
Monica Guma, Yun Wang, Benoit Viollet & Ru Liu-Bryan. (2015) AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. PLOS ONE 10:10, pages e0140452.
Crossref
Michael J. Hansen, N. Achini Bandara & Philip S. Low. (2015) Folate receptor expression on murine and human adipose tissue macrophages. Inflammation Research 64:9, pages 697-706.
Crossref
Meghna Talekar, Thanh-Huyen Tran & Mansoor Amiji. (2015) Translational Nano-Medicines: Targeted Therapeutic Delivery for Cancer and Inflammatory Diseases. The AAPS Journal 17:4, pages 813-827.
Crossref
Yeong-Jong Ko, Sang Mok Song, Woo-Chol Hyun, Soo-Kyung Yang, Chang-Khil Song, Dong-Sun Lee & Weon-Jong Yoon. (2014) Anti-inflammatory Effect of Castanopsis cuspidata Extracts in Murine Macrophage RAW 264.7 Cells. Korean Journal of Plant Resources 27:5, pages 439-446.
Crossref
Graeme Jones & Changhai Ding. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 2023 2040 .
Benoit Le Goff, Sofie Singbrant, Brett A. Tonkin, T. John Martin, Evange Romas, Natalie A. Sims & Nicole C. Walsh. (2014) Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine 68:2, pages 101-109.
Crossref
Cinzia Cantacessi, Andreas Hofmann, Darren Pickering, Severine Navarro, Makedonka Mitreva & Alex Loukas. (2013) TIMPs of parasitic helminths – a large-scale analysis of high-throughput sequence datasets. Parasites & Vectors 6:1.
Crossref
Saif Ahmad, Nadeem Fatteh, Nehal M. El-Sherbiny, Mohammad Naime, Ahmed S. Ibrahim, Ahmed M. El-Sherbini, Sally A. El-Shafey, Sohail Khan, Sadanand Fulzele, Joyce Gonzales & Gregory I. Liou. (2013) Potential role of A2A adenosine receptor in traumatic optic neuropathy. Journal of Neuroimmunology 264:1-2, pages 54-64.
Crossref
Prabha Tiwari, Lokesh P. Tripathi, Teppei Nishikawa-Matsumura, Shandar Ahmad, Soken-Nakazawa J. Song, Tomoyasu Isobe, Kenji Mizuguchi & Kazuyuki Yoshizaki. (2013) Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid A gene promoter. Biochimica et Biophysica Acta (BBA) - General Subjects 1830:6, pages 3650-3655.
Crossref
Chunsuk Kim, Sun Joo Lee, Chang-Gu Hyun & Nam Ho Lee. (2013) Chemical Constituents of Supercritical Extracts from Prunus yedoensis, Saururus chinensis, Zanthoxylum piperitum and their Anti-inflammatory Activities. International Journal of Pharmacology 9:4, pages 258-264.
Crossref
Aris N. Economides & Neil Stahl. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 143 162 .
Ahmed Taki-Eldin, Lin Zhou, Hai-Yang Xie, Kang-Jie Chen, Da Yu, Yong He & Shu-Sen Zheng. (2012) Triiodothyronine attenuates hepatic ischemia/reperfusion injury in a partial hepatectomy model through inhibition of proinflammatory cytokines, transcription factors, and adhesion molecules. Journal of Surgical Research 178:2, pages 646-656.
Crossref
Ke Zhang, Xiao-zhen Huang, Xiao-nan Li, Min Feng, Li Li, Xiao-jun Cai, Cheng Zhang, Xiao-ling Liu, Ming-xiang Zhang, Yun Zhang, Xing-li Wang & Mei Zhang. (2012) Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase ?1 via a mitogen-activated protein kinase and c-Jun pathway. Archives of Biochemistry and Biophysics 528:2, pages 127-133.
Crossref
Min-Ji Bak, Soon-Gi Hong, Jong-Won Lee & Woo-Sik Jeong. (2012) Red Ginseng Marc Oil Inhibits iNOS and COX-2 via NFκB and p38 Pathways in LPS-Stimulated RAW 264.7 Macrophages. Molecules 17:12, pages 13769-13786.
Crossref
Weon-Jong Yoon, Soo-Jin Heo, Sang-Chul Han, Hye-Ja Lee, Gyeoung-Jin Kang, Hee-Kyoung Kang, Jin-Won Hyun, Young-Sang Koh & Eun-Sook Yoo. (2012) Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells. Archives of Pharmacal Research 35:8, pages 1421-1430.
Crossref
Koichiro Matsumoto, Yukari Asai, Satoru Fukuyama, Keiko Kan-o, Yuko Matsunaga, Naotaka Noda, Hiroko Kitajima, Kentaro Tanaka, Yoichi Nakanishi & Hiromasa Inoue. (2012) IL-6 Induced by Double-Stranded RNA Augments Allergic Inflammation via Suppression of Foxp3 + T-Cell/IL-10 Axis . American Journal of Respiratory Cell and Molecular Biology 46:6, pages 740-747.
Crossref
E. Schéle, C. Fekete, P. Egri, T. Füzesi, M. Palkovits, É. Keller, Z. Liposits, B. Gereben, L. Karlsson‐Lindahl, R. Shao & J.‐O. Jansson. (2012) Interleukin‐6 Receptor α is Co‐localised with Melanin‐Concentrating Hormone in Human and Mouse Hypothalamus. Journal of Neuroendocrinology 24:6, pages 930-943.
Crossref
Corinna Jen-Hui Pan, Hui-Lin Wu, Stephanie Fang-Tzu Kuo, Jia-Horng Kao, Tai-Chung Tseng, Chen-Hua Liu, Pei-Jer Chen, Chun-Jen Liu & Ding-Shinn Chen. (2011) Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B. Hepatology International 6:3, pages 591-597.
Crossref
Jodi Muckelbauer, John S. Sack, Nazia Ahmed, James Burke, ChiehYing Y. Chang, Mian Gao, Joseph Tino, Dianlin Xie & Andrew J. Tebben. (2011) X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase. Chemical Biology & Drug Design 78:5, pages 739-748.
Crossref
Lara Baticic, Dijana Detel, Natalia Kucic, Suncica Buljevic, Ester Pernjak Pugel & Jadranka Varljen. (2011) Neuroimmunomodulative properties of dipeptidyl peptidase IV/CD26 in a TNBS-induced model of colitis in mice. Journal of Cellular Biochemistry 112:11, pages 3322-3333.
Crossref
Changhai Ding, Ran Li, Jianhua Xu, Flavia Cicuttini & Graeme Jones. (2011) Belimumab therapy for systemic lupus erythematosus and potential treatment of rheumatoid arthritis. Drug Development Research 72:7, pages 623-633.
Crossref
Da-Peng Chen, Chun-Kwok Wong, Ping-Chung Leung, Kwok-Pui Fung, Clara Bik-San Lau, Ching-Po Lau, Edmund Kwok-Ming Li, Lai-Shan Tam & Christopher Wai-Kei Lam. (2011) Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis. Journal of Ethnopharmacology 137:1, pages 457-468.
Crossref
Mesias Pedroza, Daniel J. Schneider, Harry Karmouty-Quintana, Julie Coote, Stevan Shaw, Rebecca Corrigan, Jose G. Molina, Joseph L. Alcorn, David Galas, Richard Gelinas & Michael R. Blackburn. (2011) Interleukin-6 Contributes to Inflammation and Remodeling in a Model of Adenosine Mediated Lung Injury. PLoS ONE 6:7, pages e22667.
Crossref
Janet S. Lee, Jianmei Wang, Mitchell Martin, Soren Germer, Andrew Kenwright, Ryma Benayed, Olivia Spleiss, Adam Platt, Robert Pilson, Andrew Hemmings, Michael E. Weinblatt, Neil Kaplowitz & Joel Krasnow. (2011) Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. Pharmacogenetics and Genomics 21:7, pages 365-374.
Crossref
S. A. Y. Hartgring, C. R. Willis, C. E. DeanJr.Jr., F. Broere, W. van Eden, J. W. J. Bijlsma, F. P. J. G. Lafeber & J. A. G. van Roon. (2011) Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis. Arthritis & Rheumatism 63:7, pages 1878-1887.
Crossref
Jan Suthaus, Nina Adam, Joachim Grötzinger, Jürgen Scheller & Stefan Rose-John. (2011) Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization. European Journal of Cell Biology 90:6-7, pages 495-504.
Crossref
Tai-Long Pan, Pei-Wen Wang, Shui-Ten Chen, Jia-You Fang, Teng-Kuei Hsu, Nardnisa Sintupisut, Shigeru Goto & Chao-Long Chen. (2011) Prospective highlights of serum glycoproteins in spontaneous tolerance after orthotopic liver transplantation. Clinica Chimica Acta 412:7-8, pages 604-613.
Crossref
Ji-Young MOON, Eun-Jin YANG, Sang Suk KIM, Ji-Yong KANG, Gi-Ok KIM, Nam Ho LEE & Chang-Gu HYUN. (2011) Sasa quelpaertensis Phenylpropanoid Derivative Suppresses Lipopolysaccharide-induced Nitric Oxide Synthase and Cyclo-oxygenase-2 Expressions in RAW 264.7 Cells. YAKUGAKU ZASSHI 131:6, pages 961-967.
Crossref
Sang Won Park, Sean WC Chen, Mihwa Kim, Kevin M Brown, Jay K Kolls, Vivette D D'Agati & H Thomas Lee. (2011) Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy. Laboratory Investigation 91:1, pages 63-84.
Crossref
Klaus Resch & Michael U. Martin. 2011. Principles of Immunopharmacology. Principles of Immunopharmacology 59 80 .
Caroline Jochems, Ulrika Islander, Malin Erlandsson, Cecilia Engdahl, Marie Lagerquist, Inger Gjertsson, Claes Ohlsson, Rikard Holmdahl & Hans Carlsten. (2010) Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis. BMC Musculoskeletal Disorders 11:1.
Crossref
Jason S Stumhofer, Elia D Tait, William J Quinn III, Nancy Hosken, Björn Spudy, Radhika Goenka, Ceri A Fielding, Aisling C O'Hara, Yi Chen, Michael L Jones, Christiaan J M Saris, Stefan Rose-John, Daniel J Cua, Simon A Jones, M Merle Elloso, Joachim Grötzinger, Michael P Cancro, Steven D Levin & Christopher A Hunter. (2010) A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nature Immunology 11:12, pages 1119-1126.
Crossref
Weon-Jong Yoon, Ji-Young Moon, Ji-Yong Kang, Gi-Ok Kim, Nam Ho Lee & Chang-Gu Hyun. (2010) Neolitsea Sericea Essential Oil Attenuates LPS-induced Inflammation in RAW 264.7 Macrophages by Suppressing NF-κB and MAPK Activation . Natural Product Communications 5:8, pages 1934578X1000500.
Crossref
Weici Zhang, Masanobu Tsuda, Guo-Xiang Yang, Koichi Tsuneyama, Guanghua Rong, William M. Ridgway, Aftab A. Ansari, Richard A. Flavell, Ross L. Coppel, Zhe-Xiong Lian & M. Eric Gershwin. (2010) Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor β receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology 52:1, pages 215-222.
Crossref
W.J. Yoon, J.Y. Moon, G. Song, Y.K. Lee, M.S. Han, J.S. Lee, B.S. Ihm, W.J. Lee, N.H. Lee & C.G. Hyun. (2010) Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages. Food and Chemical Toxicology 48:5, pages 1222-1229.
Crossref
KUN PARK, JI-HYE LEE, HO-CHAN CHO, SUN-YOUNG CHO & JAE-WE CHO. (2010) Down-regulation of IL-6, IL-8, TNF-α and IL-1β by glucosamine in HaCaT cells, but not in the presence of TNF-α. Oncology Letters 1:2, pages 289-292.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.