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Rho-kinase inhibitors offer a new approach in the treatment of glaucoma

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Whayoung Lee, Yuko Miyagawa, Cassandra Long, Matthew Zhang, David K. C. Cooper & Hidetaka Hara. (2016) Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation. Ocular Immunology and Inflammation 24:5, pages 579-593.
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Jeong Goo Lee & Martin Heur. (2014) Interleukin-1β-Induced Wnt5a Enhances Human Corneal Endothelial Cell Migration through Regulation of Cdc42 and RhoA. Molecular and Cellular Biology 34:18, pages 3535-3545.
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Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker & Jeremy H. Herskowitz. (2021) Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons. Molecular Brain 14:1.
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Audrey J. Weber & Jeremy H. Herskowitz. (2021) Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease. Frontiers in Cellular Neuroscience 15.
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Vasudha Abbhi & Poonam Piplani. (2020) Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility. Current Medicinal Chemistry 27:14, pages 2222-2256.
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Kelsey M. Greathouse, Benjamin W. Henderson, Erik G. Gentry & Jeremy H. Herskowitz. (2019) Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. Behavioural Brain Research 373, pages 112083.
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Adrian Julian Marcus, Igor Iezhitsa, Renu Agarwal, Pavel Vassiliev, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova & Nafeeza Mohd Ismail. (2019) Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension. European Journal of Pharmacology 850, pages 75-87.
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Cherng-Ru Hsu, Yi-Hsun Chen, Chih-Peng Liu, Chih-Hung Chen, Kuo-Kuei Huang, Jui-Wen Huang, Meng-Nan Lin, Chih-Lung Lin, Wan-Ru Chen, Yi-Ling Hsu, Tze-chung Lee, Shuen-Hsiang Chou, Chia-Mu Tu, Chrong-Shiong Hwang, Yu Chuan Huang & Da-Wen Lu. (2019) A Highly Selective Rho-Kinase Inhibitor (ITRI-E-212) Potentially Treats Glaucoma Upon Topical Administration With Low Incidence of Ocular Hyperemia. Investigative Opthalmology & Visual Science 60:2, pages 624.
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Kelsey M. Greathouse, Benjamin D. Boros, Josue F. Deslauriers, Benjamin W. Henderson, Kendall A. Curtis, Erik G. Gentry & Jeremy H. Herskowitz. (2018) Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity. Brain Structure and Function 223:9, pages 4227-4241.
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Peter X. Shaw, Alan Sang, Yan Wang, Daisy Ho, Christopher Douglas, Lara Dia & Jeffrey L. Goldberg. (2017) Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Experimental Eye Research 158, pages 33-42.
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Hiroshi YamadaMasahiko YonedaShingo InagumaMasahiko GoshoYusuke MurasawaZenzo IsogaiMasahiro Zako. (2017) A Rho-Associated Kinase Inhibitor Protects Permeability in a Cell Culture Model of Ocular Disease, and Reduces Aqueous Flare in Anterior Uveitis. Journal of Ocular Pharmacology and Therapeutics 33:3, pages 176-185.
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K.M. Coxon, M. Pahlitzsch, B.M. Davis, J. Duggan, L. Guo & M.F. Cordeiro. 2017. Reference Module in Neuroscience and Biobehavioral Psychology. Reference Module in Neuroscience and Biobehavioral Psychology.
Karen Y. Torrejon, Ellen L. Papke, Justin R. Halman, Magnus Bergkvist, John Danias, Susan T. Sharfstein & Yubing Xie. (2016) TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor. Scientific Reports 6:1.
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Alon Skaat, Jessica V. Jasien & Robert Ritch. (2016) Efficacy of Topically Administered Rho-Kinase Inhibitor AR-12286 in Patients With Exfoliation Syndrome and Ocular Hypertension or Glaucoma. Journal of Glaucoma 25:9, pages e807-e814.
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Ganesh Prasanna, Byron Li, Muneto Mogi & Dennis S. Rice. (2016) Pharmacology of novel intraocular pressure-lowering targets that enhance conventional outflow facility: Pitfalls, promises and what lies ahead?. European Journal of Pharmacology 787, pages 47-56.
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Tanuj Dada, Parul Ichhpujani, Srinivasan Senthilkumari & Alain Bron. 2016. Pharmacology of Ocular Therapeutics. Pharmacology of Ocular Therapeutics 207 227 .
Jeremy Green, Jingrong Cao, Upul K. Bandarage, Huai Gao, John Court, Craig Marhefka, Marc Jacobs, Paul Taslimi, David Newsome, Tomoko Nakayama, Sundeep Shah & Steve Rodems. (2015) Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. Journal of Medicinal Chemistry 58:12, pages 5028-5037.
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Robert N Weinreb, Tuyen Ong, Baldo Scassellati Sforzolini, Jason L Vittitow, Kuldev Singh & Paul L Kaufman. (2015) A randomised, controlled comparison of latanoprostene bunod and latanoprost 0.005% in the treatment of ocular hypertension and open angle glaucoma: the VOYAGER study. British Journal of Ophthalmology 99:6, pages 738-745.
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Sergey Yur'yevich Petrov, Nataliya Nikolaevna Podgornaya, Anna Eduardovna Aslamazova & Dar'ya Maksimovna Safonova. (2015) Biomechanical studies of the iris and the trabecular meshwork. Ophthalmology Reports 8:1, pages 69-78.
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