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Targeting angiopoietin-2 signaling in cancer therapy

, MD, , MD PhD & , MD
Pages 813-825 | Published online: 27 Apr 2013

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Xiaolan Yu, Jingfeng Sha, Shao Xiang, Sanhai Qin, Patricia Conrad, Santosh K. Ghosh, Aaron Weinberg & Fengchun Ye. (2016) Suppression of KSHV-induced angiopoietin-2 inhibits angiogenesis, infiltration of inflammatory cells, and tumor growth. Cell Cycle 15:15, pages 2053-2065.
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Articles from other publishers (29)

Komal Thapa, Heena Khan, Gagandeep Kaur, Puneet Kumar & Thakur Gurjeet Singh. (2023) Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development. Biochemical and Biophysical Research Communications 687, pages 149130.
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Ping Yu, Yaru Wang, Dahai Yuan, Yunqin Sun, Shuang Qin & Tianye Li. (2023) Vascular normalization: reshaping the tumor microenvironment and augmenting antitumor immunity for ovarian cancer. Frontiers in Immunology 14.
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Ying Zhang, Shoufang Xu, Feiyu Jiang, Mengsi Hu, Yetao Han, Yingjian Wang & Zhiwei Liu. (2023) A comprehensive insight into the role of molecular pathways affected by the Angiopoietin and Tie system involved in hematological malignancies' pathogenesis. Pathology - Research and Practice 248, pages 154677.
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Jia-Qi Zhu, Shu-Ran Fan, Xia Wei, Cui-Xian Zhang, Dong-Mei Zhang, Min-Feng Chen & Xixin He. (2022) Synthesis and biological evaluation of marine natural product, Cryptoechinuline D derivatives as novel antiangiogenic agents. Bioorganic & Medicinal Chemistry Letters 65, pages 128717.
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Tianyu Qin & Gang Chen. (2022) Recent advances in targeted therapy for ovarian cancer. Oncology and Translational Medicine, pages 28-35.
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Alicia González, Carolina Alonso-González, Alicia González-González, Javier Menéndez-Menéndez, Samuel Cos & Carlos Martínez-Campa. (2021) Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments. Cancers 13:13, pages 3263.
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El-Zahraa M. MeghezelHeba A. AhmedAshraf A AskarEmad Eldin NabilAshraf Elyamany. (2019) Role of Tie2, CD14, Angiopoietin as Angiogenetic Markers in Hepatocellular Carcinoma Complicating Hepatitis C Virus Infection. Journal of Hematology and Oncology Research 3:2, pages 23-34.
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Lijing Zhang, Yingqiu Qi, Huan Min, Chen Ni, Fei Wang, Bin Wang, Hao Qin, Yinlong Zhang, Guangna Liu, Yue Qin, Xixi Duan, Feng Li, Xuexiang Han, Ning Tao, Lirong Zhang, Zhihai Qin, Ying Zhao & Guangjun Nie. (2019) Cooperatively Responsive Peptide Nanotherapeutic that Regulates Angiopoietin Receptor Tie2 Activity in Tumor Microenvironment To Prevent Breast Tumor Relapse after Chemotherapy. ACS Nano 13:5, pages 5091-5102.
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Yuanyuan Shan, Binghe Wang & Jie Zhang. (2018) New strategies in achieving antiangiogenic effect: Multiplex inhibitors suppressing compensatory activations of RTKs. Medicinal Research Reviews 38:5, pages 1674-1705.
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Allison S. Harney, George S. Karagiannis, Jeanine Pignatelli, Bryan D. Smith, Ece Kadioglu, Scott C. Wise, Molly M. Hood, Michael D. Kaufman, Cynthia B. Leary, Wei-Ping Lu, Gada Al-Ani, Xiaoming Chen, David Entenberg, Maja H. Oktay, Yarong Wang, Lawrence Chun, Michele De Palma, Joan G. Jones, Daniel L. Flynn & John S. Condeelis. (2017) The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors. Molecular Cancer Therapeutics 16:11, pages 2486-2501.
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Ning Liang, Yaolan Li & Hau Yin Chung. (2017) Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. International Journal of Oncology 51:1, pages 213-222.
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Na Li, Yanjuan Lu, Daoming Li, Xiangyu Zheng, Jingyao Lian, Shanshan Li, Huijuan Cui, Linda Zhang, Luqian Sang, Ying Wang, Jane J. Yu & Taiying Lu. (2017) All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma. PLOS ONE 12:4, pages e0174555.
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P. Hillmann, D. Schmitz, J. Mestan, S. D’Alonzo & D. Fabbro. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 1 38 .
Zi-Xue Xuan, Su Zhang, Shou-Jun Yuan, Wei Wang & Jia Yu. (2016) Prognostic value of angiopoietin-2 in non-small cell lung cancer patients: a meta-analysis. World Journal of Surgical Oncology 14:1.
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Afshin Dowlati, Gordana Vlahovic, Ronald B. Natale, Erik Rasmussen, Indrajeet Singh, Yuying C. Hwang, John Rossi, Michael B. Bass, Gregory Friberg & Cheryl A. Pickett. (2016) A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors. Clinical Cancer Research 22:18, pages 4574-4584.
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Hyun Ho Han, Baek Gil Kim, Joo Hyun Lee, Suki Kang, Ji Eun Kim & Nam Hoon Cho. (2016) Angiopoietin-2 promotes ER+ breast cancer cell survival in bone marrow niche. Endocrine-Related Cancer 23:8, pages 609-623.
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Frederick Schatz, Ozlem Guzeloglu-Kayisli, Sefa Arlier, Umit A. Kayisli & Charles J. Lockwood. (2016) The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding. Human Reproduction Update 22:4, pages 497-515.
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Dianxi Zhu, Qifeng Xing, Ruiyuan Cao, Dongmei Zhao & Wu Zhong. (2016) Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N′-Diarylurea Derivatives. Molecules 21:5, pages 677.
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Sara Galac. (2016) Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine. Molecular and Cellular Endocrinology 421, pages 34-39.
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Ali SalajeghehAli Salajegheh. 2016. Angiogenesis in Health, Disease and Malignancy. Angiogenesis in Health, Disease and Malignancy 21 28 .
Suzanne A. Eccles, William Court & Lisa Patterson. 2016. Angiogenesis Protocols. Angiogenesis Protocols 121 147 .
Ana Luísa Coelho, António Manuel Araújo, Mónica Patrícia Gomes, Raquel Jorge Catarino, Elva Bonifácio Andrade, Agostinho Marques Lopes & Rui Manuel Medeiros. (2015) Combined Ang-2 and VEGF serum levels: holding hands as a new integral biomarker in non-small-cell lung cancers. Future Oncology 11:24, pages 3233-3242.
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Ping Yang, Na Chen, Jing-hui Jia, Xue-jiao Gao, Shi-han Li, Jing Cai & Zehua Wang. (2015) Tie-1: A potential target for anti-angiogenesis therapy. Journal of Huazhong University of Science and Technology [Medical Sciences] 35:5, pages 615-622.
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Tobias Hilbert & Sven Klaschik. (2015) The angiopoietin/TIE receptor system: Focusing its role for ischemia-reperfusion injury. Cytokine & Growth Factor Reviews 26:3, pages 281-291.
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Laura Rocchi, Stefano Caraffi, Roberto Perris & Domenica Mangieri. (2014) The angiogenic asset of soft tissue sarcomas: a new tool to discover new therapeutic targets. Bioscience Reports 34:6.
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Hao Hong, Feng Chen, Yin Zhang & Weibo Cai. (2014) New radiotracers for imaging of vascular targets in angiogenesis-related diseases. Advanced Drug Delivery Reviews 76, pages 2-20.
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Nicolò Rigamonti, Ece Kadioglu, Ioanna Keklikoglou, Céline Wyser Rmili, Ching Ching Leow & Michele De Palma. (2014) Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade. Cell Reports 8:3, pages 696-706.
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Chrissta X. Maracle & Sander W. Tas. (2014) Inhibitors of angiogenesis: Ready for prime time?. Best Practice & Research Clinical Rheumatology 28:4, pages 637-649.
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M.M.J. Kool, S. Galac, H.S. Kooistra & J.A. Mol. (2014) Expression of angiogenesis-related genes in canine cortisol-secreting adrenocortical tumors. Domestic Animal Endocrinology 47, pages 73-82.
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