Citations (72)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (7)
Tamer El Malah, Hanaa Farag, Hanem Mohamed Awad, Mohamad Taha Abdelrahman & Ahmed Hussien Shamroukh. (2023) Design and Click Synthesis of Novel 1- Substituted-4-(3,4-Dimethoxyphenyl)-1H-1,2,3-Triazole Hybrids for Anticancer Evaluation and Molecular Docking. Polycyclic Aromatic Compounds 43:8, pages 7547-7564.
Read now
Read now
Stephan Herbertz, J Scott Sawyer, Anja J Stauber, Ivelina Gueorguieva, Kyla E Driscoll, Shawn T Estrem, Ann L Cleverly, Durisala Desaiah, Susan C Guba, Karim A Benhadji, Christopher A Slapak & Michael M Lahn. (2015) Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway. Drug Design, Development and Therapy 9, pages 4479-4499.
Read now
Read now
Nagathihalli S Nagaraj & Pran K Datta. (2010) Targeting the transforming growth factor-β signaling pathway in human cancer. Expert Opinion on Investigational Drugs 19:1, pages 77-91.
Read now
Read now
Georg Feldmann, Sherri Rauenzahn & Anirban Maitra. (2009) In vitro models of pancreatic cancer for translational oncology research. Expert Opinion on Drug Discovery 4:4, pages 429-443.
Read now
Read now
Jose Baselga, Mace L. Rothenberg, Josep Tabernero, Joan Seoane, Thomas Daly, Ann Cleverly, Brandi Berry, Susanne K. Rhoades, Chad A. Ray, Jeffrey Fill, Daphne L. Farrington, Lisa Anne Wallace, Jonathan M. Yingling, Michael Lahn, Carlos Arteaga & Michael Carducci. (2008) TGF-β signalling-related markers in cancer patients with bone metastasis. Biomarkers 13:2, pages 217-236.
Read now
Read now
Lynne-Marie Postovit, Elisabeth A Seftor, Richard EB Seftor & Mary JC Hendrix. (2007) Targeting Nodal in malignant melanoma cells. Expert Opinion on Therapeutic Targets 11:4, pages 497-505.
Read now
Read now
Elizabeth Rose Rayburn, Hui Wang & Ruiwen Zhang. (2006) Antisense-based cancer therapeutics: are we there yet?. Expert Opinion on Emerging Drugs 11:2, pages 337-352.
Read now
Read now
Articles from other publishers (65)
A. K. Alshamari. (2023) Anticancer Activity and Molecular Docking of 1,2,3-Triazole Hybrids of Phenol and 4-Methoxy-2-methylphenyl: Synthesis via Click Chemistry. Russian Journal of Organic Chemistry 59:3, pages 455-464.
Crossref
Crossref
Lei Zhong, Yueshan Li, Liang Xiong, Wenjing Wang, Ming Wu, Ting Yuan, Wei Yang, Chenyu Tian, Zhuang Miao, Tianqi Wang & Shengyong Yang. (2021) Small molecules in targeted cancer therapy: advances, challenges, and future perspectives. Signal Transduction and Targeted Therapy 6:1.
Crossref
Crossref
Cristina D'Aniello, Eduardo J. Patriarca, James M. Phang & Gabriella Minchiotti. (2020) Proline Metabolism in Tumor Growth and Metastatic Progression. Frontiers in Oncology 10.
Crossref
Crossref
Guoliang Dai, Bingting Sun, Tao Gong, Zihao Pan, Qinghai Meng & Wenzheng Ju. (2019) Ginsenoside Rb2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by suppressing TGF-β/Smad signaling. Phytomedicine 56, pages 126-135.
Crossref
Crossref
Lindsay C. Spender, G. John Ferguson, Gareth D. Hughes, Barry R. Davies, Frederick W. Goldberg, Blanca Herrera, Richard G. Taylor, Lauren S. Strathearn, Owen J. Sansom, Simon T. Barry & Gareth J. Inman. (2019)
Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor
β
Superfamily Type 1 Receptors
. Molecular Pharmacology 95:2, pages 222-234.
Crossref
Crossref
Wei Li, Xue Liu, Suleiman Muhammad, JiYue Shi, YanQiu Meng & Jian Wang. (2018) Computational investigation of TGF-β receptor inhibitors for treatment of idiopathic pulmonary fibrosis: Field-based QSAR model and molecular dynamics simulation. Computational Biology and Chemistry 76, pages 139-150.
Crossref
Crossref
Jun Tian, Amal A. Al-Odaini, Yun Wang, Juliana Korah, Meiou Dai, Lan Xiao, Suhad Ali & Jean-Jacques Lebrun. (2018) KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast cancer. Cellular Signalling 42, pages 1-10.
Crossref
Crossref
Anthony W. Tolcher, Jordan D. Berlin, Jan Cosaert, John Kauh, Emily Chan, Sarina A. Piha-Paul, Alex Amaya, Shande Tang, Kyla Driscoll, Richard Kimbung, S. R. Prasad Kambhampati, Ivelina Gueorguieva & David S. Hong. (2017) A phase 1 study of anti-TGF? receptor type-II monoclonal antibody LY3022859 in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 79:4, pages 673-680.
Crossref
Crossref
Tobias F. I. Schatton & Markus H. Frank. 2017. Melanoma Development. Melanoma Development
311
337
.
X. Liu, M. Yu, Y. Chen & J. Zhang. (2016) Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats. Brazilian Journal of Medical and Biological Research 49:9.
Crossref
Crossref
W.G. Jiang, A.J. Sanders, M. Katoh, H. Ungefroren, F. Gieseler, M. Prince, S.K. Thompson, M. Zollo, D. Spano, P. Dhawan, D. Sliva, P.R. Subbarayan, M. Sarkar, K. Honoki, H. Fujii, A.G. Georgakilas, A. Amedei, E. Niccolai, A. Amin, S.S. Ashraf, L. Ye, W.G. Helferich, X. Yang, C.S. Boosani, G. Guha, M.R. Ciriolo, K. Aquilano, S. Chen, A.S. Azmi, W.N. Keith, A. Bilsland, D. Bhakta, D. Halicka, S. Nowsheen, F. Pantano & D. Santini. (2015) Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Seminars in Cancer Biology 35, pages S244-S275.
Crossref
Crossref
Yutaka Fujiwara, Hiroshi Nokihara, Yasuhide Yamada, Noboru Yamamoto, Kuniko Sunami, Hirofumi Utsumi, Hiroya Asou, Osamu TakahashI, Ken Ogasawara, Ivelina Gueorguieva & Tomohide Tamura. (2015) Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 76:6, pages 1143-1152.
Crossref
Crossref
Armin Maier, Anne-Lise Peille, Vincent Vuaroqueaux & Michael Lahn. (2015) Anti-tumor activity of the TGF-? receptor kinase inhibitor galunisertib (LY2157299 monohydrate) in patient-derived tumor xenografts. Cellular Oncology 38:2, pages 131-144.
Crossref
Crossref
Harun M. Patel, Baljeet Sing, Varun Bhardwaj, Mahesh Palkar, Mahamadhanif S. Shaikh, Rajesh Rane, Wesam S. Alwan, Andanappa K. Gadad, Malleshappa N. Noolvi & Rajshekhar Karpoormath. (2015) Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5). European Journal of Medicinal Chemistry 93, pages 599-613.
Crossref
Crossref
K. A. DiVito, C. M. Simbulan-Rosenthal, Y.-S. Chen, V. A. Trabosh & D. S. Rosenthal. (2013) Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF- -independent melanoma. Carcinogenesis 35:4, pages 951-958.
Crossref
Crossref
Yong-Hun Lee & William P Schiemann. (2014) Chemotherapeutic targeting of the TGF-β pathway in breast cancers. Breast Cancer Management 3:1, pages 73-85.
Crossref
Crossref
Mausumi Bharadwaj, Gaurav Roy, Koushik Dutta, Mohammad Misbah, Mohammad Husain & Showket Hussain. (2012) Tackling hepatitis B virus-associated hepatocellular carcinoma—the future is now. Cancer and Metastasis Reviews 32:1-2, pages 229-268.
Crossref
Crossref
Jiao Peng, Julia Yuen Shan Tsang, Daxu Li, Na Niu, Derek Hoi Hang HO, Kwok Fai Lau, Vincent Chi Hang Lui, Jonathan Robert Lamb, Yan Chen & Paul Kwong Hang Tam. (2013) Inhibition of TGF-? signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages. Cancer Letters 331:2, pages 239-249.
Crossref
Crossref
Marike Marjolijn van Beuge, Jai Prakash, Marie Lacombe, Eduard Post, Catharina Reker-Smit, Leonie Beljaars & Klaas Poelstra. (2013) Enhanced Effectivity of an ALK5-Inhibitor after Cell-Specific Delivery to Hepatic Stellate Cells in Mice with Liver Injury. PLoS ONE 8:2, pages e56442.
Crossref
Crossref
Kristian Pietras & Sara I. Cunha. 2013. TGF-β in Human Disease. TGF-β in Human Disease
435
458
.
Kerstin Krieglstein. 2013. TGF-β in Human Disease. TGF-β in Human Disease
391
412
.
Jean-Charles Neel, Laure Humbert & Jean-Jacques Lebrun. (2012) The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis. ISRN Molecular Biology 2012, pages 1-28.
Crossref
Crossref
Henriett Butz, Károly Rácz, László Hunyady & Attila Patócs. (2012) Crosstalk between TGF-β signaling and the microRNA machinery. Trends in Pharmacological Sciences 33:7, pages 382-393.
Crossref
Crossref
Melanie J. GrubishaM. E. CifuentesStephen R. Hammes & Donald B. DeFranco. (2012) A Local Paracrine and Endocrine Network Involving TGFβ, Cox-2, ROS, and Estrogen Receptor β Influences Reactive Stromal Cell Regulation of Prostate Cancer Cell Motility. Molecular Endocrinology 26:6, pages 940-954.
Crossref
Crossref
E. E. Merika, K. N. Syrigos & M. W. Saif. (2012) Desmoplasia in Pancreatic Cancer. Can We Fight It?. Gastroenterology Research and Practice 2012, pages 1-10.
Crossref
Crossref
Tobias Schatton, Jennifer Y. Lin & Markus H. Frank. 2012. Advances in Cancer Stem Cell Biology. Advances in Cancer Stem Cell Biology
301
332
.
Mark J. Anderton, Howard R. Mellor, Alex Bell, Claire Sadler, Martin Pass, Steve Powell, Samantha J. Steele, Ruth. R. A. Roberts & Annabelle Heier. (2011) Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors. Toxicologic Pathology 39:6, pages 916-924.
Crossref
Crossref
Sweta Mishra, Yuping Tang, Long Wang, Linda deGraffenried, I‐Tien Yeh, Sherry Werner, Dean Troyer, John A. Copland & Lu‐Zhe Sun. (2011) Blockade of transforming growth factor‐beta (TGFβ) signaling inhibits osteoblastic tumorigenesis by a novel human prostate cancer cell line. The Prostate 71:13, pages 1441-1454.
Crossref
Crossref
Curzio Rüegg, Yan Monnier, François Kuonen & Natsuko Imaizumi. (2011) Radiation-induced modifications of the tumor microenvironment promote metastasis. Bulletin du Cancer 98:6, pages E47-E57.
Crossref
Crossref
Gianluigi Giannelli, Antonio Mazzocca, Emilia Fransvea, Michael Lahn & Salvatore Antonaci. (2011) Inhibiting TGF-β signaling in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1815:2, pages 214-223.
Crossref
Crossref
Christian Rupp, Helmut Dolznig, Christian Haslinger, Norbert Schweifer & Pilar Garin-Chesa. 2011. Tumor-Associated Fibroblasts and their Matrix. Tumor-Associated Fibroblasts and their Matrix
383
401
.
Tobias Schatton & Markus H. Frank. 2011. Melanoma Development. Melanoma Development
255
279
.
Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Lisa Mara, Lore Gruenbaum, Armin Heckel, Roland Eils, Roland E. Kontermann, Gerald J. Roth, Florian Gantner, Andreas Schnapp, John E. Park, Andreas Weith, Karsten Quast & Detlev Mennerich. (2010) Phenocopy ? A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization. PLoS ONE 5:12, pages e14272.
Crossref
Crossref
Gerald J. Roth, Armin Heckel, Trixi Brandl, Matthias Grauert, Stefan Hoerer, Joerg T. Kley, Gisela Schnapp, Patrick Baum, Detlev Mennerich, Andreas Schnapp & John E. Park. (2010) Design, Synthesis, and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor β Receptor I (TGFβRI). Journal of Medicinal Chemistry 53:20, pages 7287-7295.
Crossref
Crossref
Natsuko Imaizumi, Yan Monnier, Monika Hegi, René-Olivier Mirimanoff & Curzio Rüegg. (2010) Radiotherapy Suppresses Angiogenesis in Mice through TGF-βRI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting. PLoS ONE 5:6, pages e11084.
Crossref
Crossref
Maria-Anna M.A. D'Souza, Roy M. Kimble & James R. McMillan. (2010) Kindler Syndrome Pathogenesis and Fermitin Family Homologue 1 (Kindlin-1) Function. Dermatologic Clinics 28:1, pages 115-118.
Crossref
Crossref
Pim J. Koelink, Lukas J.A.C. Hawinkels, Eliza Wiercinska, Cornelis F.M. Sier, Peter ten Dijke, Cornelis B.H.W. Lamers, Daan W. Hommes & Hein W. Verspaget. (2010) 5-Aminosalicylic acid inhibits TGF-β1 signalling in colorectal cancer cells. Cancer Letters 287:1, pages 82-90.
Crossref
Crossref
Rabindranath Chakrabarti, Venkateswaran Subramaniam, Salma Abdalla, Serge Jothy & Gérald J. Prud'homme. (2009) Tranilast inhibits the growth and metastasis of mammary carcinoma. Anti-Cancer Drugs 20:5, pages 334-345.
Crossref
Crossref
F. Gellibert, M.-H. Fouchet, V.-L. Nguyen, R. Wang, G. Krysa, A.-C. de Gouville, S. Huet & N. Dodic. (2009) Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors. Bioorganic & Medicinal Chemistry Letters 19:8, pages 2277-2281.
Crossref
Crossref
Dominique Bonafoux, Claudio Chuaqui, P. Ann Boriack-Sjodin, Chris Fitch, Gretchen Hankins, Serene Josiah, Cheryl Black, Gregg Hetu, Leona Ling & Wen-Cherng Lee. (2009) 2-Aminoimidazoles inhibitors of TGF-? receptor 1. Bioorganic & Medicinal Chemistry Letters 19:3, pages 912-916.
Crossref
Crossref
Vincenzo Bronte & Simone Mocellin. (2009) Suppressive Influences in the Immune Response to Cancer. Journal of Immunotherapy 32:1, pages 1-11.
Crossref
Crossref
Lars Zender, Wen Xue, Johannes Zuber, Camile P. Semighini, Alexander Krasnitz, Beicong Ma, Peggy Zender, Stefan Kubicka, John M. Luk, Peter Schirmacher, W. Richard McCombie, Michael Wigler, James Hicks, Gregory J. Hannon, Scott Powers & Scott W. Lowe. (2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell 135:5, pages 852-864.
Crossref
Crossref
Delphine Javelaud, Vasileia-Ismini Alexaki & Alain Mauviel. (2008) Transforming growth factor-β in cutaneous melanoma. Pigment Cell & Melanoma Research 21:2, pages 123-132.
Crossref
Crossref
Nicole A. Bouffard, Kenneth R. Cutroneo, Gary J. Badger, Sheryl L. White, Thomas R. Buttolph, H. Paul Ehrlich, Debbie Stevens‐Tuttle & Helene M. Langevin. (2007) Tissue stretch decreases soluble TGF‐β1 and type‐1 procollagen in mouse subcutaneous connective tissue: Evidence from ex vivo and in vivo models. Journal of Cellular Physiology 214:2, pages 389-395.
Crossref
Crossref
Jean-Pierre Gies & Yves Landry. 2008. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry
85
105
.
Hanno Riess, Andrea Goerke & Helmut OettleKarl-Hermann Schlingensiepen, Birgit Fischer-Blass, Susanne Schmaus & Sylvia Ludwig. 2008. Pancreatic Cancer. Pancreatic Cancer
137
150
.
Laurent Bartholin & Theresa Guise. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
95
123
.
Abhik Bandyopadhyay & LuZhe Sun. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
723
735
.
Leona E. Ling, Juswinder Singh, Claudio E. Chuaqui, P. Ann Boriack-Sjodin, Michael J. Corbley, Doreen J. Lepage, Erika L. Silverio, Lihong Sun, James L. Papadatos, Feng Shan, Timothy Pontz, H. -Kam Cheung, Xiamei Zhang, Robert M. Arduini, Jonathan N. Mead, Miki N. Newman, Scott Bowes, Serene Josiah & Wen-Cherng Lee. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
685
696
.
Karl-Hermann Schlingensiepen, Piotr Jachimczak, Birgit Fischer-Blass, Dagmar Fischer, Heike Specht, Susanne Schmaus & Reimar Schlingensiepen. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
635
651
.
Nancy L. McCartney-Francis & Sharon M. Wahl. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
553
570
.
Catherine M. Bollard & Cliona M. Rooney. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume II. Transforming Growth Factor-β in Cancer Therapy, Volume II
383
400
.
Sonia B. JakowlewMichael Grusch, Chantal Rodgarkia-Dara, Wilfried Bursch & Rolf Schulte-Hermann. 2008. Transforming Growth Factor-β in Cancer Therapy, Volume I. Transforming Growth Factor-β in Cancer Therapy, Volume I
483
508
.
Gérald J Prud'homme. (2007) Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations. Laboratory Investigation 87:11, pages 1077-1091.
Crossref
Crossref
Ann M. LeenCliona M. RooneyAaron E. Foster. (2007) Improving T Cell Therapy for Cancer. Annual Review of Immunology 25:1, pages 243-265.
Crossref
Crossref
T Hagemann, T Bozanovic, S Hooper, A Ljubic, V I F Slettenaar, J L Wilson, N Singh, S A Gayther, J H Shepherd & P O A Van Trappen. (2007) Molecular profiling of cervical cancer progression. British Journal of Cancer 96:2, pages 321-328.
Crossref
Crossref
Volker Wacheck. (2006) Oligonukleotid Therapeutika – eine neu entstehende SubstanzklasseOligonucleotide therapeutics – an emerging novel class of compounds. Wiener Medizinische Wochenschrift 156:17-18, pages 481-487.
Crossref
Crossref
Alexander J. Muller & Peggy A. Scherle. (2006) Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors. Nature Reviews Cancer 6:8, pages 613-625.
Crossref
Crossref
Abhik Bandyopadhyay, Joseph K. Agyin, Long Wang, Yuping Tang, Xiufen Lei, Beryl M. Story, John E. Cornell, Bradley H. Pollock, Gregory R. Mundy & Lu-Zhe Sun. (2006) Inhibition of Pulmonary and Skeletal Metastasis by a Transforming Growth Factor-β Type I Receptor Kinase Inhibitor. Cancer Research 66:13, pages 6714-6721.
Crossref
Crossref
Kristine Lacuesta, Elizabeth Buza, Hans Hauser, Laura Granville, Martin Pule, Greg Corboy, Milton Finegold, Heidi Weiss, Si Y. Chen, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney & Catherine M. Bollard. (2006) Assessing the Safety of Cytotoxic T Lymphocytes Transduced With a Dominant Negative Transforming Growth Factor-β Receptor. Journal of Immunotherapy 29:3, pages 250-260.
Crossref
Crossref
M T Lotze. (2005) Cancer Gene Therapy: The power of negative thinking. Gene Therapy 13:3, pages 191-193.
Crossref
Crossref
A. M. Gressner & R. Weiskirchen. (2007) Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF‐β as major players and therapeutic targets. Journal of Cellular and Molecular Medicine 10:1, pages 76-99.
Crossref
Crossref
K. Krieglstein. 2006. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology
123
141
.
Michael Lahn, Brandi Berry, Susanne Kloeker & Jonathan M. Yingling. 2006. Smad Signal Transduction. Smad Signal Transduction
415
442
.
Karl Hermann Schlingensiepen, Birgit Fischer-Blass, Piotr Jachimczak & Reimar Schlingensiepen. (2005) The role of transforming growth factor-β in carcinogenesis. Nature Reviews Cancer 5:12, pages 995-995.
Crossref
Crossref