1,294
Views
110
CrossRef citations to date
0
Altmetric
Reviews

Targeting TRPV1 for pain relief: limits, losers and laurels

&
Pages 1351-1369 | Published online: 11 Jul 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Mengkang Gao, Yusui Wang, Lanqi Liu, Zhenrui Qiao & Lin Yan. (2021) A patent review of transient receptor potential vanilloid type 1 modulators (2014–present). Expert Opinion on Therapeutic Patents 31:2, pages 169-187.
Read now
Asia Fernández-Carvajal, Rosario González-Muñiz, Gregorio Fernández-Ballester & Antonio Ferrer-Montiel. (2020) Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels. Expert Opinion on Investigational Drugs 29:11, pages 1209-1222.
Read now
Hong Wang & Jan Siemens. (2015) TRP ion channels in thermosensation, thermoregulation and metabolism. Temperature 2:2, pages 178-187.
Read now
Yoonji Lee, Sunhye Hong, Minghua Cui, Pankaz K Sharma, Jeewoo Lee & Sun Choi. (2015) Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 – 2014). Expert Opinion on Therapeutic Patents 25:3, pages 291-318.
Read now
Kinga Sałat, Anna Jakubowska & Katarzyna Kulig. (2014) Zucapsaicin for the treatment of neuropathic pain. Expert Opinion on Investigational Drugs 23:10, pages 1433-1440.
Read now
Kinga Sałat, Paula Kowalczyk, Beata Gryzło, Anna Jakubowska & Katarzyna Kulig. (2014) New investigational drugs for the treatment of neuropathic pain. Expert Opinion on Investigational Drugs 23:8, pages 1093-1104.
Read now

Articles from other publishers (104)

Miao Zhang, Yueming Ma, Xianglu Ye, Ning Zhang, Lei Pan & Bing Wang. (2023) TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduction and Targeted Therapy 8:1.
Crossref
Cinder Faith Cohen, Jueun Roh, Sang Hoon Lee, Chul-Kyu Park & Temugin Berta. (2023) Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine. International Journal of Molecular Sciences 24:9, pages 7897.
Crossref
Corina Andrei, Anca Zanfirescu, George Mihai Nițulescu, Octavian Tudorel Olaru & Simona Negreș. (2023) Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand–Target Interaction. Plants 12:2, pages 339.
Crossref
Corina Andrei, Dragos Paul Mihai, Anca Zanfirescu, George Mihai Nitulescu & Simona Negres. (2022) In Silico Drug Repurposing Framework Predicts Repaglinide, Agomelatine and Protokylol as TRPV1 Modulators with Analgesic Activity. Pharmaceutics 14:12, pages 2563.
Crossref
Rongfang Nie, Qian Liu & Xiaosheng Wang. (2022) TRPV1 Is a Potential Tumor Suppressor for Its Negative Association with Tumor Proliferation and Positive Association with Antitumor Immune Responses in Pan-Cancer. Journal of Oncology 2022, pages 1-15.
Crossref
Antonella S. Ríos, Ana Paula De Vincenti, Mailin Casadei, Jorge B. Aquino, Pablo R. Brumovsky, Gustavo Paratcha & Fernanda Ledda. (2022) Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation. Development 149:16.
Crossref
Y. Oka, K. Takahashi & T. Ohta. (2022) The effects of vanilloid analogues structurally related to capsaicin on the transient receptor potential vanilloid 1 channel. Biochemistry and Biophysics Reports 30, pages 101243.
Crossref
Sung-Min Hwang, Youn-Yi Jo, Cinder Faith Cohen, Yong-Ho Kim, Temugin Berta & Chul-Kyu Park. (2022) Venom Peptide Toxins Targeting the Outer Pore Region of Transient Receptor Potential Vanilloid 1 in Pain: Implications for Analgesic Drug Development. International Journal of Molecular Sciences 23:10, pages 5772.
Crossref
Qiyun Wu, Panzhu Bai, Hongsheng Guo, Maggie S. S. Guo, Yingjie Xia, Yiteng Xia, Xiong Gao, Xiaoyang Wang, Jiahui Wu, Tina T. X. Dong & Karl W. K. Tsim. (2022) Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species. Frontiers in Pharmacology 13.
Crossref
Chu Xue, Si-Xue Liu, Jie Hu, Jin Huang, Hong-Min Liu, Zhi-Xia Qiu & Fang Huang. (2021) Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway. Chinese Medicine 16:1.
Crossref
Jin Mi Kang, Sun Ok Kwon, Jihyae Ann, Sunho Lee, Changhoon Kim, Nayeon Do, Jin Ju Jeong, Peter M. Blumberg, Heejin Ha, Thi Ngoc Lan Vu, Sanghee Yoon, Sun Choi, Robert Frank-Foltyn, Bernhard Lesch, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2021) 2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 48, pages 128266.
Crossref
Mihai-Daniel Dumitrache, Ana Jieanu, Cristian Scheau, Ioana Badarau, George Popescu, Ana Caruntu, Daniel Costache, Raluca Costache, Carolina Constantin, Monica Neagu & Constantin Caruntu. (2021) Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review). Experimental and Therapeutic Medicine 22:3.
Crossref
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus & Zsuzsanna Helyes. (2021) Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain. Biomedicines 9:7, pages 749.
Crossref
Michelle D. Bagood & R. Rivkah Isseroff. (2021) TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing. International Journal of Molecular Sciences 22:11, pages 6135.
Crossref
Vipin Arora, James N. Campbell & Man-Kyo Chung. (2021) Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain. Pharmacology & Therapeutics 220, pages 107743.
Crossref
Yaroslav M. Shuba. (2021) Beyond Neuronal Heat Sensing: Diversity of TRPV1 Heat-Capsaicin Receptor-Channel Functions. Frontiers in Cellular Neuroscience 14.
Crossref
Jin Mi Kang, Sun Ok Kwon, Jihyae Ann, Peter M. Blumberg, Heejin Ha, Young Dong Yoo, Robert Frank-Foltyn, Bernhard Lesch, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2020) Discovery of 1-(1H-indazol-4-yl)-3-((1-phenyl-1H-pyrazol-5-yl)methyl) ureas as potent and thermoneutral TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 30:23, pages 127548.
Crossref
Gang Wang, Xinglin Wang, Qian Gao, Ming Zhou & Ning Wang. (2020) Effects of Heating-Conduction Dry Needling Therapy on Rats with Chronic Myofascial Pain Syndrome. Journal of Manipulative and Physiological Therapeutics 43:5, pages 506-514.
Crossref
Songyeon Ahn, Yong Soo Kim, Myeong Seup Kim, Jihyae Ann, Heejin Ha, Young Dong Yoo, Young Ho Kim, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2020) Discovery of indane propanamides as potent and selective TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 30:3, pages 126838.
Crossref
Joris Vriens & Thomas Voets. (2019) Heat sensing involves a TR i Plet of ion channels . British Journal of Pharmacology 176:20, pages 3893-3898.
Crossref
Conrard & Tyteca. (2019) Regulation of Membrane Calcium Transport Proteins by the Surrounding Lipid Environment. Biomolecules 9:10, pages 513.
Crossref
Larry V. Pearce, Jihyae Ann, Peter M. Blumberg & Jeewoo Lee. (2019) Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level. Biomolecules & Therapeutics 27:5, pages 435-441.
Crossref
Thomas Voets, Joris Vriens & Rudi Vennekens. (2019) Targeting TRP Channels – Valuable Alternatives to Combat Pain, Lower Urinary Tract Disorders, and Type 2 Diabetes?. Trends in Pharmacological Sciences 40:9, pages 669-683.
Crossref
Julia R. Sondermann, Allison M. Barry, Olaf Jahn, Niklas Michel, Reham Abdelaziz, Sebastian Kügler, David Gomez-Varela & Manuela Schmidt. (2018) Vti1b promotes TRPV1 sensitization during inflammatory pain. Pain 160:2, pages 508-527.
Crossref
Tsuyoshi Majima, Kenichi Mori, Katsumi Kadekawa, Shun Takai, Yasuhito Funahashi, Bonnie Reinhart, William F. Goins, Momokazu Gotoh, Joseph C. Glorioso & Naoki Yoshimura. (2018) The effect of herpes simplex virus vector‐mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception . Neurourology and Urodynamics 38:2, pages 582-590.
Crossref
Ana M. Lucas-Osma, Yaqing Li, Katherine C Murray, Shihao Lin, Sophie Black, Marilee J Stephens, Andrew H. Ahn, Charles J. Heckman, Keith K. Fenrich, Karim Fouad & David J. Bennett. (2019) 5-HT1D receptors inhibit the monosynaptic stretch reflex by modulating C fibre activity. Journal of Neurophysiology.
Crossref
Ana M. Lucas-Osma, Yaqing Li, Shihao Lin, Sophie Black, Rahul Singla, Karim Fouad, Keith K. Fenrich & David J. Bennett. (2018) Extrasynaptic α 5 GABA A receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord . Journal of Neurophysiology 120:6, pages 2953-2974.
Crossref
Changhoon Kim, Jihyae Ann, Sunho Lee, Wei Sun, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2018) Discovery of 2-(3,5-difluoro-4-methylsulfonaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 28:14, pages 2539-2542.
Crossref
Changhoon Kim, Jihyae Ann, Sunho Lee, Eunhye Kim, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2018) 4-Aminophenyl acetamides and propanamides as potent transient receptor potential vanilloid 1 (TRPV1) ligands. Bioorganic & Medicinal Chemistry 26:15, pages 4509-4517.
Crossref
Mateus Fortes Rossato, Flavia Karine Rigo, Sara Marchesan Oliveira, Gustavo Petri Guerra, Cássia Regina Silva, Thiago Mattar Cunha, Marcus Vinícius Gomez, Juliano Ferreira & Gabriela Trevisan. (2018) Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents. European Journal of Pharmacology 828, pages 42-51.
Crossref
Seol Rin Park, Juhyun Kim, Sun Young Lee, Young-Ho Park & Hee-Doo Kim. (2018) 2-Methylacrylamide as a bioisoster of thiourea group for 1,3-dibenzylthioureido TRPV1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 28:11, pages 2080-2083.
Crossref
Jonathan G. Bonchak & Robert A. Swerlick. (2018) Emerging therapies for atopic dermatitis: TRPV1 antagonists. Journal of the American Academy of Dermatology 78:3, pages S63-S66.
Crossref
S Takai, T Majima, B Reinhart, W F Goins, Y Funahashi, M Gotoh, P Tyagi, J C Glorioso & N Yoshimura. (2018) Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1α in a rat cystitis model induced by hydrogen peroxide. Gene Therapy 25:1, pages 20-26.
Crossref
Chen Liao, Yan Liu, Chunxia Liu, Jiaqi Zhou, Huilan Li, Nasi Wang, Jieming Li, Taiyu Liu, Hesham Ghaleb, Wenlong Huang & Hai Qian. (2018) Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide. Bioorganic & Medicinal Chemistry 26:4, pages 845-854.
Crossref
Iga Hołyńska-Iwan, Inga Dziembowska, Paulina Smyk, Magdalena Lampka & Dorota Olszewska-Słonina. (2018) Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study. Skin Pharmacology and Physiology 31:1, pages 19-27.
Crossref
Félix Viana. 2018. Thermoregulation: From Basic Neuroscience to Clinical Neurology Part I. Thermoregulation: From Basic Neuroscience to Clinical Neurology Part I 103 119 .
Jason Kyung-soo Hong & Richard Rauck. 2018. Neuromodulation. Neuromodulation 847 860 .
A. B. Beckers, Z. Z. R. M. Weerts, Z. Helyes, A. A. M. Masclee & D. Keszthelyi. (2017) Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome. Alimentary Pharmacology & Therapeutics 46:10, pages 938-952.
Crossref
Elizabeth Simonsen, Paul Komenda, Blake Lerner, Nicole Askin, Clara Bohm, James Shaw, Navdeep Tangri & Claudio Rigatto. (2017) Treatment of Uremic Pruritus: A Systematic Review. American Journal of Kidney Diseases 70:5, pages 638-655.
Crossref
Toyonobu Maeda, Atsuko Suzuki, Kaori Koga, Chihiro Miyamoto, Yojiro Maehata, Shigeyuki Ozawa, Ryu-Ichiro Hata, Yoji Nagashima, Kazuki Nabeshima, Kaoru Miyazaki & Yasumasa Kato. (2017) TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells. Oncotarget 8:45, pages 78312-78326.
Crossref
Marianna Nalli, Giorgio Ortar, Aniello Schiano Moriello, Vincenzo Di Marzo & Luciano De Petrocellis. (2017) Effects of curcumin and curcumin analogues on TRP channels. Fitoterapia 122, pages 126-131.
Crossref
Sunho Lee, Changhoon Kim, Jihyae Ann, Shivaji A. Thorat, Eunhye Kim, Jongmi Park, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2017) Pyrazole C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 27:18, pages 4383-4388.
Crossref
Yelena Mostinski, Gilad Noy, Rakesh Kumar, Dmitry Tsvelikhovsky & Avi Priel. (2017) Tricyclic Spirolactones as Modular TRPV1 Synthetic Agonists. ACS Chemical Neuroscience 8:8, pages 1688-1696.
Crossref
Manuella R. Palhares, Juliana F. Silva, Marcio Junior S. Rezende, Duana C. Santos, Cláudio A. Silva-Junior, Márcia H. Borges, Juliano Ferreira, Marcus V. Gomez & Célio J. Castro-Junior. (2017) Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice. Life Sciences 182, pages 122-128.
Crossref
Mrudhula Baskaran, Padmamalini Baskaran, Navamoney Arulsamy & Baskaran Thyagarajan. (2017) Preparation and Evaluation of PLGA-Coated Capsaicin Magnetic Nanoparticles. Pharmaceutical Research 34:6, pages 1255-1263.
Crossref
Sunho Lee, Dong Wook Kang, HyungChul Ryu, Changhoon Kim, Jihyae Ann, Hobin Lee, Eunhye Kim, Sunhye Hong, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2017) t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry 25:8, pages 2451-2462.
Crossref
Ewa-Lena Johansson, Ewa Ternestén-Hasseus, Monika Fagevik Olsén & Eva Millqvist. (2017) Physical Therapy Treatment of Impaired Chest Mobility in Patients with Airway Sensory Hyperreactivity. Physiotherapy Research International 22:2, pages e1658.
Crossref
Julia Risso Parisi, Ana Laura Martins de Andrade, Josie Resende Torres Silva & Marcelo Lourenço Silva. (2017) Antiallodynic effect of intrathecal resiniferatoxin on neuropathic pain model of chronic constriction injury. Acta Neurobiologiae Experimentalis 77:4, pages 317-322.
Crossref
Ruili Li, Chao Zhao, Minna Yao, Ying Song, Yin Wu & Aidong Wen. (2017) Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain. Journal of Ethnopharmacology 195, pages 81-88.
Crossref
Won Uk Koh, Seong-Soo Choi, Ji Hyun Kim, Hye Joo Yoon, Ho-Soo Ahn, Sun Kyung Lee, Jeong Gil Leem, Jun Gol Song & Jin Woo Shin. (2016) The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8. BMC Neuroscience 17:1.
Crossref
Vincenzo Carnevale & Tibor Rohacs. (2016) TRPV1: A Target for Rational Drug Design. Pharmaceuticals 9:3, pages 52.
Crossref
Dorothy Brown. (2016) Resiniferatoxin: The Evolution of the “Molecular Scalpel” for Chronic Pain Relief. Pharmaceuticals 9:3, pages 47.
Crossref
Jihyae Ann, Wei Sun, Xing Zhou, Aeran Jung, Jisoo Baek, Sunho Lee, Changhoon Kim, Suyoung Yoon, Sunhye Hong, Sun Choi, Noe A. Turcios, Brienna K.A. Herold, Timothy E. Esch, Nancy E. Lewin, Adelle Abramovitz, Larry V. Pearce, Peter M. Blumberg & Jeewoo Lee. (2016) Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template. Bioorganic & Medicinal Chemistry Letters 26:15, pages 3603-3607.
Crossref
Eva Millqvist. (2016) TRPV1 and TRPM8 in Treatment of Chronic Cough. Pharmaceuticals 9:3, pages 45.
Crossref
Yi Dai. (2015) TRPs and pain. Seminars in Immunopathology 38:3, pages 277-291.
Crossref
Enrico Morera, Vincenzo Di Marzo, Ludovica Monti, Marco Allarà, Aniello Schiano Moriello, Marianna Nalli, Giorgio Ortar & Luciano De Petrocellis. (2016) Arylboronic acids as dual-action FAAH and TRPV1 ligands. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1401-1405.
Crossref
Jihyae Ann, Yooran Ki, Suyoung Yoon, Myeong Seop Kim, Jung-Un Lee, Changhoon Kim, Sunho Lee, Aeran Jung, Jisoo Baek, Sunhye Hong, Sun Choi, Larry V. Pearce, Timothy E. Esch, Noe A. Turcios, Nancy E. Lewin, Adebowale E. Ogunjirin, Brienna K.A. Herold, Anna K. McCall, Peter M. Blumberg & Jeewoo Lee. (2016) 2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry 24:6, pages 1231-1240.
Crossref
Jeffrey T. Kuethe, Michel Journet, Zhihui Peng, Dalian Zhao, Arlene McKeown & Guy R. Humphrey. (2016) Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist. Organic Process Research & Development 20:2, pages 227-232.
Crossref
Marianna Nalli, Giorgio Ortar, Aniello Schiano Moriello, Enrico Morera, Vincenzo Di Marzo & Luciano De Petrocellis. (2016) TRPA1 channels as targets for resveratrol and related stilbenoids. Bioorganic & Medicinal Chemistry Letters 26:3, pages 899-902.
Crossref
Ning-Ning Wei, Hai-Ning Lv, Yang Wu, Shi-Long Yang, Xiao-Ying Sun, Ren Lai, Yong Jiang & KeWei Wang. (2016) Selective Activation of Nociceptor TRPV1 Channel and Reversal of Inflammatory Pain in Mice by a Novel Coumarin Derivative Muralatin L from Murraya alata. Journal of Biological Chemistry 291:2, pages 640-651.
Crossref
Minghua Cui, Vijayakumar Gosu, Shaherin Basith, Sunhye Hong & Sun Choi. 2016. Ion channels as therapeutic targets, part B. Ion channels as therapeutic targets, part B 81 125 .
Roman V. Frolov & Matti Weckström. 2016. Ion Channels as Therapeutic Targets, Part A. Ion Channels as Therapeutic Targets, Part A 25 95 .
Tsuyoshi MajimaYasuhito FunahashiShun TakaiWilliam F. GoinsMomokazu GotohPradeep TyagiJoseph C. GloriosoNaoki Yoshimura. (2015) Herpes Simplex Virus Vector-Mediated Gene Delivery of Poreless TRPV1 Channels Reduces Bladder Overactivity and Nociception in Rats. Human Gene Therapy 26:11, pages 734-742.
Crossref
Jihyae Ann, Aeran Jung, Mi-Yeon Kim, Hyuk-Min Kim, HyungChul Ryu, Sunjoo Kim, Dong Wook Kang, Sunhye Hong, Minghua Cui, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2015) Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry 23:21, pages 6844-6854.
Crossref
Jialie Luo, Jing Feng, Shenbin Liu, Edgar T. Walters & Hongzhen Hu. (2015) Molecular and cellular mechanisms that initiate pain and itch. Cellular and Molecular Life Sciences 72:17, pages 3201-3223.
Crossref
Xiao-Li Ma, Fang-Xiong Zhang, Fei Dong, Lan Bao & Xu Zhang. (2015) Experimental Evidence for Alleviating Nociceptive Hypersensitivity by Single Application of Capsaicin. Molecular Pain 11, pages s12990-015-0019.
Crossref
Tieying Song, Liwen Wang, Kunfeng Gu, Yunliang Yang, Lijun Yang, Pengyu Ma, Xiaojing Ma, Jianhui Zhao, Ruyv Yan, Jiao Guan, Chunping Wang, Yan Qi & Jian Ya. (2015) Involvement of peripheral TRPV1 channels in the analgesic effects of thalidomide. Neurochemistry International 85-86, pages 40-45.
Crossref
Phuong-Thao Tran, Ho Shin Kim, Jihyae Ann, Sung-Eun Kim, Changhoon Kim, Mannkyu Hong, Van-Hai Hoang, Van T.H. Ngo, Sunhye Hong, Minghua Cui, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Thomas Christoph & Jeewoo Lee. (2015) α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 25:11, pages 2326-2330.
Crossref
Jingjie Wang, Dongyan Dai, Qianqian Qiu, Xin Deng, Haiyan Lin, Hai Qian & Wenlong Huang. (2015) Evaluation of Anti-inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen. Chemical Biology & Drug Design 85:5, pages 623-632.
Crossref
Scott Earley & Joseph E. Brayden. (2015) Transient Receptor Potential Channels in the Vasculature. Physiological Reviews 95:2, pages 645-690.
Crossref
HyungChul Ryu, Sejin Seo, Jee-Young Lee, Tae-Hwan Ha, Sunho Lee, Aeran Jung, Jihyae Ann, Sung-Eun Kim, Suyoung Yoon, Mannkyu Hong, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Klaus Schiene, Hannelore Stockhausen, Thomas Christoph, Sven Frormann & Jeewoo Lee. (2015) Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists. European Journal of Medicinal Chemistry 93, pages 101-108.
Crossref
Christina Hanack, Mirko Moroni, Wanessa C. Lima, Hagen Wende, Marieluise Kirchner, Lisa Adelfinger, Katrin Schrenk-Siemens, Anke Tappe-Theodor, Christiane Wetzel, P. Henning Kuich, Martin Gassmann, Dennis Roggenkamp, Bernhard Bettler, Gary R. Lewin, Matthias Selbach & Jan Siemens. (2015) GABA Blocks Pathological but Not Acute TRPV1 Pain Signals. Cell 160:4, pages 759-770.
Crossref
Wei Sun, Hyo-Shin Kim, Sunho Lee, Aeran Jung, Sung-Eun Kim, Jihyae Ann, Suyoung Yoon, Sun Choi, Jin Hee Lee, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Klaus Schiene, Hannelore Stockhausen, Thomas Christoph, Sven Frormann & Jeewoo Lee. (2015) 6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 25:4, pages 803-806.
Crossref
Lauren M. SloskyTally M. Largent-MilnesTodd W. Vanderah. (2015) Use of Animal Models in Understanding Cancer-induced Bone Pain. Cancer Growth and Metastasis 8s1, pages CGM.S21215.
Crossref
Fei Ren, Hong Zhang, Chao Qi, Mei-ling Gao, Hong Wang & Xia-qing Li. (2015) Blockade of transient receptor potential cation channel subfamily V member 1 promotes regeneration after sciatic nerve injury. Neural Regeneration Research 10:8, pages 1324.
Crossref
Ewa Ternesten-Hasséus, Ewa-Lena Johansson & Eva Millqvist. (2015) Cough reduction using capsaicin. Respiratory Medicine 109:1, pages 27-37.
Crossref
Balázs I. Tóth, Arpad Szallasi & Tamás Bíró. 2015. Pharmacology of Itch. Pharmacology of Itch 89 133 .
Giorgio Ortar, Aniello Schiano Moriello, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo & Luciano De Petrocellis. (2014) Effect of acyclic monoterpene alcohols and their derivatives on TRP channels. Bioorganic & Medicinal Chemistry Letters 24:23, pages 5507-5511.
Crossref
Gregory Dussor, J. Yan, Jennifer Y. Xie, Michael H. Ossipov, David W. Dodick & Frank Porreca. (2014) Targeting TRP Channels For Novel Migraine Therapeutics. ACS Chemical Neuroscience 5:11, pages 1085-1096.
Crossref
Mark S. Nash, J. Martin Verkuyl & Gurdip Bhalay. 2014. Ion Channel Drug Discovery. Ion Channel Drug Discovery 186 237 .
Eric A. Voight, Arthur R. Gomtsyan, Jerome F. Daanen, Richard J. Perner, Robert G. Schmidt, Erol K. Bayburt, Stanley DiDomenico, Heath A. McDonald, Pamela S. Puttfarcken, Jun Chen, Torben R. Neelands, Bruce R. Bianchi, Ping Han, Regina M. Reilly, Pamela H. Franklin, Jason A. Segreti, Richard A. Nelson, Zhi Su, Andrew J. King, James S. Polakowski, Scott J. Baker, Donna M. Gauvin, LaGeisha R. Lewis, Joseph P. Mikusa, Shailen K. Joshi, Connie R. Faltynek, Philip R. Kym & Michael E. Kort. (2014) Discovery of ( R )-1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy . Journal of Medicinal Chemistry 57:17, pages 7412-7424.
Crossref
Joris Vriens, Bernd Nilius & Thomas Voets. (2014) Peripheral thermosensation in mammals. Nature Reviews Neuroscience 15:9, pages 573-589.
Crossref
HyungChul Ryu, Sejin Seo, Seong-Hee Cho, Ho Shin Kim, Aeran Jung, Dong Wook Kang, Karam Son, Minghua Cui, Sun-hye Hong, Pankaz Kumar Sharma, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Hannelore Stockhausen, Klaus Schiene, Thomas Christoph, Sven Frormann & Jeewoo Lee. (2014) 2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 24:16, pages 4039-4043.
Crossref
HyungChul Ryu, Sejin Seo, Myeong Seop Kim, Mi-Yeon Kim, Ho Shin Kim, Jihyae Ann, Phuong-Thao Tran, Van-Hai Hoang, Jieun Byun, Minghua Cui, Karam Son, Pankaz Kumar Sharma, Sun Choi, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Babette-Yvonne Koegel, Thomas Christoph, Sven Frormann & Jeewoo Lee. (2014) 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 24:16, pages 4044-4047.
Crossref
Bernd Nilius & Arpad Szallasi. (2014) Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine. Pharmacological Reviews 66:3, pages 676-814.
Crossref
Saifudin Khalid, Robert Murdoch, Amy Newlands, Kevin Smart, Angela Kelsall, Kimberley Holt, Rachel Dockry, Ashley Woodcock & Jaclyn A. Smith. (2014) Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial. Journal of Allergy and Clinical Immunology 134:1, pages 56-62.e4.
Crossref
Ho Shin Kim, Mi-Kyoung Jin, Sang-Uk Kang, Ju-Ok Lim, Phuong-Thao Tran, Van-Hai Hoang, Jihyae Ann, Tae-Hwan Ha, Larry V. Pearce, Vladimir A. Pavlyukovets, Peter M. Blumberg & Jeewoo Lee. (2014) α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorganic & Medicinal Chemistry Letters 24:12, pages 2685-2688.
Crossref
Yosuke Kaneko & Arpad Szallasi. (2014) Transient receptor potential (TRP) channels: a clinical perspective. British Journal of Pharmacology 171:10, pages 2474-2507.
Crossref
Adrian T. Billeter, Jason L. Hellmann, Aruni Bhatnagar & Hiram C. Polk. (2014) Transient Receptor Potential Ion Channels. Annals of Surgery 259:2, pages 229-235.
Crossref
Ming-Gang Liu & Min Zhuo. (2014) No requirement of TRPV1 in long-term potentiation or long-term depression in the anterior cingulate cortex. Molecular Brain 7:1, pages 27.
Crossref
John F. Peppin & Marco Pappagallo. (2013) Capsaicinoids in the treatment of neuropathic pain: a review. Therapeutic Advances in Neurological Disorders 7:1, pages 22-32.
Crossref
Nissar A. Darmani, Seetha Chebolu, Weixia Zhong, Chung Trinh, Bryan McClanahan & Rajivinder S. Brar. (2014) Additive antiemetic efficacy of low-doses of the cannabinoid CB1/2 receptor agonist Δ9-THC with ultralow-doses of the vanilloid TRPV1 receptor agonist resiniferatoxin in the least shrew (Cryptotis parva). European Journal of Pharmacology 722, pages 147-155.
Crossref
Ulrich Wissenbach. 2014. Pathologies of Calcium Channels. Pathologies of Calcium Channels 549 575 .
Ute A. Hellmich & Rachelle Gaudet. 2014. Mammalian Transient Receptor Potential (TRP) Cation Channels. Mammalian Transient Receptor Potential (TRP) Cation Channels 991 1004 .
Istvan Nagy, Dominic Friston, João Sousa Valente, Jose Vicente Torres Perez & Anna P. Andreou. 2014. Capsaicin as a Therapeutic Molecule. Capsaicin as a Therapeutic Molecule 39 76 .
Jessica L. Esseltine & John D. Scott. (2013) AKAP signaling complexes: pointing towards the next generation of therapeutic targets?. Trends in Pharmacological Sciences 34:12, pages 648-655.
Crossref
Sabatino Maione, Barbara Costa & Vincenzo Di Marzo. (2013) Endocannabinoids: A unique opportunity to develop multitarget analgesics. Pain 154:Supplement 1, pages S87-S93.
Crossref
Tae-Hwan Ha, HyungChul Ryu, Sung-Eun Kim, Ho Shin Kim, Jihyae Ann, Phuong-Thao Tran, Van-Hai Hoang, Karam Son, Minghua Cui, Sun Choi, Peter M. Blumberg, Robert Frank, Gregor Bahrenberg, Klaus Schiene, Thomas Christoph, Sven Frormann & Jeewoo Lee. (2013) TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides. Bioorganic & Medicinal Chemistry 21:21, pages 6657-6664.
Crossref
David Julius. (2013) TRP Channels and Pain. Annual Review of Cell and Developmental Biology 29:1, pages 355-384.
Crossref
Sara L. Morales‐Lázaro, Sidney A. Simon & Tamara Rosenbaum. (2013) The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). The Journal of Physiology 591:13, pages 3109-3121.
Crossref
Shivaji A. Thorat, Dong Wook Kang, HyungChul Ryu, Myeong Seop Kim, Ho Shin Kim, Jihyae Ann, Taehwan Ha, Sung-Eun Kim, Karam Son, Sun Choi, Peter M. Blumberg, Robert Frank, Gregor Bahrenberg, Klaus Schiene, Thomas Christoph & Jeewoo Lee. (2013) 2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: Structure activity relationships of the 2-oxy pyridine C-region. European Journal of Medicinal Chemistry 64, pages 589-602.
Crossref
M. Kaßmann, C. Harteneck, Z. Zhu, B. Nürnberg, M. Tepel & M. Gollasch. (2013) Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney. Acta Physiologica 207:3, pages 546-564.
Crossref
Giorgio Ortar, Luciano De Petrocellis, Aniello Schiano Moriello, Marco Allarà, Enrico Morera, Marianna Nalli & Vincenzo Di Marzo. (2013) Tetrahydro-β-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels. Bioorganic & Medicinal Chemistry Letters 23:1, pages 138-142.
Crossref
Ismet Dorange, Rickard Forsblom, Istvan Macsari, Mats Svensson, Johan Bylund, Yevgeni Besidski, Jan Blid, Daniel Sohn & Ylva Gravenfors. (2012) Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists. Bioorganic & Medicinal Chemistry Letters 22:22, pages 6888-6895.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.