603
Views
69
CrossRef citations to date
0
Altmetric
Miscellaneous

Nitric oxide donor drugs: current status and future trends

&
Pages 587-601 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Michel Félétou, Ralf Köhler & Paul M. Vanhoutte. (2012) Nitric oxide: Orchestrator of endothelium-dependent responses. Annals of Medicine 44:7, pages 694-716.
Read now
Adam Friedman & Joel Friedman. (2009) New biomaterials for the sustained release of nitric oxide: past, present and future. Expert Opinion on Drug Delivery 6:10, pages 1113-1122.
Read now
Roberto Scatena. (2007) New nitric oxide-releasing polymers for implantable devices. Expert Opinion on Therapeutic Patents 17:11, pages 1397-1400.
Read now
Roberto Scatena, Patrizia Bottoni, Giuseppe E Martorana & Bruno Giardina. (2005) Nitric oxide donor drugs: an update on pathophysiology and therapeutic potential. Expert Opinion on Investigational Drugs 14:7, pages 835-846.
Read now
Juan Carlos Kaski, Juan Cosín Sales & Ramón Arroyo Espliguero. (2005) Silent myocardial ischaemia: clinical relevance and treatment. Expert Opinion on Investigational Drugs 14:4, pages 423-434.
Read now

Articles from other publishers (64)

Alexia Marques Silva, Laísa Bonafim Negri, Juliana Cristina Biazzotto, Sergio de Paula Machado, Jeimison Duarte Santos, Jorge Fernandes Nasser Batista, Pedro Ivo S. Maia, Victor Marcelo Deflon, Lusiane M. Bendhack, Michael R. Hamblin & Roberto S. da Silva. (2023) Influence of nitro ruthenium isomerization on photochemically induced nitric oxide release: Vasorelaxant activities. Journal of Inorganic Biochemistry 243, pages 112166.
Crossref
Govinda R. Navale, Sain Singh & Kaushik Ghosh. (2023) NO donors as the wonder molecules with therapeutic potential: Recent trends and future perspectives. Coordination Chemistry Reviews 481, pages 215052.
Crossref
Dan Gao, Sajid Asghar, Rongfeng Hu, Su Chen, Ruixin Niu, Jia Liu, Zhipeng Chen & Yanyu Xiao. (2023) Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy. Acta Pharmaceutica Sinica B 13:4, pages 1498-1521.
Crossref
Olesya V. Pokidova, Veronika O. Novikova, Nina S. Emel'yanova, Alexandra Yu. Kormukhina, Alexander V. Kulikov, Andrey N. Utenyshev, Vladimir A. Lazarenko, Nikolai S. Ovanesyan, Arina A. Starostina & Natalya A. Sanina. (2023) A nitrosyl iron complex with 3.4-dichlorothiophenolyl ligands: synthesis, structures and its reactions with targets – carriers of nitrogen oxide (NO) in vivo . Dalton Transactions 52:9, pages 2641-2662.
Crossref
You-Lin Tain, Hung-Wei Yang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin & Chien-Ning Hsu. (2023) Anti-Hypertensive Property of an NO Nanoparticle in an Adenine-Induced Chronic Kidney Disease Young Rat Model. Antioxidants 12:2, pages 513.
Crossref
Anna Bubley, Alexaner Erofeev, Peter Gorelkin, Elena Beloglazkina, Alexander Majouga & Olga Krasnovskaya. (2023) Tacrine-Based Hybrids: Past, Present, and Future. International Journal of Molecular Sciences 24:2, pages 1717.
Crossref
Ayantika Sengupta, Subhamoy Chakraborty, Sampurna Datta & Sanjay Ghosh. 2023. Nitric Oxide: From Research to Therapeutics. Nitric Oxide: From Research to Therapeutics 177 210 .
Zahra Bahadoran, Parvin Mirmiran, Mehrnoosh Bahmani & Asghar Ghasemi. 2022. The Role of Nitric Oxide in Type 2 Diabetes. The Role of Nitric Oxide in Type 2 Diabetes 324 349 .
Xingyue Ji & Zhiyuan Zhong. (2022) External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release. Journal of Controlled Release 351, pages 81-101.
Crossref
Mei Yang, Jin Zhang, Wu Shi, Jie Zhang & Chuanmin Tao. (2022) Recent advances in metal–organic frameworks and their composites for the phototherapy of skin wounds. Journal of Materials Chemistry B 10:25, pages 4695-4713.
Crossref
Mingzhu Luan, Yaoyao Xu, Xiaofan Zhang, Dalei Li, Mengjun Yan, Guige Hou, Qingguo Meng, Feng Zhao & Fenglan Zhao. (2022) Design and synthesis of novel aza-ursolic acid derivatives: in vitro cytotoxicity and nitric oxide release inhibitory activity . Future Medicinal Chemistry 14:8, pages 535-555.
Crossref
Negar Omidkhah & Razieh Ghodsi. (2022) NO-HDAC dual inhibitors. European Journal of Medicinal Chemistry 227, pages 113934.
Crossref
Chuyi Han, Qinghua Yu, Junhao Jiang, Xianming Zhang, Fan Wang, Mingyue Jiang, Ruihong Yu, Tao Deng & Chao Yu. (2021) Bioenzyme-responsive l -arginine-based carbon dots: the replenishment of nitric oxide for nonpharmaceutical therapy . Biomaterials Science 9:22, pages 7432-7443.
Crossref
Grady L. Nelson, Conor T. Ronayne, Lucas N. Solano, Sravan K. Jonnalagadda, Shirisha Jonnalagadda, Tanner J. Schumacher, Zachary S. Gardner, Hithardha Palle, Chinnadurai Mani, Jon Rumbley & Venkatram R. Mereddy. (2021) Synthesis and biological evaluation of N, N-dialkylcarboxy coumarin-NO donor conjugates as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 52, pages 128411.
Crossref
Yiqi Yang, Kai Huang, Minqi Wang, Qishan Wang, Haishuang Chang, Yakun Liang, Qing Wang, Jie Zhao, Tingting Tang & Shengbing Yang. (2021) Ubiquitination Flow Repressors: Enhancing Wound Healing of Infectious Diabetic Ulcers through Stabilization of Polyubiquitinated Hypoxia‐Inducible Factor‐1α by Theranostic Nitric Oxide Nanogenerators. Advanced Materials 33:45, pages 2103593.
Crossref
Joel Mintz, Anastasia Vedenko, Omar Rosete, Khushi Shah, Gabriella Goldstein, Joshua M. Hare, Ranjith Ramasamy & Himanshu Arora. (2021) Current Advances of Nitric Oxide in Cancer and Anticancer Therapeutics. Vaccines 9:2, pages 94.
Crossref
Grigory V. Zyryanov, Dmitry S. Kopchuk, Igor S. Kovalev, Sougata Santra, Matiur Rahman, Albert F. Khasanov, Alexey P. Krinochkin, Olga S. Taniya, Oleg N. Chupakhin & Valery N. Charushin. (2020) Rational synthetic methods in creating promising (hetero)aromatic molecules and materials. Mendeleev Communications 30:5, pages 537-554.
Crossref
Shane O’Sullivan, Jun Wang, Marek W. Radomski, John F. Gilmer & Carlos Medina. (2020) Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway. Biomolecules 10:5, pages 808.
Crossref
Houman Alimoradi, Khaled Greish, Allan B. Gamble & Gregory I. Giles. (2019) Controlled Delivery of Nitric Oxide for Cancer Therapy. Pharmaceutical Nanotechnology 7:4, pages 279-303.
Crossref
Xiao Zhang, Xixin He, Qiuhe Chen, Junfeng Lu, Simona Rapposelli & Rongbiao Pi. (2018) A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer’s disease. Bioorganic & Medicinal Chemistry 26:3, pages 543-550.
Crossref
Zuyong Wang, Feng Wen, Rongkai Zhang & Qinyuan Zhang. (2017) Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality. MRS Communications 7:3, pages 348-360.
Crossref
Samuel K. Kutty, Kitty Ka Kit Ho & Naresh Kumar. 2017. Nitric Oxide Donors. Nitric Oxide Donors 169 189 .
A. K. Ustinov, I. V. Serkov, A. N. Proshin, N. V. Kovaleva, N. P. Boltneva, G. F. Makhaeva & S. O. Bachurin. (2017) Synthesis of γ-carbolines containing NO-donor fragment and assessment of their anticholinesterase activity. Russian Chemical Bulletin 65:11, pages 2718-2721.
Crossref
Michal Kielbik, Izabela Szulc-Kielbik, Marek Nowak, Zofia Sulowska & Magdalena Klink. (2016) Evaluation of nitric oxide donors impact on cisplatin resistance in various ovarian cancer cell lines. Toxicology in Vitro 36, pages 26-37.
Crossref
Ziqian Zhang, Jiayao Wu, Zhihao Shang, Chao Wang, Jiagao Cheng, Xuhong Qian, Yi Xiao, Zhiping Xu & Youjun Yang. (2016) Photocalibrated NO Release from N-Nitrosated Napthalimides upon One-Photon or Two-Photon Irradiation. Analytical Chemistry 88:14, pages 7274-7280.
Crossref
P. H. Ratz, A. S. Miner, Y. Huang, C. A. Smith & R. W. Barbee. (2016) Vascular smooth muscle desensitization in rabbit epigastric and mesenteric arteries during hemorrhagic shock. American Journal of Physiology-Heart and Circulatory Physiology 311:1, pages H157-H167.
Crossref
Woo Je Lee, Sanshiro Tateya, Andrew M. Cheng, Norma Rizzo-DeLeon, Nicholas F. Wang, Priya Handa, Carole L. Wilson, Alexander W. Clowes, Ian R. Sweet, Karol Bomsztyk, Michael W. Schwartz & Francis Kim. (2015) M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling. Diabetes 64:8, pages 2836-2846.
Crossref
Qin‐Yuan Zhang, Zu‐Yong Wang, Feng Wen, Lei Ren, Jun Li, Swee Hin Teoh & Eng San Thian. (2014) Gelatin–siloxane nanoparticles to deliver nitric oxide for vascular cell regulation: Synthesis, cytocompatibility, and cellular responses. Journal of Biomedical Materials Research Part A 103:3, pages 929-938.
Crossref
Nadiia Rozmaritsa, Torsten Christ, David R. Van Wagoner, Hannelore Haase, Johannes-Peter Stasch, Klaus Matschke & Ursula Ravens. (2014) Attenuated response of L-type calcium current to nitric oxide in atrial fibrillation. Cardiovascular Research 101:3, pages 533-542.
Crossref
Ryan Spitler, Raphaela Schwappacher, Tao Wu, Xiangduo Kong, Kyoko Yokomori, Renate B. Pilz, Gerry R. Boss & Michael W. Berns. (2013) Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cellular Signalling 25:12, pages 2374-2382.
Crossref
Marianne Parent, Ariane Boudier, François Dupuis, Cécile Nouvel, Anne Sapin, Isabelle Lartaud, Jean-Luc Six, Pierre Leroy & Philippe Maincent. (2013) Are in situ formulations the keys for the therapeutic future of S-nitrosothiols?. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 640-649.
Crossref
Francesca Ghirga, Ilaria D’Acquarica, Giuliano Delle Monache, Luisa Mannina, Carmela Molinaro, Laura Nevola, Anatoly P. Sobolev, Marco Pierini & Bruno Botta. (2013) Reaction of Nitrosonium Cation with Resorc[4]arenes Activated by Supramolecular Control: Covalent Bond Formation. The Journal of Organic Chemistry 78:14, pages 6935-6946.
Crossref
Srividya Kidambi & Theodore A. Kotchen. (2013) Treatment of Hypertension in Obese Patients. American Journal of Cardiovascular Drugs 13:3, pages 163-175.
Crossref
Xiaoli Wang, Linna Wang, Zhangjian Huang, Xiao Sheng, Tingting Li, Hui Ji, Jinyi Xu & Yihua Zhang. (2013) Synthesis and biological evaluation of nitric oxide releasing derivatives of 6-amino-3-n-butylphthalide as potential antiplatelet agents. Bioorganic & Medicinal Chemistry Letters 23:7, pages 1985-1988.
Crossref
Madhavi Kalidindi, Luxmi Velauthar, Khalid Khan & Joseph Aquilina. (2012) The role of nitrates in the prevention of preeclampsia. Current Opinion in Obstetrics & Gynecology 24:6, pages 361-367.
Crossref
Andrew Nortcliffe, James Ross, Fouad Habib, David O’Hagan & Nigel Botting. (2012) Nitric oxide donating conjugates of sulindac for the treatment of hormone refractory prostate cancer. Nitric Oxide 27, pages S32.
Crossref
Yao Chen, Jianfei Sun, Lei Fang, Mei Liu, Sixun Peng, Hong Liao, Jochen Lehmann & Yihua Zhang. (2012) Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors. Journal of Medicinal Chemistry 55:9, pages 4309-4321.
Crossref
Anna Steinberg & A. Ingela M. Nilsson Remahl. (2012) Role of Nitric Oxide in Cluster Headache. Current Pain and Headache Reports 16:2, pages 185-190.
Crossref
Bruno P. Carreira, Caetana M. Carvalho & Inês M. Araújo. (2012) Regulation of Injury-Induced Neurogenesis by Nitric Oxide. Stem Cells International 2012, pages 1-15.
Crossref
Alexis W. Carpenter & Mark H. Schoenfisch. (2012) Nitric oxide release: Part II. Therapeutic applications. Chemical Society Reviews 41:10, pages 3742.
Crossref
Ana-Maria Oprea, Lenuta Profire, Catalina Elena Lupusoru, Cristina Mihaela Ghiciuc, Diana Ciolacu & Cornelia Vasile. (2012) Synthesis and characterization of some cellulose/chondroitin sulphate hydrogels and their evaluation as carriers for drug delivery. Carbohydrate Polymers 87:1, pages 721-729.
Crossref
Raffaella Priora, Antonios Margaritis, Simona Frosali, Lucia Coppo, Domenico Summa, Danila Di Giuseppe, Carlo Aldinucci, GianPaolo Pessina, Anna Di Stefano & Paolo Di Simplicio. (2011) In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways. Pharmacological Research 64:3, pages 289-297.
Crossref
Christopher G. Kevil, Gopi K. Kolluru, Christopher B. Pattillo & Tony Giordano. (2011) Inorganic nitrite therapy: historical perspective and future directions. Free Radical Biology and Medicine 51:3, pages 576-593.
Crossref
Michel Félétou. (2011) The Endothelium, Part I: Multiple Functions of the Endothelial Cells -- Focus on Endothelium-Derived Vasoactive Mediators. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 3:4, pages 1-306.
Crossref
Michel Félétou. (2011) The Endothelium, Part II: EDHF-Mediated Responses "The Classical Pathway". Colloquium Series on Integrated Systems Physiology: From Molecule to Function 3:4, pages 1-306.
Crossref
Xuliang Wang, Yang Li, Qian Zhao, Zhenli Min, Chao Zhang, Yisheng Lai, Hui Ji, Sixun Peng & Yihua Zhang. (2011) Design, synthesis and evaluation of nitric oxide releasing derivatives of 3-n-butylphthalide as antiplatelet and antithrombotic agents. Organic & Biomolecular Chemistry 9:16, pages 5670.
Crossref
Oyebola A. Oladeinde, Sam Y. Hong, Ryan J. Holland, Anna E. Maciag, Larry K. Keefer, Joseph E. Saavedra & Rahul S. Nandurdikar. (2010) “Click” Reaction in Conjunction with Diazeniumdiolate Chemistry: Developing High-Load Nitric Oxide Donors. Organic Letters 12:19, pages 4256-4259.
Crossref
Rahul S. Nandurdikar, Anna E. Maciag, Sam Y. Hong, Harinath Chakrapani, Michael L. Citro, Larry K. Keefer & Joseph E. Saavedra. (2009) Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs. Organic Letters 12:1, pages 56-59.
Crossref
Tao Wang, Yi‐Hua Zhang, Xiang‐Wen Kong, Yi‐Sheng Lai, Hui Ji, Yan‐Ping Chen & Si‐Xun Peng. (2009) Synthesis and Biological Evaluation of Nitric Oxide‐Donating Thalidomide Analogues as Anticancer Agents. Chemistry & Biodiversity 6:4, pages 466-474.
Crossref
Ian L. Megson & Mark R. Miller. 2009. cGMP: Generators, Effectors and Therapeutic Implications. cGMP: Generators, Effectors and Therapeutic Implications 247 276 .
Michelle Le BrocqStephen J. LesliePhilip MillikenIan L. Megson. (2008) Endothelial Dysfunction: From Molecular Mechanisms to Measurement, Clinical Implications, and Therapeutic Opportunities. Antioxidants & Redox Signaling 10:9, pages 1631-1674.
Crossref
Lei Fang, Dorothea Appenroth, Michael Decker, Michael Kiehntopf, Carolin Roegler, Thomas Deufel, Christian Fleck, Sixun Peng, Yihua Zhang & Jochen Lehmann. (2008) Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates. Journal of Medicinal Chemistry 51:4, pages 713-716.
Crossref
R.B.H. Wills, L. Soegiarto & M.C. Bowyer. (2007) Use of a solid mixture containing diethylenetriamine/nitric oxide (DETANO) to liberate nitric oxide gas in the presence of horticultural produce to extend postharvest life. Nitric Oxide 17:1, pages 44-49.
Crossref
M R Miller & I L Megson. (2009) Recent developments in nitric oxide donor drugs. British Journal of Pharmacology 151:3, pages 305-321.
Crossref
Daryl O Schwenke, James T Pearson, Hirotsugu Tsuchimochi, Kenji Kangawa & Mikiyasu Shirai. (2007) PULMONARY VASCULAR REACTIVITY OF SPONTANEOUSLY HYPERTENSIVE RATS IS EXACERBATED IN RESPONSE TO THE CENTRAL ADMINISTRATION OF EXOGENOUS NITRIC OXIDE. Clinical and Experimental Pharmacology and Physiology 34:1-2, pages 88-94.
Crossref
Daryl O. Schwenke, James T. Pearson, Hidezo Mori & Mikiyasu Shirai. (2006) Does central nitric oxide elicit pulmonary hypertension in conscious rats?. Respiratory Physiology & Neurobiology 153:3, pages 250-260.
Crossref
Sabrina CorazzaLia ScarabottoloStefan LohmerChiara Liberati. (2006) An Innovative Cell-Based Assay for the Detection of Modulators of Soluble Guanylate Cyclase. ASSAY and Drug Development Technologies 4:2, pages 165-173.
Crossref
Daryl O Schwenke, James T Pearson, Hirotsugu Tsuchimochi, Hidezo Mori & Mikiyasu Shirai. (2005) Exogenous nitric oxide centrally enhances pulmonary reactivity in the normal and hypertensive rat. Clinical and Experimental Pharmacology and Physiology 32:11, pages 952-959.
Crossref
Yanlong Kang, Grigory V. Zyryanov & Dmitry M. Rudkevich. (2005) Towards Supramolecular Fixation of NO X Gases: Encapsulated Reagents for Nitrosation . Chemistry – A European Journal 11:6, pages 1924-1932.
Crossref
Yanlong Kang & Dmitry M. Rudkevich. (2004) Polymer-supported calix[4]arenes for sensing and conversion of NO2/N2O4. Tetrahedron 60:49, pages 11219-11225.
Crossref
Darren Griffith, Ennio Zangrando, Enzo Alessio & Celine Marmion. (2004) A novel ruthenium nitrosyl complex which also contains a free NO-donor moiety. Inorganica Chimica Acta 357:12, pages 3770-3774.
Crossref
Fabio L. M. Ricciardolo, Peter J. Sterk, Benjamin Gaston & Gert Folkerts. (2004) Nitric Oxide in Health and Disease of the Respiratory System. Physiological Reviews 84:3, pages 731-765.
Crossref
Peter M. Schmidt, Matthias Schramm, Henning Schröder, Frank Wunder & Johannes-Peter Stasch. (2004) Identification of Residues Crucially Involved in the Binding of the Heme Moiety of Soluble Guanylate Cyclase. Journal of Biological Chemistry 279:4, pages 3025-3032.
Crossref
Giovanni Sorba, Ubaldina Galli, Clara Cena, Roberta Fruttero, Alberto Gasco, Giuseppina Morini, Maristella Adami, Gabriella Coruzzi, Maria Immacolata Brenciaglia & Francesco Dubini. (2003) A New Furoxan NO-Donor Rabeprazole Derivative and Related Compounds. ChemBioChem 4:9, pages 899-903.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.