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Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

, PhD, , MD PhD, , MD, , MD PhD, , PhD, , MD PhD, , PhD & , MD show all
Pages 325-341 | Published online: 11 Jan 2011

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David A. Loeffler. (2023) Antibody-Mediated Clearance of Brain Amyloid-β: Mechanisms of Action, Effects of Natural and Monoclonal Anti-Aβ Antibodies, and Downstream Effects. Journal of Alzheimer's Disease Reports 7:1, pages 873-899.
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David A. Loeffler. (2023) Experimental approaches for altering the expression of Abeta‐degrading enzymes. Journal of Neurochemistry 164:6, pages 725-763.
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Mingzhou Guo, Yang Niu, Min Xie, Xiansheng Liu & Xiaochen Li. (2023) Notch signaling, hypoxia, and cancer. Frontiers in Oncology 13.
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Željko M. Svedružić, Vesna Šendula Jengić & Lucija Ostojić. (2023) The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer’s Disease. International Journal of Molecular Sciences 24:3, pages 1835.
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Ruolan Xia, Maosen Xu, Jing Yang & Xuelei Ma. (2022) The role of Hedgehog and Notch signaling pathway in cancer. Molecular Biomedicine 3:1.
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Nicholas CullenShorena JanelidzeSebastian PalmqvistErik StomrudNiklas Mattsson-CarlgrenOskar Hansson. (2022) Association of CSF Aβ 38 Levels With Risk of Alzheimer Disease–Related Decline . Neurology 98:9.
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Kimberly Malka & Lucy Liaw. (2022) NOTCH3 as a modulator of vascular disease: a target in elastin deficiency and arterial pathologies. Journal of Clinical Investigation 132:5.
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Željko M. Svedružić, Katarina Vrbnjak, Manuel Martinović & Vedran Miletić. (2021) Structural Analysis of the Simultaneous Activation and Inhibition of γ-Secretase Activity in the Development of Drugs for Alzheimer’s Disease. Pharmaceutics 13:4, pages 514.
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Samarpan Majumder, Judy S. Crabtree, Todd E. Golde, Lisa M. Minter, Barbara A. Osborne & Lucio Miele. (2020) Targeting Notch in oncology: the path forward. Nature Reviews Drug Discovery 20:2, pages 125-144.
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Asmaa Awad, Hedia Fgaier, Ibrahim Mustafa, Ali Elkamel & Said Elnashaie. (2019) Pharmacokinetic/Pharmacodynamic modeling and simulation of the effect of medications on β-amyloid aggregates and cholinergic neurocycle. Computers & Chemical Engineering 126, pages 231-240.
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Kewal K. JainKewal K. Jain. 2019. The Handbook of Neuroprotection. The Handbook of Neuroprotection 465 585 .
Ryuichi Sekioka, Eriko Honjo, Shugo Honda, Hideyoshi Fuji, Hiroki Akashiba, Yasuyuki Mitani & Shingo Yamasaki. (2018) Discovery of novel scaffolds for γ-secretase modulators without an arylimidazole moiety. Bioorganic & Medicinal Chemistry 26:2, pages 435-442.
Crossref
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius & Henrik Zetterberg. (2017) Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ. Molecular and Cellular Neuroscience 85, pages 211-219.
Crossref
Hadi Khani, Mohammad B. Sepehrifar & Shantia Yarahmadian. (2017) An improvement on the prediction power of the 3D-QSAR CoMFA models using a hybrid of statistical and machine learning methods: a case study on γ‑secretase modulators of Alzheimer’s disease. Medicinal Chemistry Research 26:6, pages 1184-1200.
Crossref
Zhenzhen Sun, Yujie Xie, Yintong Chen, Qinghu Yang, Zhenzhen Quan, Rongji Dai & Hong Qing. (2017) Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution. Molecular Neurobiology.
Crossref
Kevin D. Rynearson, Ronald N. Buckle, Keith D. Barnes, R. Jason Herr, Nicholas J. Mayhew, William D. Paquette, Samuel A. Sakwa, Phuong D. Nguyen, Graham Johnson, Rudolph E. Tanzi & Steven L. Wagner. (2016) Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorganic & Medicinal Chemistry Letters 26:16, pages 3928-3937.
Crossref
Zi-Xuan Wang, Lan Tan, Jinyuan Liu & Jin-Tai Yu. (2015) The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease. Molecular Neurobiology 53:3, pages 1905-1924.
Crossref
Jianliang Shi, Dmitry Zuev, Li Xu, Kimberley A. Lentz, James E. Grace, Jeremy H. Toyn, Richard E. Olson, John E. Macor & Lorin A. Thompson. (2016) Design and optimization of tricyclic gamma-secretase modulators. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1498-1502.
Crossref
M.S. Wolfe. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 950 959 .
M.S. Wolfe. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 661 669 .
D. M. Janzen, E. Tiourin, J. A. Salehi, D. Y. Paik, J. Lu, M. Pellegrini & S. Memarzadeh. (2015) RETRACTED ARTICLE: An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer. Nature Communications 6:1.
Crossref
Daniel Flesch, Julia Ness, Christina Lamers, Friederike Dehm, Sven Popella, Ramona Steri, Isabella Ogorek, Martina Hieke, Gerd Dannhardt, Oliver Werz, Sascha Weggen & Manfred Schubert-Zsilavecz. (2015) SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 25:4, pages 841-846.
Crossref
Martin Pettersson, Douglas S. Johnson, John M. Humphrey, Christopher W. am Ende, Edelweiss Evrard, Ivan Efremov, Gregory W. Kauffman, Antonia F. Stepan, Cory M. Stiff, Longfei Xie, Kelly R. Bales, Eva Hajos-Korcsok, Heather E. Murrey, Leslie R. Pustilnik, Stefanus J. Steyn, Kathleen M. Wood & Patrick R. Verhoest. (2015) Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin. Bioorganic & Medicinal Chemistry Letters 25:4, pages 908-913.
Crossref
Carla J. Cox, Fahd Choudhry, Eleanor Peacey, Michael S. Perkinton, Jill C. Richardson, David R. Howlett, Stefan F. Lichtenthaler, Paul T. Francis & Robert J. Williams. (2015) Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiology of Aging 36:1, pages 178-187.
Crossref
Xian Zhang, Yanfang Li, Huaxi Xu & Yun-wu Zhang. (2014) The γ-secretase complex: from structure to function. Frontiers in Cellular Neuroscience 8.
Crossref
Debomoy K. Lahiri, Bryan Maloney, Justin M. Long & Nigel H. Greig. (2014) Lessons from a BACE1 inhibitor trial: Off‐site but not off base. Alzheimer's & Dementia 10:5S.
Crossref
Yoshihiro Konishi, Li-Bang Yang, Ping He, Kristina Lindholm, Bai Lu, Rena Li & Yong Shen. (2014) Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death. The Journal of Neuroscience 34:39, pages 13127-13138.
Crossref
Kihyuck Kwak, Rosie Jiang, Joshua W. Wang, Subhashini Jagu, Reinhard Kirnbauer & Richard B. S. Roden. (2014) Impact of Inhibitors and L2 Antibodies upon the Infectivity of Diverse Alpha and Beta Human Papillomavirus Types. PLoS ONE 9:5, pages e97232.
Crossref
Yanke Yu, Veronika Logovinsky, Edgar Schuck, June Kaplow, Min-kun Chang, Takehiko Miyagawa, Nancy Wong & Jim Ferry. (2014) Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects. The Journal of Clinical Pharmacology 54:5, pages 528-536.
Crossref
Martin Pettersson, Douglas S. Johnson, Chakrapani Subramanyam, Kelly R. Bales, Christopher W. am Ende, Benjamin A. Fish, Michael E. Green, Gregory W. Kauffman, Patrick B. Mullins, Thayalan Navaratnam, Subas M. Sakya, Cory M. Stiff, Tuan P. Tran, Longfei Xie, Liming Zhang, Leslie R. Pustilnik, Beth C. Vetelino, Kathleen M. Wood, Nikolay Pozdnyakov, Patrick R. Verhoest & Christopher J. O’Donnell. (2014) Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators. Journal of Medicinal Chemistry 57:3, pages 1046-1062.
Crossref
R. Anand, Kiran Dip Gill & Abbas Ali Mahdi. (2014) Therapeutics of Alzheimer's disease: Past, present and future. Neuropharmacology 76, pages 27-50.
Crossref
Boris Decourt, MiMi Macias, Marwan Sabbagh & Abdu Adem. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 518 546 .
Vageesh Revadigar, Raza Murad Ghalib, Vikneswaran Murugaiyah, Mohamed A. Embaby, Ali Jawad, Sayed Hasan Mehdi, Rokiah Hashim & Othman Sulaiman. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 142 198 .
Nady Braidy, Anne Poljak, Tharusha Jayasena & Perminder Sachdev. 2014. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1173 1190 .
Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas, Chester Yuan, Albert Amegadzie, Qingyian Liu, Thomas Nixey, Joe Zhu, Mqhele Ncube, Robert M. Rzasa, Frank ChavezJr.Jr., Ning Chen, Frenel DeMorin, Shannon Rumfelt, Christopher M. Tegley, Jennifer R. Allen, Stephen Hitchcock, Randy Hungate, Michael D. Bartberger, Leeanne Zalameda, Yichin Liu, John D. McCarter, Jianhua Zhang, Li Zhu, Safura Babu-Khan, Yi Luo, Jodi Bradley, Paul H. Wen, Darren L. Reid, Frank Koegler, Charles DeanJr.Jr., Dean Hickman, Tiffany L. Correll, Toni Williamson & Stephen Wood. (2013) Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 23:23, pages 6447-6454.
Crossref
Lucía Chávez‐Gutiérrez. (2013) Dissecting γ‐secretase function. Journal of Neurochemistry 125:1, pages 1-3.
Crossref
Charles F. Albright, Randy C. Dockens, Jere E. MeredithJr.Jr., Richard E. Olson, Randy Slemmon, Kimberley A. Lentz, Jun-Sheng Wang, R. Rex Denton, Gary Pilcher, Paul W. Rhyne, Joseph J. Raybon, Donna M. Barten, Catherine Burton, Jeremy H. Toyn, Sethu Sankaranarayanan, Craig Polson, Valerie Guss, Randy White, Frank Simutis, Thomas Sanderson, Kevin W. Gillman, John E. StarrettJr.Jr., Joanne Bronson, Oleksandr Sverdlov, Shu-Pang Huang, Lorna Castaneda, Howard Feldman, Vlad Coric, Robert Zaczek, John E. Macor, John Houston, Robert M. Berman & Gary Tong. (2013) Pharmacodynamics of Selective Inhibition of γ -Secretase by Avagacestat . Journal of Pharmacology and Experimental Therapeutics 344:3, pages 686-695.
Crossref
Lian-Feng Lin, Min-Jing Liao, Xiao-Yan Xue, Wei Zhang, Li Yan, Liang Cai, Xiao-Wen Zhou, Xing Zhou & Huan-Min Luo. (2012) Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer’s disease. Neuroscience Bulletin 29:1, pages 111-120.
Crossref
Jon B Toledo, Leslie M Shaw & John Q Trojanowski. (2013) Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker. Alzheimer's Research & Therapy 5:2, pages 8.
Crossref
Ishrut Hussain, Julien Fabrègue, Laurence Anderes, Solenne Ousson, Frédéric Borlat, Valérie Eligert, Sébastien Berger, Mitko Dimitrov, Jean-René Alattia, Patrick C. Fraering & Dirk Beher. (2013) The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation. Journal of Biological Chemistry 288:4, pages 2521-2531.
Crossref
Hongmei Li, Jun Qin, Pawan Dhondi, Wei Zhou, Monica Vicarel, Thomas Bara, David Cole, Hubert Josien, Dmitri Pissarnitski, Zhaoning Zhu, Anandan Palani, Robert Aslanian, John Clader, Michael Czarniecki, William Greenlee, Mary Cohen-Williams, Lynn Hyde, Lixin Song, Lili Zhang, Inhou Chu & Xianhai Huang. (2013) The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters 23:2, pages 466-471.
Crossref
Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka, Zhiming Tu, Faris Albayya, Winnie Lee, Sarah Hopp, Mary-Jo Miller, Darcie Spaulding, Zhiyong Yang, Hilliary Hodgdon, Scott Nolan, Melody Wen, Don Costa, Jean-Francois Blain, Emily Freeman, Bart De Strooper, Veerle Vulsteke, Louise Scrocchi, Henrik Zetterberg, Erik Portelius, Birgit Hutter-Paier, Daniel Havas, Michael Ahlijanian, Dorothy Flood, Liza Leventhal, Gideon Shapiro, Holger Patzke, Richard Chesworth & Gerhard Koenig. (2012) Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Molecular Neurodegeneration 7:1.
Crossref
Tomas Borgegård, Susanne Gustavsson, Charlotte Nilsson, Santiago Parpal, Rebecka Klintenberg, Anna-Lena Berg, Susanne Rosqvist, Lutgarde Serneels, Samuel Svensson, Fredrik Olsson, Shaobo Jin, Hongmei Yan, Johanna Wanngren, Anders Jureus, Anna Ridderstad-Wollberg, Patrik Wollberg, Kenneth Stockling, Helena Karlström, Åsa Malmberg, Johan Lund, Per I. Arvidsson, Bart De Strooper, Urban Lendahl & Johan Lundkvist. (2012) Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy. The Journal of Neuroscience 32:48, pages 17297-17305.
Crossref
Yasong Lu, David Riddell, Eva Hajos-Korcsok, Kelly Bales, Kathleen M. Wood, Charles E. Nolan, Ashley E. Robshaw, Liming Zhang, Louis Leung, Stacey L. Becker, Elaine Tseng, Jason Barricklow, Emily H. Miller, Sarah Osgood, Brian T. O'Neill, Michael A. Brodney, Douglas S. Johnson & Martin Pettersson. (2012) Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses. Journal of Pharmacology and Experimental Therapeutics 342:2, pages 366-375.
Crossref
Joel N. Buxbaum & Reinhold P. Linke. (2012) A Molecular History of the Amyloidoses. Journal of Molecular Biology 421:2-3, pages 142-159.
Crossref
S. Nasoohi, A.A. Hemmati, F. Moradi & A. Ahmadiani. (2012) The γ-secretase blocker DAPT impairs recovery from lipopolysaccharide-induced inflammation in rat brain. Neuroscience 210, pages 99-109.
Crossref
E. Anders Kolb, Richard Gorlick, Stephen T. Keir, John M. Maris, Richard Lock, Hernan Carol, Raushan T. Kurmasheva, C. Patrick Reynolds, Min H. Kang, Jianrong Wu, Peter J. Houghton & Malcolm A. Smith. (2011) Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ‐secretase inhibitor targeting notch signaling. Pediatric Blood & Cancer 58:5, pages 815-818.
Crossref
Ting Li, Yunhong Huang, Shiyi Jin, Liang Ye, Na Rong, Xiujuan Yang, Yu Ding, Ziqiang Cheng, Jinqiang Zhang, Zehong Wan, David C. Harrison, Ishrut Hussain, Adrian Hall, Daniel Hong Seng Lee, Lit-Fui Lau & Yasuji Matsuoka. (2012) γ-Secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment. Journal of Neurochemistry 121:2, pages 277-286.
Crossref
Ji-Yeun Hur, Yasuhiro Teranishi, Takahiro Kihara, Natsuko Goto Yamamoto, Mitsuhiro Inoue, Waltteri Hosia, Masakazu Hashimoto, Bengt Winblad, Susanne Frykman & Lars O. Tjernberg. (2012) Identification of Novel γ-Secretase-associated Proteins in Detergent-resistant Membranes from Brain. Journal of Biological Chemistry 287:15, pages 11991-12005.
Crossref
Haythum O. Tayeb, Hyun Duk Yang, Bruce H. Price & Frank I. Tarazi. (2012) Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors. Pharmacology & Therapeutics 134:1, pages 8-25.
Crossref
Johannes Prox, Andrea Rittger & Paul Saftig. (2011) Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin. Experimental Brain Research 217:3-4, pages 331-341.
Crossref
Željko M. Svedružić, Katarina Popović, Ivana Smoljan & Vesna Šendula-Jengić. (2012) Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease. PLoS ONE 7:3, pages e32293.
Crossref
Michael C Woodward. (2012) Drug Treatments in Development for Alzheimer's Disease. Journal of Pharmacy Practice and Research 42:1, pages 58-65.
Crossref
Francesco PanzaVincenza Frisardi, Vincenzo Solfrizzi, Bruno P Imbimbo, Giancarlo Logroscino, Andrea Santamato, Antonio Greco, Davide Seripa & Alberto Pilotto. (2012) Immunotherapy for Alzheimer’s disease: from anti-β-amyloid to tau-based immunization strategies. Immunotherapy 4:2, pages 213-238.
Crossref
Mateen C. Moghbel, Babak Saboury, Sandip Basu, Scott D. Metzler, Drew A. Torigian, Bengt Långström & Abass Alavi. (2011) Amyloid-β imaging with PET in Alzheimer’s disease: is it feasible with current radiotracers and technologies?. European Journal of Nuclear Medicine and Molecular Imaging 39:2, pages 202-208.
Crossref
Thorsten Jumpertz, Andreas Rennhack, Julia Ness, Sandra Baches, Claus U. Pietrzik, Bruno Bulic & Sascha Weggen. (2012) Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells. PLoS ONE 7:1, pages e30484.
Crossref
Christine E. Oborski, Rathna Iyer, Bruce A. Maguire, Gary Bora, Kevin Atchison, Nikolay Pozdnyakov, Kathleen Wood, Christine Parker, Timothy A. Subashi, Martin Pettersson, Douglas S. Johnson & Kelly R. Bales. (2012) Pharmacological Assessment of <i>γ</i>-Secretase Activity from Rodent and Human Brain. Neuroscience and Medicine 03:02, pages 149-161.
Crossref
Hui Wang, Andrea Megill, Kaiwen He, Alfredo Kirkwood & Hey-Kyoung Lee. (2012) Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity. Neural Plasticity 2012, pages 1-24.
Crossref
Barbara Tate, Timothy D. McKee, Robyn M. B. Loureiro, Jo Ann Dumin, Weiming Xia, Kevin Pojasek, Wesley F. Austin, Nathan O. Fuller, Jed L. Hubbs, Ruichao Shen, Jeff Jonker, Jeff Ives & Brian S. Bronk. (2012) Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease. International Journal of Alzheimer's Disease 2012, pages 1-10.
Crossref
Michael S. Wolfe. 2012. Current State of Alzheimer's Disease Research and Therapeutics. Current State of Alzheimer's Disease Research and Therapeutics 127 153 .
Y. Lu, L. Zhang, C. E. Nolan, S. L. Becker, K. Atchison, A. E. Robshaw, L. R. Pustilnik, S. M. Osgood, E. H. Miller, A. F. Stepan, C. Subramanyam, I. Efremov, A. J. Hallgren & D. Riddell. (2011) Quantitative Pharmacokinetic/Pharmacodynamic Analyses Suggest That the 129/SVE Mouse Is a Suitable Preclinical Pharmacology Model for Identifying Small-Molecule  -Secretase Inhibitors. Journal of Pharmacology and Experimental Therapeutics 339:3, pages 922-934.
Crossref
Thomas Lübbers, Alexander Flohr, Synese Jolidon, Pascale David-Pierson, Helmut Jacobsen, Laurence Ozmen & Karlheinz Baumann. (2011) Aminothiazoles as γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters 21:21, pages 6554-6558.
Crossref
D. R. George & P. J. Whitehouse. (2011) Marketplace of Memory: What the Brain Fitness Technology Industry Says About Us and How We Can Do Better. The Gerontologist 51:5, pages 590-596.
Crossref
Vincenza Frisardi, Francesco Panza, Davide Seripa, Tahira Farooqui & Akhlaq A. Farooqui. (2011) Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer’s disease pathology. Progress in Lipid Research 50:4, pages 313-330.
Crossref
Jun Qin, Wei Zhou, Xianhai Huang, Pawan Dhondi, Anandan Palani, Robert Aslanian, Zhaoning Zhu, William Greenlee, Mary Cohen-Williams, Nicholas Jones, Lynn Hyde & Lili Zhang. (2011) Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators. ACS Medicinal Chemistry Letters 2:6, pages 471-476.
Crossref
Taisuke Tomita & Philip C Wong. (2011) Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's. Alzheimer's Research & Therapy 3:2, pages 7.
Crossref
Anthony J. Veloso, Hiroyuki Yoshikawa, Xin R. Cheng, Eiichi Tamiya & Kagan Kerman. (2011) Optical trapping for the characterization of amyloid-beta aggregation kinetics. The Analyst 136:20, pages 4164.
Crossref

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