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Peng Zhao, Shang-Ke Chen, Ying-Hong Cai, Xiao Lu, Zhe Li, Yuen-Kit Cheng, Cuixian Zhang, Xiaopeng Hu, Xixin He & Hai-Bin Luo. (2013) The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:10, pages 2089-2096.
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Stefan Ückert, Eginhard S. Waldkirch, Joachim E. Sonnenberg, Peter Sandner, Markus A. Kuczyk & Petter Hedlund. (2011) Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. The Journal of Sexual Medicine 8:11, pages 3058-3065.
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SANG-DO LEE, DAVID S. C. HUI, AZIAH A. MAHAYIDDIN, CAMILO C. ROA JR, KHENG HOE KWA, UDO-MICHAEL GOEHRING, DIRK BREDENBRÖKER & HAN-PIN KUO. (2011) Roflumilast in Asian patients with COPD: A randomized placebo-controlled trial. Respirology 16:8, pages 1249-1257.
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Gezim Lahu, Nassr Nassr, Rolf Herzog, Martin Elmlinger, Peter Ruth, Markus Hinder & Andreas Huennemeyer. (2011) Effect of Steady-State Enoxacin on Single-Dose Pharmacokinetics of Roflumilast and Roflumilast N-Oxide. The Journal of Clinical Pharmacology 51:4, pages 586-593.
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Bora InceogluKaren WagnerNils H. SchebbChristophe MorisseauSteven L. Jinks, Arzu UluChristine HegedusTristan RoseRobert Brosnan & Bruce D. Hammock. (2011) Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proceedings of the National Academy of Sciences 108:12, pages 5093-5097.
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Stephen K. Field. (2011) Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 5, pages CCRPM.S7049.
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Chris Rundfeldt, Katarzyna Socała & Piotr Wlaź. (2010) The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. Journal of Neural Transmission 117:11, pages 1319-1325.
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Armin Hatzelmann, Esteban J. Morcillo, Giuseppe Lungarella, Serge Adnot, Shahin Sanjar, Rolf Beume, Christian Schudt & Hermann Tenor. (2010) The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 23:4, pages 235-256.
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Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari, Maria Paola Giovannoni, Agostino Cilibrizzi, Vittorio Dal Piaz, Claudia Vergelli, Letizia Crocetti, Maurizio Delcanale, Elisabetta Armani, Andrea Rizzi, Paola Puccini, Paola Maria Gallo, Daniele Spinabelli & Paola Caruso. (2010) Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity. Bioorganic & Medicinal Chemistry 18:10, pages 3506-3517.
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