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Neutrophil elastase inhibitors as treatment for COPD

Pages 965-980 | Published online: 24 Feb 2005

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L Crocetti, MT Quinn, IA Schepetkin & MP Giovannoni. (2019) A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications. Expert Opinion on Therapeutic Patents 29:7, pages 555-578.
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Guoli Huang, Li Feng, Bo Liu, Yi He, Yiming Li & Yegao Chen. (2015) Synthesis and biological evaluation of nigranoic acid esters as novel human neutrophil elastase inhibitors. Natural Product Research 29:17, pages 1650-1656.
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William C Groutas, Dengfeng Dou & Kevin R Alliston. (2011) Neutrophil elastase inhibitors. Expert Opinion on Therapeutic Patents 21:3, pages 339-354.
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Rachid Kacem & Zahia Meraihi. (2009) The effect of essential oil extracted from Nigella sativa (L.) seeds on human neutrophil functions. Natural Product Research 23:13, pages 1168-1175.
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Sarah E Dunsmore. (2008) Treatment of COPD: A matrix perspective. International Journal of Chronic Obstructive Pulmonary Disease 3:1, pages 113-122.
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William M Brown. (2007) Treating COPD with PDE 4 inhibitors. International Journal of Chronic Obstructive Pulmonary Disease 2:4, pages 517-533.
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John C L Erve. (2006) Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 923-946.
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R Al-Jamal, WAH Wallace & DJ Harrison. (2005) Gene therapy for chronic obstructive pulmonary disease: twilight or triumph?. Expert Opinion on Biological Therapy 5:3, pages 333-346.
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. (2004) Elastase inhibitors. Expert Opinion on Therapeutic Patents 14:10, pages 1511-1516.
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Maria G Belvisi, David J Hele & Mark A Birrell. (2004) New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease. Expert Opinion on Therapeutic Targets 8:4, pages 265-285.
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Louise E Donnelly & Duncan F Rogers. (2003) Antiproteases and retinoids for treatment of chronic obstructive pulmonary disease. Expert Opinion on Therapeutic Patents 13:9, pages 1345-1372.
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Tomasz M Ziedalski, Viji Sankaranarayanan & Rajinder K Chitkara. (2003) Advances in the management of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 4:7, pages 1063-1082.
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David J Hele & Maria G Belvisi. (2003) Novel therapies for the treatment of inflammatory airway disease. Expert Opinion on Investigational Drugs 12:1, pages 5-18.
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Articles from other publishers (56)

Tingting Liu, Xiang Li, Yuan Qiu, Yilan Zhao, Xiaogang Luo, Genyan Liu & Qi Sun. (2024) A strategy for constructing novel red emitting fluorescent probes for neutrophil elastase tracking based on self-immolative linker and TICT effect. Dyes and Pigments 222, pages 111872.
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Pandit Bagus Tri Saputra, Dinda Dwi Purwati, Alyaa Ulaa Dhiya Ulhaq, Sherly Yolanda, Yovita Citra Eka Dewi Djatioetomo, Alfian Nur Rosyid & Arief Bakhtiar. (2023) Neutrophil Elastase in the Pathogenesis of Chronic Obstructive Pulmonary Disease: A Review. Current Respiratory Medicine Reviews 19:1, pages 29-35.
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Yan Liu, Peng Jiang, Liqin An, Mengying Zhu, Jin Li, Yue Wang, Qin Huang, Yi Xiang, Xiaorong Li, Qiong Shi & Yaguang Weng. (2022) The role of neutrophil elastase in aortic valve calcification. Journal of Translational Medicine 20:1.
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Hongxuan Li, Cong Qiao, Lingyu Zhao, Qingxu Jing, Dongbo Xue & Yingmei Zhang. (2022) Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis. Journal of Leukocyte Biology 112:6, pages 1427-1443.
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Yuriy V. Sheludko, Sjoerd Slagman, Samantha Gittings, Simon J. Charnock, Henrik Land, Per Berglund & Wolf‐Dieter Fessner. (2022) Enantioselective Synthesis of Pharmaceutically Relevant Bulky Arylbutylamines Using Engineered Transaminases. Advanced Synthesis & Catalysis 364:17, pages 2972-2981.
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Camilla Margaroli, Matthew C. Madison, Liliana Viera, Derek W. Russell, Amit Gaggar, Kristopher R. Genschmer & J. Edwin Blalock. (2022) An in vivo model for extracellular vesicle–induced emphysema. JCI Insight 7:4.
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Chandrika Bhattacharyya, Chitrarpita Das, Arnab Ghosh, Animesh K. Singh, Souvik Mukherjee, Partha P. Majumder, Analabha Basu & Nidhan K. Biswas. (2021) SARS-CoV-2 mutation 614G creates an elastase cleavage site enhancing its spread in high AAT-deficient regions. Infection, Genetics and Evolution 90, pages 104760.
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Patrick Mäder & Lars Kattner. (2020) Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry. Journal of Medicinal Chemistry 63:23, pages 14243-14275.
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Mingjun Zhou, Yun Qian, Yumeng Zhu & John Matson. (2020) Elastase-triggered H 2 S delivery from polymer hydrogels . Chemical Communications 56:7, pages 1085-1088.
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Jie Zhang, Hao-Yang Xu, Yu-Juan Wu, Xing Zhang, Liu-Qiang Zhang & Yi-Ming Li. (2019) Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves). Journal of Ethnopharmacology 242, pages 111713.
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Carina Kärrman Mårdh, James Root, Mohib Uddin, Kristina Stenvall, Anna Malmgren, Kostas Karabelas & Matthew Thomas. (2017) Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease. Journal of Immunology Research 2017, pages 1-13.
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KAI-LING JIANG, PENG-PENG MA, XIAO-QUN YANG, LIANG ZHONG, HUI WANG, XIN-YU ZHU & BEI-ZHONG LIU. (2015) Neutrophil elastase and its therapeutic effect on leukemia cells. Molecular Medicine Reports 12:3, pages 4165-4172.
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