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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 7
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Drug Evaluation

Nilotinib: a novel Bcr-Abl tyrosine kinase inhibitor for the treatment of leukemias

Elias Jabbour The University of Texas MD Anderson Cancer Center, Department of Leukemia, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA +1 713 792 7305; +1 713 794 4997; [email protected]
,
Samih El Ahdab The University of Texas MD Anderson Cancer Center, Department of Leukemia, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA +1 713 792 7305; +1 713 794 4997; [email protected]
,
Jorge Cortes The University of Texas MD Anderson Cancer Center, Department of Leukemia, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA +1 713 792 7305; +1 713 794 4997; [email protected]
&
Hagop Kantarjian The University of Texas MD Anderson Cancer Center, Department of Leukemia, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA +1 713 792 7305; +1 713 794 4997; [email protected]
Pages 1127-1136 | Published online: 12 Jun 2008

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Ravikanth Nanduri, Rashi Kalra, Ella Bhagyaraj, Anuja P. Chacko, Nancy Ahuja, Drishti Tiwari, Sumit Kumar, Monika Jain, Raman Parkesh & Pawan Gupta. (2019) AutophagySMDB: a curated database of small molecules that modulate protein targets regulating autophagy. Autophagy 15:7, pages 1280-1295.
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A. N. Fedarkevich, O. L. Sharko & V. V. Shmanai. (2020) Computer Modeling and Synthesis of Potential Inhibitors of Tyrosine Kinase BCR-ABL with the T315I Mutation. Russian Journal of Bioorganic Chemistry 46:2, pages 187-198.
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Lysann Kroschwald, Josephine Tauer, Sonja Kroschwald, Meinolf Suttorp, Anne Wiedenfeld, Stefan Beissert, Andrea Bauer & Martina Rauner. (2019) Imatinib mesylate and nilotinib decrease synthesis of bone matrix in�vitro. Oncology Letters.
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Lysann Kroschwald, Meinolf Suttorp, Josephine Tauer, Nick Zimmermann, Claudia G�nther & Andrea Bauer. (2017) Off‑target effect of imatinib and nilotinib on human vitamin D3 metabolism. Molecular Medicine Reports.
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Kirsten Bleckmann & Martin Schrappe. (2016) Advances in therapy for Philadelphia-positive acute lymphoblastic leukaemia of childhood and adolescence. British Journal of Haematology 172:6, pages 855-869.
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Sandip B. Bharate, Sanghapal D. Sawant, Parvinder Pal Singh & Ram A. Vishwakarma. (2013) Kinase Inhibitors of Marine Origin. Chemical Reviews 113:8, pages 6761-6815.
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Suneet Shukla, Amanda P. Skoumbourdis, Martin J. Walsh, Anika M. S. Hartz, King Leung Fung, Chung-Pu Wu, Michael M. Gottesman, Björn Bauer, Craig J. Thomas & Suresh V. Ambudkar. (2011) Synthesis and Characterization of a BODIPY Conjugate of the BCR-ABL Kinase Inhibitor Tasigna (Nilotinib): Evidence for Transport of Tasigna and Its Fluorescent Derivative by ABC Drug Transporters. Molecular Pharmaceutics 8:4, pages 1292-1302.
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S. Schenone, O. Bruno, M. Radi & M. Botta. (2010) New insights into small‐molecule inhibitors of Bcr‐Abl. Medicinal Research Reviews 31:1, pages 1-41.
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Donald J. AbrahamRobert H. Bradbury. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 295 344 .
Ji Zhang & Jie Jack Li. 2010. Modern Drug Synthesis. Modern Drug Synthesis 111 122 .
David J. Matthews & Mary E. Gerritsen. 2010. Targeting Protein Kinases for Cancer Therapy. Targeting Protein Kinases for Cancer Therapy 435 525 .
Catriona H. Jamieson. (2008) Chronic Myeloid Leukemia Stem Cells. Hematology 2008:1, pages 436-442.
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