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Volume 14, Issue 6

Expert Opinion on Investigational Drugs

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Expert Opinion on Investigational Drugs, Volume 14, Issue 6 (2005)

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Expert Opinion on Investigational Drugs, Volume 14, Issue 6 (2005)

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Review

Article

Peroxisome proliferator-activated receptor-γ ligands for the treatment of breast cancer

Martin H Fenner & Elena Elstner

Pages: 557-568

Published online: 11 Jul 2005

AbstractforPeroxisome proliferator-activated receptor-γ ligands for the treatment of breast cancer | References | PDF (149 KB)

242 Views
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Article

Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

Jennifer S Isaacs

Pages: 569-589

Published online: 11 Jul 2005

AbstractforHeat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up? | References | PDF (240.3 KB)

61 Views
22 CrossRef citations
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Article

ADAM proteases, ErbB pathways and cancer

Bin-Bing S Zhou, Jordan S Fridman, Xiangdong Liu, Steve M Friedman, Robert C Newton & Peggy A Scherle

Pages: 591-606

Published online: 11 Jul 2005

AbstractforADAM proteases, ErbB pathways and cancer | References | PDF (250 KB)

113 Views
20 CrossRef citations
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Article

Beyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer

Kenneth Khamly, Michael Jefford, Michael Michael & John Zalcberg

Pages: 607-628

Published online: 11 Jul 2005

AbstractforBeyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer | References | PDF (265 KB)

41 Views
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Article

TGF-β inhibitors for the treatment of cancer

Michael Lahn, Susanne Kloeker & Brandi S Berry

Pages: 629-643

Published online: 11 Jul 2005

AbstractforTGF-β inhibitors for the treatment of cancer | References | PDF (172.7 KB)

448 Views
72 CrossRef citations
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Article

Novel therapeutics in adult malignant brain gliomas

Michele Reni, Elena Mazza, Alicia Tosoni & Alba A Brandes

Pages: 643-658

Published online: 11 Jul 2005

AbstractforNovel therapeutics in adult malignant brain gliomas | References | PDF (171.1 KB)

39 Views
4 CrossRef citations
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Article

An emerging role for calcium sensitisation in the treatment of heart failure

Leif Erhardt

Pages: 659-670

Published online: 11 Jul 2005

AbstractforAn emerging role for calcium sensitisation in the treatment of heart failure | References | PDF (182.2 KB)

43 Views
9 CrossRef citations
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Article

Lipoprotein-associated phospholipase A₂: a novel marker of cardiovascular risk and potential therapeutic target

Colin Macphee, G Martin Benson, Yi Shi & Andrew Zalewski

Pages: 671-679

Published online: 11 Jul 2005

AbstractforLipoprotein-associated phospholipase A₂: a novel marker of cardiovascular risk and potential therapeutic target | References | PDF (120.9 KB)

49 Views
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Article

The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV

Donglei Yu, Carl T Wild, David E Martin, Susan L Morris-Natschke, Chin-Ho Chen, Graham P Allaway & Kuo-Hsiung Lee

Pages: 681-693

Published online: 11 Jul 2005

AbstractforThe discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV | References | PDF (194.1 KB)

104 Views
41 CrossRef citations
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Article

Therapeutic potential of cannabinoid receptor agonists as analgesic agents

Alyson Fox & Stuart Bevan

Pages: 695-703

Published online: 11 Jul 2005

AbstractforTherapeutic potential of cannabinoid receptor agonists as analgesic agents | References | PDF (111.7 KB)

152 Views
51 CrossRef citations
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Article

The incretin effect and its potentiation by glucagon-like peptide 1-based therapies: a revolution in diabetes management

Octaviano A Roges, Marilyn Baron & Athena Philis-Tsimikas

Pages: 705-727

Published online: 11 Jul 2005

AbstractforThe incretin effect and its potentiation by glucagon-like peptide 1-based therapies: a revolution in diabetes management | References | PDF (249.6 KB)

69 Views
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Drug Evaluation

Article

Istradefylline, a novel adenosine A_2A receptor antagonist, for the treatment of Parkinson’s disease

Peter Jenner

Pages: 729-738

Published online: 11 Jul 2005

AbstractforIstradefylline, a novel adenosine A_2A receptor antagonist, for the treatment of Parkinson’s disease | References | PDF (127.8 KB)

422 Views
127 CrossRef citations
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Key Paper Evaluation

Article

RITA - a small-molecule anticancer drug that targets p53

ISSAEVA N, BOZKO P, ENGE M et al.: Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours. Nat. Med. (2004) 12:1321-1328.

Sheila A Doggrell

Pages: 739-742

Published online: 11 Jul 2005

AbstractforRITA - a small-molecule anticancer drug that targets p53 | References | PDF (54 KB)

360 Views
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Meeting Highlights

Article

Euroconference on tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions

Paris, France, March 17 – 18, 2005

Martin Braddock

Pages: 743-749

Published online: 11 Jul 2005

AbstractforEuroconference on tissue repair and ulcer/wound healing: molecular mechanisms, therapeutic targets and future directions | References | PDF (88.7 KB)

61 Views
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