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Therapeutic potential of cannabinoid receptor agonists as analgesic agents

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Pages 695-703 | Published online: 11 Jul 2005

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Keith A. Kwan Cheung, Murray D. Mitchell & Helen S. Heussler. (2021) Cannabidiol and Neurodevelopmental Disorders in Children. Frontiers in Psychiatry 12.
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R. B. Raffa & J. V. Pergolizzi Jr. (2011) Deciphering the mechanism(s) of action of natural products: analgesic peroxide oil as example. Journal of Clinical Pharmacy and Therapeutics 36:3, pages 283-298.
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Robert J. Gleave, Paul J. Beswick, Andrew J. Brown, Gerard M.P. Giblin, Carl P. Haslam, David Livermore, Andrew Moses, Neville H. Nicholson, Lee W. Page, Brian Slingsby & Martin E. Swarbrick. (2009) 2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships. Bioorganic & Medicinal Chemistry Letters 19:23, pages 6578-6581.
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Saniya Aggarwal, Behnam Shavalian, Esther Kim & Scott M. Rawls. (2009) Agmatine enhances cannabinoid action in the hot-plate assay of thermal nociception. Pharmacology Biochemistry and Behavior 93:4, pages 426-432.
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I Mancini, R Brusa, G Quadrato, C Foglia, P Scandroglio, LS Silverman, D Tulshian, A Reggiani & M Beltramo. (2009) Constitutive activity of cannabinoid-2 (CB 2 ) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242 . British Journal of Pharmacology 158:1, pages 382-391.
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Ian W. Rodger. (2009) Analgesic targets: today and tomorrow. Inflammopharmacology 17:3, pages 151-161.
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Jörg Ahrens, Martin Leuwer, Reyhan Demir, Klaus Krampfl, Jeanne de la Roche, Nilufar Foadi, Matthias Karst & Gertrud Haeseler. (2008) Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine α1- and α1β-receptors. Naunyn-Schmiedeberg's Archives of Pharmacology 379:4, pages 371-378.
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Sumner H. Burstein & Robert B. Zurier. (2009) Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation. The AAPS Journal 11:1.
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Mikael Brusberg, Susanne Arvidsson, Daiwu Kang, Håkan Larsson, Erik Lindström & Vicente Martinez. (2009) CB 1 Receptors Mediate the Analgesic Effects of Cannabinoids on Colorectal Distension-Induced Visceral Pain in Rodents . The Journal of Neuroscience 29:5, pages 1554-1564.
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Roger G Pertwee. (2009) Emerging strategies for exploiting cannabinoid receptor agonists as medicines. British Journal of Pharmacology 156:3, pages 397-411.
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Betty B. Yao, Gin Hsieh, Anthony V. Daza, Yihong Fan, George K. Grayson, Tiffany Runyan Garrison, Odile El Kouhen, Bradley A. Hooker, Madhavi Pai, Erica J. Wensink, Anita K. Salyers, Prasant Chandran, Chang Z. Zhu, Chengmin Zhong, Keith Ryther, Megan E. Gallagher, Chih-Liang Chin, Ann E. Tovcimak, Vincent P. Hradil, Gerard B. Fox, Michael J. Dart, Prisca Honore & Michael D. Meyer. (2009) Characterization of a Cannabinoid CB 2 Receptor-Selective Agonist, A-836339 [2,2,3,3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4,5-dimethyl-3 H -thiazol-(2 Z )-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging . Journal of Pharmacology and Experimental Therapeutics 328:1, pages 141-151.
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Roger G. Pertwee & Adèle Thomas. 2009. The Cannabinoid Receptors. The Cannabinoid Receptors 361 392 .
Penny C. Staton, Jon P. Hatcher, Deborah J. Walker, Alastair D. Morrison, Ellen M. Shapland, Jane P. Hughes, Elizabeth Chong, Palwinder K. Mander, Paula J. Green, Andy Billinton, Michael Fulleylove, Hilary C. Lancaster, Jason C. Smith, Leigh T. Bailey, Alan Wise, Andrew J. Brown, Jill C. Richardson & Iain P. Chessell. (2008) The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain 139:1, pages 225-236.
Crossref
Christophe Mallet, Laurence Daulhac, Jérôme Bonnefont, Catherine Ledent, Monique Etienne, Eric Chapuy, Frédéric Libert & Alain Eschalier. (2008) Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia. Pain 139:1, pages 190-200.
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Yuan Cheng, Brian K. Albrecht, James Brown, John L. Buchanan, William H. Buckner, Erin F. DiMauro, Renee Emkey, Robert T. FremeauJr.Jr., Jean-Christophe Harmange, Beth J. Hoffman, Liyue Huang, Ming Huang, Josie Han Lee, Fen-Fen Lin, Matthew W. Martin, Hung Q. Nguyen, Vinod F. Patel, Susan A. Tomlinson, Ryan D. White, Xiaoyang Xia & Stephen A. Hitchcock. (2008) Discovery and Optimization of a Novel Series of N -Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB 2 ) Agonists . Journal of Medicinal Chemistry 51:16, pages 5019-5034.
Crossref
A. Dray. (2008) Neuropathic pain: emerging treatments. British Journal of Anaesthesia 101:1, pages 48-58.
Crossref
Roger G. Pertwee. (2008) Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addiction Biology 13:2, pages 147-159.
Crossref
Andy Dray. (2008) New Horizons in Pharmacologic Treatment for Rheumatic Disease Pain. Rheumatic Disease Clinics of North America 34:2, pages 481-505.
Crossref
B B Yao, G C Hsieh, J M Frost, Y Fan, T R Garrison, A V Daza, G K Grayson, C Z Zhu, M Pai, P Chandran, A K Salyers, E J Wensink, P Honore, J P Sullivan, M J Dart & M D Meyer. (2008) In vitro and in vivo characterization of A-796260: a selective cannabinoid CB 2 receptor agonist exhibiting analgesic activity in rodent pain models . British Journal of Pharmacology 153:2, pages 390-401.
Crossref
R G Pertwee. (2008) The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 -tetrahydrocannabinol, cannabidiol and Δ 9 -tetrahydrocannabivarin . British Journal of Pharmacology 153:2, pages 199-215.
Crossref
A. Dray. 2008. The Senses: A Comprehensive Reference. The Senses: A Comprehensive Reference 795 819 .
Andrea S. HeimannIvone GomesCamila S. DaleRosana L. PaganoAchla GuptaLaura L. de SouzaAugusto D. LuchessiLeandro M. Castro, Renata GiorgiVanessa Rioli, Emer S. Ferro & Lakshmi A. Devi. (2007) Hemopressin is an inverse agonist of CB 1 cannabinoid receptors . Proceedings of the National Academy of Sciences 104:51, pages 20588-20593.
Crossref
Pedro Emilio Bermejo Velasco & Rocío Velasco Calvo. (2007) Nuevos fármacos antiepilépticos y dolor neuropático. De la medicina molecular a la clínica. Medicina Clínica 129:14, pages 542-550.
Crossref
a. a. izzo. (2007) The cannabinoid CB 2 receptor: a good friend in the gut . Neurogastroenterology & Motility 19:9, pages 704-708.
Crossref
k. hillsley, c. mccaul, j. aerssens, p. j. peeters, h. gijsen, d. moechars, b. coulie, d. grundy & r. h. stead. (2007) Activation of the cannabinoid 2 (CB2) receptor inhibits murine mesenteric afferent nerve activity. Neurogastroenterology & Motility 19:9, pages 769-777.
Crossref
Ken Mackie. (2007) From Active Ingredients to the Discovery of the Targets: The Cannabinoid Receptors. Chemistry & Biodiversity 4:8, pages 1693-1706.
Crossref
Tuba Esfandyari, Michael Camilleri, Irene Busciglio, Duane Burton, Kari Baxter & Alan R. Zinsmeister. (2007) Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. American Journal of Physiology-Gastrointestinal and Liver Physiology 293:1, pages G137-G145.
Crossref
S.Y. Sit, Charlie Conway, Robert Bertekap, Kai Xie, Clotilde Bourin, Kevin Burris & Hongfeng Deng. (2007) Novel inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters 17:12, pages 3287-3291.
Crossref
Pál Pacher, Sándor Bátkai & George Kunos. (2006) The Endocannabinoid System as an Emerging Target of Pharmacotherapy. Pharmacological Reviews 58:3, pages 389-462.
Crossref
B B Yao, S Mukherjee, Y Fan, T R Garrison, A V Daza, G K Grayson, B A Hooker, M J Dart, J P Sullivan & M D Meyer. (2006) In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB 2 receptor? . British Journal of Pharmacology 149:2, pages 145-154.
Crossref

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